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The map label for this gene is purL [H]

Identifier: 94984172

GI number: 94984172

Start: 61809

End: 64049

Strand: Reverse

Name: purL [H]

Synonym: Dgeo_0064

Alternate gene names: 94984172

Gene position: 64049-61809 (Counterclockwise)

Preceding gene: 94984173

Following gene: 94984171

Centisome position: 2.6

GC content: 68.36

Gene sequence:

>2241_bases
GTGACACACACCGAGTCTCTCCGGCCCCAGGCCGCCACCTTTGGCCTCACCTCCGAAGAATTCGATCTGCTTGTCTCCAG
GCTGGGTCGCGAGCCGAATGCGCTGGAGGCGGCCATCGTGGGCGCGATGTGGTCCGAGCACTGCGGCTACAAGAACTCGC
GGCCCCTCTTTTCCGCCTTTCCCACGACCGGGCCGCAGGTGCTGCAAGGCCCCGGCGAGAACGCGGGCGTGGTGGATATC
GGCGAAGGCTGGGGCGTGGCCTTTAAGATGGAAAGCCACAACCACCCCTCGGCCGTCGAACCCGTGCAGGGCGCGGCGAC
CGGTGTGGGCGGCATCCTGCGCGACATCTTTGCGATGGGGGCGCGGCCCTTTGCGGTGCTCGACTCGCTCCGGTTCGGTA
ACCCCGACTCCCCCCGCACCCGCTTCCTGCTCAACGGCGTGGTGGAGGGTATCTCCCACTACGGCAACGCGATCGGCGTG
CCCACCGTGGGCGGCGAGGTGACCTTTCATCCCTCCTATCAGGAGAACCCGCTGGTCAATGTGATGGCCCTGGGCCTGCT
GCGGCATGAGGACCTCGCCAAGGGAACGATGGGGGCGGTCGGCAACCAGATCGTGTATGTCGGCTCCAAGACCGGGCGCG
ACGGGCTGGGCGGCGCGGTGTTCTCGTCGGCAGACCTCAGCGCGGCCAGTCAGGCCGACCGCCCCGCCGTGCAGGTGGGC
GACCCTTTTATGGAGAAGCTGCTGCTGGAGGCCACCCTCGAGGCGATTCAGGCCGGGCTGGTGGCGGGTGTGCAGGACAT
GGGCGCGGCGGGGCTGGTCAGTTCGACCTGCGAGATGGCGTACCGCGCGGGCCTGGGCATCACCCTGGAGCTGGACCGGA
TCCCCACCCGTGAGGAAGGCATGGTCCCGATGGAGCTGTGCCTTTCCGAGTCGCAGGAGCGCATGATCCTGGTGCCGGTG
CCGGGGCGCGAACAGGAACTCCTCGACCTCCTCGCCCGCTGGGAACTCGACGTGGTGACCATCGGGGAGGTGGAAGCGCA
TGACCGCTACCGCCTGACCTGGCGCGGTGAGGTGGTGTGCGACCTGCCCGTCGCCCTGCTGAACGAGGCGCCCAAATACA
CCCGCGAGGGCGTAGAGTCGGCGGAGATCCGCGCCAAACGCGAGCGCGACCTGAGCGGCGTGCCGGTGCCGGGTGACCTC
GGCGCGGTGCTGGTCGAGCTGCTCTCGCACCCCACGATTGCCTCCAAGCGCCCGATTTTTGAACGCTATGACCATCAGGT
GATGACGAACACGGTGGTCGTGCCGGGTGCGGCCGACGCCGCCGTGCTGCGCGTGAAGGGGAGCCAGCTGGGTGTGGCCG
CCACCTCGGACTGCAACCCGCGCTTCGTGTATCTCGATCCCTACACTGGCGCTGCCGCTGCCGTCGCGGAGGCCGCCCGC
AACCTCGCTTGCGTGGGCGCGACGCCGCTGGCGATCACCGACAACCTCAACTTCGGAAACCCCTACGAGCCGGGCGTGTA
CTTCCAGCTGCAGCAGTCGGTGCAGGGCATCGCGGACGCCTGCCGAGCGCTGAACACGCCGGTCACGGGCGGCAACGTGA
GCCTCTACAACCAGTATGCGGAGGGCGACCACAAAGTCGCCATCCACCCCACCCCCACGATCGGCATGGTGGGCGTGCTG
CCCGACGTGACCCGGCGGGCGACGCTGGACCTCAAGCCGGGGCCGCATCTCCTCTATCTGCTGGGCCGCCACGCGACCAC
CATCGGCGCCTCGCAGTATCTCGAAACGGTGCACGGTCTAGAAGCGGGCCAGGTGCCGGACCTCGACCTGGAGCTGGAGA
GGCGGGTGATCGAGGGGACGCTGGCCCTGATCCGCGCGGGGCTGACGGACGCAGCGCACGACTGCTCGGAAGGCGGCCTC
GCCGTGGCCCTCGCCGAGATGGCGATGGCGGGCGGACAGGGGTTGAAGGTGGAGATCAAGGCTCCCGCAGGCGTTCGCCC
GGATGCCCTGCTCTTCGGGGAGGCGCACAGCCGCATCGTGGTGGCGGTACCGTTGGGCCACGAGCAGGCCGCGCAGGACC
TGCTGGAGGACCTCGGCGTTCCCTATACGGCGCTGGGCGAAAGCCTGCCGGGGAGTGACCGCGTCACCATTTCGGTCACG
GGCGCAAACGTACAGTTGAGCGTGACCCTCGACACCCTCAAAACTGCCTTTGAAACGCCGCTGCGGGAGATTTTGGGATG
A

Upstream 100 bases:

>100_bases
TCCTTGGCATGATGCCCCACCCCGAACGGGCGGTCGAGGCGCTGCTGGGGAGCGAAGACGGGCGGGGCATCTTCGAGAGC
CTGAAAGGGGCGCTGGTCCA

Downstream 100 bases:

>100_bases
TCTTTGACCCCGCCACCGACAAGCCGCAAGACGAGTGCGGGGTGTTCGGCCTGTACTCGCCGCAGCCGCAGGATCTCGCG
TGGCTGACGTACCTGGGTCT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 746; Mature: 745

Protein sequence:

>746_residues
MTHTESLRPQAATFGLTSEEFDLLVSRLGREPNALEAAIVGAMWSEHCGYKNSRPLFSAFPTTGPQVLQGPGENAGVVDI
GEGWGVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMGARPFAVLDSLRFGNPDSPRTRFLLNGVVEGISHYGNAIGV
PTVGGEVTFHPSYQENPLVNVMALGLLRHEDLAKGTMGAVGNQIVYVGSKTGRDGLGGAVFSSADLSAASQADRPAVQVG
DPFMEKLLLEATLEAIQAGLVAGVQDMGAAGLVSSTCEMAYRAGLGITLELDRIPTREEGMVPMELCLSESQERMILVPV
PGREQELLDLLARWELDVVTIGEVEAHDRYRLTWRGEVVCDLPVALLNEAPKYTREGVESAEIRAKRERDLSGVPVPGDL
GAVLVELLSHPTIASKRPIFERYDHQVMTNTVVVPGAADAAVLRVKGSQLGVAATSDCNPRFVYLDPYTGAAAAVAEAAR
NLACVGATPLAITDNLNFGNPYEPGVYFQLQQSVQGIADACRALNTPVTGGNVSLYNQYAEGDHKVAIHPTPTIGMVGVL
PDVTRRATLDLKPGPHLLYLLGRHATTIGASQYLETVHGLEAGQVPDLDLELERRVIEGTLALIRAGLTDAAHDCSEGGL
AVALAEMAMAGGQGLKVEIKAPAGVRPDALLFGEAHSRIVVAVPLGHEQAAQDLLEDLGVPYTALGESLPGSDRVTISVT
GANVQLSVTLDTLKTAFETPLREILG

Sequences:

>Translated_746_residues
MTHTESLRPQAATFGLTSEEFDLLVSRLGREPNALEAAIVGAMWSEHCGYKNSRPLFSAFPTTGPQVLQGPGENAGVVDI
GEGWGVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMGARPFAVLDSLRFGNPDSPRTRFLLNGVVEGISHYGNAIGV
PTVGGEVTFHPSYQENPLVNVMALGLLRHEDLAKGTMGAVGNQIVYVGSKTGRDGLGGAVFSSADLSAASQADRPAVQVG
DPFMEKLLLEATLEAIQAGLVAGVQDMGAAGLVSSTCEMAYRAGLGITLELDRIPTREEGMVPMELCLSESQERMILVPV
PGREQELLDLLARWELDVVTIGEVEAHDRYRLTWRGEVVCDLPVALLNEAPKYTREGVESAEIRAKRERDLSGVPVPGDL
GAVLVELLSHPTIASKRPIFERYDHQVMTNTVVVPGAADAAVLRVKGSQLGVAATSDCNPRFVYLDPYTGAAAAVAEAAR
NLACVGATPLAITDNLNFGNPYEPGVYFQLQQSVQGIADACRALNTPVTGGNVSLYNQYAEGDHKVAIHPTPTIGMVGVL
PDVTRRATLDLKPGPHLLYLLGRHATTIGASQYLETVHGLEAGQVPDLDLELERRVIEGTLALIRAGLTDAAHDCSEGGL
AVALAEMAMAGGQGLKVEIKAPAGVRPDALLFGEAHSRIVVAVPLGHEQAAQDLLEDLGVPYTALGESLPGSDRVTISVT
GANVQLSVTLDTLKTAFETPLREILG
>Mature_745_residues
THTESLRPQAATFGLTSEEFDLLVSRLGREPNALEAAIVGAMWSEHCGYKNSRPLFSAFPTTGPQVLQGPGENAGVVDIG
EGWGVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMGARPFAVLDSLRFGNPDSPRTRFLLNGVVEGISHYGNAIGVP
TVGGEVTFHPSYQENPLVNVMALGLLRHEDLAKGTMGAVGNQIVYVGSKTGRDGLGGAVFSSADLSAASQADRPAVQVGD
PFMEKLLLEATLEAIQAGLVAGVQDMGAAGLVSSTCEMAYRAGLGITLELDRIPTREEGMVPMELCLSESQERMILVPVP
GREQELLDLLARWELDVVTIGEVEAHDRYRLTWRGEVVCDLPVALLNEAPKYTREGVESAEIRAKRERDLSGVPVPGDLG
AVLVELLSHPTIASKRPIFERYDHQVMTNTVVVPGAADAAVLRVKGSQLGVAATSDCNPRFVYLDPYTGAAAAVAEAARN
LACVGATPLAITDNLNFGNPYEPGVYFQLQQSVQGIADACRALNTPVTGGNVSLYNQYAEGDHKVAIHPTPTIGMVGVLP
DVTRRATLDLKPGPHLLYLLGRHATTIGASQYLETVHGLEAGQVPDLDLELERRVIEGTLALIRAGLTDAAHDCSEGGLA
VALAEMAMAGGQGLKVEIKAPAGVRPDALLFGEAHSRIVVAVPLGHEQAAQDLLEDLGVPYTALGESLPGSDRVTISVTG
ANVQLSVTLDTLKTAFETPLREILG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=638, Percent_Identity=27.8996865203762, Blast_Score=106, Evalue=9e-23,
Organism=Escherichia coli, GI48994899, Length=838, Percent_Identity=26.6109785202864, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17553022, Length=676, Percent_Identity=25.2958579881657, Blast_Score=113, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321498, Length=732, Percent_Identity=24.1803278688525, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24582111, Length=714, Percent_Identity=25.3501400560224, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24582109, Length=714, Percent_Identity=25.3501400560224, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17137292, Length=714, Percent_Identity=25.3501400560224, Blast_Score=109, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 78864; Mature: 78732

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTESLRPQAATFGLTSEEFDLLVSRLGREPNALEAAIVGAMWSEHCGYKNSRPLFSAF
CCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEC
PTTGPQVLQGPGENAGVVDIGEGWGVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMG
CCCCHHHHCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
ARPFAVLDSLRFGNPDSPRTRFLLNGVVEGISHYGNAIGVPTVGGEVTFHPSYQENPLVN
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHH
VMALGLLRHEDLAKGTMGAVGNQIVYVGSKTGRDGLGGAVFSSADLSAASQADRPAVQVG
HHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCCCCCCCHHCCCCCCCHHHCCCCCCEECC
DPFMEKLLLEATLEAIQAGLVAGVQDMGAAGLVSSTCEMAYRAGLGITLELDRIPTREEG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
MVPMELCLSESQERMILVPVPGREQELLDLLARWELDVVTIGEVEAHDRYRLTWRGEVVC
CCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCEEE
DLPVALLNEAPKYTREGVESAEIRAKRERDLSGVPVPGDLGAVLVELLSHPTIASKRPIF
ECCHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHH
ERYDHQVMTNTVVVPGAADAAVLRVKGSQLGVAATSDCNPRFVYLDPYTGAAAAVAEAAR
HHHCCEEECCEEEECCCCCEEEEEEECCEECEEEECCCCCEEEEECCCCCHHHHHHHHHH
NLACVGATPLAITDNLNFGNPYEPGVYFQLQQSVQGIADACRALNTPVTGGNVSLYNQYA
CEEEECCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEHHC
EGDHKVAIHPTPTIGMVGVLPDVTRRATLDLKPGPHLLYLLGRHATTIGASQYLETVHGL
CCCCEEEECCCCCCCCEECCCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCC
EAGQVPDLDLELERRVIEGTLALIRAGLTDAAHDCSEGGLAVALAEMAMAGGQGLKVEIK
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEE
APAGVRPDALLFGEAHSRIVVAVPLGHEQAAQDLLEDLGVPYTALGESLPGSDRVTISVT
CCCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEE
GANVQLSVTLDTLKTAFETPLREILG
CCEEEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THTESLRPQAATFGLTSEEFDLLVSRLGREPNALEAAIVGAMWSEHCGYKNSRPLFSAF
CCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEC
PTTGPQVLQGPGENAGVVDIGEGWGVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMG
CCCCHHHHCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
ARPFAVLDSLRFGNPDSPRTRFLLNGVVEGISHYGNAIGVPTVGGEVTFHPSYQENPLVN
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHH
VMALGLLRHEDLAKGTMGAVGNQIVYVGSKTGRDGLGGAVFSSADLSAASQADRPAVQVG
HHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCCCCCCCHHCCCCCCCHHHCCCCCCEECC
DPFMEKLLLEATLEAIQAGLVAGVQDMGAAGLVSSTCEMAYRAGLGITLELDRIPTREEG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
MVPMELCLSESQERMILVPVPGREQELLDLLARWELDVVTIGEVEAHDRYRLTWRGEVVC
CCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCEEE
DLPVALLNEAPKYTREGVESAEIRAKRERDLSGVPVPGDLGAVLVELLSHPTIASKRPIF
ECCHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHH
ERYDHQVMTNTVVVPGAADAAVLRVKGSQLGVAATSDCNPRFVYLDPYTGAAAAVAEAAR
HHHCCEEECCEEEECCCCCEEEEEEECCEECEEEECCCCCEEEEECCCCCHHHHHHHHHH
NLACVGATPLAITDNLNFGNPYEPGVYFQLQQSVQGIADACRALNTPVTGGNVSLYNQYA
CEEEECCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEHHC
EGDHKVAIHPTPTIGMVGVLPDVTRRATLDLKPGPHLLYLLGRHATTIGASQYLETVHGL
CCCCEEEECCCCCCCCEECCCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCC
EAGQVPDLDLELERRVIEGTLALIRAGLTDAAHDCSEGGLAVALAEMAMAGGQGLKVEIK
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEE
APAGVRPDALLFGEAHSRIVVAVPLGHEQAAQDLLEDLGVPYTALGESLPGSDRVTISVT
CCCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEE
GANVQLSVTLDTLKTAFETPLREILG
CCEEEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]