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The map label for this gene is strD [H]

Identifier: 94984448

GI number: 94984448

Start: 341415

End: 342482

Strand: Reverse

Name: strD [H]

Synonym: Dgeo_0340

Alternate gene names: 94984448

Gene position: 342482-341415 (Counterclockwise)

Preceding gene: 94984459

Following gene: 94984447

Centisome position: 13.88

GC content: 65.92

Gene sequence:

>1068_bases
ATGCCCGCAATGAAAGCCATCATTCCTGCTGCTGGGCTTGGCACTCGCCTCCGCCCCCTGACCTACACGCGGCCCAAGCC
GGTCTTGCCGGTGGCGGGCGCGCCGATCATCGTGCATGCCCTCCGGACCCTGCTGGCCGCTGGGATCAACGAGGTGGGCA
TCATCGTGTCGGACGCGACCCGGGCTGAGATTGCGCAGACCCTGGAACAGGTGCCCGAAGTGCAGGTCACCCTGATTAAT
CAGCACGAACAGCTGGGGCTGGGGCACGCCGTTCTGACCGCCCGCAACTGGGTGGGACAGCAGAACTTCTGCGTCTATCT
GGGTGACAACCTGTTTGAGCATGGTGTAGCGCCCTTTATCGAACGCTTCCAGCGTGAGCAGGCCGCGGCGGTGATCGCCC
TGGTGGAAGTGCCTGATCCTACGGCCTTTGGTGTGGCGGAGCTGGAAGGCGAGCGCATCACGCGCCTGGTTGAGAAGCCC
AAGGTCCCGCCCAGCAACCTGGCGGTGGCGGGGCTGTACTGCTTCACGCCGGAGGTCTTCGATGTGCTTGACGGGATGCC
GCCCTCCGCACGCGGTGAGTACGAAATCACCGACGCGATCCAGGGTCTGGTTGACCGTGGTCAAACGGTGCTGGGCCAGT
GCGTGCAGGGTTGGTGGAAGGACACGGGCCGCCCCGCCGATCTGCTCGACGCCAACCGCCTGCTGCTCGAACAGATCGGC
GCGGACGTGCAGGGCGAGGTGGAAGGCTCCCGGCTGACCGGCCGGGTCATCATTCCTGCCTCAGCACGGGTCACACGCAG
CAAGATCGTCGGACCGGTGCTGCTGGGCGAGGGGGTGGTGGTCGAGGACGCGTATATCGGTCCCTTTACCAGTATCGGGC
CGGGCAGCGTGGTGCGGCAGGCCGAGGTGGAACACAGCGTGGTGGACGCCGAAGCGCGGATCGAGCACCTCAGCACCCGC
CTTCAGGACTGTCTGATCGGCGTGCGGGCACAGGTGCGCGGCGGCCACAAGATCCCGCGCACGCACAAGCTCACCCTTTC
GGATGCGAGCGTGGTGGAACTGGCCTAA

Upstream 100 bases:

>100_bases
CCTTCCCACAGACAAACCATCAACGAACTATAAGGGCAGCTCCGGCGCCATGTTGAAGAAATGCTAGGCTAAGACCTTAA
CCTGTGAGCGCCACTCTAGA

Downstream 100 bases:

>100_bases
CGGCGATCTTCGCCCTCCCGACAACCCTGTCCATCCTTACCGAGACGATGGAGTGCGCCCCCTGTCCGGAATGACACTGC
GGCCTGACCCTGCTTCTACG

Product: glucose-1-phosphate thymidyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MPAMKAIIPAAGLGTRLRPLTYTRPKPVLPVAGAPIIVHALRTLLAAGINEVGIIVSDATRAEIAQTLEQVPEVQVTLIN
QHEQLGLGHAVLTARNWVGQQNFCVYLGDNLFEHGVAPFIERFQREQAAAVIALVEVPDPTAFGVAELEGERITRLVEKP
KVPPSNLAVAGLYCFTPEVFDVLDGMPPSARGEYEITDAIQGLVDRGQTVLGQCVQGWWKDTGRPADLLDANRLLLEQIG
ADVQGEVEGSRLTGRVIIPASARVTRSKIVGPVLLGEGVVVEDAYIGPFTSIGPGSVVRQAEVEHSVVDAEARIEHLSTR
LQDCLIGVRAQVRGGHKIPRTHKLTLSDASVVELA

Sequences:

>Translated_355_residues
MPAMKAIIPAAGLGTRLRPLTYTRPKPVLPVAGAPIIVHALRTLLAAGINEVGIIVSDATRAEIAQTLEQVPEVQVTLIN
QHEQLGLGHAVLTARNWVGQQNFCVYLGDNLFEHGVAPFIERFQREQAAAVIALVEVPDPTAFGVAELEGERITRLVEKP
KVPPSNLAVAGLYCFTPEVFDVLDGMPPSARGEYEITDAIQGLVDRGQTVLGQCVQGWWKDTGRPADLLDANRLLLEQIG
ADVQGEVEGSRLTGRVIIPASARVTRSKIVGPVLLGEGVVVEDAYIGPFTSIGPGSVVRQAEVEHSVVDAEARIEHLSTR
LQDCLIGVRAQVRGGHKIPRTHKLTLSDASVVELA
>Mature_354_residues
PAMKAIIPAAGLGTRLRPLTYTRPKPVLPVAGAPIIVHALRTLLAAGINEVGIIVSDATRAEIAQTLEQVPEVQVTLINQ
HEQLGLGHAVLTARNWVGQQNFCVYLGDNLFEHGVAPFIERFQREQAAAVIALVEVPDPTAFGVAELEGERITRLVEKPK
VPPSNLAVAGLYCFTPEVFDVLDGMPPSARGEYEITDAIQGLVDRGQTVLGQCVQGWWKDTGRPADLLDANRLLLEQIGA
DVQGEVEGSRLTGRVIIPASARVTRSKIVGPVLLGEGVVVEDAYIGPFTSIGPGSVVRQAEVEHSVVDAEARIEHLSTRL
QDCLIGVRAQVRGGHKIPRTHKLTLSDASVVELA

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=338, Percent_Identity=30.4733727810651, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI11761621, Length=338, Percent_Identity=30.4733727810651, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI31881779, Length=316, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI45447090, Length=316, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=33.7552742616034, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788351, Length=241, Percent_Identity=33.195020746888, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1787488, Length=269, Percent_Identity=32.3420074349442, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788355, Length=273, Percent_Identity=30.03663003663, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI133931050, Length=342, Percent_Identity=30.7017543859649, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320148, Length=361, Percent_Identity=27.1468144044321, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355443, Length=363, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24644084, Length=363, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 38089; Mature: 37958

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMKAIIPAAGLGTRLRPLTYTRPKPVLPVAGAPIIVHALRTLLAAGINEVGIIVSDAT
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCH
RAEIAQTLEQVPEVQVTLINQHEQLGLGHAVLTARNWVGQQNFCVYLGDNLFEHGVAPFI
HHHHHHHHHHCCCEEEEEECCHHHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHCHHHHH
ERFQREQAAAVIALVEVPDPTAFGVAELEGERITRLVEKPKVPPSNLAVAGLYCFTPEVF
HHHHHHHHEEEEEEEECCCCCCCCHHHHCHHHHHHHHHCCCCCCCCEEEEEEEECCHHHH
DVLDGMPPSARGEYEITDAIQGLVDRGQTVLGQCVQGWWKDTGRPADLLDANRLLLEQIG
HHHCCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
ADVQGEVEGSRLTGRVIIPASARVTRSKIVGPVLLGEGVVVEDAYIGPFTSIGPGSVVRQ
CCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCEEECCCEEEECCCCCCCCCCCCCHHHHH
AEVEHSVVDAEARIEHLSTRLQDCLIGVRAQVRGGHKIPRTHKLTLSDASVVELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECC
>Mature Secondary Structure 
PAMKAIIPAAGLGTRLRPLTYTRPKPVLPVAGAPIIVHALRTLLAAGINEVGIIVSDAT
CCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCH
RAEIAQTLEQVPEVQVTLINQHEQLGLGHAVLTARNWVGQQNFCVYLGDNLFEHGVAPFI
HHHHHHHHHHCCCEEEEEECCHHHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHCHHHHH
ERFQREQAAAVIALVEVPDPTAFGVAELEGERITRLVEKPKVPPSNLAVAGLYCFTPEVF
HHHHHHHHEEEEEEEECCCCCCCCHHHHCHHHHHHHHHCCCCCCCCEEEEEEEECCHHHH
DVLDGMPPSARGEYEITDAIQGLVDRGQTVLGQCVQGWWKDTGRPADLLDANRLLLEQIG
HHHCCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
ADVQGEVEGSRLTGRVIIPASARVTRSKIVGPVLLGEGVVVEDAYIGPFTSIGPGSVVRQ
CCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCEEECCCEEEECCCCCCCCCCCCCHHHHH
AEVEHSVVDAEARIEHLSTRLQDCLIGVRAQVRGGHKIPRTHKLTLSDASVVELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]