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The map label for this gene is sdhA [H]

Identifier: 94995354

GI number: 94995354

Start: 1911711

End: 1912583

Strand: Direct

Name: sdhA [H]

Synonym: MGAS10750_Spy1958

Alternate gene names: 94995354

Gene position: 1911711-1912583 (Clockwise)

Preceding gene: 94995353

Following gene: 94995363

Centisome position: 98.69

GC content: 41.47

Gene sequence:

>873_bases
ATGTTTTATACTATTGAAGAACTTGTCAAACAAGCTGACCAACAATTTAATGGAAATATTGCTGAACTCATGATTGCCAC
GGAAGTGGAGATGTCTGGAAGAAATCGAGAAGATATTATCAAAATCATGTCACGCAATTTACAAGTTATGAAAGCAGCTG
TAACAGAAGGACTAACCTCAACCAAATCTATCAGTGGTTTGACAGGGGGCGATGCGGTCAAAATGGATAACTACATTAAA
AAAGGGAACAGCCTTTCTGATACTACTATTCTTAATGCTGTTAGAAATGCTATAGCTGTAAACGAATTAAATGCTAAAAT
GGGACTTGTCTGTGCAACGCCCACTGCAGGAAGTGCAGGATGCTTACCAGCAGTGCTCGCAACAGCTATTGAAAAACTTG
ACTTATCAGAAAAAAAACAATTAGAGTTTTTATTTACTGCAGGAGCTTTTGGTCTTGTTATTGGAAATAACGCCTCTATT
TCTGGTGCAGAAGGTGGATGCCAAGCAGAAGTTGGTTCTGCAGCTGCTATGAGTGCAGCTGCTCTTGTTAAGGCAGCTGG
TGGAACATCTCATCAAGCTAGTCAAGCTATTGCGTTTGTTATCAAAAATTTATTAGGACTTGTCTGTGATCCTGTTGCCG
GCCTAGTAGAAGTGCCTTGTGTCAAACGCAATGCCCTAGGAGCAAGTTTCGCCCTTGTCGCAGCTGATATGGCTTTAGCT
GATATTGAATCTCAAATTCCTGTTGACGAAGTTATTGATGCTATGTATCAAGTCGGCTCTGCCATGCCAACTGCTTTCCG
TGAAACAGCAGAAGGTGGTTTAGCCGCTACTCCAACTGGACGACGTTACAGCGTAGAAATATTTGGCGAATAA

Upstream 100 bases:

>100_bases
TTATAGAAGTCGATTCTAGAGAGTGCCAAGAAGCAGCCAACCAAATTGCAAAAATTCCTCATATTTATAATGTCAACTTC
TTTGACTAGAAAGGAAAGCT

Downstream 100 bases:

>100_bases
ATAGATAGTTAGAAAAATTCTTAGAAATATTTGAAAGCGTTTTATTTTTCTGCTATATATTCACTAAAATGACTAATAGA
TAGCTATCAAGCTATGTTGT

Product: L-serinedehydratase alpha subunit

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MFYTIEELVKQADQQFNGNIAELMIATEVEMSGRNREDIIKIMSRNLQVMKAAVTEGLTSTKSISGLTGGDAVKMDNYIK
KGNSLSDTTILNAVRNAIAVNELNAKMGLVCATPTAGSAGCLPAVLATAIEKLDLSEKKQLEFLFTAGAFGLVIGNNASI
SGAEGGCQAEVGSAAAMSAAALVKAAGGTSHQASQAIAFVIKNLLGLVCDPVAGLVEVPCVKRNALGASFALVAADMALA
DIESQIPVDEVIDAMYQVGSAMPTAFRETAEGGLAATPTGRRYSVEIFGE

Sequences:

>Translated_290_residues
MFYTIEELVKQADQQFNGNIAELMIATEVEMSGRNREDIIKIMSRNLQVMKAAVTEGLTSTKSISGLTGGDAVKMDNYIK
KGNSLSDTTILNAVRNAIAVNELNAKMGLVCATPTAGSAGCLPAVLATAIEKLDLSEKKQLEFLFTAGAFGLVIGNNASI
SGAEGGCQAEVGSAAAMSAAALVKAAGGTSHQASQAIAFVIKNLLGLVCDPVAGLVEVPCVKRNALGASFALVAADMALA
DIESQIPVDEVIDAMYQVGSAMPTAFRETAEGGLAATPTGRRYSVEIFGE
>Mature_290_residues
MFYTIEELVKQADQQFNGNIAELMIATEVEMSGRNREDIIKIMSRNLQVMKAAVTEGLTSTKSISGLTGGDAVKMDNYIK
KGNSLSDTTILNAVRNAIAVNELNAKMGLVCATPTAGSAGCLPAVLATAIEKLDLSEKKQLEFLFTAGAFGLVIGNNASI
SGAEGGCQAEVGSAAAMSAAALVKAAGGTSHQASQAIAFVIKNLLGLVCDPVAGLVEVPCVKRNALGASFALVAADMALA
DIESQIPVDEVIDAMYQVGSAMPTAFRETAEGGLAATPTGRRYSVEIFGE

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=282, Percent_Identity=35.8156028368794, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1788116, Length=258, Percent_Identity=36.4341085271318, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1789161, Length=269, Percent_Identity=34.9442379182156, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005130
- InterPro:   IPR004642 [H]

Pfam domain/function: PF03313 SDH_alpha [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 29985; Mature: 29985

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYTIEELVKQADQQFNGNIAELMIATEVEMSGRNREDIIKIMSRNLQVMKAAVTEGLTS
CCCCHHHHHHHHHHHHCCCHHHEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TKSISGLTGGDAVKMDNYIKKGNSLSDTTILNAVRNAIAVNELNAKMGLVCATPTAGSAG
HHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
CLPAVLATAIEKLDLSEKKQLEFLFTAGAFGLVIGNNASISGAEGGCQAEVGSAAAMSAA
HHHHHHHHHHHHHCCCCHHHEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
ALVKAAGGTSHQASQAIAFVIKNLLGLVCDPVAGLVEVPCVKRNALGASFALVAADMALA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHH
DIESQIPVDEVIDAMYQVGSAMPTAFRETAEGGLAATPTGRRYSVEIFGE
HHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCEEEEEEECC
>Mature Secondary Structure
MFYTIEELVKQADQQFNGNIAELMIATEVEMSGRNREDIIKIMSRNLQVMKAAVTEGLTS
CCCCHHHHHHHHHHHHCCCHHHEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TKSISGLTGGDAVKMDNYIKKGNSLSDTTILNAVRNAIAVNELNAKMGLVCATPTAGSAG
HHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
CLPAVLATAIEKLDLSEKKQLEFLFTAGAFGLVIGNNASISGAEGGCQAEVGSAAAMSAA
HHHHHHHHHHHHHCCCCHHHEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
ALVKAAGGTSHQASQAIAFVIKNLLGLVCDPVAGLVEVPCVKRNALGASFALVAADMALA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHH
DIESQIPVDEVIDAMYQVGSAMPTAFRETAEGGLAATPTGRRYSVEIFGE
HHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]