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The map label for this gene is alkK [H]

Identifier: 94984532

GI number: 94984532

Start: 432683

End: 434380

Strand: Reverse

Name: alkK [H]

Synonym: Dgeo_0424

Alternate gene names: 94984532

Gene position: 434380-432683 (Counterclockwise)

Preceding gene: 94984533

Following gene: 94984531

Centisome position: 17.61

GC content: 66.73

Gene sequence:

>1698_bases
ATGCAAGGCAACATGATGAACGTTCCCCTCACCCTCCCCTTCATTCTGGAGCGCGTCCGCACGCAGTACGCCGAGCGCGA
GATCGTGAGCCTGTTGGTGGGTGGACGCGACGCCGCCGGGCAGCCGGTACCGCACAAGCACCGCACCACCTACGGCGAGG
TGGCGGACCGGGCGCTGCGGCTGGGGGCCGGGTTGCAGGCACTGGGCCTGAACCGGGGGGACCGGGTGGCGACGCTGGCG
GTCAACTCCTTCCGGCATCTGGAGGCGTACCTGGGCATCCCGTCAGCGGGCTTTGTGGTCCATACCGTCAACATCCGGCT
GCATCCCGACCAAATCGCCTGGATTCTGAACGATGCCGGAGACCGGGTGCTGCTCGTCGAAAACCTCTTTGCCCCCCTGA
TTCCGGCCCTGCGCGCCGCCTGTCCACAACTTGAGCGGGTGTTTGTATTCGGGCCGCTGCCCACCCCCATCGAGGGCGCC
GAAGCGTACGACAGCTGGGTGATGGCCCAGGAACCGCTGCCCCACTATCCCCAGCTTGACGAGAATGAGGCGGCGGGCAT
GTGCTACACCAGCGGCACCACCGGTAACCCCAAGGGCATCCTGTATACGCACCGCTCGACCATCCTGCACTCCCTGGCCA
GTGCGCCCAAAGACGCGCTCAACGTGGGCGAACACGACACCGTGCTCCCCATCGTGCCGATGTTTCACGTGAACGCCTGG
GGCATCCCGTATACCTGCGCGATGTACGGCGCGAAGCAGGTGTATGCCGGCGCCTTCACCGACGGACCCACCCTCGCCAC
GCTGATGCAGGACGAGGCAGTGACGCTGACCGCGGGCGTGCCGACCATCTGGATGGGTCTGCTGGCCGAACTTGACCGCG
CGAAGGCCGCGGGACATCCCTATGACCTCTCCCGGCTGGAGCGCCTGGTGGTGGGGGGCAGCGCCGCGCCGGAAAGCCTG
ATCCGCGCCTTCCAGGAGCGGCACGGCCTCAAACTGGCCCAAGCCTGGGGCATGACCGAGACCCATCCGCTGGGAACGGC
CAGCCAAGTCCCGCCCGACATCGCCGAGACCAGCGATGAGGGGTACCGGCTGCGAGCCAAACAGGGCCGACCCGTGCCGC
TGGTGTTTCTCGACATCATCTCAGAAGAGGGCCAGCGCCTCCCGCACGACGGCAAGACGATGGGCCGCCTGATTGCGCGT
GGCCCCTGGATCGCGGGAAGCTACTACAAGGGCGAGGGGCAGCACAATTTCTTTGAACTAGACGGCGAACTGTGGTTCGA
CACCGGCGACATCGCCACGCTGGATGAGCGCGGCTTCATGCACATCCAGGACCGGGCCAAGGATCTGATCAAGTCGGGAG
GCGAGTGGATCAGCTCGGTGGACCTCGAAAACGCGATCATGGCCCACCCCTCCGTCGCCCAGGCCGCCGTGATCGCGATG
GACGATCCCAAGTGGGACGAGCGGCCCCTGGCGGTGATCACCCTCAAGCCGGGCATGAGCGTCACCCATGAGGAGCTGCG
TGACTTCCTGGCTCCCAGGTTCGCCAAGTGGTGGCTCCCCGACGCGACTGTCGTCGTGGAGAGCATCCCCATCGGCGCGA
CCGGCAAGTTCCTGAAACGCGAACTGCGCGAACAGTACCGGGACTACGGCAGCACCCGCGGCCTGGTGCCCTCCGCCGCG
CCCGACCGCAGCGCGTAG

Upstream 100 bases:

>100_bases
CGGCAGAGTGGCTAGAATGCACGCATACACAGCTGCAGCTTCAGCAGTCGGCCCAGGTGGCCGCCCCCCCCGTTCCCTTT
CTATGCCCCGGAGGTCAGCG

Downstream 100 bases:

>100_bases
CACCCCCTCAGCGCGCGCAGGAACAAGGCCCTCCACCCTCCCCCGCCCCGTACAATCGCACCCATGGCCGTTTCGGTGCA
GGGACAGCAGGTTATCTTTT

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MQGNMMNVPLTLPFILERVRTQYAEREIVSLLVGGRDAAGQPVPHKHRTTYGEVADRALRLGAGLQALGLNRGDRVATLA
VNSFRHLEAYLGIPSAGFVVHTVNIRLHPDQIAWILNDAGDRVLLVENLFAPLIPALRAACPQLERVFVFGPLPTPIEGA
EAYDSWVMAQEPLPHYPQLDENEAAGMCYTSGTTGNPKGILYTHRSTILHSLASAPKDALNVGEHDTVLPIVPMFHVNAW
GIPYTCAMYGAKQVYAGAFTDGPTLATLMQDEAVTLTAGVPTIWMGLLAELDRAKAAGHPYDLSRLERLVVGGSAAPESL
IRAFQERHGLKLAQAWGMTETHPLGTASQVPPDIAETSDEGYRLRAKQGRPVPLVFLDIISEEGQRLPHDGKTMGRLIAR
GPWIAGSYYKGEGQHNFFELDGELWFDTGDIATLDERGFMHIQDRAKDLIKSGGEWISSVDLENAIMAHPSVAQAAVIAM
DDPKWDERPLAVITLKPGMSVTHEELRDFLAPRFAKWWLPDATVVVESIPIGATGKFLKRELREQYRDYGSTRGLVPSAA
PDRSA

Sequences:

>Translated_565_residues
MQGNMMNVPLTLPFILERVRTQYAEREIVSLLVGGRDAAGQPVPHKHRTTYGEVADRALRLGAGLQALGLNRGDRVATLA
VNSFRHLEAYLGIPSAGFVVHTVNIRLHPDQIAWILNDAGDRVLLVENLFAPLIPALRAACPQLERVFVFGPLPTPIEGA
EAYDSWVMAQEPLPHYPQLDENEAAGMCYTSGTTGNPKGILYTHRSTILHSLASAPKDALNVGEHDTVLPIVPMFHVNAW
GIPYTCAMYGAKQVYAGAFTDGPTLATLMQDEAVTLTAGVPTIWMGLLAELDRAKAAGHPYDLSRLERLVVGGSAAPESL
IRAFQERHGLKLAQAWGMTETHPLGTASQVPPDIAETSDEGYRLRAKQGRPVPLVFLDIISEEGQRLPHDGKTMGRLIAR
GPWIAGSYYKGEGQHNFFELDGELWFDTGDIATLDERGFMHIQDRAKDLIKSGGEWISSVDLENAIMAHPSVAQAAVIAM
DDPKWDERPLAVITLKPGMSVTHEELRDFLAPRFAKWWLPDATVVVESIPIGATGKFLKRELREQYRDYGSTRGLVPSAA
PDRSA
>Mature_565_residues
MQGNMMNVPLTLPFILERVRTQYAEREIVSLLVGGRDAAGQPVPHKHRTTYGEVADRALRLGAGLQALGLNRGDRVATLA
VNSFRHLEAYLGIPSAGFVVHTVNIRLHPDQIAWILNDAGDRVLLVENLFAPLIPALRAACPQLERVFVFGPLPTPIEGA
EAYDSWVMAQEPLPHYPQLDENEAAGMCYTSGTTGNPKGILYTHRSTILHSLASAPKDALNVGEHDTVLPIVPMFHVNAW
GIPYTCAMYGAKQVYAGAFTDGPTLATLMQDEAVTLTAGVPTIWMGLLAELDRAKAAGHPYDLSRLERLVVGGSAAPESL
IRAFQERHGLKLAQAWGMTETHPLGTASQVPPDIAETSDEGYRLRAKQGRPVPLVFLDIISEEGQRLPHDGKTMGRLIAR
GPWIAGSYYKGEGQHNFFELDGELWFDTGDIATLDERGFMHIQDRAKDLIKSGGEWISSVDLENAIMAHPSVAQAAVIAM
DDPKWDERPLAVITLKPGMSVTHEELRDFLAPRFAKWWLPDATVVVESIPIGATGKFLKRELREQYRDYGSTRGLVPSAA
PDRSA

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=528, Percent_Identity=28.7878787878788, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI187761345, Length=537, Percent_Identity=28.8640595903166, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI187761343, Length=537, Percent_Identity=28.8640595903166, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI28416953, Length=563, Percent_Identity=25.9325044404973, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI42544132, Length=517, Percent_Identity=22.0502901353965, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38505220, Length=493, Percent_Identity=22.5152129817444, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI58082049, Length=512, Percent_Identity=23.2421875, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI122937307, Length=495, Percent_Identity=23.2323232323232, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI13375727, Length=380, Percent_Identity=25.5263157894737, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI157311624, Length=503, Percent_Identity=22.6640159045726, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI157311622, Length=503, Percent_Identity=22.6640159045726, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI115511026, Length=513, Percent_Identity=21.2475633528265, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI13325057, Length=542, Percent_Identity=23.6162361623616, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI145693145, Length=515, Percent_Identity=28.1553398058252, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI221142682, Length=511, Percent_Identity=26.2230919765166, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788107, Length=527, Percent_Identity=25.8064516129032, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786810, Length=370, Percent_Identity=29.7297297297297, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789201, Length=390, Percent_Identity=26.1538461538462, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790505, Length=545, Percent_Identity=23.302752293578, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788595, Length=478, Percent_Identity=25.5230125523013, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=522, Percent_Identity=26.2452107279693, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17531443, Length=516, Percent_Identity=25.7751937984496, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17560308, Length=529, Percent_Identity=24.007561436673, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=574, Percent_Identity=23.3449477351916, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71994694, Length=574, Percent_Identity=23.3449477351916, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71994690, Length=574, Percent_Identity=23.3449477351916, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17558820, Length=519, Percent_Identity=25.8188824662813, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=521, Percent_Identity=25.1439539347409, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=511, Percent_Identity=24.6575342465753, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=522, Percent_Identity=23.9463601532567, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17560140, Length=509, Percent_Identity=24.3614931237721, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI25147511, Length=493, Percent_Identity=22.5152129817444, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17553312, Length=489, Percent_Identity=24.7443762781186, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=377, Percent_Identity=25.4641909814324, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=375, Percent_Identity=26.9333333333333, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI18859661, Length=541, Percent_Identity=25.8780036968577, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24581924, Length=528, Percent_Identity=24.2424242424242, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355181, Length=515, Percent_Identity=26.0194174757282, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356441, Length=495, Percent_Identity=23.030303030303, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922652, Length=522, Percent_Identity=21.8390804597701, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648260, Length=530, Percent_Identity=22.6415094339623, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24656500, Length=519, Percent_Identity=23.121387283237, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648253, Length=494, Percent_Identity=21.2550607287449, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648255, Length=494, Percent_Identity=21.2550607287449, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281365686, Length=378, Percent_Identity=23.2804232804233, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24653035, Length=497, Percent_Identity=20.1207243460765, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161076582, Length=514, Percent_Identity=21.2062256809339, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356947, Length=514, Percent_Identity=19.6498054474708, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 61885; Mature: 61885

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGNMMNVPLTLPFILERVRTQYAEREIVSLLVGGRDAAGQPVPHKHRTTYGEVADRALR
CCCCEEECCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LGAGLQALGLNRGDRVATLAVNSFRHLEAYLGIPSAGFVVHTVNIRLHPDQIAWILNDAG
HCCCCCEECCCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHEEEEEECCC
DRVLLVENLFAPLIPALRAACPQLERVFVFGPLPTPIEGAEAYDSWVMAQEPLPHYPQLD
CEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHEEECCCCCCCCCCC
ENEAAGMCYTSGTTGNPKGILYTHRSTILHSLASAPKDALNVGEHDTVLPIVPMFHVNAW
CCCCCCEEEECCCCCCCCEEEEECHHHHHHHHHHCCHHHHCCCCCCCEEEEEEEEEEECC
GIPYTCAMYGAKQVYAGAFTDGPTLATLMQDEAVTLTAGVPTIWMGLLAELDRAKAAGHP
CCCHHHHHHCCHHHEEECCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
YDLSRLERLVVGGSAAPESLIRAFQERHGLKLAQAWGMTETHPLGTASQVPPDIAETSDE
CCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCCCCCCCCHHHCCCC
GYRLRAKQGRPVPLVFLDIISEEGQRLPHDGKTMGRLIARGPWIAGSYYKGEGQHNFFEL
CEEEEECCCCCCCEEHEEHHHHCCCCCCCCCHHHHHHHHCCCEEECCEECCCCCCCEEEE
DGELWFDTGDIATLDERGFMHIQDRAKDLIKSGGEWISSVDLENAIMAHPSVAQAAVIAM
CCEEEEECCCEEEECCCCCEEHHHHHHHHHHCCCHHHHHCCHHHHHHCCCCHHHEEEEEE
DDPKWDERPLAVITLKPGMSVTHEELRDFLAPRFAKWWLPDATVVVESIPIGATGKFLKR
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHH
ELREQYRDYGSTRGLVPSAAPDRSA
HHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQGNMMNVPLTLPFILERVRTQYAEREIVSLLVGGRDAAGQPVPHKHRTTYGEVADRALR
CCCCEEECCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LGAGLQALGLNRGDRVATLAVNSFRHLEAYLGIPSAGFVVHTVNIRLHPDQIAWILNDAG
HCCCCCEECCCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHEEEEEECCC
DRVLLVENLFAPLIPALRAACPQLERVFVFGPLPTPIEGAEAYDSWVMAQEPLPHYPQLD
CEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHEEECCCCCCCCCCC
ENEAAGMCYTSGTTGNPKGILYTHRSTILHSLASAPKDALNVGEHDTVLPIVPMFHVNAW
CCCCCCEEEECCCCCCCCEEEEECHHHHHHHHHHCCHHHHCCCCCCCEEEEEEEEEEECC
GIPYTCAMYGAKQVYAGAFTDGPTLATLMQDEAVTLTAGVPTIWMGLLAELDRAKAAGHP
CCCHHHHHHCCHHHEEECCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
YDLSRLERLVVGGSAAPESLIRAFQERHGLKLAQAWGMTETHPLGTASQVPPDIAETSDE
CCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCCCCCCCCHHHCCCC
GYRLRAKQGRPVPLVFLDIISEEGQRLPHDGKTMGRLIARGPWIAGSYYKGEGQHNFFEL
CEEEEECCCCCCCEEHEEHHHHCCCCCCCCCHHHHHHHHCCCEEECCEECCCCCCCEEEE
DGELWFDTGDIATLDERGFMHIQDRAKDLIKSGGEWISSVDLENAIMAHPSVAQAAVIAM
CCEEEEECCCEEEECCCCCEEHHHHHHHHHHCCCHHHHHCCHHHHHHCCCCHHHEEEEEE
DDPKWDERPLAVITLKPGMSVTHEELRDFLAPRFAKWWLPDATVVVESIPIGATGKFLKR
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHH
ELREQYRDYGSTRGLVPSAAPDRSA
HHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]