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The map label for this gene is glmS [H]

Identifier: 94984119

GI number: 94984119

Start: 9612

End: 11432

Strand: Reverse

Name: glmS [H]

Synonym: Dgeo_0010

Alternate gene names: 94984119

Gene position: 11432-9612 (Counterclockwise)

Preceding gene: 94984120

Following gene: 94984115

Centisome position: 0.46

GC content: 63.7

Gene sequence:

>1821_bases
ATGTGTGGAATCGTCGGTTATATCGGTACCCGGCAGGCGCAAGACGTTCTGCTCTCGGGCCTCTCCCGGCTGGAATATCG
CGGCTACGACAGTGCGGGCGTCGCGGTGGGCGACGGCGCCTGCATTGCGGTGAAGAAGAAGGCGGGAAAGCTCGCCAACC
TCAGCGGTGAGCTTGAGCAGGCACCGCTGAGGGGCACCCTGGGCATCGGCCACACCCGCTGGGCCACCCACGGGCTGCCC
AACGACACCAACGCCCACCCCCACGCGACCGAAGACGGCAAGATCGTCATCATTCACAATGGGATCATCGAGAATTACCT
CAGTCTCAAGGAAGGGTTGATCGCGCGCGGGCACACCTTCAAGAGTGAAACCGACTCGGAGGTGCTGGCCCACCTGATCG
AAGAGGCGTATACGGGCGACCTGTATGAGGCGGTGCGGCAGGCTCTCTTGCAGGTGCGAGGGGCCTACAGCCTCGTCGTT
ACGCATGTTCACCACCGCGAGATTGTGGCGGCCCGCACCGTCAGCCCGCTCGTGATGGGCGTTGGGGAAGGCGAGATGTT
CTTGGCCTCGGATGTGCCCGCCCTGCTGCCCTATACCCGCCGGATGGTCTTCCTGCACGATGGCGACATGGCCGTGCTGA
ACGACGACGGCTACCGCCTCACCGATCTTCAGGGCAAGCCGGTCGAGCGGCCAGTGGACCTGATAGAGTGGGACGCTGAG
GCCGCGGAAAAGGGCGGGTTTGACACCTATATGCTCAAAGAAATCTACGAGCAGCCCCAAGCCCTGACCAACACCCTGAT
TGGCCGCCTGCACGACGAGACGGGCGAGGTAAACCTCGATATCGACCTTGACCCGCAGAGCTTCAAGCGGATCTCCATCA
TCGCCTGCGGCACCGCGTACTACGCCGGTCTGGTAGGCGAGTATCTCATTGAGCAGCTCGCGCGGATTCCAGTCGAGGTG
GACGTGGCCTCGGAGTACCGTTACCGCACGCCCATTGTGAACGAGGAGACGCTCGCCATTGTGGTCAGCCAGTCAGGTGA
GACCATCGATACCCTCGAAGCGCTGCGCGAGGCGAAGAAGGGCGGAGCACAGACCTTAGGCGTGATCAACGCCAAGGGCA
GCTCGATGACCCGCGAACTCGACCACACGCTCTACATCCATGCCGGGCCGGAGATCGGGGTTGCCAGCACCAAGGCGTAC
ACCAGTATGGTCAGCGCCTTTGTGCTGCTCTCGCTCTGGCTGGGCCGCGCGCGCGGCACGCTCTCCGAGGAGCAGGCGCA
GGAACTGTTGCACGCCACCCGCGAGCTGCCGCGCCTGGTGGAAGAGGCCCTGGCCCCCGAACGCGTGGAGAACATCAGGC
GGGTGGCCGAGAAGTACGCCCACGCCCGCGACTATCTCTTCCTGGGCCGCGGCGTGAACGCGCCGACTGCCTATGAGGGC
GCCCTCAAGCTCAAGGAGATCAGCTATATCCACGCCGAAGCCTATGCGGCGGGCGAGATGAAGCATGGTCCTATCGCCCT
GATTGACGAGCACCTGCCCGTGGTGGTGATGGCCACCGCCAGCCGCCTGCTGGAAAAGACCATCAGCAACATCCAGGAGG
TCAAGGCCCGCTCCGGCAAGGTGATTGCCCTCCTCAGCGACGGCGATACCGAGAACGCCCGCCACGCCGACGACGTGCTG
TATGTTCCCCACGCGCATGAACTGGTCAGCCCGGTGGTGAATGCGGTCGCCATGCAGCTTCTCGCCTACTTCACGGCAAC
CGCCCTGGGCAAGGATGTGGATAAGCCGCGCAACTTGGCGAAAAGCGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
AACCCCCACGGTGACGTGGACATAAGGCCGCGCAGTGCCACAATCCCAATCCAGACACCTCCCGCCCGGGCACTGCGCTC
GGTGCGGGTCAGGAGTTCTT

Downstream 100 bases:

>100_bases
AGGCAAACGGGGCAGAAGGTGCTTTTTGCACGATGCATACAGTTGACTTCCCCTGCATCCCACGCTATTCTTTTTCTATC
AGCGTCCGCAAGGGCGCTTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MCGIVGYIGTRQAQDVLLSGLSRLEYRGYDSAGVAVGDGACIAVKKKAGKLANLSGELEQAPLRGTLGIGHTRWATHGLP
NDTNAHPHATEDGKIVIIHNGIIENYLSLKEGLIARGHTFKSETDSEVLAHLIEEAYTGDLYEAVRQALLQVRGAYSLVV
THVHHREIVAARTVSPLVMGVGEGEMFLASDVPALLPYTRRMVFLHDGDMAVLNDDGYRLTDLQGKPVERPVDLIEWDAE
AAEKGGFDTYMLKEIYEQPQALTNTLIGRLHDETGEVNLDIDLDPQSFKRISIIACGTAYYAGLVGEYLIEQLARIPVEV
DVASEYRYRTPIVNEETLAIVVSQSGETIDTLEALREAKKGGAQTLGVINAKGSSMTRELDHTLYIHAGPEIGVASTKAY
TSMVSAFVLLSLWLGRARGTLSEEQAQELLHATRELPRLVEEALAPERVENIRRVAEKYAHARDYLFLGRGVNAPTAYEG
ALKLKEISYIHAEAYAAGEMKHGPIALIDEHLPVVVMATASRLLEKTISNIQEVKARSGKVIALLSDGDTENARHADDVL
YVPHAHELVSPVVNAVAMQLLAYFTATALGKDVDKPRNLAKSVTVE

Sequences:

>Translated_606_residues
MCGIVGYIGTRQAQDVLLSGLSRLEYRGYDSAGVAVGDGACIAVKKKAGKLANLSGELEQAPLRGTLGIGHTRWATHGLP
NDTNAHPHATEDGKIVIIHNGIIENYLSLKEGLIARGHTFKSETDSEVLAHLIEEAYTGDLYEAVRQALLQVRGAYSLVV
THVHHREIVAARTVSPLVMGVGEGEMFLASDVPALLPYTRRMVFLHDGDMAVLNDDGYRLTDLQGKPVERPVDLIEWDAE
AAEKGGFDTYMLKEIYEQPQALTNTLIGRLHDETGEVNLDIDLDPQSFKRISIIACGTAYYAGLVGEYLIEQLARIPVEV
DVASEYRYRTPIVNEETLAIVVSQSGETIDTLEALREAKKGGAQTLGVINAKGSSMTRELDHTLYIHAGPEIGVASTKAY
TSMVSAFVLLSLWLGRARGTLSEEQAQELLHATRELPRLVEEALAPERVENIRRVAEKYAHARDYLFLGRGVNAPTAYEG
ALKLKEISYIHAEAYAAGEMKHGPIALIDEHLPVVVMATASRLLEKTISNIQEVKARSGKVIALLSDGDTENARHADDVL
YVPHAHELVSPVVNAVAMQLLAYFTATALGKDVDKPRNLAKSVTVE
>Mature_606_residues
MCGIVGYIGTRQAQDVLLSGLSRLEYRGYDSAGVAVGDGACIAVKKKAGKLANLSGELEQAPLRGTLGIGHTRWATHGLP
NDTNAHPHATEDGKIVIIHNGIIENYLSLKEGLIARGHTFKSETDSEVLAHLIEEAYTGDLYEAVRQALLQVRGAYSLVV
THVHHREIVAARTVSPLVMGVGEGEMFLASDVPALLPYTRRMVFLHDGDMAVLNDDGYRLTDLQGKPVERPVDLIEWDAE
AAEKGGFDTYMLKEIYEQPQALTNTLIGRLHDETGEVNLDIDLDPQSFKRISIIACGTAYYAGLVGEYLIEQLARIPVEV
DVASEYRYRTPIVNEETLAIVVSQSGETIDTLEALREAKKGGAQTLGVINAKGSSMTRELDHTLYIHAGPEIGVASTKAY
TSMVSAFVLLSLWLGRARGTLSEEQAQELLHATRELPRLVEEALAPERVENIRRVAEKYAHARDYLFLGRGVNAPTAYEG
ALKLKEISYIHAEAYAAGEMKHGPIALIDEHLPVVVMATASRLLEKTISNIQEVKARSGKVIALLSDGDTENARHADDVL
YVPHAHELVSPVVNAVAMQLLAYFTATALGKDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=38.0466472303207, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=36.2573099415205, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI29570798, Length=188, Percent_Identity=28.7234042553192, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=48.0582524271845, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1788651, Length=262, Percent_Identity=27.8625954198473, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17532899, Length=724, Percent_Identity=31.6298342541436, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17532897, Length=446, Percent_Identity=38.1165919282511, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17539970, Length=447, Percent_Identity=37.3601789709172, Blast_Score=286, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=435, Percent_Identity=37.7011494252874, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=31.264367816092, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323730, Length=211, Percent_Identity=38.3886255924171, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=35.5685131195335, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI28573187, Length=266, Percent_Identity=30.4511278195489, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24659598, Length=249, Percent_Identity=29.718875502008, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24659604, Length=242, Percent_Identity=29.3388429752066, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66062; Mature: 66062

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGTRQAQDVLLSGLSRLEYRGYDSAGVAVGDGACIAVKKKAGKLANLSGELEQ
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCHHC
APLRGTLGIGHTRWATHGLPNDTNAHPHATEDGKIVIIHNGIIENYLSLKEGLIARGHTF
CCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCC
KSETDSEVLAHLIEEAYTGDLYEAVRQALLQVRGAYSLVVTHVHHREIVAARTVSPLVMG
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHCHHEEE
VGEGEMFLASDVPALLPYTRRMVFLHDGDMAVLNDDGYRLTDLQGKPVERPVDLIEWDAE
CCCCCEEEECCCCHHCCCCCEEEEEECCCEEEECCCCCEEECCCCCCCCCCHHHHHCCHH
AAEKGGFDTYMLKEIYEQPQALTNTLIGRLHDETGEVNLDIDLDPQSFKRISIIACGTAY
HHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEECCHHHCCEEEEEEECHHH
YAGLVGEYLIEQLARIPVEVDVASEYRYRTPIVNEETLAIVVSQSGETIDTLEALREAKK
HHHHHHHHHHHHHHHCCEEEEECCCCEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHC
GGAQTLGVINAKGSSMTRELDHTLYIHAGPEIGVASTKAYTSMVSAFVLLSLWLGRARGT
CCCCEEEEEECCCCHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
LSEEQAQELLHATRELPRLVEEALAPERVENIRRVAEKYAHARDYLFLGRGVNAPTAYEG
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHC
ALKLKEISYIHAEAYAAGEMKHGPIALIDEHLPVVVMATASRLLEKTISNIQEVKARSGK
CEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
VIALLSDGDTENARHADDVLYVPHAHELVSPVVNAVAMQLLAYFTATALGKDVDKPRNLA
EEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KSVTVE
HHCCCC
>Mature Secondary Structure
MCGIVGYIGTRQAQDVLLSGLSRLEYRGYDSAGVAVGDGACIAVKKKAGKLANLSGELEQ
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCHHC
APLRGTLGIGHTRWATHGLPNDTNAHPHATEDGKIVIIHNGIIENYLSLKEGLIARGHTF
CCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCC
KSETDSEVLAHLIEEAYTGDLYEAVRQALLQVRGAYSLVVTHVHHREIVAARTVSPLVMG
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHCHHEEE
VGEGEMFLASDVPALLPYTRRMVFLHDGDMAVLNDDGYRLTDLQGKPVERPVDLIEWDAE
CCCCCEEEECCCCHHCCCCCEEEEEECCCEEEECCCCCEEECCCCCCCCCCHHHHHCCHH
AAEKGGFDTYMLKEIYEQPQALTNTLIGRLHDETGEVNLDIDLDPQSFKRISIIACGTAY
HHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEECCHHHCCEEEEEEECHHH
YAGLVGEYLIEQLARIPVEVDVASEYRYRTPIVNEETLAIVVSQSGETIDTLEALREAKK
HHHHHHHHHHHHHHHCCEEEEECCCCEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHC
GGAQTLGVINAKGSSMTRELDHTLYIHAGPEIGVASTKAYTSMVSAFVLLSLWLGRARGT
CCCCEEEEEECCCCHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
LSEEQAQELLHATRELPRLVEEALAPERVENIRRVAEKYAHARDYLFLGRGVNAPTAYEG
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHC
ALKLKEISYIHAEAYAAGEMKHGPIALIDEHLPVVVMATASRLLEKTISNIQEVKARSGK
CEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
VIALLSDGDTENARHADDVLYVPHAHELVSPVVNAVAMQLLAYFTATALGKDVDKPRNLA
EEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KSVTVE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA