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The map label for this gene is glcD [H]

Identifier: 94971878

GI number: 94971878

Start: 77075

End: 78499

Strand: Direct

Name: glcD [H]

Synonym: Dgeo_2410

Alternate gene names: 94971878

Gene position: 77075-78499 (Clockwise)

Preceding gene: 94971879

Following gene: 94971877

Centisome position: 13.42

GC content: 71.3

Gene sequence:

>1425_bases
TTGACAGAGGGAAGAGGGAACTGGCTCACGGCCCTGCGCGAGCGGCTGGGGGGACGGGTCAGCGTGCAGTCCGGCGACCT
CAAGGCGCATGCGCGCGACGAGGGCACACCGTACACCTGGACGCCCGGCACGGTGGTGTTCGCCCAGAGCGAGGCGGACG
TGTTGGCCACCCTCGCAGTCGCGCGTGAATACGGCGTCCCGGTGACGCCCTGGGGTGCGGGCACCAGCCTGGAGGGGGCC
GCCTTGCCGGTGCCGGGCGCCATTTCCCTCGATCTCAGTGGCCTGGACACGGTGGGCGCGGTGGACCCGCTGGGCTTCAC
GGTGACGGTGGGACCAGGGGTGCGCCGGGTGGCCCTCAACCGCCGGTTGCGCCCGCACGGCCTATTTTTTCCGGTGGACC
CCGGCGCGGACGCGAGCCTGGGCGGGATGGCGGCCACCAATGCGAGTGGCACGACCACGGTTCGTTACGGCGGCATGCGT
GAGAACGTCGCGGCCTTGCGGGTGGCCCTGCTGGACGGGCGCGTCCTGTCGCTGGGCAGCGCCGCGCGCAAGAGCAGCAG
CGGCTACGCGCTCAAGCACCTCTTCATCGGCTCGGAGGGGACCCTGGGCGTGATCACGGCCCTCACCCTGCGGCTGCATC
CGCTTCCTCCCGTGACCGCCAGCGTGCAGCTTGTCTTCCCGGATGTGGCGTCCGCCGTGCAGGCGAGTGTGACCGCCCGC
GGCCTGGGCGTCACGCCCGAGCGGCTGGAGTTCGTGGACGCGCAGACCGTGCGGGCTGTGAACCGCCACCGCGACCGCCA
CGACCCTGAGGCGCCCACCCTCTGGGCCGAGGTTGCGGGCCGGGATGCGGCCGATGTGGAGGCGGGGCTTGCCCTGCTGC
GCGAGGCGGCGCAGCTGCATGGCGGGCAGGTGGTGGGCGAGGCCCGCACGCCCGAGGCGCAGGGCGCGCTCTGGGCCGCT
CGTCACGGTGTGTATGACGCGTTGCGTGCCGCTTGGCCTGGCCATACCACCCGCATCGGGGACGTGTGTGTGCCCCTCCC
GGCGCTGGCGGAGACCGTCGCCCTCGCCCTGCGGCTGCTGGAGGAGCAGGGCCTGAGCGCGCCGCTGGTTGGTCACATCG
GGGACGGCAACCTGCACCTCTTGATGCACGCCCCACCCGACGACGCTGCTGCCTGGGCCCGCATCGATCACGTGCTGCAT
GACCTCGCCACCCATGCCGTCGCCGTTGGCGGCACCTGCACCGGTGAACATGGCGTGGGCCTGCGCAAACGCCCCTACCT
GCGTGCCGAACACGGGGCCGCGCTGGACGTGATGCGGGACGTGAAGACCTTGTTTGATCCCCGCGGTTTGCTCAACCCCG
GCAAGGTGGTGGGTGACCCCGAGACTCTGCCCTCATGGAGGAATGATGTTTCAACCCGACTTTGA

Upstream 100 bases:

>100_bases
CCCAGGATCACCTGGGTCTGGACGCCCGGAGCCGCGTGATGGTGCAGGTCGCGGACGGCACCTGGAAACTGATCAAGTAA
GGCCCGAACGAGGCGGGGCG

Downstream 100 bases:

>100_bases
AGCGCTGCCCCTTTCCGACCTGCGCGCCCTGCAACTCGCGCGGCTGCAGGCGATGGTGGCCCGCCAGTTTGAACATGTCC
CCGCCTACCGCGCCAAGTTC

Product: FAD linked oxidase-like

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTEGRGNWLTALRERLGGRVSVQSGDLKAHARDEGTPYTWTPGTVVFAQSEADVLATLAVAREYGVPVTPWGAGTSLEGA
ALPVPGAISLDLSGLDTVGAVDPLGFTVTVGPGVRRVALNRRLRPHGLFFPVDPGADASLGGMAATNASGTTTVRYGGMR
ENVAALRVALLDGRVLSLGSAARKSSSGYALKHLFIGSEGTLGVITALTLRLHPLPPVTASVQLVFPDVASAVQASVTAR
GLGVTPERLEFVDAQTVRAVNRHRDRHDPEAPTLWAEVAGRDAADVEAGLALLREAAQLHGGQVVGEARTPEAQGALWAA
RHGVYDALRAAWPGHTTRIGDVCVPLPALAETVALALRLLEEQGLSAPLVGHIGDGNLHLLMHAPPDDAAAWARIDHVLH
DLATHAVAVGGTCTGEHGVGLRKRPYLRAEHGAALDVMRDVKTLFDPRGLLNPGKVVGDPETLPSWRNDVSTRL

Sequences:

>Translated_474_residues
MTEGRGNWLTALRERLGGRVSVQSGDLKAHARDEGTPYTWTPGTVVFAQSEADVLATLAVAREYGVPVTPWGAGTSLEGA
ALPVPGAISLDLSGLDTVGAVDPLGFTVTVGPGVRRVALNRRLRPHGLFFPVDPGADASLGGMAATNASGTTTVRYGGMR
ENVAALRVALLDGRVLSLGSAARKSSSGYALKHLFIGSEGTLGVITALTLRLHPLPPVTASVQLVFPDVASAVQASVTAR
GLGVTPERLEFVDAQTVRAVNRHRDRHDPEAPTLWAEVAGRDAADVEAGLALLREAAQLHGGQVVGEARTPEAQGALWAA
RHGVYDALRAAWPGHTTRIGDVCVPLPALAETVALALRLLEEQGLSAPLVGHIGDGNLHLLMHAPPDDAAAWARIDHVLH
DLATHAVAVGGTCTGEHGVGLRKRPYLRAEHGAALDVMRDVKTLFDPRGLLNPGKVVGDPETLPSWRNDVSTRL
>Mature_473_residues
TEGRGNWLTALRERLGGRVSVQSGDLKAHARDEGTPYTWTPGTVVFAQSEADVLATLAVAREYGVPVTPWGAGTSLEGAA
LPVPGAISLDLSGLDTVGAVDPLGFTVTVGPGVRRVALNRRLRPHGLFFPVDPGADASLGGMAATNASGTTTVRYGGMRE
NVAALRVALLDGRVLSLGSAARKSSSGYALKHLFIGSEGTLGVITALTLRLHPLPPVTASVQLVFPDVASAVQASVTARG
LGVTPERLEFVDAQTVRAVNRHRDRHDPEAPTLWAEVAGRDAADVEAGLALLREAAQLHGGQVVGEARTPEAQGALWAAR
HGVYDALRAAWPGHTTRIGDVCVPLPALAETVALALRLLEEQGLSAPLVGHIGDGNLHLLMHAPPDDAAAWARIDHVLHD
LATHAVAVGGTCTGEHGVGLRKRPYLRAEHGAALDVMRDVKTLFDPRGLLNPGKVVGDPETLPSWRNDVSTRL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=456, Percent_Identity=43.2017543859649, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI37595754, Length=481, Percent_Identity=41.3721413721414, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI119964728, Length=426, Percent_Identity=32.3943661971831, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4501993, Length=198, Percent_Identity=28.7878787878788, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1789351, Length=463, Percent_Identity=32.3974082073434, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1787977, Length=553, Percent_Identity=29.2947558770344, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI48994907, Length=166, Percent_Identity=28.9156626506024, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994914, Length=144, Percent_Identity=29.8611111111111, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71992373, Length=450, Percent_Identity=35.3333333333333, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71992381, Length=454, Percent_Identity=34.3612334801762, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71992392, Length=356, Percent_Identity=38.4831460674157, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17534361, Length=471, Percent_Identity=28.0254777070064, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17556096, Length=200, Percent_Identity=29.5, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320027, Length=469, Percent_Identity=31.7697228144989, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6320023, Length=457, Percent_Identity=28.8840262582057, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6320764, Length=460, Percent_Identity=26.304347826087, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18921117, Length=478, Percent_Identity=29.4979079497908, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24639277, Length=478, Percent_Identity=29.4979079497908, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24639275, Length=478, Percent_Identity=29.4979079497908, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24653753, Length=199, Percent_Identity=32.1608040201005, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 49654; Mature: 49523

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEGRGNWLTALRERLGGRVSVQSGDLKAHARDEGTPYTWTPGTVVFAQSEADVLATLAV
CCCCCCHHHHHHHHHHCCEEEEECCCEEEECCCCCCCEEECCCEEEEECCCHHHHHHHHH
AREYGVPVTPWGAGTSLEGAALPVPGAISLDLSGLDTVGAVDPLGFTVTVGPGVRRVALN
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHH
RRLRPHGLFFPVDPGADASLGGMAATNASGTTTVRYGGMRENVAALRVALLDGRVLSLGS
CCCCCCCCEEECCCCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCEEECCH
AARKSSSGYALKHLFIGSEGTLGVITALTLRLHPLPPVTASVQLVFPDVASAVQASVTAR
HHHCCCCCCEEEEEEECCCCCHHHEEEEEHEECCCCCCCCEEEEECCHHHHHHHHHHHHC
GLGVTPERLEFVDAQTVRAVNRHRDRHDPEAPTLWAEVAGRDAADVEAGLALLREAAQLH
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHC
GGQVVGEARTPEAQGALWAARHGVYDALRAAWPGHTTRIGDVCVPLPALAETVALALRLL
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHHHH
EEQGLSAPLVGHIGDGNLHLLMHAPPDDAAAWARIDHVLHDLATHAVAVGGTCTGEHGVG
HHCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
LRKRPYLRAEHGAALDVMRDVKTLFDPRGLLNPGKVVGDPETLPSWRNDVSTRL
CCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCHHHHHHCCC
>Mature Secondary Structure 
TEGRGNWLTALRERLGGRVSVQSGDLKAHARDEGTPYTWTPGTVVFAQSEADVLATLAV
CCCCCHHHHHHHHHHCCEEEEECCCEEEECCCCCCCEEECCCEEEEECCCHHHHHHHHH
AREYGVPVTPWGAGTSLEGAALPVPGAISLDLSGLDTVGAVDPLGFTVTVGPGVRRVALN
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHH
RRLRPHGLFFPVDPGADASLGGMAATNASGTTTVRYGGMRENVAALRVALLDGRVLSLGS
CCCCCCCCEEECCCCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCEEECCH
AARKSSSGYALKHLFIGSEGTLGVITALTLRLHPLPPVTASVQLVFPDVASAVQASVTAR
HHHCCCCCCEEEEEEECCCCCHHHEEEEEHEECCCCCCCCEEEEECCHHHHHHHHHHHHC
GLGVTPERLEFVDAQTVRAVNRHRDRHDPEAPTLWAEVAGRDAADVEAGLALLREAAQLH
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHC
GGQVVGEARTPEAQGALWAARHGVYDALRAAWPGHTTRIGDVCVPLPALAETVALALRLL
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHHHH
EEQGLSAPLVGHIGDGNLHLLMHAPPDDAAAWARIDHVLHDLATHAVAVGGTCTGEHGVG
HHCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
LRKRPYLRAEHGAALDVMRDVKTLFDPRGLLNPGKVVGDPETLPSWRNDVSTRL
CCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]