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The map label for this gene is dxr [H]

Identifier: 94985148

GI number: 94985148

Start: 1116145

End: 1117308

Strand: Reverse

Name: dxr [H]

Synonym: Dgeo_1044

Alternate gene names: 94985148

Gene position: 1117308-1116145 (Counterclockwise)

Preceding gene: 94985149

Following gene: 94985147

Centisome position: 45.29

GC content: 69.76

Gene sequence:

>1164_bases
ATGAAGCTGACGGTTCTGGGCAGTACGGGCAGTATCGGCACGCAGGCGCTGGAGGTGGCGCGGGAACGCGGCTGGGAGAT
CGGGGCGCTCGCCGCAGGGCGCAATCTCGACCTGCTGGAAGCGCAGGTACGGGCGTTCCAGCCGCAGGTGGTGAGTGTGG
CGGCGGAGGTGTACGCGCAGGCGCGGCAGCGGCTGTCCGGCGTGCGGGTGATCGCGGACCCCACGGAGGCGGCGGCGCTG
CCCGCAGACGTGGTCGTCAACGCGATGAGCGGACTGGTTGGGTTGGCGCCCACGCGGGCAGCACTGGAAGCTGGGCAAGC
TCTGGCCCTGGCGACAAAAGAGGCCATGGTCACGGCAGCGCACCTGATGTGGGAGGCCGCAGCCAGCGGCGGCGGCTGCC
TCGTACCGGTCGATTCGGAACACACCGGCATGTACCAGTGCCTGACCGGCGAGGACCTCGCGGATGTAGCCGAACTGATT
CTGACGGCCTCGGGTGGCCCCTTTTGTGACGGCCCGGCGGACTTGAGCGGCGTGACGCCGGCCCAGGCCCTGAAGCATCC
CTCGTGGAAGATGGGACCGAAGGTAACGCTGGATTCCGCCACCCTGATGAACAAGGGGCTGGAGGTGATGGAGTGCGCTT
CCCTCTACGGCTTGCCCCTCTCGCAGGTGAGCGTCGTCGTGCATCCGCAGAGCATCGTCCACGCGGCGGTCCGCTTCCGC
GACGGCAGCCTGAAGGGACAGTTCGGACCGACCGACATGCGCCTGGCGATTGCCTACGCGATCGACGCCGCGCCGACCGG
AATGCGCCGCCCCGGTGACGTACGCGGGGCGCGGCGCGGGCCCGAGGTGGCCGAGCACTTGGGCTGGCCGCTGCAGGGGA
GCTGGGAGTTCCGCGCACCGGACGTGGCCCGCTTTCCCTGCCTGGATCTGGCCTACCGCGCAGGACAGGCGGGCGGCCTC
CTCCCGACAGCCCTGAACGCGGCGGATGAGGTGGCCGTGGAAGCCTTTCTGGACGGAAGAATCGGCTTTATGGACATCCC
GCGGCTGATCGAACGCGTGCTGGACGAGACGCCTGCCGGAGCGCTGACCTGGGAGACGCTGCTGGAGACAGACGCCTGGG
CGCGGGCGCGGGCCCAGGAACTGACGGTGGGGGTACGGGCGTGA

Upstream 100 bases:

>100_bases
GAATATCAGCGTGTTTACGCGGTGAGCGCGAGGAGCTGCTCTGAGCTTTTTTCACCCCTTCCCACCATCCGTCCGGCGCG
TATGCGCCATCCTGTCTCCA

Downstream 100 bases:

>100_bases
ATATTCTGCACAGCATTGCGGCGGCCCTCACCCCGGTGGGGCTGCTGTGGACCCTGGTCATCATCGGCGTGGCGACCTTT
CTGCACGAGCTGGCGCACTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKLTVLGSTGSIGTQALEVARERGWEIGALAAGRNLDLLEAQVRAFQPQVVSVAAEVYAQARQRLSGVRVIADPTEAAAL
PADVVVNAMSGLVGLAPTRAALEAGQALALATKEAMVTAAHLMWEAAASGGGCLVPVDSEHTGMYQCLTGEDLADVAELI
LTASGGPFCDGPADLSGVTPAQALKHPSWKMGPKVTLDSATLMNKGLEVMECASLYGLPLSQVSVVVHPQSIVHAAVRFR
DGSLKGQFGPTDMRLAIAYAIDAAPTGMRRPGDVRGARRGPEVAEHLGWPLQGSWEFRAPDVARFPCLDLAYRAGQAGGL
LPTALNAADEVAVEAFLDGRIGFMDIPRLIERVLDETPAGALTWETLLETDAWARARAQELTVGVRA

Sequences:

>Translated_387_residues
MKLTVLGSTGSIGTQALEVARERGWEIGALAAGRNLDLLEAQVRAFQPQVVSVAAEVYAQARQRLSGVRVIADPTEAAAL
PADVVVNAMSGLVGLAPTRAALEAGQALALATKEAMVTAAHLMWEAAASGGGCLVPVDSEHTGMYQCLTGEDLADVAELI
LTASGGPFCDGPADLSGVTPAQALKHPSWKMGPKVTLDSATLMNKGLEVMECASLYGLPLSQVSVVVHPQSIVHAAVRFR
DGSLKGQFGPTDMRLAIAYAIDAAPTGMRRPGDVRGARRGPEVAEHLGWPLQGSWEFRAPDVARFPCLDLAYRAGQAGGL
LPTALNAADEVAVEAFLDGRIGFMDIPRLIERVLDETPAGALTWETLLETDAWARARAQELTVGVRA
>Mature_387_residues
MKLTVLGSTGSIGTQALEVARERGWEIGALAAGRNLDLLEAQVRAFQPQVVSVAAEVYAQARQRLSGVRVIADPTEAAAL
PADVVVNAMSGLVGLAPTRAALEAGQALALATKEAMVTAAHLMWEAAASGGGCLVPVDSEHTGMYQCLTGEDLADVAELI
LTASGGPFCDGPADLSGVTPAQALKHPSWKMGPKVTLDSATLMNKGLEVMECASLYGLPLSQVSVVVHPQSIVHAAVRFR
DGSLKGQFGPTDMRLAIAYAIDAAPTGMRRPGDVRGARRGPEVAEHLGWPLQGSWEFRAPDVARFPCLDLAYRAGQAGGL
LPTALNAADEVAVEAFLDGRIGFMDIPRLIERVLDETPAGALTWETLLETDAWARARAQELTVGVRA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=402, Percent_Identity=37.8109452736318, Blast_Score=216, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40616; Mature: 40616

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTVLGSTGSIGTQALEVARERGWEIGALAAGRNLDLLEAQVRAFQPQVVSVAAEVYAQ
CEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHH
ARQRLSGVRVIADPTEAAALPADVVVNAMSGLVGLAPTRAALEAGQALALATKEAMVTAA
HHHHHCCCEEEECCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCCEEEHHHHHHHHHHH
HLMWEAAASGGGCLVPVDSEHTGMYQCLTGEDLADVAELILTASGGPFCDGPADLSGVTP
HHHHHHHCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
AQALKHPSWKMGPKVTLDSATLMNKGLEVMECASLYGLPLSQVSVVVHPQSIVHAAVRFR
HHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHHCCCHHHEEEEECCHHHHHHHHHCC
DGSLKGQFGPTDMRLAIAYAIDAAPTGMRRPGDVRGARRGPEVAEHLGWPLQGSWEFRAP
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCC
DVARFPCLDLAYRAGQAGGLLPTALNAADEVAVEAFLDGRIGFMDIPRLIERVLDETPAG
CCCCCCHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
ALTWETLLETDAWARARAQELTVGVRA
CCHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKLTVLGSTGSIGTQALEVARERGWEIGALAAGRNLDLLEAQVRAFQPQVVSVAAEVYAQ
CEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHH
ARQRLSGVRVIADPTEAAALPADVVVNAMSGLVGLAPTRAALEAGQALALATKEAMVTAA
HHHHHCCCEEEECCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCCEEEHHHHHHHHHHH
HLMWEAAASGGGCLVPVDSEHTGMYQCLTGEDLADVAELILTASGGPFCDGPADLSGVTP
HHHHHHHCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
AQALKHPSWKMGPKVTLDSATLMNKGLEVMECASLYGLPLSQVSVVVHPQSIVHAAVRFR
HHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHHCCCHHHEEEEECCHHHHHHHHHCC
DGSLKGQFGPTDMRLAIAYAIDAAPTGMRRPGDVRGARRGPEVAEHLGWPLQGSWEFRAP
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCC
DVARFPCLDLAYRAGQAGGLLPTALNAADEVAVEAFLDGRIGFMDIPRLIERVLDETPAG
CCCCCCHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
ALTWETLLETDAWARARAQELTVGVRA
CCHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]