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The map label for this gene is sdhA [H]

Identifier: 94984994

GI number: 94984994

Start: 947471

End: 949222

Strand: Reverse

Name: sdhA [H]

Synonym: Dgeo_0887

Alternate gene names: 94984994

Gene position: 949222-947471 (Counterclockwise)

Preceding gene: 94984995

Following gene: 94984993

Centisome position: 38.47

GC content: 64.27

Gene sequence:

>1752_bases
ATGCACCATCGTTACGACGTACTGGTGGTTGGCGCGGGCGGCGCGGGACTGATGGCCGCCCTGTACGCCGCCAAGGGCAA
CGTGTCGGTTGCCTGCATCAGCAAGCTCTATCCCACCCGGTCCCACACCGGCGCTGCCCAGGGTGGCATCGGCGCGGCGC
TTGGCAACGTGTCCGAGGACCACTGGGAATGGCACATGTTCGACACCGTCAAGGGCGGCGACTACCTCACCGACCAGGAC
GCAGCGGAGATCTTTGCCAAGGACATCATCGAGGCGGTGTACGAACTCGAACACATGGGGCTGCCCTTTAGCCGCCTCCC
CAACGGCAAGATTGCGCAGCGCAAGTTCGGCGGCCACACCCGTGACTTCGGGAAGGCGGCGGTCGAGCGCTCCTGCTACG
CACAAGACCGCACCGGCCACATGATTCTGCAAACGCTCTACCAGCAGAACGTCAAGGCCGGAACCACCTTCTACAACGAG
TTTCACGTCACCGACCTCATCCTCGAAAACGGGCGCTGCTGCGGCGTGGTTGCCTACCACCTGGCCACGGGCGAGATTCA
CACCTTCCACGCCAAGGCCGTGATCCTGGCGGCGGGTGGCTACGGGCGCGTCTACAAGATCACTTCCAACGCCCTCACGC
TGACCGGCGACCTGATGAGCATCTACTACCGCAAAGGCCTGCCGCTGGAGGACATGGAGTTCTACCAGTTCCACCCCACC
GGCCTCGCCAAGCTAGGGATTCTGGTGACGGAAGGCATTCGCGGTGAGGGCGGTATCCTGCGCAACTCCAGCGGCGAGCG
CTTCATGGAACGCTATGCGCCCACCATCAAAGACCTCGCGCCGCGTGACATCGTCTCGCGTTCGATCATCACCGAGATTC
GCGAGGGCCGCGGTGTGGGCCGCGATAAGGACGCGGTCTATATCGACCTGACGCACCTGCCGCGCGAAGTCATCGAGGTC
AAGCTGGCCGAGATCACCGACCTGGCGCGCACCTACCTGGGGCAGGACCCAGTCAAGGACCTGGTCGCCGTGCAGCCGAC
GGCGCACTACGCGATGGGCGGCATTCCCACCGACGTGAACGGCCTGTGCCTGGCAGACGGACAGGGCACCAAGGTCGAGG
GGCTGTACGCGGCAGGTGAGCAGGCCTGTGTCTCGCTGCACGGCGCCAACCGCCTGGGGACCAACTCGCTGGGCGACCTG
ATCGTGTTCGGTCGGCGCGCCGGGATTGCCGCGGCCCTGTACGCGCGCCAGGCCGAATACGCCGAGATGCCCGAGCACCC
CGAGCGCGACACTGTGGAGATGATTGCGCGCTTGCGGAATGCGAGCGGCAAGGACAGCCCTGCTGTGATCCGCAAGGAGC
TGCAAGAGTCGATGATGAACAACGTCGGCATCTTCCGCAACGGCCCGGATATGGAAAAGCAGGTCGAAATCATCAAGGAG
CTCAAGGAGCGCTACCAGAATGTCGCGGTGACCGACCCCGGTGCTCGCTACAACAGCGACCTCATCGAGGCGATGGAACT
CGGCTTCCTGCTCGACTGTGCCGAAGCTGCCACCGCCAGTGCGCTCAATCGCAAGGAGTCGCGCGGCGCCCACGACCGCG
AGGATTATCCTGAGCGCGATGACCAGAACTGGCTGAAGCACACGATGGCGTACAAGGATCTGAGCCGCCCCGGCAATGTG
GTGATCGGCTACAAGGAAGTCGCCCTCAAGGGCTACACCCGGGCCTTCGAGCCGAAGCCGCGCGTGTACTGA

Upstream 100 bases:

>100_bases
AACAGCGGGTCTCCCCGAAGCTTCTGTGCGGACGGACCAGCTCCTGTTCATTCCACCCGGATGCGCCTGGGGCAACTCCG
GAGAGGTTTAAAGGACTGAT

Downstream 100 bases:

>100_bases
CCAGCAAAGGAATGAAGTATGCCTGAAGTTTCTTCTGCTCCCGCCAGCAACGCCGCCCAGGACGTAGCGATGCTGCGGAT
CAATGTCAAGATCCTGCGCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MHHRYDVLVVGAGGAGLMAALYAAKGNVSVACISKLYPTRSHTGAAQGGIGAALGNVSEDHWEWHMFDTVKGGDYLTDQD
AAEIFAKDIIEAVYELEHMGLPFSRLPNGKIAQRKFGGHTRDFGKAAVERSCYAQDRTGHMILQTLYQQNVKAGTTFYNE
FHVTDLILENGRCCGVVAYHLATGEIHTFHAKAVILAAGGYGRVYKITSNALTLTGDLMSIYYRKGLPLEDMEFYQFHPT
GLAKLGILVTEGIRGEGGILRNSSGERFMERYAPTIKDLAPRDIVSRSIITEIREGRGVGRDKDAVYIDLTHLPREVIEV
KLAEITDLARTYLGQDPVKDLVAVQPTAHYAMGGIPTDVNGLCLADGQGTKVEGLYAAGEQACVSLHGANRLGTNSLGDL
IVFGRRAGIAAALYARQAEYAEMPEHPERDTVEMIARLRNASGKDSPAVIRKELQESMMNNVGIFRNGPDMEKQVEIIKE
LKERYQNVAVTDPGARYNSDLIEAMELGFLLDCAEAATASALNRKESRGAHDREDYPERDDQNWLKHTMAYKDLSRPGNV
VIGYKEVALKGYTRAFEPKPRVY

Sequences:

>Translated_583_residues
MHHRYDVLVVGAGGAGLMAALYAAKGNVSVACISKLYPTRSHTGAAQGGIGAALGNVSEDHWEWHMFDTVKGGDYLTDQD
AAEIFAKDIIEAVYELEHMGLPFSRLPNGKIAQRKFGGHTRDFGKAAVERSCYAQDRTGHMILQTLYQQNVKAGTTFYNE
FHVTDLILENGRCCGVVAYHLATGEIHTFHAKAVILAAGGYGRVYKITSNALTLTGDLMSIYYRKGLPLEDMEFYQFHPT
GLAKLGILVTEGIRGEGGILRNSSGERFMERYAPTIKDLAPRDIVSRSIITEIREGRGVGRDKDAVYIDLTHLPREVIEV
KLAEITDLARTYLGQDPVKDLVAVQPTAHYAMGGIPTDVNGLCLADGQGTKVEGLYAAGEQACVSLHGANRLGTNSLGDL
IVFGRRAGIAAALYARQAEYAEMPEHPERDTVEMIARLRNASGKDSPAVIRKELQESMMNNVGIFRNGPDMEKQVEIIKE
LKERYQNVAVTDPGARYNSDLIEAMELGFLLDCAEAATASALNRKESRGAHDREDYPERDDQNWLKHTMAYKDLSRPGNV
VIGYKEVALKGYTRAFEPKPRVY
>Mature_583_residues
MHHRYDVLVVGAGGAGLMAALYAAKGNVSVACISKLYPTRSHTGAAQGGIGAALGNVSEDHWEWHMFDTVKGGDYLTDQD
AAEIFAKDIIEAVYELEHMGLPFSRLPNGKIAQRKFGGHTRDFGKAAVERSCYAQDRTGHMILQTLYQQNVKAGTTFYNE
FHVTDLILENGRCCGVVAYHLATGEIHTFHAKAVILAAGGYGRVYKITSNALTLTGDLMSIYYRKGLPLEDMEFYQFHPT
GLAKLGILVTEGIRGEGGILRNSSGERFMERYAPTIKDLAPRDIVSRSIITEIREGRGVGRDKDAVYIDLTHLPREVIEV
KLAEITDLARTYLGQDPVKDLVAVQPTAHYAMGGIPTDVNGLCLADGQGTKVEGLYAAGEQACVSLHGANRLGTNSLGDL
IVFGRRAGIAAALYARQAEYAEMPEHPERDTVEMIARLRNASGKDSPAVIRKELQESMMNNVGIFRNGPDMEKQVEIIKE
LKERYQNVAVTDPGARYNSDLIEAMELGFLLDCAEAATASALNRKESRGAHDREDYPERDDQNWLKHTMAYKDLSRPGNV
VIGYKEVALKGYTRAFEPKPRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=574, Percent_Identity=45.993031358885, Blast_Score=494, Evalue=1e-139,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=49.1496598639456, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=41.3612565445026, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=32.5581395348837, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17550100, Length=607, Percent_Identity=45.9637561779242, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17505833, Length=587, Percent_Identity=43.4412265758092, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322701, Length=572, Percent_Identity=49.8251748251748, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322416, Length=572, Percent_Identity=48.951048951049, Blast_Score=521, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320788, Length=481, Percent_Identity=26.6112266112266, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17137288, Length=587, Percent_Identity=46.3373083475298, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24655642, Length=587, Percent_Identity=46.3373083475298, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24655647, Length=587, Percent_Identity=46.3373083475298, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24663005, Length=610, Percent_Identity=43.2786885245902, Blast_Score=465, Evalue=1e-131,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64166; Mature: 64166

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHRYDVLVVGAGGAGLMAALYAAKGNVSVACISKLYPTRSHTGAAQGGIGAALGNVSED
CCCEEEEEEEECCCHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCCCCCCHHHHCCCCCC
HWEWHMFDTVKGGDYLTDQDAAEIFAKDIIEAVYELEHMGLPFSRLPNGKIAQRKFGGHT
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHCCCCC
RDFGKAAVERSCYAQDRTGHMILQTLYQQNVKAGTTFYNEFHVTDLILENGRCCGVVAYH
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCEEEEEEEE
LATGEIHTFHAKAVILAAGGYGRVYKITSNALTLTGDLMSIYYRKGLPLEDMEFYQFHPT
EECCCEEEEEEEEEEEEECCCCEEEEEECCCEEEEHHHHHHHHHCCCCCCCCCCEEECCC
GLAKLGILVTEGIRGEGGILRNSSGERFMERYAPTIKDLAPRDIVSRSIITEIREGRGVG
CHHHHHHHEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCC
RDKDAVYIDLTHLPREVIEVKLAEITDLARTYLGQDPVKDLVAVQPTAHYAMGGIPTDVN
CCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHCCCCCCCCC
GLCLADGQGTKVEGLYAAGEQACVSLHGANRLGTNSLGDLIVFGRRAGIAAALYARQAEY
CEEEECCCCCEEEEEECCCCHHEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHH
AEMPEHPERDTVEMIARLRNASGKDSPAVIRKELQESMMNNVGIFRNGPDMEKQVEIIKE
HCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LKERYQNVAVTDPGARYNSDLIEAMELGFLLDCAEAATASALNRKESRGAHDREDYPERD
HHHHHHCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DQNWLKHTMAYKDLSRPGNVVIGYKEVALKGYTRAFEPKPRVY
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHHRYDVLVVGAGGAGLMAALYAAKGNVSVACISKLYPTRSHTGAAQGGIGAALGNVSED
CCCEEEEEEEECCCHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCCCCCCHHHHCCCCCC
HWEWHMFDTVKGGDYLTDQDAAEIFAKDIIEAVYELEHMGLPFSRLPNGKIAQRKFGGHT
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHCCCCC
RDFGKAAVERSCYAQDRTGHMILQTLYQQNVKAGTTFYNEFHVTDLILENGRCCGVVAYH
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCEEEEEEEE
LATGEIHTFHAKAVILAAGGYGRVYKITSNALTLTGDLMSIYYRKGLPLEDMEFYQFHPT
EECCCEEEEEEEEEEEEECCCCEEEEEECCCEEEEHHHHHHHHHCCCCCCCCCCEEECCC
GLAKLGILVTEGIRGEGGILRNSSGERFMERYAPTIKDLAPRDIVSRSIITEIREGRGVG
CHHHHHHHEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCC
RDKDAVYIDLTHLPREVIEVKLAEITDLARTYLGQDPVKDLVAVQPTAHYAMGGIPTDVN
CCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHCCCCCCCCC
GLCLADGQGTKVEGLYAAGEQACVSLHGANRLGTNSLGDLIVFGRRAGIAAALYARQAEY
CEEEECCCCCEEEEEECCCCHHEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHH
AEMPEHPERDTVEMIARLRNASGKDSPAVIRKELQESMMNNVGIFRNGPDMEKQVEIIKE
HCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LKERYQNVAVTDPGARYNSDLIEAMELGFLLDCAEAATASALNRKESRGAHDREDYPERD
HHHHHHCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DQNWLKHTMAYKDLSRPGNVVIGYKEVALKGYTRAFEPKPRVY
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA