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The map label for this gene is scpA [H]

Identifier: 94993735

GI number: 94993735

Start: 344160

End: 346895

Strand: Direct

Name: scpA [H]

Synonym: MGAS10750_Spy0339

Alternate gene names: 94993735

Gene position: 344160-346895 (Clockwise)

Preceding gene: 94993734

Following gene: 94993736

Centisome position: 17.77

GC content: 41.74

Gene sequence:

>2736_bases
GTGGAGAAAAAGCAACGTTTTTCCCTTAGAAAATACAAATCAGGAACGTTTTCGGTCTTAATAGGAAGCGTTTTCTTGAT
GATGATGACGACAACAACAGTAGCAGCAGATGAGCTAACCACAACGAGTGAACCAACAATCACGAATCACGCTCAACAAC
AAGCGCAACATCTCACCAATACAGAGTTGAGCTCAGCTGAATCACAATCCCCAGACACATCACAAATCACTCCCAAGACA
AATCGTGAAAAAGAGCAACCACAAGGTCTAGTCTCTGAGCCAACCACAACTGAGCTAGCTGACACAGATGCAGCATCAAT
GGCTAATACAGGTCCTGATGCGACTCAAAAAAGCGCTTCTTTACCGCCAGTCAATACAGATGTTCACGATTGGGTAAAAA
CCAAAGGAGCTTGGGACAAGGGATACAAAGGACAAGGCAAGGTTGTCGCAGTTATTGACACAGGGATCGATCCGGCCCAT
CAAAGCATGCGCATCAGTGATGTATCAACTGCTAAAGTAAAATCAAAAGAAGACATGCTAGCACGCCAAAAAGCCGCCGG
TATTAATTATGGGAGTTGGATAAATGATAAAGTTGTTTTTGCACATAATTATGTGGAAAATAGCGATAATATCAAAGAAA
ATCAATTCGGGGATTTTGATGAGGACTGGGAAAACTTTGAGTTTGATGCAGAGCCAAAAGCCATCAAAAAAAACAAGATC
TATCGTCCCCAATCAACCCAGGCACCGAAAGAAACTGTTATCAAAACAGAAGAAACAGATGGTTCACATGATATTGACTG
GACACAAACAGACGATGACACCAAATACGAGTCACACGGTATGCATGTGACAGGTATTGTAGCCGGTAATAGCAAAGAAG
CCGCTGCTACTGGAGAACGCTTTTTAGGAATTGCACCAGAGGCCCAAGTCATGTTCATGCGTGTTTTTGCCAACGACGTC
ATGGGATCAGCTGAATCACTCTTTATCAAAGCTATCGAAGATGCCGTGGCTTTAGGAGCAGATGTGATCAACCTGAGTCT
TGGAACCGCTAATGGGGCACAGCTTAGTGGCAGCAAGCCTCTAATGGAAGCAATTGAAAAAGCTAAAAAAGCCGGTGTAT
CAGTTGTTGTAGCAGCAGGAAATGAGCGCGTCTATGGATCTGACCATGATGATCCATTGGCAACAAATCCAGACTATGGT
TTGGTCGGTTCTCCCTCAACAGGTCGAACACCAACATCAGTGGCAGCTATAAACAGTAAGTGGGTGATTCAACGTCTAAT
GACGGCCAAAGAATTAGAAAACCGTGCCGATTTAAACCATGGTAAAGCCATCTATTCAGAGTCTGTCGACTTTAAAAACA
TAAAAGATAGCCTAGGTTATGATAAATCGCATCAATTTGCTTATGTCAAAGAGTCAACTGATGCGGGTTATAAAGCACAA
GACGTTAAAGATAAAATTGCTTTAATTGAACGTGATCCCAATAAAACCTATGACGAAATGATTGCTTTGGCTAAGAAACA
TGGAGCCCTGGGAGTACTTATTTTTAATAACAAGCCTGGTCAATCAAACCGCTCAATGCGTCTAACAGCTAATGGGATGG
GGATACCATCTGCTTTCATATCGCACGAATTTGGTAAGGCCATGTCCCAATTAAATGGCAATGGTACAGGAAGTTTAGAG
TTTGACAGTGTGGTCTCAAAAGCACCGAGTCAAAAAGGCAATGAAATGAATCATTTTTCAAATTGGGGCCTAACTTCTGA
TGGCTATTTAAAACCTGACATTACTGCACCAGGTGGCGATATCTACTCTACCTATAACGATAACCACTATGGTAGCCAAA
CAGGAACAAGTATGGCCTCTCCTCAGATTGCTGGCGCCAGCCTTTTGGTCAAACAATACCTAGAAAAGACTCAGCCAAAC
TTGCCAAAAGAAAAAATTGCTGATATCGTTAAGAACCTATTGATGAGCAATGCTCAAATTCATGTTAATCCAGAGACAAA
AACGACCACCTCACCGCGTCAGCAAGGGGCAGGATTACTTAATATTGACGGAGCTGTCACTAGCGGACTTTATGTGACAG
GAAAAGACAACTATGGCAGTATATCATTAGGCAACATCACAGATACGATGACGTTTGATGTGACTGTTCACAACCTAAGC
AATAAAGACAAAACATTACGTTATGACACAGAATTGCTAACAGATCATGTAGACCCACAAAAGGGCCGCTTCACTTTGAC
TTCTCGCTCCTTAAAAACGTACCAAGGAGGAGAAGTTACAGTCCCAGCTAATGGAAAAGTGACTGTAAGGGTTACCATGG
ATGTCTCACAGTTCACAAAAGAGCTAACAAAACAGATGCCAAATGGTTACTATCTAGAAGGTTTTGTCCGCTTTAGAGAT
AGTCAAGATGACCAACTAAATAGAGTAAACATTCCTTTTGTTGGTTTTAAAGGACAATTTGAAAACTTAGCAGTTGCAGA
AGAGTCCATTTACAGGTTAAAATCTCAAGGCAAAACCGGTTTTTACTTTGATGAATCAGGTCCAAAAGACGATATCTATG
TCGGTAAACACTTTACAGGACTCGTCACTCTTGGTTCAGAGACCAATGTGTCAACCAAAACGATTTCTGACAACGGTCTA
CACACACTTGGTACCTTTAAAAATGCAGATGGCAAATTTATGTTAGAAAAAAATGCCCAAGGAAACCCTGTCTTAGCCAT
TTCTCCAAAATGGTGA

Upstream 100 bases:

>100_bases
CTCAGAAAAATGTGGTTAAATAATCAAATATTATTAACGAAAAATGAGTTAACGATTAACATTAAACTGGTTTTAGTTAA
AACATTTAGGAGGGTATCAG

Downstream 100 bases:

>100_bases
TAACAACCAAGATTTTGCAGCCTTCAAAGGTGTTTTCTTGAGAAAATATCAAGGCTTAAAAGCAAGTGTCTACCATGCTA
GTGACAAGGAACACAAAAAT

Product: endopeptidase lactocepin

Products: NA

Alternate protein names: SCP [H]

Number of amino acids: Translated: 911; Mature: 911

Protein sequence:

>911_residues
MEKKQRFSLRKYKSGTFSVLIGSVFLMMMTTTTVAADELTTTSEPTITNHAQQQAQHLTNTELSSAESQSPDTSQITPKT
NREKEQPQGLVSEPTTTELADTDAASMANTGPDATQKSASLPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAH
QSMRISDVSTAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQFGDFDEDWENFEFDAEPKAIKKNKI
YRPQSTQAPKETVIKTEETDGSHDIDWTQTDDDTKYESHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDV
MGSAESLFIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSDHDDPLATNPDYG
LVGSPSTGRTPTSVAAINSKWVIQRLMTAKELENRADLNHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAGYKAQ
DVKDKIALIERDPNKTYDEMIALAKKHGALGVLIFNNKPGQSNRSMRLTANGMGIPSAFISHEFGKAMSQLNGNGTGSLE
FDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGTSMASPQIAGASLLVKQYLEKTQPN
LPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLS
NKDKTLRYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEGFVRFRD
SQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTISDNGL
HTLGTFKNADGKFMLEKNAQGNPVLAISPKW

Sequences:

>Translated_911_residues
MEKKQRFSLRKYKSGTFSVLIGSVFLMMMTTTTVAADELTTTSEPTITNHAQQQAQHLTNTELSSAESQSPDTSQITPKT
NREKEQPQGLVSEPTTTELADTDAASMANTGPDATQKSASLPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAH
QSMRISDVSTAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQFGDFDEDWENFEFDAEPKAIKKNKI
YRPQSTQAPKETVIKTEETDGSHDIDWTQTDDDTKYESHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDV
MGSAESLFIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSDHDDPLATNPDYG
LVGSPSTGRTPTSVAAINSKWVIQRLMTAKELENRADLNHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAGYKAQ
DVKDKIALIERDPNKTYDEMIALAKKHGALGVLIFNNKPGQSNRSMRLTANGMGIPSAFISHEFGKAMSQLNGNGTGSLE
FDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGTSMASPQIAGASLLVKQYLEKTQPN
LPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLS
NKDKTLRYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEGFVRFRD
SQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTISDNGL
HTLGTFKNADGKFMLEKNAQGNPVLAISPKW
>Mature_911_residues
MEKKQRFSLRKYKSGTFSVLIGSVFLMMMTTTTVAADELTTTSEPTITNHAQQQAQHLTNTELSSAESQSPDTSQITPKT
NREKEQPQGLVSEPTTTELADTDAASMANTGPDATQKSASLPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAH
QSMRISDVSTAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQFGDFDEDWENFEFDAEPKAIKKNKI
YRPQSTQAPKETVIKTEETDGSHDIDWTQTDDDTKYESHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDV
MGSAESLFIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSDHDDPLATNPDYG
LVGSPSTGRTPTSVAAINSKWVIQRLMTAKELENRADLNHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAGYKAQ
DVKDKIALIERDPNKTYDEMIALAKKHGALGVLIFNNKPGQSNRSMRLTANGMGIPSAFISHEFGKAMSQLNGNGTGSLE
FDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGTSMASPQIAGASLLVKQYLEKTQPN
LPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLS
NKDKTLRYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEGFVRFRD
SQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTISDNGL
HTLGTFKNADGKFMLEKNAQGNPVLAISPKW

Specific function: This virulence factor of S.pyogenes specifically cleaves the human serum chemotaxin C5a at '68-Lys-|-Asp-69' bond near its C-terminus, destroying its ability to serve as a chemoattractant [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR010435
- InterPro:   IPR003137
- InterPro:   IPR001899 [H]

Pfam domain/function: PF06280 DUF1034; PF02225 PA; PF00082 Peptidase_S8 [H]

EC number: =3.4.21.110 [H]

Molecular weight: Translated: 99313; Mature: 99313

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKQRFSLRKYKSGTFSVLIGSVFLMMMTTTTVAADELTTTSEPTITNHAQQQAQHLTN
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
TELSSAESQSPDTSQITPKTNREKEQPQGLVSEPTTTELADTDAASMANTGPDATQKSAS
CHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCCCCCCCCCCCC
LPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDVSTAKVKSKEDML
CCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHCEEECCCCHHHHCCHHHHH
ARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQFGDFDEDWENFEFDAEPKAIKKNKI
HHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
YRPQSTQAPKETVIKTEETDGSHDIDWTQTDDDTKYESHGMHVTGIVAGNSKEAAATGER
CCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCCCHHHCCCC
FLGIAPEAQVMFMRVFANDVMGSAESLFIKAIEDAVALGADVINLSLGTANGAQLSGSKP
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCH
LMEAIEKAKKAGVSVVVAAGNERVYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSK
HHHHHHHHHHCCCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHH
WVIQRLMTAKELENRADLNHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAGYKAQ
HHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCHH
DVKDKIALIERDPNKTYDEMIALAKKHGALGVLIFNNKPGQSNRSMRLTANGMGIPSAFI
HHHCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHH
SHEFGKAMSQLNGNGTGSLEFDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGD
HHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCCCCCCHHCCCCCCCCCEECCCCCCCCCC
IYSTYNDNHYGSQTGTSMASPQIAGASLLVKQYLEKTQPNLPKEKIADIVKNLLMSNAQI
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEE
HVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLS
EECCCCCCCCCHHHHCCCEEEECCCCCCCEEEEECCCCCCEEECCCCEEEEEEEEEECCC
NKDKTLRYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTK
CCCCEEEECHHHHHCCCCCCCCEEEEEECCCEEECCCEEEECCCCEEEEEEEECHHHHHH
ELTKQMPNGYYLEGFVRFRDSQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTG
HHHHHCCCCEEEEEEEEECCCCCCCCCEECCCEEECCCCCCCHHHHHHHHHHHHHCCCCC
FYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTISDNGLHTLGTFKNADGKFMLEKNAQ
EEECCCCCCCCEEECCCEEEEEEECCCCCCEEEEECCCCCEEECCEECCCCCEEEECCCC
GNPVLAISPKW
CCEEEEECCCC
>Mature Secondary Structure
MEKKQRFSLRKYKSGTFSVLIGSVFLMMMTTTTVAADELTTTSEPTITNHAQQQAQHLTN
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
TELSSAESQSPDTSQITPKTNREKEQPQGLVSEPTTTELADTDAASMANTGPDATQKSAS
CHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCCCCCCCCCCCC
LPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDVSTAKVKSKEDML
CCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHCEEECCCCHHHHCCHHHHH
ARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQFGDFDEDWENFEFDAEPKAIKKNKI
HHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
YRPQSTQAPKETVIKTEETDGSHDIDWTQTDDDTKYESHGMHVTGIVAGNSKEAAATGER
CCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCCCHHHCCCC
FLGIAPEAQVMFMRVFANDVMGSAESLFIKAIEDAVALGADVINLSLGTANGAQLSGSKP
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCH
LMEAIEKAKKAGVSVVVAAGNERVYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSK
HHHHHHHHHHCCCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHH
WVIQRLMTAKELENRADLNHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAGYKAQ
HHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCHH
DVKDKIALIERDPNKTYDEMIALAKKHGALGVLIFNNKPGQSNRSMRLTANGMGIPSAFI
HHHCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHH
SHEFGKAMSQLNGNGTGSLEFDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGD
HHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCCCCCCHHCCCCCCCCCEECCCCCCCCCC
IYSTYNDNHYGSQTGTSMASPQIAGASLLVKQYLEKTQPNLPKEKIADIVKNLLMSNAQI
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEE
HVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLS
EECCCCCCCCCHHHHCCCEEEECCCCCCCEEEEECCCCCCEEECCCCEEEEEEEEEECCC
NKDKTLRYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTK
CCCCEEEECHHHHHCCCCCCCCEEEEEECCCEEECCCEEEECCCCEEEEEEEECHHHHHH
ELTKQMPNGYYLEGFVRFRDSQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTG
HHHHHCCCCEEEEEEEEECCCCCCCCCEECCCEEECCCCCCCHHHHHHHHHHHHHCCCCC
FYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTISDNGLHTLGTFKNADGKFMLEKNAQ
EEECCCCCCCCEEECCCEEEEEEECCCCCCEEEEECCCCCEEECCEECCCCCEEEECCCC
GNPVLAISPKW
CCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA