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The map label for this gene is sdhB [H]

Identifier: 94984993

GI number: 94984993

Start: 946691

End: 947452

Strand: Reverse

Name: sdhB [H]

Synonym: Dgeo_0886

Alternate gene names: 94984993

Gene position: 947452-946691 (Counterclockwise)

Preceding gene: 94984994

Following gene: 94984982

Centisome position: 38.4

GC content: 62.2

Gene sequence:

>762_bases
ATGCCTGAAGTTTCTTCTGCTCCCGCCAGCAACGCCGCCCAGGACGTAGCGATGCTGCGGATCAATGTCAAGATCCTGCG
CTTTGATCCAGAAAAGGACCGCAAAGCCCACTGGAAAATGTATTCGGTTGAGGCGCAACCCGGCGACCGCGTGCTGGACG
TGATCAACTGGGTGAAGTGGTACATCGACCCCTCGCTCACCTTCCGCCGCTCCTGCGGACACGGCATCTGTGGCAGCGAC
GCGATGATGATCAACGGGCGCAACCGTCTGGCCTGCAAGACGCTGGTGCGCGACGTGGCAAAAGACGGCGGCACCATCAC
CGTCGAGCCTATTCGCGGACTCAAGGTTGAGAAGGACCTGCTGGTGGACATGGACCCCTTCTTCGATGCGTACCGGGCGA
TCATGCCCTACTTCATCAACGAGGATCCGCCGCCCCCCGCCGAGCGGCTCCAGTCGCCCGAGCAGATCGACCGGATCAGC
CACTCCAGCAACTGCATCCTGTGCGCGTGCTGCACCACCTCCTGCCCGATCTTCTGGGTGAATGGCTCGTACCTGGGGCC
GGCGGCCATTGTGCAGGCGCACCGCTTCATCTTCGACAGCCGCGACCAGGCGACCAACCAGCGGCTGAACATCATGAACC
AGAACACCGGCGTCTGGCGCTGCCGCACCGCCTACAACTGCACTGAGGCGTGTCCACGCGACATCCCGATCACTACGATC
ATCGAGGAGGTCAAGCGCGCGGTGATGTACCAGCAGGCGTAA

Upstream 100 bases:

>100_bases
CGGCAATGTGGTGATCGGCTACAAGGAAGTCGCCCTCAAGGGCTACACCCGGGCCTTCGAGCCGAAGCCGCGCGTGTACT
GACCAGCAAAGGAATGAAGT

Downstream 100 bases:

>100_bases
TCGGCTCTCCGCCCCAACACCGGTCAAACAACCCAAAAAGCAGCTTGGAATGTATTCCAAGCTGCTTTTTGCTGACCGCT
CAAAAGCCGGCGTTCTCAGA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MPEVSSAPASNAAQDVAMLRINVKILRFDPEKDRKAHWKMYSVEAQPGDRVLDVINWVKWYIDPSLTFRRSCGHGICGSD
AMMINGRNRLACKTLVRDVAKDGGTITVEPIRGLKVEKDLLVDMDPFFDAYRAIMPYFINEDPPPPAERLQSPEQIDRIS
HSSNCILCACCTTSCPIFWVNGSYLGPAAIVQAHRFIFDSRDQATNQRLNIMNQNTGVWRCRTAYNCTEACPRDIPITTI
IEEVKRAVMYQQA

Sequences:

>Translated_253_residues
MPEVSSAPASNAAQDVAMLRINVKILRFDPEKDRKAHWKMYSVEAQPGDRVLDVINWVKWYIDPSLTFRRSCGHGICGSD
AMMINGRNRLACKTLVRDVAKDGGTITVEPIRGLKVEKDLLVDMDPFFDAYRAIMPYFINEDPPPPAERLQSPEQIDRIS
HSSNCILCACCTTSCPIFWVNGSYLGPAAIVQAHRFIFDSRDQATNQRLNIMNQNTGVWRCRTAYNCTEACPRDIPITTI
IEEVKRAVMYQQA
>Mature_252_residues
PEVSSAPASNAAQDVAMLRINVKILRFDPEKDRKAHWKMYSVEAQPGDRVLDVINWVKWYIDPSLTFRRSCGHGICGSDA
MMINGRNRLACKTLVRDVAKDGGTITVEPIRGLKVEKDLLVDMDPFFDAYRAIMPYFINEDPPPPAERLQSPEQIDRISH
SSNCILCACCTTSCPIFWVNGSYLGPAAIVQAHRFIFDSRDQATNQRLNIMNQNTGVWRCRTAYNCTEACPRDIPITTII
EEVKRAVMYQQA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=247, Percent_Identity=40.080971659919, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786943, Length=239, Percent_Identity=40.5857740585774, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=36.2445414847162, Blast_Score=166, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17533915, Length=229, Percent_Identity=38.8646288209607, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=39.8268398268398, Blast_Score=168, Evalue=6e-43,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=39.6551724137931, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24643156, Length=230, Percent_Identity=39.1304347826087, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28602; Mature: 28471

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEVSSAPASNAAQDVAMLRINVKILRFDPEKDRKAHWKMYSVEAQPGDRVLDVINWVKW
CCCCCCCCCCCHHHHEEEEEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHH
YIDPSLTFRRSCGHGICGSDAMMINGRNRLACKTLVRDVAKDGGTITVEPIRGLKVEKDL
HCCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCEECHHH
LVDMDPFFDAYRAIMPYFINEDPPPPAERLQSPEQIDRISHSSNCILCACCTTSCPIFWV
EECCCHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHCCCCCEEEEEEECCCCCEEEE
NGSYLGPAAIVQAHRFIFDSRDQATNQRLNIMNQNTGVWRCRTAYNCTEACPRDIPITTI
CCCCCCHHHHHHHHHHHHCCCCHHCCHHEEEEECCCCEEEEECCCCHHHCCCCCCCHHHH
IEEVKRAVMYQQA
HHHHHHHHHHCCC
>Mature Secondary Structure 
PEVSSAPASNAAQDVAMLRINVKILRFDPEKDRKAHWKMYSVEAQPGDRVLDVINWVKW
CCCCCCCCCCHHHHEEEEEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHH
YIDPSLTFRRSCGHGICGSDAMMINGRNRLACKTLVRDVAKDGGTITVEPIRGLKVEKDL
HCCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCEECHHH
LVDMDPFFDAYRAIMPYFINEDPPPPAERLQSPEQIDRISHSSNCILCACCTTSCPIFWV
EECCCHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHCCCCCEEEEEEECCCCCEEEE
NGSYLGPAAIVQAHRFIFDSRDQATNQRLNIMNQNTGVWRCRTAYNCTEACPRDIPITTI
CCCCCCHHHHHHHHHHHHCCCCHHCCHHEEEEECCCCEEEEECCCCHHHCCCCCCCHHHH
IEEVKRAVMYQQA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]