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The map label for this gene is hutU [H]

Identifier: 94995259

GI number: 94995259

Start: 1822213

End: 1824243

Strand: Direct

Name: hutU [H]

Synonym: MGAS10750_Spy1863

Alternate gene names: 94995259

Gene position: 1822213-1824243 (Clockwise)

Preceding gene: 94995257

Following gene: 94995260

Centisome position: 94.07

GC content: 44.46

Gene sequence:

>2031_bases
ATGTCATTTTACAGTGAAACTGACATAGCTGCCGCTATGACTGTTAAGTTAGACGATGTTTTACCGGAAAAGACTGTGTT
TGAAGAAGGTATCCGAAGAGCACCAGACAGAGGTTTTCGATTGACCCAGGCTCAGACCGAAATCGCCTTGAAAAATGCCC
TACGCTATGTACCTACGAAGTTCCACGAAGAAGTCATTCCAGAATTTTTGGAAGAACTCAAAACCCGTGGCCGTATTTAT
GGCTACCGCTTTAGACCAAAAGACCGCATTTACGGCAAACCCATTGACGAGTACAAGGGAAATTGTACAGCTGCCAAGGC
CATGCAGGTCATGATTGACAATAACTTGAGTTTTGAAATTGCCTTGTACCCTTACGAACTAGTCACATATGGAGAAACTG
GTTCTGTTTGTGCCAACTGGATGCAATATTGTTTGATTAAAAAATACCTAGAAGTCATGACTGATGAACAAACCTTGGTG
GTTGAGTCTGGTCATCCAGTTGGTCTTTTCAAATCCAAACCTGAAGCGCCTCGTGTGATTATTACTAATGGCCTTTTGGT
GGGTGAATACGACAACATGAAAGACTGGGAAATCGCTGAAGAGATGGGTGTCACCAACTATGGTCAAATGACCGCAGGTG
GTTGGATGTATATTGGCCCACAAGGAATCGTTCATGGAACATTTAATACTCTCTTAAATGCTGGTCGTCTCAAACTTGGA
GTGGCTGACGATGGTGATTTGACCGGTAAACTCTTTATCTCATCTGGTTTAGGAGGCATGAGTGGGGCACAAGGTAAGGC
TGCTGAAATTGCTAAAGCAGTTGCCATTATTGCTGAAGTTGACCAATCTCGGATTGAAACCCGTCATTCGCAAGGTTGGG
TTAGCCAAATTGCTGAGAGCCCTGAAGAAGCTCTGCAATTAGCCCAAAAAGCCATAGATGCTAAGGAGTCCACTTCGATT
GCTTACCATGGTAATATCGTTGATCTTTTAGAGTACGTCAATGACAAGCAGATTCATGTTGATCTTTTGTCTGACCAAAC
CTCTTGTCACAACATTTATGACGGTGGCTACTGCCCAGCTGGCATTAGCTTTGACGAAAGAACCCGGCTCTTGGCAGAAG
ACAAGGATACCTTCCACCAAATGGTTGATGATACCTTGGCACGGCATTTTGAAGCTATTAAGACGTTAACTGAAAATGGC
ACCTATTTCTTTGACTACGGTAATGCCTTTATGAAGTCTGTTTACGACTCTGGTATTACAGAAATTTCTAAGAATGGTCG
TAACGACAAAGACGGCTTTATCTGGCCTTCTTATGTTGAAGACATCATGGGACCTATGCTTTTTGACTATGGCTATGGAC
CTTTCCGTTGGGTCTGCTTGAGTGGTAAACACGAAGACTTGGTGGCCACTGACAAAGCTGCCATGGAAGCTATCGATCCT
GACCGCCGTTATCAAGACCGTGATAACTACAACTGGATTCGTGATGCTGAGAAAAATCAACTCGTAGTTGGTACCCAAGC
CCGGATCCTTTACCAAGACTGTATCGGTCGTGTGACTATCGCCCTTAAATTTAATGAATTGGTCCGCAAAGGCAAGATTG
GTCCTGTCATGATTGGTCGTGACCACCATGACGTGTCTGGTACCGACTCACCATTTCGTGAAACCTCAAACATTAAAGAC
GGTTCCAATGTGACCTGTGATATGGCGGTTCAATGTTACGCTGGTAACGCTGCGCGTGGTATGAGTTTAGTGGCTCTTCA
TAACGGTGGCGGAACTGGTATTGGTAAAGCCATCAATGGTGGTTTCGGTCTTGTTTTAGATGGCAGCGAACGCATTGATG
AGATTATTAAATCTGCCATTGCTTGGGACACCATGGGTGGTGTTGCTCGTCGCAATTGGGCTCGCAATGAGCACGCTATT
GAAACCGCTATTGAATACAACCGTCTCCATGCAGGTACTGATCATATCACTATCCCATATTTGGCTGACGATGACCTTGT
GATTTCAGCGGTAGATCAATTATTTCACTAA

Upstream 100 bases:

>100_bases
TTTAGACTTTTTTCGCATTTCAAAGCGTGGTTGACTTTTTATAGACTAGACTAAGTTAGACTAATCTCGACAATAAAAAG
GAGTTGAGGAGGAGTTTTCT

Downstream 100 bases:

>100_bases
TAACTGCTAGCTAAAAATGTAAGCGTTATCTAAAGTAGGTAACCTATTCCCTTAATGAGTAACTCAATGACATAAAAGGA
GATTAACATGGCAAAAATTG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MSFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTKFHEEVIPEFLEELKTRGRIY
GYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEIALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLV
VESGHPVGLFKSKPEAPRVIITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIETRHSQGWVSQIAESPEEALQLAQKAIDAKESTSI
AYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNIYDGGYCPAGISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENG
TYFFDYGNAFMKSVYDSGITEISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVATDKAAMEAIDP
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGRDHHDVSGTDSPFRETSNIKD
GSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAINGGFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAI
ETAIEYNRLHAGTDHITIPYLADDDLVISAVDQLFH

Sequences:

>Translated_676_residues
MSFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTKFHEEVIPEFLEELKTRGRIY
GYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEIALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLV
VESGHPVGLFKSKPEAPRVIITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIETRHSQGWVSQIAESPEEALQLAQKAIDAKESTSI
AYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNIYDGGYCPAGISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENG
TYFFDYGNAFMKSVYDSGITEISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVATDKAAMEAIDP
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGRDHHDVSGTDSPFRETSNIKD
GSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAINGGFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAI
ETAIEYNRLHAGTDHITIPYLADDDLVISAVDQLFH
>Mature_675_residues
SFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTKFHEEVIPEFLEELKTRGRIYG
YRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEIALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLVV
ESGHPVGLFKSKPEAPRVIITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLGV
ADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIETRHSQGWVSQIAESPEEALQLAQKAIDAKESTSIA
YHGNIVDLLEYVNDKQIHVDLLSDQTSCHNIYDGGYCPAGISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENGT
YFFDYGNAFMKSVYDSGITEISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVATDKAAMEAIDPD
RRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGRDHHDVSGTDSPFRETSNIKDG
SNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAINGGFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAIE
TAIEYNRLHAGTDHITIPYLADDDLVISAVDQLFH

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=668, Percent_Identity=46.2574850299401, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI260306182, Length=728, Percent_Identity=42.032967032967, Blast_Score=533, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71997891, Length=649, Percent_Identity=46.9953775038521, Blast_Score=592, Evalue=1e-169,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 75205; Mature: 75074

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00024 HEMOPEXIN ; PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTK
CCCCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCHH
FHEEVIPEFLEELKTRGRIYGYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEI
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCHHHHEEEEECCCCEEEE
ALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLVVESGHPVGLFKSKPEAPRVI
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCEEE
ITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
EECCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHCCCCEEEE
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIETRHSQGWVSQIAES
ECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEEALQLAQKAIDAKESTSIAYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNIYDGGYCPA
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
GISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENGTYFFDYGNAFMKSVYDSGIT
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
EISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVATDKAAMEAIDP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCC
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGR
CCCCCCCCCCCHHCCCCCCEEEEECHHHHHHHHHHCEEEEEEEHHHHHHCCCCCCEEECC
DHHDVSGTDSPFRETSNIKDGSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAING
CCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCHHCCC
GFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAIETAIEYNRLHAGTDHITIPY
CEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHEECCCCCEEEEE
LADDDLVISAVDQLFH
ECCCCHHHHHHHHHCC
>Mature Secondary Structure 
SFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTK
CCCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCHH
FHEEVIPEFLEELKTRGRIYGYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEI
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCHHHHEEEEECCCCEEEE
ALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLVVESGHPVGLFKSKPEAPRVI
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCEEE
ITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
EECCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHCCCCEEEE
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIETRHSQGWVSQIAES
ECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEEALQLAQKAIDAKESTSIAYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNIYDGGYCPA
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
GISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENGTYFFDYGNAFMKSVYDSGIT
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
EISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVATDKAAMEAIDP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCC
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGR
CCCCCCCCCCCHHCCCCCCEEEEECHHHHHHHHHHCEEEEEEEHHHHHHCCCCCCEEECC
DHHDVSGTDSPFRETSNIKDGSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAING
CCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCHHCCC
GFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAIETAIEYNRLHAGTDHITIPY
CEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHEECCCCCEEEEE
LADDDLVISAVDQLFH
ECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA