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The map label for this gene is lon [H]

Identifier: 94984535

GI number: 94984535

Start: 436153

End: 438615

Strand: Reverse

Name: lon [H]

Synonym: Dgeo_0427

Alternate gene names: 94984535

Gene position: 438615-436153 (Counterclockwise)

Preceding gene: 94984536

Following gene: 94984534

Centisome position: 17.78

GC content: 64.92

Gene sequence:

>2463_bases
ATGTCCAACGAGAACCAACCCATTGCACTGCCTGCCAACGTGCCTGTGTGCCCGGTACGTGGCAGCGTGATTTATCCGAC
GATGGTGCAGCATATTGACGCGAGCCGCGCCATCTCTATTCGTGCGATCGAAGCGGCCTTGCAGGGCGATAAGGTCATCC
TGATCGTATCGCAGCGCGACAAGGACGTGGACGACCCACAGGGCAGTGACCTCTACGACGTCGGCACAGCCTGCAATGTG
CTGCGTGTTCGCAAGAACCCCGACGGGACCGTGCAGATGCTCGTTGCTGCTGTTGCCCGGGCGCGCGTGTTGCACTACAG
CCGCGCCGACTACCTGCGCGCCGAGATCGAGGTTCTGCCTACCGAGACCGGCGATCCCGTCGAACTCCAGGCCCTTACCC
GCGAGTTGCGCGAGAAGTTCGAGGCCGTGGCGCAGGGCGGCAAGGTCAGCGCCGAGAGCATCCAGGCCATCCAGAGCAAG
GATGATCCCGGCGAAATGGCCGACCACATCGCCTTTAATCTGGATTTCAAGCTGGAAGACAAGCAGGCGGTGCTGGAAGC
CAGCCGCCTGACGGACCGCATCCGCCGCGTGCTGACGCTGCTGGACACCGAGCAGGAAGTGCAGGCCGTGCAGGCCCGCA
TCCGCGCACAGGTCAAGGAAGAGATCGACAAGAACCAGCGCGAGTACTACCTGCGCGAGCAGATGAAGGTCATTCAGAAA
GAACTTCAGGGCGGGGAAGGCGATGAGGACGGCGACGAGGCCGAAGCCTTCCGCACCAAGATCGACGCGCTGGGTCTCTC
GCCCGAGGTCAAAAAGGAAGTTGACCGCGAGGTGAACCGTCTGGCCCGGATGCATCCCGACGCCGCCGAGGCTTCGGTGA
TCCGCACCTACCTCACCTGGATCACCGAGCTGCCCTGGAGCGTTCGCAGCGACGACCGGCTCGACGTGGCGGAAGCGGCC
AAGATTTTGGATGAGGACCACTACGGCCTGGAAAAGGTCAAGGACCGCGTGCTGGAGTTTCTGGCCGTGCGCCGCCTGCG
CAAGGAACGCGCCGAACGCGGCGAGATCGACGCCTCTGAGGTCAACAAGGGGCCGATTCTGGTCTTTACCGGCCCTCCTG
GCGTCGGCAAGACCTCCATCGCGCAGAGCATCGCCAAGGCGCTGGGCCGCAAGTACGTGCGCATCGCGCTGGGCGGCGCC
CGTGACGAGTCTGACATCCGCGGCCACCGCCGCACCTACATCGGGGCGATGCCGGGGCGCATCATCCAGGGCATCCGCAC
GGCGGGCACCAAGAACCCCGTGATTCTGCTCGACGAGGTGGACAAGCTCGGCAGTTCCTATCAGGGTGACCCCTCGGCGG
CGCTGCTGGAAGTGCTCGACCCCGCGCAAAACCAGCACTTCACCGACCACTACCTGGGCGTGCCCTTCGACCTCTCCGAA
GTGATGTTCATCGCGACCGCCAACTACCCCGAGCAGATCCCCGCGGCGCTGATGGACCGTATGGAAGTGATCGACTTTTC
TTCCTACATCGAGCAGGAGAAGCTGGAGATCGCCAAGCGTTACCTGCTGCCGCGCCAGATCACCGCCAACGGCCTGAAGC
CCAACCAGATCAGCTTCACAGACGCGGCGCTCGAACGTCTGATCAGCCACTACACCCGCGAGGCGGGCGTGCGCAACCTG
GAACGCGAGATCGGCACCGTCGCCCGCAAGGTGGCCCGCCGCATCGCCACCGGCGAAGTCAAGCGCGTCAAGGTGACCGA
CAAGGAACTCGACCGCTACCTGGGCCAGCACCGCTACCTGCCGGAAACGGAGGGTCAGGAGGACAAGGTCGGCGTGTCCA
CCGGGATGTTCTACACGCCGGTTGGGGGCGATATCCTGTTTGTGGAAACCAGCGTGATGCCCGGCAAGGGCCTGGTGCTC
ACCGGCCAGCTCGGGGACGTGATGAAGGAGTCGGCCCGCGCCGCCCTGACCTACGCCAAGAGCAATGCTGAACGCTTCCA
CCTCGACCGTGACCGGATCGACAATTCCGAGATTCACATCCACGTGCCAGCCGGGGCAATCCCCAAGGAAGGCCCCAGCG
CGGGCGGTGCGATGGTCACCTCCCTCATCTCGGCCCTGAGCGGCATCCCCGTCCGGCACGACGTGGCGATGACCGGCGAG
ATGACGCTCACCGGGCGTTATCTGCCCATCGGCGGCCTGAAGGAAAAGGTGCTGGGCGCCCGGCGTGCGGGCATCAAGCA
CATCATCATGCCCAAGGCGAACGAGGGGGACCTACGGGATATCCCGCTCCACCTGCGGGCCTCGATGCGCTTCCACCCCT
GTGAGACGGTGGATCAGGTCCTGGATGTCGCCCTGGTCGGCGGCCTGAAGGCGCTGGAAACCCCGCGCGACGGCACGGCC
GTGACCACGCCGCTGCCCCCCAAGCGCAAGACGACTCGGCGCAATGCGGGCGCAAGTGCCTAG

Upstream 100 bases:

>100_bases
CGCTCCTCTCAAAAAATTGATATAGTTGCACTCAGGTTTCCTGGTATTAAGAGTGCCAGAAGCCTTCCAAACGGAGCCAT
CTGGGGCGAAAGGAGCCTCC

Downstream 100 bases:

>100_bases
GCCGGGCGCATAGGCAGCGTCATCACCCCCCTCCCCGTCACCGTGCGGGGAGGGGCGTTGTTTTGGCTAAACGCTGTGTC
TGGGCTAAACGCTGTGGGCC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 820; Mature: 819

Protein sequence:

>820_residues
MSNENQPIALPANVPVCPVRGSVIYPTMVQHIDASRAISIRAIEAALQGDKVILIVSQRDKDVDDPQGSDLYDVGTACNV
LRVRKNPDGTVQMLVAAVARARVLHYSRADYLRAEIEVLPTETGDPVELQALTRELREKFEAVAQGGKVSAESIQAIQSK
DDPGEMADHIAFNLDFKLEDKQAVLEASRLTDRIRRVLTLLDTEQEVQAVQARIRAQVKEEIDKNQREYYLREQMKVIQK
ELQGGEGDEDGDEAEAFRTKIDALGLSPEVKKEVDREVNRLARMHPDAAEASVIRTYLTWITELPWSVRSDDRLDVAEAA
KILDEDHYGLEKVKDRVLEFLAVRRLRKERAERGEIDASEVNKGPILVFTGPPGVGKTSIAQSIAKALGRKYVRIALGGA
RDESDIRGHRRTYIGAMPGRIIQGIRTAGTKNPVILLDEVDKLGSSYQGDPSAALLEVLDPAQNQHFTDHYLGVPFDLSE
VMFIATANYPEQIPAALMDRMEVIDFSSYIEQEKLEIAKRYLLPRQITANGLKPNQISFTDAALERLISHYTREAGVRNL
EREIGTVARKVARRIATGEVKRVKVTDKELDRYLGQHRYLPETEGQEDKVGVSTGMFYTPVGGDILFVETSVMPGKGLVL
TGQLGDVMKESARAALTYAKSNAERFHLDRDRIDNSEIHIHVPAGAIPKEGPSAGGAMVTSLISALSGIPVRHDVAMTGE
MTLTGRYLPIGGLKEKVLGARRAGIKHIIMPKANEGDLRDIPLHLRASMRFHPCETVDQVLDVALVGGLKALETPRDGTA
VTTPLPPKRKTTRRNAGASA

Sequences:

>Translated_820_residues
MSNENQPIALPANVPVCPVRGSVIYPTMVQHIDASRAISIRAIEAALQGDKVILIVSQRDKDVDDPQGSDLYDVGTACNV
LRVRKNPDGTVQMLVAAVARARVLHYSRADYLRAEIEVLPTETGDPVELQALTRELREKFEAVAQGGKVSAESIQAIQSK
DDPGEMADHIAFNLDFKLEDKQAVLEASRLTDRIRRVLTLLDTEQEVQAVQARIRAQVKEEIDKNQREYYLREQMKVIQK
ELQGGEGDEDGDEAEAFRTKIDALGLSPEVKKEVDREVNRLARMHPDAAEASVIRTYLTWITELPWSVRSDDRLDVAEAA
KILDEDHYGLEKVKDRVLEFLAVRRLRKERAERGEIDASEVNKGPILVFTGPPGVGKTSIAQSIAKALGRKYVRIALGGA
RDESDIRGHRRTYIGAMPGRIIQGIRTAGTKNPVILLDEVDKLGSSYQGDPSAALLEVLDPAQNQHFTDHYLGVPFDLSE
VMFIATANYPEQIPAALMDRMEVIDFSSYIEQEKLEIAKRYLLPRQITANGLKPNQISFTDAALERLISHYTREAGVRNL
EREIGTVARKVARRIATGEVKRVKVTDKELDRYLGQHRYLPETEGQEDKVGVSTGMFYTPVGGDILFVETSVMPGKGLVL
TGQLGDVMKESARAALTYAKSNAERFHLDRDRIDNSEIHIHVPAGAIPKEGPSAGGAMVTSLISALSGIPVRHDVAMTGE
MTLTGRYLPIGGLKEKVLGARRAGIKHIIMPKANEGDLRDIPLHLRASMRFHPCETVDQVLDVALVGGLKALETPRDGTA
VTTPLPPKRKTTRRNAGASA
>Mature_819_residues
SNENQPIALPANVPVCPVRGSVIYPTMVQHIDASRAISIRAIEAALQGDKVILIVSQRDKDVDDPQGSDLYDVGTACNVL
RVRKNPDGTVQMLVAAVARARVLHYSRADYLRAEIEVLPTETGDPVELQALTRELREKFEAVAQGGKVSAESIQAIQSKD
DPGEMADHIAFNLDFKLEDKQAVLEASRLTDRIRRVLTLLDTEQEVQAVQARIRAQVKEEIDKNQREYYLREQMKVIQKE
LQGGEGDEDGDEAEAFRTKIDALGLSPEVKKEVDREVNRLARMHPDAAEASVIRTYLTWITELPWSVRSDDRLDVAEAAK
ILDEDHYGLEKVKDRVLEFLAVRRLRKERAERGEIDASEVNKGPILVFTGPPGVGKTSIAQSIAKALGRKYVRIALGGAR
DESDIRGHRRTYIGAMPGRIIQGIRTAGTKNPVILLDEVDKLGSSYQGDPSAALLEVLDPAQNQHFTDHYLGVPFDLSEV
MFIATANYPEQIPAALMDRMEVIDFSSYIEQEKLEIAKRYLLPRQITANGLKPNQISFTDAALERLISHYTREAGVRNLE
REIGTVARKVARRIATGEVKRVKVTDKELDRYLGQHRYLPETEGQEDKVGVSTGMFYTPVGGDILFVETSVMPGKGLVLT
GQLGDVMKESARAALTYAKSNAERFHLDRDRIDNSEIHIHVPAGAIPKEGPSAGGAMVTSLISALSGIPVRHDVAMTGEM
TLTGRYLPIGGLKEKVLGARRAGIKHIIMPKANEGDLRDIPLHLRASMRFHPCETVDQVLDVALVGGLKALETPRDGTAV
TTPLPPKRKTTRRNAGASA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=855, Percent_Identity=39.766081871345, Blast_Score=547, Evalue=1e-155,
Organism=Homo sapiens, GI21396489, Length=673, Percent_Identity=43.3878157503715, Blast_Score=544, Evalue=1e-154,
Organism=Escherichia coli, GI1786643, Length=778, Percent_Identity=48.7146529562982, Blast_Score=722, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=658, Percent_Identity=39.9696048632219, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17556486, Length=562, Percent_Identity=41.6370106761566, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319449, Length=723, Percent_Identity=37.7593360995851, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24666867, Length=675, Percent_Identity=40.7407407407407, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221513036, Length=675, Percent_Identity=40.7407407407407, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90529; Mature: 90397

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNENQPIALPANVPVCPVRGSVIYPTMVQHIDASRAISIRAIEAALQGDKVILIVSQRD
CCCCCCCEEECCCCCEECCCCCEEHHHHHHHCCCCCCEEHHHHHHHHCCCEEEEEEECCC
KDVDDPQGSDLYDVGTACNVLRVRKNPDGTVQMLVAAVARARVLHYSRADYLRAEIEVLP
CCCCCCCCCCCCHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
TETGDPVELQALTRELREKFEAVAQGGKVSAESIQAIQSKDDPGEMADHIAFNLDFKLED
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHEEEEEEEEECH
KQAVLEASRLTDRIRRVLTLLDTEQEVQAVQARIRAQVKEEIDKNQREYYLREQMKVIQK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ELQGGEGDEDGDEAEAFRTKIDALGLSPEVKKEVDREVNRLARMHPDAAEASVIRTYLTW
HHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ITELPWSVRSDDRLDVAEAAKILDEDHYGLEKVKDRVLEFLAVRRLRKERAERGEIDASE
HHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VNKGPILVFTGPPGVGKTSIAQSIAKALGRKYVRIALGGARDESDIRGHRRTYIGAMPGR
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHEECCCCHH
IIQGIRTAGTKNPVILLDEVDKLGSSYQGDPSAALLEVLDPAQNQHFTDHYLGVPFDLSE
HHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCHHH
VMFIATANYPEQIPAALMDRMEVIDFSSYIEQEKLEIAKRYLLPRQITANGLKPNQISFT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHH
DAALERLISHYTREAGVRNLEREIGTVARKVARRIATGEVKRVKVTDKELDRYLGQHRYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCC
PETEGQEDKVGVSTGMFYTPVGGDILFVETSVMPGKGLVLTGQLGDVMKESARAALTYAK
CCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHH
SNAERFHLDRDRIDNSEIHIHVPAGAIPKEGPSAGGAMVTSLISALSGIPVRHDVAMTGE
CCCHHEECCHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECC
MTLTGRYLPIGGLKEKVLGARRAGIKHIIMPKANEGDLRDIPLHLRASMRFHPCETVDQV
EEEECEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHH
LDVALVGGLKALETPRDGTAVTTPLPPKRKTTRRNAGASA
HHHHHHCCHHHHCCCCCCCEEECCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
SNENQPIALPANVPVCPVRGSVIYPTMVQHIDASRAISIRAIEAALQGDKVILIVSQRD
CCCCCCEEECCCCCEECCCCCEEHHHHHHHCCCCCCEEHHHHHHHHCCCEEEEEEECCC
KDVDDPQGSDLYDVGTACNVLRVRKNPDGTVQMLVAAVARARVLHYSRADYLRAEIEVLP
CCCCCCCCCCCCHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
TETGDPVELQALTRELREKFEAVAQGGKVSAESIQAIQSKDDPGEMADHIAFNLDFKLED
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHEEEEEEEEECH
KQAVLEASRLTDRIRRVLTLLDTEQEVQAVQARIRAQVKEEIDKNQREYYLREQMKVIQK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ELQGGEGDEDGDEAEAFRTKIDALGLSPEVKKEVDREVNRLARMHPDAAEASVIRTYLTW
HHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ITELPWSVRSDDRLDVAEAAKILDEDHYGLEKVKDRVLEFLAVRRLRKERAERGEIDASE
HHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VNKGPILVFTGPPGVGKTSIAQSIAKALGRKYVRIALGGARDESDIRGHRRTYIGAMPGR
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHEECCCCHH
IIQGIRTAGTKNPVILLDEVDKLGSSYQGDPSAALLEVLDPAQNQHFTDHYLGVPFDLSE
HHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCHHH
VMFIATANYPEQIPAALMDRMEVIDFSSYIEQEKLEIAKRYLLPRQITANGLKPNQISFT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHH
DAALERLISHYTREAGVRNLEREIGTVARKVARRIATGEVKRVKVTDKELDRYLGQHRYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCC
PETEGQEDKVGVSTGMFYTPVGGDILFVETSVMPGKGLVLTGQLGDVMKESARAALTYAK
CCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHH
SNAERFHLDRDRIDNSEIHIHVPAGAIPKEGPSAGGAMVTSLISALSGIPVRHDVAMTGE
CCCHHEECCHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECC
MTLTGRYLPIGGLKEKVLGARRAGIKHIIMPKANEGDLRDIPLHLRASMRFHPCETVDQV
EEEECEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHH
LDVALVGGLKALETPRDGTAVTTPLPPKRKTTRRNAGASA
HHHHHHCCHHHHCCCCCCCEEECCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]