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The map label for this gene is lctO [C]

Identifier: 94993734

GI number: 94993734

Start: 342707

End: 343894

Strand: Direct

Name: lctO [C]

Synonym: MGAS10750_Spy0338

Alternate gene names: 94993734

Gene position: 342707-343894 (Clockwise)

Preceding gene: 94993732

Following gene: 94993735

Centisome position: 17.69

GC content: 42.34

Gene sequence:

>1188_bases
ATGTCAATGGCACAAAAAACAGTCATCACCGAAGAAACAACCGATTTTGTTATGGATTTCAAAACAAGTAGCGCTGAGGG
AAATGTTGATTTTATTAACGTTTTTGACCTTGAGAAAATGGCACAACAGGTCATCCCTAAAGGAGCCTTTGGTTATATTG
CTAGTGGTGCTGGTGATACCTTTACCCTCCATGAAAATATTCGCTCATTTAATCATAAATTAATTGTCCCTCACTCCCTC
AAAGGGGTTGAAAATCCGTCAACAGAGATTACGTTTGATGGCGATCACTTAACCTCTCCTCTTATTTTAGCACCTGTAGC
GGCTCATAAACTGGCCAATGAACAAGGAGAAGTAGCGTCTGCCAAAGGATTGAAGGAATTTGGAAGTATCTACACCACTA
GTTCCTACTCAACAACTGACCTGCCAGAAATCAGTGCTGCCTTAGGTGAGACACCCCATTGGTTTCAATTTTATTACAGT
AAAGACGATGGCATTAATCGTAATATTATGGATCGTGTCAAAGCACAAGGTTGCAAAGCTATCGTTTTGACAGCAGATGC
AACAGTTGGAGGAAACCGCGAAGTTGATAGGCGAAACGGTTTTGTTTTTCCGGTCGGTATGCCAATTGTTCAAGAATATT
TACCTGATGGTGCAGGTAAAACAATGGATTATGTCTATAAATCAGCTAAACAAGCGCTTACCTCAAAAGATATTGAATAT
ATCGCAACCTACTCAGGCCTGCCTGTTTATGTCAAAGGACCACAGTGTGCTGAGGATACCTTGCGGGCATTGGACGCAGG
AGCATCAGGCATCTGGGTAACCAATCATGGTGGCCGTCAATTAGATGGTGGTCCAGCTGCTTTTGATTCCTTACAAGAAG
TCGCTGAAGCAGTTGATCAAAAAGTTCCTATTGTCTTTGATTCAGGTATAAGACGGGGTCAACATATTTTCAAAGCTCTT
GCTTCAGGTGCTGACCTTGTTGCCTTGGGGCGTCCAGCGATTTATGGCTTGGCTATGGGAGGAAGCATTGGTACTCGTCA
GGTCTTTGAAAAGTTAAATGACGAGTTAAAAATGGTCATGCAACTGGCTGGGACACAAACTATCCAAGATGTTAAAGCCT
TTAACCTTCGCCACAATCCGTATGATTCATCGATTCCATTTGATCAAAATGCGCTACGCTTAGATTAG

Upstream 100 bases:

>100_bases
CAAGGAGGTGATCAGTGAGCATATCGTTTGACAGTTAAGAGTAGGATTACTATAATAGAAGCATAAATGTAAGCGCTAAC
AAAATAAAAAATATAGGAGA

Downstream 100 bases:

>100_bases
AACAGACAAAAACCTCTGCTATCATGTCACAAATAGTAGAGGTTTTACACTGCAAAAAGAGGTGTGAAAATTCAATAACA
TAGTTACAAGGCTTTCGTTT

Product: L-lactate oxidase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSMAQKTVITEETTDFVMDFKTSSAEGNVDFINVFDLEKMAQQVIPKGAFGYIASGAGDTFTLHENIRSFNHKLIVPHSL
KGVENPSTEITFDGDHLTSPLILAPVAAHKLANEQGEVASAKGLKEFGSIYTTSSYSTTDLPEISAALGETPHWFQFYYS
KDDGINRNIMDRVKAQGCKAIVLTADATVGGNREVDRRNGFVFPVGMPIVQEYLPDGAGKTMDYVYKSAKQALTSKDIEY
IATYSGLPVYVKGPQCAEDTLRALDAGASGIWVTNHGGRQLDGGPAAFDSLQEVAEAVDQKVPIVFDSGIRRGQHIFKAL
ASGADLVALGRPAIYGLAMGGSIGTRQVFEKLNDELKMVMQLAGTQTIQDVKAFNLRHNPYDSSIPFDQNALRLD

Sequences:

>Translated_395_residues
MSMAQKTVITEETTDFVMDFKTSSAEGNVDFINVFDLEKMAQQVIPKGAFGYIASGAGDTFTLHENIRSFNHKLIVPHSL
KGVENPSTEITFDGDHLTSPLILAPVAAHKLANEQGEVASAKGLKEFGSIYTTSSYSTTDLPEISAALGETPHWFQFYYS
KDDGINRNIMDRVKAQGCKAIVLTADATVGGNREVDRRNGFVFPVGMPIVQEYLPDGAGKTMDYVYKSAKQALTSKDIEY
IATYSGLPVYVKGPQCAEDTLRALDAGASGIWVTNHGGRQLDGGPAAFDSLQEVAEAVDQKVPIVFDSGIRRGQHIFKAL
ASGADLVALGRPAIYGLAMGGSIGTRQVFEKLNDELKMVMQLAGTQTIQDVKAFNLRHNPYDSSIPFDQNALRLD
>Mature_394_residues
SMAQKTVITEETTDFVMDFKTSSAEGNVDFINVFDLEKMAQQVIPKGAFGYIASGAGDTFTLHENIRSFNHKLIVPHSLK
GVENPSTEITFDGDHLTSPLILAPVAAHKLANEQGEVASAKGLKEFGSIYTTSSYSTTDLPEISAALGETPHWFQFYYSK
DDGINRNIMDRVKAQGCKAIVLTADATVGGNREVDRRNGFVFPVGMPIVQEYLPDGAGKTMDYVYKSAKQALTSKDIEYI
ATYSGLPVYVKGPQCAEDTLRALDAGASGIWVTNHGGRQLDGGPAAFDSLQEVAEAVDQKVPIVFDSGIRRGQHIFKALA
SGADLVALGRPAIYGLAMGGSIGTRQVFEKLNDELKMVMQLAGTQTIQDVKAFNLRHNPYDSSIPFDQNALRLD

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=361, Percent_Identity=32.9639889196676, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI54234014, Length=343, Percent_Identity=31.7784256559767, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI7705393, Length=343, Percent_Identity=31.7784256559767, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1790033, Length=364, Percent_Identity=31.5934065934066, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI193208036, Length=354, Percent_Identity=37.0056497175141, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=259, Percent_Identity=36.6795366795367, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323587, Length=358, Percent_Identity=32.6815642458101, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI78707188, Length=357, Percent_Identity=35.2941176470588, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281363140, Length=357, Percent_Identity=35.2941176470588, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI78707190, Length=357, Percent_Identity=35.2941176470588, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 42845; Mature: 42714

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMAQKTVITEETTDFVMDFKTSSAEGNVDFINVFDLEKMAQQVIPKGAFGYIASGAGDT
CCCCHHHEECCCCHHHEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCCCCEEECCCCCE
FTLHENIRSFNHKLIVPHSLKGVENPSTEITFDGDHLTSPLILAPVAAHKLANEQGEVAS
EEEHHHHHHCCCEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHH
AKGLKEFGSIYTTSSYSTTDLPEISAALGETPHWFQFYYSKDDGINRNIMDRVKAQGCKA
HHHHHHHCCEEECCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCE
IVLTADATVGGNREVDRRNGFVFPVGMPIVQEYLPDGAGKTMDYVYKSAKQALTSKDIEY
EEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCE
IATYSGLPVYVKGPQCAEDTLRALDAGASGIWVTNHGGRQLDGGPAAFDSLQEVAEAVDQ
EEECCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
KVPIVFDSGIRRGQHIFKALASGADLVALGRPAIYGLAMGGSIGTRQVFEKLNDELKMVM
CCCEEECCCCHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
QLAGTQTIQDVKAFNLRHNPYDSSIPFDQNALRLD
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure 
SMAQKTVITEETTDFVMDFKTSSAEGNVDFINVFDLEKMAQQVIPKGAFGYIASGAGDT
CCCHHHEECCCCHHHEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCCCCEEECCCCCE
FTLHENIRSFNHKLIVPHSLKGVENPSTEITFDGDHLTSPLILAPVAAHKLANEQGEVAS
EEEHHHHHHCCCEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHH
AKGLKEFGSIYTTSSYSTTDLPEISAALGETPHWFQFYYSKDDGINRNIMDRVKAQGCKA
HHHHHHHCCEEECCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCE
IVLTADATVGGNREVDRRNGFVFPVGMPIVQEYLPDGAGKTMDYVYKSAKQALTSKDIEY
EEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCE
IATYSGLPVYVKGPQCAEDTLRALDAGASGIWVTNHGGRQLDGGPAAFDSLQEVAEAVDQ
EEECCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
KVPIVFDSGIRRGQHIFKALASGADLVALGRPAIYGLAMGGSIGTRQVFEKLNDELKMVM
CCCEEECCCCHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
QLAGTQTIQDVKAFNLRHNPYDSSIPFDQNALRLD
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]