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The map label for this gene is upp [H]

Identifier: 94985397

GI number: 94985397

Start: 1376123

End: 1376746

Strand: Reverse

Name: upp [H]

Synonym: Dgeo_1296

Alternate gene names: 94985397

Gene position: 1376746-1376123 (Counterclockwise)

Preceding gene: 94985398

Following gene: 94985396

Centisome position: 55.8

GC content: 66.51

Gene sequence:

>624_bases
ATGCTGACTGTTGTCACCCATCCGCTCGTCCAGCACAAGCTCTCCCTGATGCGCGACGTTCACACCGGCGTCAAGGAATT
TCGCGAGCTGGCTGCCGAGGTGTCCATGCTGCTCGCCTACGAGGCGATGCGCGACCTCGAACTGGAACCCACCCGCCTGC
AAACGCCCCTTCAGGAGGGTGAATTCCCGATGCTCAGCGGCAAGAAGCTCGCGCTGGTCGCCATCTTGCGCGCGGGGCTG
GTGATGACCGACGCCATCGTGAATCTGGTGCCTGCCGCGAAGGTGGGTCACATCGGCCTCTACCGCGATCCCCAGACCCT
CCAGCCCGTCGCCTACTACAACAAGCTCCCTGCCGACATCGCGGACCGCCGGGTTTTTCTCACCGATCCGATGCTGGCCA
CCGGGGGCAGCGCCGCCGCAGCGATCGCGTCCCTGAAGGCGGCCGGCGCTCAGAGCATCAAGCTGATGTCCATCCTCGCC
GCGCCCGAGGGCGTCGCCGCCGTGGAACGCGACCACCCCGACGTGGAGATCGTGGTCGCCGCGGTGGACGAGCGGCTGAA
CGACCACGGCTACATCGTGCCGGGCCTAGGGGACGCGGGGGACCGGATCTACGGAACCAAATAG

Upstream 100 bases:

>100_bases
GAAGAGGCTGCCGCTCAACACGTTGGCTCAGCACTTCGGCGCAACACTTCGGCGCAACGCCCGGTGTCCACAGGCTGCAT
GTCCCCGCTATCGTGAGGCC

Downstream 100 bases:

>100_bases
GCCCACATGGGGGCAAGCCCGGGCGTGAGCTTCCTGCCCTTCCTTCCCCCCGAGCCTTTAGACTCCAGTCAGCTTATGGA
GTTCCTCAAGGCCCTCGCGG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLTVVTHPLVQHKLSLMRDVHTGVKEFRELAAEVSMLLAYEAMRDLELEPTRLQTPLQEGEFPMLSGKKLALVAILRAGL
VMTDAIVNLVPAAKVGHIGLYRDPQTLQPVAYYNKLPADIADRRVFLTDPMLATGGSAAAAIASLKAAGAQSIKLMSILA
APEGVAAVERDHPDVEIVVAAVDERLNDHGYIVPGLGDAGDRIYGTK

Sequences:

>Translated_207_residues
MLTVVTHPLVQHKLSLMRDVHTGVKEFRELAAEVSMLLAYEAMRDLELEPTRLQTPLQEGEFPMLSGKKLALVAILRAGL
VMTDAIVNLVPAAKVGHIGLYRDPQTLQPVAYYNKLPADIADRRVFLTDPMLATGGSAAAAIASLKAAGAQSIKLMSILA
APEGVAAVERDHPDVEIVVAAVDERLNDHGYIVPGLGDAGDRIYGTK
>Mature_207_residues
MLTVVTHPLVQHKLSLMRDVHTGVKEFRELAAEVSMLLAYEAMRDLELEPTRLQTPLQEGEFPMLSGKKLALVAILRAGL
VMTDAIVNLVPAAKVGHIGLYRDPQTLQPVAYYNKLPADIADRRVFLTDPMLATGGSAAAAIASLKAAGAQSIKLMSILA
APEGVAAVERDHPDVEIVVAAVDERLNDHGYIVPGLGDAGDRIYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=34.1584158415842, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=34.1584158415842, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=25.8823529411765, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=52.7093596059113, Blast_Score=223, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17539892, Length=210, Percent_Identity=27.1428571428571, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=210, Percent_Identity=27.1428571428571, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=34.375, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45550449, Length=208, Percent_Identity=33.1730769230769, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28573516, Length=208, Percent_Identity=33.1730769230769, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28573514, Length=208, Percent_Identity=33.1730769230769, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28573512, Length=208, Percent_Identity=33.1730769230769, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22212; Mature: 22212

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVVTHPLVQHKLSLMRDVHTGVKEFRELAAEVSMLLAYEAMRDLELEPTRLQTPLQEG
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHCC
EFPMLSGKKLALVAILRAGLVMTDAIVNLVPAAKVGHIGLYRDPQTLQPVAYYNKLPADI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHCCCCCH
ADRRVFLTDPMLATGGSAAAAIASLKAAGAQSIKLMSILAAPEGVAAVERDHPDVEIVVA
HCCEEEEECCCHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHCCCCCCEEEEE
AVDERLNDHGYIVPGLGDAGDRIYGTK
EHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLTVVTHPLVQHKLSLMRDVHTGVKEFRELAAEVSMLLAYEAMRDLELEPTRLQTPLQEG
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHCC
EFPMLSGKKLALVAILRAGLVMTDAIVNLVPAAKVGHIGLYRDPQTLQPVAYYNKLPADI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHCCCCCH
ADRRVFLTDPMLATGGSAAAAIASLKAAGAQSIKLMSILAAPEGVAAVERDHPDVEIVVA
HCCEEEEECCCHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHCCCCCCEEEEE
AVDERLNDHGYIVPGLGDAGDRIYGTK
EHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]