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The map label for this gene is tyrS [H]

Identifier: 94984115

GI number: 94984115

Start: 6295

End: 7536

Strand: Reverse

Name: tyrS [H]

Synonym: Dgeo_0006

Alternate gene names: 94984115

Gene position: 7536-6295 (Counterclockwise)

Preceding gene: 94984119

Following gene: NA

Centisome position: 0.31

GC content: 65.14

Gene sequence:

>1242_bases
ATGACCACCACGGAGATTCGCCCCAACCTGCCTGTCGACGAACAGCTCGCCATCCTGAGACGTGGCGTCGTGGACCTTGT
GACCGAGGATGACCTGCGACGTAAGCTGGAAAGGGGCCAACCGCTGCGCATCAAGCTGGGCGCCGACCCCACCCGCCCCG
ACCTGCACCTCGGCCACGCCGTCATTCTCCGCAAGATGCGGCAGTTTCAGGACCTGGGCCACAAGGTCATCATGCTGATC
GGGGACTTCACCGCGATGATCGGCGATCCCAGCGGCAAGTCCAAAACCCGGCCGCCTCTTACGTTGGAGGAGACGCGCGC
GAACGCGCAAAGTTACCTGGAGCAGTGCCGCCTGATTCTGCGTGACGAGCCCGAGCTGCTGGAACTGCGCTTTAACAGCG
AGTGGCTGGAGCCGCTGGGCTACGCCGATGTGATCCGCCTCGCCAGCCGGTACACGGTGGCCCGCATCCTCGAACGCGAC
GACTTCACCAAGCGGCTCAGCGCCGGAACGCCCATCAGCCTGCACGAGCTGCTCTACCCACTCACCCAGGGCTACGACAG
CGTGGCGCTCCACTCAGACGTGGAACTGGGCGGCACTGACCAGCTCTTTAACAACCTGGTGGGCCGCGCCCTGCAACGCG
ACTACGGTCAGGAACCGCAGGTGGTGATGACGCTGCCGCTGCTGGTCGGCCTGGACGGCACCGAGAAGATGTCCAAGAGC
CTGGACAACTACATCGGCCTCACCGACGAGCCAGACGTGATGTTCGCAGGGCTGATGAAGGTGCCTGACCCCCTGCTGGA
AAACTACTTCACCCTGCTCACTGACCTGCCGCCCGAACGTATCCAGGCACTGCTGGCCGGGCATCCGGTGGCCGCCCACC
GCGAACTCGCCCGCCAGGTTGTCGCCTGGCTGCATCCGCAGGCCGACCTCGACGCCGCTGAGGAGCGCTTCCGGGCCGTG
GCAAAGGGCGGCATTCCGGAGAACGTCCCCACCGTGACCGTGGCTCGCGAGGAACTCGGCGAGAGTGGGCGCGTCAGTAT
GGCGCGGCTGGTCGTGCTGGCGGGGTTAGAACCCAGCAACGGCGCGGCCCGCAAGCTGATTGGCAACCGTGGCTTGAAAC
TCAACGGGAAGCCGTACACCGAACCGCAAGGTACGCTGAGCCAGGACGAGCTGACAGAAGAAGGCGGCGTGGTCATTCAG
AAGGGCAAGGACCGCTTCGTGCGGCTGATCCTGGGCACCTGA

Upstream 100 bases:

>100_bases
GCTTGCCGCTAGGGTGGGCGGGTCAGTTACAGCCTGAAATCCAACCCCGCGGCGGCGCACCCGGCGAAGAGCGAGTGCGC
CGCCGCCCTTTGGAGAACCC

Downstream 100 bases:

>100_bases
CCTGCCCTCACCCTTCGCCGGGGCTGGCTCTGCTGGGCGCCCCGGTTTTCTCCGTGGATGGAGAACACGGCCAGACCAGC
CAACCTAAATGCTCCGCCCT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTTTEIRPNLPVDEQLAILRRGVVDLVTEDDLRRKLERGQPLRIKLGADPTRPDLHLGHAVILRKMRQFQDLGHKVIMLI
GDFTAMIGDPSGKSKTRPPLTLEETRANAQSYLEQCRLILRDEPELLELRFNSEWLEPLGYADVIRLASRYTVARILERD
DFTKRLSAGTPISLHELLYPLTQGYDSVALHSDVELGGTDQLFNNLVGRALQRDYGQEPQVVMTLPLLVGLDGTEKMSKS
LDNYIGLTDEPDVMFAGLMKVPDPLLENYFTLLTDLPPERIQALLAGHPVAAHRELARQVVAWLHPQADLDAAEERFRAV
AKGGIPENVPTVTVAREELGESGRVSMARLVVLAGLEPSNGAARKLIGNRGLKLNGKPYTEPQGTLSQDELTEEGGVVIQ
KGKDRFVRLILGT

Sequences:

>Translated_413_residues
MTTTEIRPNLPVDEQLAILRRGVVDLVTEDDLRRKLERGQPLRIKLGADPTRPDLHLGHAVILRKMRQFQDLGHKVIMLI
GDFTAMIGDPSGKSKTRPPLTLEETRANAQSYLEQCRLILRDEPELLELRFNSEWLEPLGYADVIRLASRYTVARILERD
DFTKRLSAGTPISLHELLYPLTQGYDSVALHSDVELGGTDQLFNNLVGRALQRDYGQEPQVVMTLPLLVGLDGTEKMSKS
LDNYIGLTDEPDVMFAGLMKVPDPLLENYFTLLTDLPPERIQALLAGHPVAAHRELARQVVAWLHPQADLDAAEERFRAV
AKGGIPENVPTVTVAREELGESGRVSMARLVVLAGLEPSNGAARKLIGNRGLKLNGKPYTEPQGTLSQDELTEEGGVVIQ
KGKDRFVRLILGT
>Mature_412_residues
TTTEIRPNLPVDEQLAILRRGVVDLVTEDDLRRKLERGQPLRIKLGADPTRPDLHLGHAVILRKMRQFQDLGHKVIMLIG
DFTAMIGDPSGKSKTRPPLTLEETRANAQSYLEQCRLILRDEPELLELRFNSEWLEPLGYADVIRLASRYTVARILERDD
FTKRLSAGTPISLHELLYPLTQGYDSVALHSDVELGGTDQLFNNLVGRALQRDYGQEPQVVMTLPLLVGLDGTEKMSKSL
DNYIGLTDEPDVMFAGLMKVPDPLLENYFTLLTDLPPERIQALLAGHPVAAHRELARQVVAWLHPQADLDAAEERFRAVA
KGGIPENVPTVTVAREELGESGRVSMARLVVLAGLEPSNGAARKLIGNRGLKLNGKPYTEPQGTLSQDELTEEGGVVIQK
GKDRFVRLILGT

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=323, Percent_Identity=29.1021671826625, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1787925, Length=420, Percent_Identity=27.3809523809524, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25145802, Length=326, Percent_Identity=26.6871165644172, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325160, Length=384, Percent_Identity=23.6979166666667, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130383, Length=384, Percent_Identity=25.2604166666667, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45886; Mature: 45755

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTEIRPNLPVDEQLAILRRGVVDLVTEDDLRRKLERGQPLRIKLGADPTRPDLHLGHA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
VILRKMRQFQDLGHKVIMLIGDFTAMIGDPSGKSKTRPPLTLEETRANAQSYLEQCRLIL
HHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RDEPELLELRFNSEWLEPLGYADVIRLASRYTVARILERDDFTKRLSAGTPISLHELLYP
CCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LTQGYDSVALHSDVELGGTDQLFNNLVGRALQRDYGQEPQVVMTLPLLVGLDGTEKMSKS
HHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCHHHHHHH
LDNYIGLTDEPDVMFAGLMKVPDPLLENYFTLLTDLPPERIQALLAGHPVAAHRELARQV
HHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHH
VAWLHPQADLDAAEERFRAVAKGGIPENVPTVTVAREELGESGRVSMARLVVLAGLEPSN
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHCCCCCCC
GAARKLIGNRGLKLNGKPYTEPQGTLSQDELTEEGGVVIQKGKDRFVRLILGT
CHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEECC
>Mature Secondary Structure 
TTTEIRPNLPVDEQLAILRRGVVDLVTEDDLRRKLERGQPLRIKLGADPTRPDLHLGHA
CCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
VILRKMRQFQDLGHKVIMLIGDFTAMIGDPSGKSKTRPPLTLEETRANAQSYLEQCRLIL
HHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RDEPELLELRFNSEWLEPLGYADVIRLASRYTVARILERDDFTKRLSAGTPISLHELLYP
CCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LTQGYDSVALHSDVELGGTDQLFNNLVGRALQRDYGQEPQVVMTLPLLVGLDGTEKMSKS
HHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCHHHHHHH
LDNYIGLTDEPDVMFAGLMKVPDPLLENYFTLLTDLPPERIQALLAGHPVAAHRELARQV
HHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHH
VAWLHPQADLDAAEERFRAVAKGGIPENVPTVTVAREELGESGRVSMARLVVLAGLEPSN
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHCCCCCCC
GAARKLIGNRGLKLNGKPYTEPQGTLSQDELTEEGGVVIQKGKDRFVRLILGT
CHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]