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The map label for this gene is hisG

Identifier: 94984889

GI number: 94984889

Start: 840546

End: 841208

Strand: Reverse

Name: hisG

Synonym: Dgeo_0782

Alternate gene names: 94984889

Gene position: 841208-840546 (Counterclockwise)

Preceding gene: 94984890

Following gene: 94984883

Centisome position: 34.1

GC content: 69.53

Gene sequence:

>663_bases
ATGACGCCCGCGCCAGCGCGTGACCCGGACCACCTCACCCTGGCGCTTCCGAAGGGCCGCATCCTGGAAGACGCAGTGAC
CCTGCTCGCGCGCGCCGGACTGCCCCTCACCCTCCCCGAAAAATCCCGCGCGCTGCGGCACGAGTTCCCGGGCGTGACCG
TGCTCGAGCTGCGCAACCAGGATGTGCCGGTCTACGTCGACCTGGGGGTGGCGGACGCAGGGATCGTAGGCAAGGACGTG
CTGATCGAGTCGGGCCGCGCCGTCTACGAGCCCGTCGATCTGCGCTTTGCGGCCTGTCACCTGTCACTGATTCGGGAGGT
GGGGGCCAGCGGTCCCATCGGGCGGGTCGCCACCAAGTATCCCCGGTCGGCCCGCGCGTACCTCGCCTCGCGCGGCATTC
CCGCCGAGGTGGTGAAGCTGTCGGGCAACATCGAGCTGGCCGCGCTGACTGGCCTGGCCGACGCCGTGGTGGACCTGGTG
CAGACGGGGAGCACGCTGCGGGCCAATCACCTCGAAGAAATCGACGTGCTGTACCACTCCAGCGCCCGCTTGATCGTCAA
CCGCGCAGCGCTGAAGCTGCGGCGCGCCAGACTGCGGCCCCTGATCGAGCGACTGCGGGAACTGGTAGAGCGTGACGCGC
AGGAGGGCACGGGCAACCTGTAG

Upstream 100 bases:

>100_bases
AACTCGCCTGGACCGACAACCAAGTAGAACTGCTCGCCTACTGCCAGAAACGGGGCATCCGCCGCTGGGCGCAGGGCGAC
ACGCTGGTGGAGGTGACCGC

Downstream 100 bases:

>100_bases
GACCCGGCCCGTACCCCCGCTCTCAGCGGCTTTCCAGCGCTGCGGGCACCTGCGCGCCCAGGGCGTCCGCCATCCTTTCC
AGCGCCTCGACCAGGAGGCG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTPAPARDPDHLTLALPKGRILEDAVTLLARAGLPLTLPEKSRALRHEFPGVTVLELRNQDVPVYVDLGVADAGIVGKDV
LIESGRAVYEPVDLRFAACHLSLIREVGASGPIGRVATKYPRSARAYLASRGIPAEVVKLSGNIELAALTGLADAVVDLV
QTGSTLRANHLEEIDVLYHSSARLIVNRAALKLRRARLRPLIERLRELVERDAQEGTGNL

Sequences:

>Translated_220_residues
MTPAPARDPDHLTLALPKGRILEDAVTLLARAGLPLTLPEKSRALRHEFPGVTVLELRNQDVPVYVDLGVADAGIVGKDV
LIESGRAVYEPVDLRFAACHLSLIREVGASGPIGRVATKYPRSARAYLASRGIPAEVVKLSGNIELAALTGLADAVVDLV
QTGSTLRANHLEEIDVLYHSSARLIVNRAALKLRRARLRPLIERLRELVERDAQEGTGNL
>Mature_219_residues
TPAPARDPDHLTLALPKGRILEDAVTLLARAGLPLTLPEKSRALRHEFPGVTVLELRNQDVPVYVDLGVADAGIVGKDVL
IESGRAVYEPVDLRFAACHLSLIREVGASGPIGRVATKYPRSARAYLASRGIPAEVVKLSGNIELAALTGLADAVVDLVQ
TGSTLRANHLEEIDVLYHSSARLIVNRAALKLRRARLRPLIERLRELVERDAQEGTGNL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=194, Percent_Identity=39.1752577319588, Blast_Score=106, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320896, Length=197, Percent_Identity=32.48730964467, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_DEIGD (Q1J0A0)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_604253.1
- ProteinModelPortal:   Q1J0A0
- SMR:   Q1J0A0
- STRING:   Q1J0A0
- GeneID:   4058637
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_0782
- NMPDR:   fig|68909.1.peg.2555
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   Q1J0A0
- ProtClustDB:   PRK01686
- BioCyc:   DGEO319795:DGEO_0782-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23791; Mature: 23660

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAPARDPDHLTLALPKGRILEDAVTLLARAGLPLTLPEKSRALRHEFPGVTVLELRNQ
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCC
DVPVYVDLGVADAGIVGKDVLIESGRAVYEPVDLRFAACHLSLIREVGASGPIGRVATKY
CCCEEEECCCCCCCCCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
PRSARAYLASRGIPAEVVKLSGNIELAALTGLADAVVDLVQTGSTLRANHLEEIDVLYHS
CHHHHHHHHHCCCCHHEEEECCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SARLIVNRAALKLRRARLRPLIERLRELVERDAQEGTGNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TPAPARDPDHLTLALPKGRILEDAVTLLARAGLPLTLPEKSRALRHEFPGVTVLELRNQ
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCC
DVPVYVDLGVADAGIVGKDVLIESGRAVYEPVDLRFAACHLSLIREVGASGPIGRVATKY
CCCEEEECCCCCCCCCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
PRSARAYLASRGIPAEVVKLSGNIELAALTGLADAVVDLVQTGSTLRANHLEEIDVLYHS
CHHHHHHHHHCCCCHHEEEECCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SARLIVNRAALKLRRARLRPLIERLRELVERDAQEGTGNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA