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The map label for this gene is ytpA [H]

Identifier: 94984632

GI number: 94984632

Start: 553099

End: 553968

Strand: Reverse

Name: ytpA [H]

Synonym: Dgeo_0525

Alternate gene names: 94984632

Gene position: 553968-553099 (Counterclockwise)

Preceding gene: 94984634

Following gene: 94984628

Centisome position: 22.45

GC content: 69.31

Gene sequence:

>870_bases
ATGCACAGCACGGGCTGGGAAGCGTCAGAGTGGAACCTGTCCACCGGAAGAGAGAGGGCACCGGTTCGTGGCTACGTATG
GCCTGCCCAGCATCCCCGTGCCGCTGTGCTGCTCACGCACGGACTGGGCGAATACGCGGGCCGCTACGTGGAACGCTACC
ACCGTCTGATTCCAGCACTGGTGGAGGCCGGATTCAGCGTGTACGCCTACGACCAGCGCGGCCACGGACACTCGGAGGGC
CGCCGAGCCGTGGTGGACGCGGCGGTGCTGGTCGAAGACCACCTGCGCGCGCGCGAGGCGCTGCGGGGTCAGCCGCTTCC
GGTGTTTGCCTTTGGGCACTCGCTGGGCGGCCTGGTCACGGCGGCAAGCGTCGCCCGTGATCCCCGCGGCCTCAGCGGCG
TCATTCTCTCCAGCCCGGCCCTCCTGATTGGGGAGAACCAGCCCAGCTGGATCAAAGCTCTTGCGCCCGTGCTGGCGAGG
CTCGCGCCTGCCGCTCCCGCCGCCGATCTGGGCAAGGGGGGCCTCTCGCGCCTCGCAGAAGAGGTCGAGGCTTACCAAGC
CGATCCGAACATCTTCCAAGGGCAGGTGCCCGCGCTGACGGCCGCCTCCATGCTGCGCCTCAGCGAGACGCTGTGGCCGC
AGTACGCGCGCTGGACGCTCCCCACGCTGGTTCTTCACGGCACCGCCGACCGCATCACCGACCCGCACGGCTCGCGCCGC
TTCGTGGAGGCGATCGCGGCCCCCGACAAGACCCTGCGTCTGGTCGAAGGCGGCTATCACGAACTCCTGAACGACGAGGG
GCGCGAGGAGGTGCGAGGCTGGATTCTGGCCTGGCTCCAGGAACGAACCGAGCAGCCCCAACGGGCCTAG

Upstream 100 bases:

>100_bases
ATATCTGCCATGTCAGGCAGTTTGCTCTAGGAATTGCGCCAGGAAGAGGTGAGGCACATTGAGCCTCACTTAACATCGCG
CAAGGGCTAGACTGCTTCTC

Downstream 100 bases:

>100_bases
CGCCGGACGCTGTCCACGGGCCGCACTGCCCCCTGAAGCCCGAAGTCCTCCGCGATCAGCCGGGCGGTCATCTTGGCGCT
CATCATCACGCTGGGTGTGC

Product: alpha/beta hydrolase fold

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MHSTGWEASEWNLSTGRERAPVRGYVWPAQHPRAAVLLTHGLGEYAGRYVERYHRLIPALVEAGFSVYAYDQRGHGHSEG
RRAVVDAAVLVEDHLRAREALRGQPLPVFAFGHSLGGLVTAASVARDPRGLSGVILSSPALLIGENQPSWIKALAPVLAR
LAPAAPAADLGKGGLSRLAEEVEAYQADPNIFQGQVPALTAASMLRLSETLWPQYARWTLPTLVLHGTADRITDPHGSRR
FVEAIAAPDKTLRLVEGGYHELLNDEGREEVRGWILAWLQERTEQPQRA

Sequences:

>Translated_289_residues
MHSTGWEASEWNLSTGRERAPVRGYVWPAQHPRAAVLLTHGLGEYAGRYVERYHRLIPALVEAGFSVYAYDQRGHGHSEG
RRAVVDAAVLVEDHLRAREALRGQPLPVFAFGHSLGGLVTAASVARDPRGLSGVILSSPALLIGENQPSWIKALAPVLAR
LAPAAPAADLGKGGLSRLAEEVEAYQADPNIFQGQVPALTAASMLRLSETLWPQYARWTLPTLVLHGTADRITDPHGSRR
FVEAIAAPDKTLRLVEGGYHELLNDEGREEVRGWILAWLQERTEQPQRA
>Mature_289_residues
MHSTGWEASEWNLSTGRERAPVRGYVWPAQHPRAAVLLTHGLGEYAGRYVERYHRLIPALVEAGFSVYAYDQRGHGHSEG
RRAVVDAAVLVEDHLRAREALRGQPLPVFAFGHSLGGLVTAASVARDPRGLSGVILSSPALLIGENQPSWIKALAPVLAR
LAPAAPAADLGKGGLSRLAEEVEAYQADPNIFQGQVPALTAASMLRLSETLWPQYARWTLPTLVLHGTADRITDPHGSRR
FVEAIAAPDKTLRLVEGGYHELLNDEGREEVRGWILAWLQERTEQPQRA

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI6005786, Length=265, Percent_Identity=33.5849056603774, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI51242953, Length=265, Percent_Identity=33.5849056603774, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322756, Length=295, Percent_Identity=29.4915254237288, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 31638; Mature: 31638

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSTGWEASEWNLSTGRERAPVRGYVWPAQHPRAAVLLTHGLGEYAGRYVERYHRLIPAL
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
VEAGFSVYAYDQRGHGHSEGRRAVVDAAVLVEDHLRAREALRGQPLPVFAFGHSLGGLVT
HHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHH
AASVARDPRGLSGVILSSPALLIGENQPSWIKALAPVLARLAPAAPAADLGKGGLSRLAE
HHHHHCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHH
EVEAYQADPNIFQGQVPALTAASMLRLSETLWPQYARWTLPTLVLHGTADRITDPHGSRR
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCCCCHHH
FVEAIAAPDKTLRLVEGGYHELLNDEGREEVRGWILAWLQERTEQPQRA
HHHHHHCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHSTGWEASEWNLSTGRERAPVRGYVWPAQHPRAAVLLTHGLGEYAGRYVERYHRLIPAL
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
VEAGFSVYAYDQRGHGHSEGRRAVVDAAVLVEDHLRAREALRGQPLPVFAFGHSLGGLVT
HHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHH
AASVARDPRGLSGVILSSPALLIGENQPSWIKALAPVLARLAPAAPAADLGKGGLSRLAE
HHHHHCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHH
EVEAYQADPNIFQGQVPALTAASMLRLSETLWPQYARWTLPTLVLHGTADRITDPHGSRR
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCCCCHHH
FVEAIAAPDKTLRLVEGGYHELLNDEGREEVRGWILAWLQERTEQPQRA
HHHHHHCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]