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The map label for this gene is pgi [H]

Identifier: 94985405

GI number: 94985405

Start: 1384152

End: 1386101

Strand: Reverse

Name: pgi [H]

Synonym: Dgeo_1304

Alternate gene names: 94985405

Gene position: 1386101-1384152 (Counterclockwise)

Preceding gene: 94985408

Following gene: 94985404

Centisome position: 56.18

GC content: 65.18

Gene sequence:

>1950_bases
ATGACAGGAGATCCTTTCGCAAGAAGGTCGGGGGCAGGAGACGGGACAGTTCGACCGACATTCAAGCGCGGGCGGCACTC
GGTTTCCAGAGTCAGGGTCCGCTATTCGGAACGCCCGCACCTGACACTTGCGAGGTCAGACCCACGTGTTGGCCTGCACC
TCGCCACCGCCCCATGGTCAGAGGCTCCGGCCTTCTTTGCCGTCTCTTCATGCCAAGCCTTCCGGTTCGGGCGGATTGGG
GGCCGCTGGTATGCTCGCCCCATGCGTGACTCTTCCTCCCCGGCGCGGCCCTCCCTGACCCAGCTTCCCGCCTGGCAGGC
CCTGAAGTCGCACTTTGAGACGATGCGCGACAGGCATCTGCGCGACCTCTTCGCTGCCGACCCCCGGCGCGGCGAACGCC
TGGTTGCCGAGGGGGCGGGCGTCTACCTCGACTACTCCAAAAACCGCATAACGGACGAGACGCTGCGCCTGCTGCTGCAA
CTTGCGCGCGAAGCGGGGGTAGAGGCGCGGCGCGACGCAATGTTCGCGGGCGAGCGCATCAACCTGACGGAGAACCGCGC
GGTGCTGCATTCTGCCCTGCGCGCTCCGCGCGGCGCAGCCGTGACCGTGGACGGCACGAATGTGGTGCAGGAGGTGCAGG
AGGTGCTGGACCGCATGAGCGCCTTCGCGGACCGCGTGCGCGCCGGGACCTGGCTGGGCGCGACCGGCAAGCCCATCCGC
AACATCGTGAACATCGGCATCGGCGGCTCGGATCTCGGTCCGGTGATGGCCTACGAGGCGCTGAAGTTTTACGCGGACCG
CCGCCTCACGCTGCGCTTCGTGTCCAATGTGGACGGCACCGATCTGGTGGAGAAGACCCGCGACCTCGACCCGGCAGAAA
CCCTCTTCATCGTGTCCAGCAAGACCTTCACTACGCTGGAGACGATGGCGAACGCGCAAAGCGCGCGGGCCTGGCTGCTT
GCTGGGCTGGAGAACGTGCCGGATGAGAACGCGGCGATTGCCCGCCCCATCATCAGCAGGCACTTCGTCGCCGTCAGCAC
AAACGCTGCCGAGGTCGAGCGTTTCGGGATCGACACCGCGAACATGTTTGGCTTCTGGGACTGGGTGGGGGGCCGCTACA
GCGTGGACAGCGCAATCGGTCTCTCACTGATGATCGCCATCGGGCCGAACGGCTTCCGCGACTTTCTGGCGGGCTTTCAC
GCCATGGACGAGCATTTCCGCAGCGCGCCCCTGGAACAGAATCTCCCCGTCCTGCTGGGTGTTCTGGGCGTGTGGTACCG
TAACTTTTTCGGTGCGCAGACCTACGCGGTGCTGCCCTATGACCAGTACCTCGCCTACTTCCCGACCTATCTCCAGCAGC
TTGACATGGAGAGCAACGGCAAACACGTCACCCTCGACGGGCAACCGGTGGACTACGACACCGGCCCGGTGGTGTGGGGG
CAGCCGGGAACGAACGGCCAGCATGCCTTTTACCAACTCATCCACCAGGGCACCACGCTGATTCCCTGCGATTTCCTGGG
CTTCTGCCAGACCCTCAACCCCCTGCCCACCCCGGGCGGCCCCTCTCACCATGACCTCCTGATGGCGAACATGTTCGCAC
AGACCGAAGCCCTGGCCTTCGGCAAGTCGCTCGAGCAGGTGCAGGCTGAGGGGGTGGCCGCTGACCTCGCTCCACACCGC
GTCTTTGAGGGCAACCGGCCCACGAACACGCTGCTGTTAGACCGCCTCACGCCCCGCACGCTGGGCACCCTGATCGCCCT
CTACGAACACAAGGTCTTTGTGCAGGGTGCGATCTGGAACATCAACTCCTTTGATCAGTGGGGCGTCGAACTCGGTAAGG
TGCTGGCCAGCAAGATCGTGCCGGAACTGGAGGCGCCGGGCGAGCCGGAGCTGAAGCACGACTCCAGCACCAACGCCTTG
ATCCGGCGCTACCGAGCGCGCCGGAGATAA

Upstream 100 bases:

>100_bases
GCGCACAGCCGAGAGCGAACCGCGAATCGCGCCGATGGGCGAACGAACCGCGGAAACAATCACCACATCGCGGTCTTGCA
GGACAGGGGAGGAGGTGGAC

Downstream 100 bases:

>100_bases
GGGCGAGGGGGCAAATTGGGCCAGAGCCGTCCAGCCCCCCGCGCTCTCCACCGTTTGCTCGCCTGTTCCTCACCTCCTGC
CTCTAGCCTGCCGGGATGAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MTGDPFARRSGAGDGTVRPTFKRGRHSVSRVRVRYSERPHLTLARSDPRVGLHLATAPWSEAPAFFAVSSCQAFRFGRIG
GRWYARPMRDSSSPARPSLTQLPAWQALKSHFETMRDRHLRDLFAADPRRGERLVAEGAGVYLDYSKNRITDETLRLLLQ
LAREAGVEARRDAMFAGERINLTENRAVLHSALRAPRGAAVTVDGTNVVQEVQEVLDRMSAFADRVRAGTWLGATGKPIR
NIVNIGIGGSDLGPVMAYEALKFYADRRLTLRFVSNVDGTDLVEKTRDLDPAETLFIVSSKTFTTLETMANAQSARAWLL
AGLENVPDENAAIARPIISRHFVAVSTNAAEVERFGIDTANMFGFWDWVGGRYSVDSAIGLSLMIAIGPNGFRDFLAGFH
AMDEHFRSAPLEQNLPVLLGVLGVWYRNFFGAQTYAVLPYDQYLAYFPTYLQQLDMESNGKHVTLDGQPVDYDTGPVVWG
QPGTNGQHAFYQLIHQGTTLIPCDFLGFCQTLNPLPTPGGPSHHDLLMANMFAQTEALAFGKSLEQVQAEGVAADLAPHR
VFEGNRPTNTLLLDRLTPRTLGTLIALYEHKVFVQGAIWNINSFDQWGVELGKVLASKIVPELEAPGEPELKHDSSTNAL
IRRYRARRR

Sequences:

>Translated_649_residues
MTGDPFARRSGAGDGTVRPTFKRGRHSVSRVRVRYSERPHLTLARSDPRVGLHLATAPWSEAPAFFAVSSCQAFRFGRIG
GRWYARPMRDSSSPARPSLTQLPAWQALKSHFETMRDRHLRDLFAADPRRGERLVAEGAGVYLDYSKNRITDETLRLLLQ
LAREAGVEARRDAMFAGERINLTENRAVLHSALRAPRGAAVTVDGTNVVQEVQEVLDRMSAFADRVRAGTWLGATGKPIR
NIVNIGIGGSDLGPVMAYEALKFYADRRLTLRFVSNVDGTDLVEKTRDLDPAETLFIVSSKTFTTLETMANAQSARAWLL
AGLENVPDENAAIARPIISRHFVAVSTNAAEVERFGIDTANMFGFWDWVGGRYSVDSAIGLSLMIAIGPNGFRDFLAGFH
AMDEHFRSAPLEQNLPVLLGVLGVWYRNFFGAQTYAVLPYDQYLAYFPTYLQQLDMESNGKHVTLDGQPVDYDTGPVVWG
QPGTNGQHAFYQLIHQGTTLIPCDFLGFCQTLNPLPTPGGPSHHDLLMANMFAQTEALAFGKSLEQVQAEGVAADLAPHR
VFEGNRPTNTLLLDRLTPRTLGTLIALYEHKVFVQGAIWNINSFDQWGVELGKVLASKIVPELEAPGEPELKHDSSTNAL
IRRYRARRR
>Mature_648_residues
TGDPFARRSGAGDGTVRPTFKRGRHSVSRVRVRYSERPHLTLARSDPRVGLHLATAPWSEAPAFFAVSSCQAFRFGRIGG
RWYARPMRDSSSPARPSLTQLPAWQALKSHFETMRDRHLRDLFAADPRRGERLVAEGAGVYLDYSKNRITDETLRLLLQL
AREAGVEARRDAMFAGERINLTENRAVLHSALRAPRGAAVTVDGTNVVQEVQEVLDRMSAFADRVRAGTWLGATGKPIRN
IVNIGIGGSDLGPVMAYEALKFYADRRLTLRFVSNVDGTDLVEKTRDLDPAETLFIVSSKTFTTLETMANAQSARAWLLA
GLENVPDENAAIARPIISRHFVAVSTNAAEVERFGIDTANMFGFWDWVGGRYSVDSAIGLSLMIAIGPNGFRDFLAGFHA
MDEHFRSAPLEQNLPVLLGVLGVWYRNFFGAQTYAVLPYDQYLAYFPTYLQQLDMESNGKHVTLDGQPVDYDTGPVVWGQ
PGTNGQHAFYQLIHQGTTLIPCDFLGFCQTLNPLPTPGGPSHHDLLMANMFAQTEALAFGKSLEQVQAEGVAADLAPHRV
FEGNRPTNTLLLDRLTPRTLGTLIALYEHKVFVQGAIWNINSFDQWGVELGKVLASKIVPELEAPGEPELKHDSSTNALI
RRYRARRR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=565, Percent_Identity=52.212389380531, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI296080693, Length=573, Percent_Identity=48.8656195462478, Blast_Score=535, Evalue=1e-152,
Organism=Escherichia coli, GI1790457, Length=558, Percent_Identity=55.1971326164875, Blast_Score=611, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI71996708, Length=565, Percent_Identity=53.2743362831858, Blast_Score=570, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71996703, Length=557, Percent_Identity=53.5008976660682, Blast_Score=569, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319673, Length=564, Percent_Identity=51.9503546099291, Blast_Score=579, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24651916, Length=567, Percent_Identity=53.6155202821869, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24651914, Length=567, Percent_Identity=53.6155202821869, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI17737445, Length=567, Percent_Identity=53.6155202821869, Blast_Score=591, Evalue=1e-169,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 71948; Mature: 71817

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGDPFARRSGAGDGTVRPTFKRGRHSVSRVRVRYSERPHLTLARSDPRVGLHLATAPWS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEECCCCCCEEEEEECCCC
EAPAFFAVSSCQAFRFGRIGGRWYARPMRDSSSPARPSLTQLPAWQALKSHFETMRDRHL
CCCCEEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHH
RDLFAADPRRGERLVAEGAGVYLDYSKNRITDETLRLLLQLAREAGVEARRDAMFAGERI
HHHHHCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCEE
NLTENRAVLHSALRAPRGAAVTVDGTNVVQEVQEVLDRMSAFADRVRAGTWLGATGKPIR
CCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHH
NIVNIGIGGSDLGPVMAYEALKFYADRRLTLRFVSNVDGTDLVEKTRDLDPAETLFIVSS
HHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEC
KTFTTLETMANAQSARAWLLAGLENVPDENAAIARPIISRHFVAVSTNAAEVERFGIDTA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEEEECCHHHHHHHCCCHH
NMFGFWDWVGGRYSVDSAIGLSLMIAIGPNGFRDFLAGFHAMDEHFRSAPLEQNLPVLLG
HHHHHHHCCCCCEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGVWYRNFFGAQTYAVLPYDQYLAYFPTYLQQLDMESNGKHVTLDGQPVDYDTGPVVWG
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEC
QPGTNGQHAFYQLIHQGTTLIPCDFLGFCQTLNPLPTPGGPSHHDLLMANMFAQTEALAF
CCCCCCHHHHHHHHHCCCEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GKSLEQVQAEGVAADLAPHRVFEGNRPTNTLLLDRLTPRTLGTLIALYEHKVFVQGAIWN
HHHHHHHHHCCCHHHCCCHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHCEEEEEEEEEC
INSFDQWGVELGKVLASKIVPELEAPGEPELKHDSSTNALIRRYRARRR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TGDPFARRSGAGDGTVRPTFKRGRHSVSRVRVRYSERPHLTLARSDPRVGLHLATAPWS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEECCCCCCEEEEEECCCC
EAPAFFAVSSCQAFRFGRIGGRWYARPMRDSSSPARPSLTQLPAWQALKSHFETMRDRHL
CCCCEEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHH
RDLFAADPRRGERLVAEGAGVYLDYSKNRITDETLRLLLQLAREAGVEARRDAMFAGERI
HHHHHCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCEE
NLTENRAVLHSALRAPRGAAVTVDGTNVVQEVQEVLDRMSAFADRVRAGTWLGATGKPIR
CCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHH
NIVNIGIGGSDLGPVMAYEALKFYADRRLTLRFVSNVDGTDLVEKTRDLDPAETLFIVSS
HHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEC
KTFTTLETMANAQSARAWLLAGLENVPDENAAIARPIISRHFVAVSTNAAEVERFGIDTA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEEEECCHHHHHHHCCCHH
NMFGFWDWVGGRYSVDSAIGLSLMIAIGPNGFRDFLAGFHAMDEHFRSAPLEQNLPVLLG
HHHHHHHCCCCCEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGVWYRNFFGAQTYAVLPYDQYLAYFPTYLQQLDMESNGKHVTLDGQPVDYDTGPVVWG
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEC
QPGTNGQHAFYQLIHQGTTLIPCDFLGFCQTLNPLPTPGGPSHHDLLMANMFAQTEALAF
CCCCCCHHHHHHHHHCCCEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GKSLEQVQAEGVAADLAPHRVFEGNRPTNTLLLDRLTPRTLGTLIALYEHKVFVQGAIWN
HHHHHHHHHCCCHHHCCCHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHCEEEEEEEEEC
INSFDQWGVELGKVLASKIVPELEAPGEPELKHDSSTNALIRRYRARRR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA