Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 94985099

GI number: 94985099

Start: 1066801

End: 1068702

Strand: Reverse

Name: dxs

Synonym: Dgeo_0994

Alternate gene names: 94985099

Gene position: 1068702-1066801 (Counterclockwise)

Preceding gene: 94985100

Following gene: 94985095

Centisome position: 43.32

GC content: 65.72

Gene sequence:

>1902_bases
ATGAGTGAGCCAACTGCCAACCTCCAGCCTGCCAGCCGCACCCCGCTGCTGGACCGGGTGAATAGCCCGGAAGACCTCAA
ACGGCTCGGACGCGACCAGCTGCCCCAGCTCGCTGCCGAACTGCGCGAGGAGATCGTGCGGGTCTGCTCGGTGGGCGGTC
TGCACCTTGCCAGTTCCTTGGGCGCGACGGACCTGATCGTGGCACTACATTACGTGCTGCATTCGCCGCGCGACCGCATC
CTGTTCGACGTGGGGCATCAGGCCTACGCCCACAAGATGCTCACGGGCCGCCGCCACCTGATGCACACCGTCAAGAAGGA
AGGCGGGCTGTCGGGCTTCACCAAGGTGAGTGAGTCCGAACACGACGCCATCACGGTGGGCCATGCCAGCACCTCCCTCG
CCAATGCGCTGGGCATGGCGCTTGCACGGGACGCTTTGGGACAGGATTACAAGGTGGCTGCCGTGATCGGGGACGGCTCG
CTGACGGGCGGCATGGCGCTGGCGGCGCTGAATACCATCGGGGACCTGGGGCGGCGAATGCTGATTGTGCTCAACGACAA
CGAGATGAGCATCAGCGAGAACGTGGGGGCCATCAACCGCTTCATGCGGGGTCTCCAGGTGCAGAAGTGGTTCCAGGAGG
GCGAGGAAGCCGGGAAAAAGGCCGTGCAGGCGGTCAGCAAGCCGCTCGCCAACTTGATGAGCCGCGCCAAGAGTTCCACG
CGGCACTTTTTCGATCCCGCCAGTGTCAATCCCTTTGCCGCGATGGGCGTGCGCTATGTGGGACCGGTGGACGGCCACAA
CGTGCAGGAATTGGTGTGGCTGATCGAGCGGCTGGTCGACCTCGATGGGCCGACCATTCTGCACGTCGTCACCAAAAAGG
GCAAGGGCCTGAGCTACGCCGAGGCCGACCCGATCAAATGGCATGGCCCGGGCAAGTTTGACCCGGCGACGGGTGAGTCG
GTGCCCAGCAATGCCTACTCGTGGAGCAGCGCCTTTGGAGACGCGGTGACCGAGCTTGCACGGCTGGACCCCCGTACCTT
TGTGATCACGCCCGCGATGCGCGAGGGCAGCGGCCTGGTGCGCTACAGCCAGGTTCACCCCCACCGTTACCTGGATGTCG
GTATCGCGGAGGACGTGGCCGTCACCACGGCCGCCGGAATGGCGCTTCAGGGGATGCGGCCCATCGTGGCGATCTACTCC
ACTTTCCTGCAACGCGCCTACGATCAGGTGCTGCACGACGTCGCCATCGAGAATCTGAACGTGACCTTCGCCATCGACCG
TGGGGGCATCGTGGGCGCAGACGGAGCCACCCACAACGGCGTCTTCGACCTGAGTTACCTGCGCTCGATTCCGAATGTCG
GCATTGGCCTGCCGAAGGACGCCGCCGAGCTGCGCGGGATGCTGAAGTATGCCCAGGAGCATGCTGGCCCCTTCGCCATC
CGCTATCCGCGCGGCAACGTGGAACGCGTGCCGGAAGGCACCTGGCCGGAGCTGAGGTGGGGCACCTGGGAACGCTTGCA
AGACGGCGACGACGTGGTGATTCTGGCGGGAGGCAAGGCGCTGGAGTACGCGCTGAAGGCCGCCCGCGACCTCCCCGGCG
TGGGCGTGGTGAATGCCCGTTTCGTGAAGCCGCTCGACCAAGGGATGCTGCGCGAGGTGGCGACCAAAGCCCGCGCACTG
GTCACGGTGGAGGACAACACGGTCGTCGGTGGGTTCGGAAGTGCCGTCCTGGAAGCCCTCAGCGCGCTGGGGCTGAGAAC
CCCGGTGCGGGTTCTCGGCATCCCCGACGCGTTTCAGGATCACGCGACCGTAGAGAGCGTGCATGCCCGTGCGGGGATTG
ACGCGCCTGCCATCCGCACGGTCCTGGCCGAACTTGGCGTGGACGTGCCGCTGGAGGTCTAG

Upstream 100 bases:

>100_bases
ACCGGGCGCAACTTTGGTGGGAAGTAAGCATGCCGACCTTCCGCTACCCTGGGGGGATGACCCTCGCCGCCCCCTCTTCG
ACCTCTCCGGGAGGCCAGCC

Downstream 100 bases:

>100_bases
AGAAGGAGGTGTAGAGACCGGTCACGCGGGGCGTGACGCGGCTGGGGCTTGAAGCCTCAGCCGTTGCTTTCTACTCCCGC
ACCTGCCCGTCCCCCACGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MSEPTANLQPASRTPLLDRVNSPEDLKRLGRDQLPQLAAELREEIVRVCSVGGLHLASSLGATDLIVALHYVLHSPRDRI
LFDVGHQAYAHKMLTGRRHLMHTVKKEGGLSGFTKVSESEHDAITVGHASTSLANALGMALARDALGQDYKVAAVIGDGS
LTGGMALAALNTIGDLGRRMLIVLNDNEMSISENVGAINRFMRGLQVQKWFQEGEEAGKKAVQAVSKPLANLMSRAKSST
RHFFDPASVNPFAAMGVRYVGPVDGHNVQELVWLIERLVDLDGPTILHVVTKKGKGLSYAEADPIKWHGPGKFDPATGES
VPSNAYSWSSAFGDAVTELARLDPRTFVITPAMREGSGLVRYSQVHPHRYLDVGIAEDVAVTTAAGMALQGMRPIVAIYS
TFLQRAYDQVLHDVAIENLNVTFAIDRGGIVGADGATHNGVFDLSYLRSIPNVGIGLPKDAAELRGMLKYAQEHAGPFAI
RYPRGNVERVPEGTWPELRWGTWERLQDGDDVVILAGGKALEYALKAARDLPGVGVVNARFVKPLDQGMLREVATKARAL
VTVEDNTVVGGFGSAVLEALSALGLRTPVRVLGIPDAFQDHATVESVHARAGIDAPAIRTVLAELGVDVPLEV

Sequences:

>Translated_633_residues
MSEPTANLQPASRTPLLDRVNSPEDLKRLGRDQLPQLAAELREEIVRVCSVGGLHLASSLGATDLIVALHYVLHSPRDRI
LFDVGHQAYAHKMLTGRRHLMHTVKKEGGLSGFTKVSESEHDAITVGHASTSLANALGMALARDALGQDYKVAAVIGDGS
LTGGMALAALNTIGDLGRRMLIVLNDNEMSISENVGAINRFMRGLQVQKWFQEGEEAGKKAVQAVSKPLANLMSRAKSST
RHFFDPASVNPFAAMGVRYVGPVDGHNVQELVWLIERLVDLDGPTILHVVTKKGKGLSYAEADPIKWHGPGKFDPATGES
VPSNAYSWSSAFGDAVTELARLDPRTFVITPAMREGSGLVRYSQVHPHRYLDVGIAEDVAVTTAAGMALQGMRPIVAIYS
TFLQRAYDQVLHDVAIENLNVTFAIDRGGIVGADGATHNGVFDLSYLRSIPNVGIGLPKDAAELRGMLKYAQEHAGPFAI
RYPRGNVERVPEGTWPELRWGTWERLQDGDDVVILAGGKALEYALKAARDLPGVGVVNARFVKPLDQGMLREVATKARAL
VTVEDNTVVGGFGSAVLEALSALGLRTPVRVLGIPDAFQDHATVESVHARAGIDAPAIRTVLAELGVDVPLEV
>Mature_632_residues
SEPTANLQPASRTPLLDRVNSPEDLKRLGRDQLPQLAAELREEIVRVCSVGGLHLASSLGATDLIVALHYVLHSPRDRIL
FDVGHQAYAHKMLTGRRHLMHTVKKEGGLSGFTKVSESEHDAITVGHASTSLANALGMALARDALGQDYKVAAVIGDGSL
TGGMALAALNTIGDLGRRMLIVLNDNEMSISENVGAINRFMRGLQVQKWFQEGEEAGKKAVQAVSKPLANLMSRAKSSTR
HFFDPASVNPFAAMGVRYVGPVDGHNVQELVWLIERLVDLDGPTILHVVTKKGKGLSYAEADPIKWHGPGKFDPATGESV
PSNAYSWSSAFGDAVTELARLDPRTFVITPAMREGSGLVRYSQVHPHRYLDVGIAEDVAVTTAAGMALQGMRPIVAIYST
FLQRAYDQVLHDVAIENLNVTFAIDRGGIVGADGATHNGVFDLSYLRSIPNVGIGLPKDAAELRGMLKYAQEHAGPFAIR
YPRGNVERVPEGTWPELRWGTWERLQDGDDVVILAGGKALEYALKAARDLPGVGVVNARFVKPLDQGMLREVATKARALV
TVEDNTVVGGFGSAVLEALSALGLRTPVRVLGIPDAFQDHATVESVHARAGIDAPAIRTVLAELGVDVPLEV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=626, Percent_Identity=23.6421725239617, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI4507521, Length=626, Percent_Identity=23.6421725239617, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI133778974, Length=370, Percent_Identity=26.7567567567568, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI225637459, Length=261, Percent_Identity=28.3524904214559, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI225637463, Length=261, Percent_Identity=28.3524904214559, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI225637461, Length=261, Percent_Identity=28.3524904214559, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786622, Length=609, Percent_Identity=46.9622331691297, Blast_Score=519, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17539652, Length=663, Percent_Identity=23.3785822021116, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319698, Length=271, Percent_Identity=26.5682656826568, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45551847, Length=369, Percent_Identity=27.10027100271, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550715, Length=369, Percent_Identity=27.10027100271, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645119, Length=369, Percent_Identity=27.10027100271, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666278, Length=541, Percent_Identity=25.3234750462107, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_DEIGD (Q1IZP0)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_604463.1
- ProteinModelPortal:   Q1IZP0
- SMR:   Q1IZP0
- STRING:   Q1IZP0
- GeneID:   4058130
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_0994
- NMPDR:   fig|68909.1.peg.2020
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   RESILRY
- PhylomeDB:   Q1IZP0
- ProtClustDB:   PRK05444
- BioCyc:   DGEO319795:DGEO_0994-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68040; Mature: 67908

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPTANLQPASRTPLLDRVNSPEDLKRLGRDQLPQLAAELREEIVRVCSVGGLHLASSL
CCCCCCCCCCCCCCCHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GATDLIVALHYVLHSPRDRILFDVGHQAYAHKMLTGRRHLMHTVKKEGGLSGFTKVSESE
CHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCC
HDAITVGHASTSLANALGMALARDALGQDYKVAAVIGDGSLTGGMALAALNTIGDLGRRM
CCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
LIVLNDNEMSISENVGAINRFMRGLQVQKWFQEGEEAGKKAVQAVSKPLANLMSRAKSST
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHFFDPASVNPFAAMGVRYVGPVDGHNVQELVWLIERLVDLDGPTILHVVTKKGKGLSYA
HHCCCCCCCCHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
EADPIKWHGPGKFDPATGESVPSNAYSWSSAFGDAVTELARLDPRTFVITPAMREGSGLV
CCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCE
RYSQVHPHRYLDVGIAEDVAVTTAAGMALQGMRPIVAIYSTFLQRAYDQVLHDVAIENLN
EEECCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VTFAIDRGGIVGADGATHNGVFDLSYLRSIPNVGIGLPKDAAELRGMLKYAQEHAGPFAI
EEEEEECCCEEECCCCCCCCEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
RYPRGNVERVPEGTWPELRWGTWERLQDGDDVVILAGGKALEYALKAARDLPGVGVVNAR
ECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHH
FVKPLDQGMLREVATKARALVTVEDNTVVGGFGSAVLEALSALGLRTPVRVLGIPDAFQD
HHCHHHHHHHHHHHHHHHEEEEECCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHH
HATVESVHARAGIDAPAIRTVLAELGVDVPLEV
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SEPTANLQPASRTPLLDRVNSPEDLKRLGRDQLPQLAAELREEIVRVCSVGGLHLASSL
CCCCCCCCCCCCCCHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GATDLIVALHYVLHSPRDRILFDVGHQAYAHKMLTGRRHLMHTVKKEGGLSGFTKVSESE
CHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCC
HDAITVGHASTSLANALGMALARDALGQDYKVAAVIGDGSLTGGMALAALNTIGDLGRRM
CCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
LIVLNDNEMSISENVGAINRFMRGLQVQKWFQEGEEAGKKAVQAVSKPLANLMSRAKSST
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHFFDPASVNPFAAMGVRYVGPVDGHNVQELVWLIERLVDLDGPTILHVVTKKGKGLSYA
HHCCCCCCCCHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
EADPIKWHGPGKFDPATGESVPSNAYSWSSAFGDAVTELARLDPRTFVITPAMREGSGLV
CCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCE
RYSQVHPHRYLDVGIAEDVAVTTAAGMALQGMRPIVAIYSTFLQRAYDQVLHDVAIENLN
EEECCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VTFAIDRGGIVGADGATHNGVFDLSYLRSIPNVGIGLPKDAAELRGMLKYAQEHAGPFAI
EEEEEECCCEEECCCCCCCCEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
RYPRGNVERVPEGTWPELRWGTWERLQDGDDVVILAGGKALEYALKAARDLPGVGVVNAR
ECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHH
FVKPLDQGMLREVATKARALVTVEDNTVVGGFGSAVLEALSALGLRTPVRVLGIPDAFQD
HHCHHHHHHHHHHHHHHHEEEEECCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHH
HATVESVHARAGIDAPAIRTVLAELGVDVPLEV
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA