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The map label for this gene is gyrA [H]

Identifier: 94985121

GI number: 94985121

Start: 1089765

End: 1092194

Strand: Reverse

Name: gyrA [H]

Synonym: Dgeo_1016

Alternate gene names: 94985121

Gene position: 1092194-1089765 (Counterclockwise)

Preceding gene: 94985126

Following gene: 94985120

Centisome position: 44.27

GC content: 63.62

Gene sequence:

>2430_bases
ATGACTGGAATCCATCCCGTTGACATCACCAGCGAAGTCAAGACCAACTTCATCAATTACGCGATGAACGTGATTGTGGA
CCGCGCGCTCCCCGACGTTCGCGACGGTCTCAAGCCGGTGCAGCGCCGAATCATGTACGCGATGCTGCAAGAAGGCCTCG
CCTCCAACCAGAAGCACGCCAAGTCGGCGGCGGTGGTGGGCGAGGTGATGAAGAAGTACCACCCGCACGGCGACGCCTCG
ATCTACGACGCGATGGTCCGGCTGGGCCAGTGGTGGAACATGCGCTACACCCTGGTGGATCCTCAGGGCAACTTCGGCTC
GATCGACGGCGACCCGCCCGCCGCCATGCGCTACACCGAAGCGCGCATGACCAAGATCGCGGAGGAGGTGCTGGCCGACC
TCGAAAAGGAGACGGTCCTCCTCAAGCCCAACTACGACGAGACGACCGTGGAACCGGCGGTGCTGCCATCGGCGGTGCCG
AACCTGCTGATCAACGGTGCGGCGGGCATCGCGGTGGGCATGGCGACGAACATCCCGCCGCACAACCTCACCGAGATCAG
CAACGGGCTGCTCGCCCTGATCGACAAGCCCGACATCACGCTCGACGAGATGATGACGCACGTTCTAGGGCCGGATTTTC
CGACCGGCGGCCGCATCTCGCGGCAGGGCATCCGTGAGGCGTATGCCACCGGACACGCCGGGCTGAAGGTGCGCGGCAAG
GCCCGGATTGATGAGAAGAACGGGCGGGCGCAGATCGTGATCACGGAAATCCCGTATCAGGTCAACAAGACCAATCTGAT
CCAGACGATCAGCGCGATGTACAAGGCCGGGAAGATTCCCGACATCTCCGCCCTGCGCGATGAGTCCGATCGCAAGGAAC
CGGTGCGCATTGTCGTGGAGCTGAAGCGCGGCGCGATTCCCACGCTGGTCCTGAACCAGCTCTACAAGTACACCCAGCTT
CAGAGCACCTTCACAGTGATGAATCTCAGCATCGTGAACGGCGAGCCGCGGGTGCTGCCGCTGATCGATACCATGCGCGC
CTTCCTCGATCACCGCCGCGACGTGGTGACCCGGCGCACACAGTACGACCTGAAGAAGGCTGAAGAACGCGCCCACATCC
TGGAAGGGTTGATCAAGGCGCTCGACCACATCGACGAGGTGATTGAGCGCATCCGGGCCAGCAACACGGCGGCCGAGGCC
CGCGACGCCCTGATGCAGCGCTTCACGCTGACCGAGATTCAGGCCCAGGCGATCCTGGACATGCGCCTCCAGCGCTTGGT
GGGGCTGGAACGCGAGAAGCTCGTGGCCGAGTACGACGAACTGCAGAAGGTGATTGCCCGGCTGCGCTCGATCCTGGGTG
ACGAGCGGCTGCTGTGGCGCGAGATCAAGAAGGAAATCCGCGATATCCGCGACCGCTACGGTGACGAGCGCCGCTCGACG
ATCACTGACCTGGAAGACGACATCTCCAAGGAAGACCTGATTGCCGTCGAGGACATGGTCATCACCATGACGAAGGCGGG
GTACCTCAAGCGCACCAAGCTGGATGCCTACCGGGCACAGAGCCGCGGCGGACGTGGCGCGAGCGGGGGGCGGCTGCGCG
AGGAGGATGCGAACACCAGGGTCTTTGTGGGATCCACGCACGACTACCTGCTGTTCTTCACAGATCAGGGCCGCGTCTTC
CACGAGAAGATCTACGACCTGCCGGAGGCGGGACGCGACGCAAAGGGAACCCACATCCGCAACCTGATTCCTGCGCTTCG
CGAAGACGAAAACATCGCCTCGGTGCTGAGCGTGAAAGGCTTCAACGAGCCGGGTTCCTTTGTCTTTGCCACCAAGCGCG
GCATGGTCAAAAAGACCCTGATCACCGAGTACGGCAACATCACCTCGGCGGGCCTGATTGCCATCAACCTGCAGCCTGGC
GACGAACTGATCGGCGTGGATATCCAGCGCGACGGGGACGACGTGGTACTGGCGACCAAGGAGGGCCAGGCCATGCGCTT
TGCGGCCACTGAGGTGCGCGACACTGGCCGCGCGACCCAAGGCGTGATTGGGATCCGCCTGCGCGAGGGCGACGAGGTGG
TCAGCATGGCGCTGGTGCCGAGCGGCGAGGAGAGCAGCGAACTGCTCGCGATCAGCGAGTGCGGCCTGGGCAAACGCACC
CCAGTCAGCGACTACCCCAGCAAGGGGCGCGGTGGCCTGGGCGTGATCACGCTGGACGTGACCGACAAGACCGGCAAGCT
GGTCGCGCTCACCCACGTGGCCGGAAACGAGGAATTGATGGTGCTCACCGAAAAGGGCACCGTGATTCGCACGCGCGTCG
AGGAGGTCCGGGTCACCGGCCGCAACGCGCAGGGCGTGAAGGTGATCAACCTCGGAGAAAAGGACCGCGTAATCAGCGCC
TTCCCGATCCGCCGCGAGGACGAACTGTAA

Upstream 100 bases:

>100_bases
ATGTGCTATACTTATTCCATCTCCGGCAAGGGCGCCGGACCGCTTCCTCTCTCGCCGTCAGCAAGCCCTGTCCGGCTGGC
GCGATCCTGACTGGAGTCTC

Downstream 100 bases:

>100_bases
AGTCCGGCGATCTCAGGCGTGCCCAGCCTGCGCGGCTGGGCGCTGTTGTTTGGAGCTGACTGTGCGAGTTGGCCTTTCCT
GCGCTGGCTGCTTCTCGTCT

Product: DNA gyrase, A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MTGIHPVDITSEVKTNFINYAMNVIVDRALPDVRDGLKPVQRRIMYAMLQEGLASNQKHAKSAAVVGEVMKKYHPHGDAS
IYDAMVRLGQWWNMRYTLVDPQGNFGSIDGDPPAAMRYTEARMTKIAEEVLADLEKETVLLKPNYDETTVEPAVLPSAVP
NLLINGAAGIAVGMATNIPPHNLTEISNGLLALIDKPDITLDEMMTHVLGPDFPTGGRISRQGIREAYATGHAGLKVRGK
ARIDEKNGRAQIVITEIPYQVNKTNLIQTISAMYKAGKIPDISALRDESDRKEPVRIVVELKRGAIPTLVLNQLYKYTQL
QSTFTVMNLSIVNGEPRVLPLIDTMRAFLDHRRDVVTRRTQYDLKKAEERAHILEGLIKALDHIDEVIERIRASNTAAEA
RDALMQRFTLTEIQAQAILDMRLQRLVGLEREKLVAEYDELQKVIARLRSILGDERLLWREIKKEIRDIRDRYGDERRST
ITDLEDDISKEDLIAVEDMVITMTKAGYLKRTKLDAYRAQSRGGRGASGGRLREEDANTRVFVGSTHDYLLFFTDQGRVF
HEKIYDLPEAGRDAKGTHIRNLIPALREDENIASVLSVKGFNEPGSFVFATKRGMVKKTLITEYGNITSAGLIAINLQPG
DELIGVDIQRDGDDVVLATKEGQAMRFAATEVRDTGRATQGVIGIRLREGDEVVSMALVPSGEESSELLAISECGLGKRT
PVSDYPSKGRGGLGVITLDVTDKTGKLVALTHVAGNEELMVLTEKGTVIRTRVEEVRVTGRNAQGVKVINLGEKDRVISA
FPIRREDEL

Sequences:

>Translated_809_residues
MTGIHPVDITSEVKTNFINYAMNVIVDRALPDVRDGLKPVQRRIMYAMLQEGLASNQKHAKSAAVVGEVMKKYHPHGDAS
IYDAMVRLGQWWNMRYTLVDPQGNFGSIDGDPPAAMRYTEARMTKIAEEVLADLEKETVLLKPNYDETTVEPAVLPSAVP
NLLINGAAGIAVGMATNIPPHNLTEISNGLLALIDKPDITLDEMMTHVLGPDFPTGGRISRQGIREAYATGHAGLKVRGK
ARIDEKNGRAQIVITEIPYQVNKTNLIQTISAMYKAGKIPDISALRDESDRKEPVRIVVELKRGAIPTLVLNQLYKYTQL
QSTFTVMNLSIVNGEPRVLPLIDTMRAFLDHRRDVVTRRTQYDLKKAEERAHILEGLIKALDHIDEVIERIRASNTAAEA
RDALMQRFTLTEIQAQAILDMRLQRLVGLEREKLVAEYDELQKVIARLRSILGDERLLWREIKKEIRDIRDRYGDERRST
ITDLEDDISKEDLIAVEDMVITMTKAGYLKRTKLDAYRAQSRGGRGASGGRLREEDANTRVFVGSTHDYLLFFTDQGRVF
HEKIYDLPEAGRDAKGTHIRNLIPALREDENIASVLSVKGFNEPGSFVFATKRGMVKKTLITEYGNITSAGLIAINLQPG
DELIGVDIQRDGDDVVLATKEGQAMRFAATEVRDTGRATQGVIGIRLREGDEVVSMALVPSGEESSELLAISECGLGKRT
PVSDYPSKGRGGLGVITLDVTDKTGKLVALTHVAGNEELMVLTEKGTVIRTRVEEVRVTGRNAQGVKVINLGEKDRVISA
FPIRREDEL
>Mature_808_residues
TGIHPVDITSEVKTNFINYAMNVIVDRALPDVRDGLKPVQRRIMYAMLQEGLASNQKHAKSAAVVGEVMKKYHPHGDASI
YDAMVRLGQWWNMRYTLVDPQGNFGSIDGDPPAAMRYTEARMTKIAEEVLADLEKETVLLKPNYDETTVEPAVLPSAVPN
LLINGAAGIAVGMATNIPPHNLTEISNGLLALIDKPDITLDEMMTHVLGPDFPTGGRISRQGIREAYATGHAGLKVRGKA
RIDEKNGRAQIVITEIPYQVNKTNLIQTISAMYKAGKIPDISALRDESDRKEPVRIVVELKRGAIPTLVLNQLYKYTQLQ
STFTVMNLSIVNGEPRVLPLIDTMRAFLDHRRDVVTRRTQYDLKKAEERAHILEGLIKALDHIDEVIERIRASNTAAEAR
DALMQRFTLTEIQAQAILDMRLQRLVGLEREKLVAEYDELQKVIARLRSILGDERLLWREIKKEIRDIRDRYGDERRSTI
TDLEDDISKEDLIAVEDMVITMTKAGYLKRTKLDAYRAQSRGGRGASGGRLREEDANTRVFVGSTHDYLLFFTDQGRVFH
EKIYDLPEAGRDAKGTHIRNLIPALREDENIASVLSVKGFNEPGSFVFATKRGMVKKTLITEYGNITSAGLIAINLQPGD
ELIGVDIQRDGDDVVLATKEGQAMRFAATEVRDTGRATQGVIGIRLREGDEVVSMALVPSGEESSELLAISECGLGKRTP
VSDYPSKGRGGLGVITLDVTDKTGKLVALTHVAGNEELMVLTEKGTVIRTRVEEVRVTGRNAQGVKVINLGEKDRVISAF
PIRREDEL

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=520, Percent_Identity=25, Blast_Score=85, Evalue=4e-16,
Organism=Homo sapiens, GI19913406, Length=190, Percent_Identity=31.5789473684211, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=845, Percent_Identity=48.7573964497041, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=805, Percent_Identity=35.1552795031056, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI212645845, Length=379, Percent_Identity=24.0105540897098, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=188, Percent_Identity=29.2553191489362, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=382, Percent_Identity=25.3926701570681, Blast_Score=76, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=33.5106382978723, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17136538, Length=367, Percent_Identity=23.9782016348774, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89895; Mature: 89764

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGIHPVDITSEVKTNFINYAMNVIVDRALPDVRDGLKPVQRRIMYAMLQEGLASNQKHA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KSAAVVGEVMKKYHPHGDASIYDAMVRLGQWWNMRYTLVDPQGNFGSIDGDPPAAMRYTE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
ARMTKIAEEVLADLEKETVLLKPNYDETTVEPAVLPSAVPNLLINGAAGIAVGMATNIPP
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
HNLTEISNGLLALIDKPDITLDEMMTHVLGPDFPTGGRISRQGIREAYATGHAGLKVRGK
CCHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEECC
ARIDEKNGRAQIVITEIPYQVNKTNLIQTISAMYKAGKIPDISALRDESDRKEPVRIVVE
EEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCEEEEEE
LKRGAIPTLVLNQLYKYTQLQSTFTVMNLSIVNGEPRVLPLIDTMRAFLDHRRDVVTRRT
ECCCCCHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHH
QYDLKKAEERAHILEGLIKALDHIDEVIERIRASNTAAEARDALMQRFTLTEIQAQAILD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MRLQRLVGLEREKLVAEYDELQKVIARLRSILGDERLLWREIKKEIRDIRDRYGDERRST
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHH
ITDLEDDISKEDLIAVEDMVITMTKAGYLKRTKLDAYRAQSRGGRGASGGRLREEDANTR
HHHHHHCCCHHHHEEHHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
VFVGSTHDYLLFFTDQGRVFHEKIYDLPEAGRDAKGTHIRNLIPALREDENIASVLSVKG
EEEECCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCC
FNEPGSFVFATKRGMVKKTLITEYGNITSAGLIAINLQPGDELIGVDIQRDGDDVVLATK
CCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEC
EGQAMRFAATEVRDTGRATQGVIGIRLREGDEVVSMALVPSGEESSELLAISECGLGKRT
CCCEEEEEHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCC
PVSDYPSKGRGGLGVITLDVTDKTGKLVALTHVAGNEELMVLTEKGTVIRTRVEEVRVTG
CCCCCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEEHHHHHEEC
RNAQGVKVINLGEKDRVISAFPIRREDEL
CCCCCEEEEECCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TGIHPVDITSEVKTNFINYAMNVIVDRALPDVRDGLKPVQRRIMYAMLQEGLASNQKHA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KSAAVVGEVMKKYHPHGDASIYDAMVRLGQWWNMRYTLVDPQGNFGSIDGDPPAAMRYTE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
ARMTKIAEEVLADLEKETVLLKPNYDETTVEPAVLPSAVPNLLINGAAGIAVGMATNIPP
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
HNLTEISNGLLALIDKPDITLDEMMTHVLGPDFPTGGRISRQGIREAYATGHAGLKVRGK
CCHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEECC
ARIDEKNGRAQIVITEIPYQVNKTNLIQTISAMYKAGKIPDISALRDESDRKEPVRIVVE
EEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCEEEEEE
LKRGAIPTLVLNQLYKYTQLQSTFTVMNLSIVNGEPRVLPLIDTMRAFLDHRRDVVTRRT
ECCCCCHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHH
QYDLKKAEERAHILEGLIKALDHIDEVIERIRASNTAAEARDALMQRFTLTEIQAQAILD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MRLQRLVGLEREKLVAEYDELQKVIARLRSILGDERLLWREIKKEIRDIRDRYGDERRST
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHH
ITDLEDDISKEDLIAVEDMVITMTKAGYLKRTKLDAYRAQSRGGRGASGGRLREEDANTR
HHHHHHCCCHHHHEEHHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
VFVGSTHDYLLFFTDQGRVFHEKIYDLPEAGRDAKGTHIRNLIPALREDENIASVLSVKG
EEEECCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCC
FNEPGSFVFATKRGMVKKTLITEYGNITSAGLIAINLQPGDELIGVDIQRDGDDVVLATK
CCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEC
EGQAMRFAATEVRDTGRATQGVIGIRLREGDEVVSMALVPSGEESSELLAISECGLGKRT
CCCEEEEEHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCC
PVSDYPSKGRGGLGVITLDVTDKTGKLVALTHVAGNEELMVLTEKGTVIRTRVEEVRVTG
CCCCCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEEHHHHHEEC
RNAQGVKVINLGEKDRVISAFPIRREDEL
CCCCCEEEEECCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]