BacMap

Definition	Deinococcus geothermalis DSM 11300 plasmid pDGEO01, complete sequence.
Accession	NC_008010
Length	574,127

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The map label for this gene is bdhA [H]

Identifier: 94971866

GI number: 94971866

Start: 90009

End: 90818

Strand: Direct

Name: bdhA [H]

Synonym: Dgeo_2398

Alternate gene names: 94971866

Gene position: 90009-90818 (Clockwise)

Preceding gene: 94971867

Following gene: 94971865

Centisome position: 15.68

GC content: 67.41

Gene sequence:

>810_bases
ATGGAATTCCAGAACAAGATCATCGTCGTCACCGGCGCCGCTTCCGGCATCGGCCTGGCGCTCGCGACCCGCTTTGTGCG
GGAGGGCGCGACCGTGGTCGCCTCCGACCGCAACGTGGCGGGAGGGGAGGCGCAGGCCGCGCAGATTGGCGTCCGCTTTG
TCCCGGCGGACGTGTCGCAGGAAGAAGGTGTGGCGAACCTGATCGCGGACGTGCTGGGCCGCGAGGGCCGCATCGACCTC
TTCTGCTCGAACGCAGGCATTGCTGTGGGCGCTGGGCCGGAAACCGAAAACCGCATCTGGGATCTGATCTACCGCGTGAA
TGTGATGAGCCACGTGTGGGCGGCGCGGCACCTGCTCCCGCACTATCTCTCGCGTGGCGCGGGTTATTTCCTGAACACGG
CGTCGGCGGCAGGCCTCCTGACCGAGCTGCATTCGGCCCCCTACGCGGTCACCAAGCACGCGGCGCTCGCCTTTGCGGAG
TGGTTGGCGATCACCTATGCCGAGCGCGGGGTCAAGGTGTCGGCTCTCTGCCCCGAAGGGGTCTGGACCCCGATGATCCA
GAACGCGCCCATCCTCCAGCAGACGGCCATCAGCACGGATCAGCTTGTGGACGTGACCCTGCAGGCGCTGCGGGAGGAAC
GCTTCCTGATCACCACCCACCCGACCACCCTGGCGGGCTTTCAGCTCAAGGCGCAGGACTACGGCACCTGGATCGGCAAG
ATGGTGCGGCTGCGCGGCAAGGCGATGGCGCTCTTGGAGGGGCAGCAGACCTCTCAGGCTGAGGTGCCCCGCACCGGGGG
CCACCCGTGA

Upstream 100 bases:

>100_bases
TCTCCGCGCGGCGCAGGGCCAGTGGCCCGACCCTAGGGCGGTGGCGGACGCGTTGGGGCCGCTCCACTGTTCGAGAGCCT
GAAGATCAAGGAGCCTGAAT

Downstream 100 bases:

>100_bases
CCCGCCCCGACACCGCCCCCGTCCGCCCTGGCGAAGAACTGCCCCTTCCAGCCCTTCGGGAAGCGTTGCGCGGCAAGGTG
GCGGGAGATGTCGACCACCT

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: BDH; 3-hydroxybutyrate dehydrogenase; 3-HBDH [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MEFQNKIIVVTGAASGIGLALATRFVREGATVVASDRNVAGGEAQAAQIGVRFVPADVSQEEGVANLIADVLGREGRIDL
FCSNAGIAVGAGPETENRIWDLIYRVNVMSHVWAARHLLPHYLSRGAGYFLNTASAAGLLTELHSAPYAVTKHAALAFAE
WLAITYAERGVKVSALCPEGVWTPMIQNAPILQQTAISTDQLVDVTLQALREERFLITTHPTTLAGFQLKAQDYGTWIGK
MVRLRGKAMALLEGQQTSQAEVPRTGGHP

Sequences:

>Translated_269_residues
MEFQNKIIVVTGAASGIGLALATRFVREGATVVASDRNVAGGEAQAAQIGVRFVPADVSQEEGVANLIADVLGREGRIDL
FCSNAGIAVGAGPETENRIWDLIYRVNVMSHVWAARHLLPHYLSRGAGYFLNTASAAGLLTELHSAPYAVTKHAALAFAE
WLAITYAERGVKVSALCPEGVWTPMIQNAPILQQTAISTDQLVDVTLQALREERFLITTHPTTLAGFQLKAQDYGTWIGK
MVRLRGKAMALLEGQQTSQAEVPRTGGHP
>Mature_269_residues
MEFQNKIIVVTGAASGIGLALATRFVREGATVVASDRNVAGGEAQAAQIGVRFVPADVSQEEGVANLIADVLGREGRIDL
FCSNAGIAVGAGPETENRIWDLIYRVNVMSHVWAARHLLPHYLSRGAGYFLNTASAAGLLTELHSAPYAVTKHAALAFAE
WLAITYAERGVKVSALCPEGVWTPMIQNAPILQQTAISTDQLVDVTLQALREERFLITTHPTTLAGFQLKAQDYGTWIGK
MVRLRGKAMALLEGQQTSQAEVPRTGGHP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40807363, Length=222, Percent_Identity=29.7297297297297, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI59889578, Length=164, Percent_Identity=31.0975609756098, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4758504, Length=201, Percent_Identity=32.8358208955224, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=33.695652173913, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI32483357, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI5031737, Length=182, Percent_Identity=34.0659340659341, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI31542939, Length=201, Percent_Identity=27.8606965174129, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI210032110, Length=265, Percent_Identity=26.4150943396226, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI142976729, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI83715985, Length=202, Percent_Identity=32.1782178217822, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=29.8342541436464, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI66933014, Length=184, Percent_Identity=28.804347826087, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4504505, Length=191, Percent_Identity=28.2722513089005, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI224922801, Length=169, Percent_Identity=27.810650887574, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI7706318, Length=199, Percent_Identity=26.1306532663317, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=195, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789378, Length=190, Percent_Identity=27.8947368421053, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787335, Length=211, Percent_Identity=24.6445497630332, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787820, Length=176, Percent_Identity=26.1363636363636, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=253, Percent_Identity=30.4347826086957, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=201, Percent_Identity=28.8557213930348, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=198, Percent_Identity=30.8080808080808, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=182, Percent_Identity=31.3186813186813, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=204, Percent_Identity=27.9411764705882, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=194, Percent_Identity=27.319587628866, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=195, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=198, Percent_Identity=30.3030303030303, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=198, Percent_Identity=26.7676767676768, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=231, Percent_Identity=26.4069264069264, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=230, Percent_Identity=25.6521739130435, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=195, Percent_Identity=28.7179487179487, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=194, Percent_Identity=29.8969072164948, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=188, Percent_Identity=28.7234042553192, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=190, Percent_Identity=28.4210526315789, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=190, Percent_Identity=26.8421052631579, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=193, Percent_Identity=27.4611398963731, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI23397609, Length=199, Percent_Identity=33.1658291457286, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357041, Length=206, Percent_Identity=31.0679611650485, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21358495, Length=255, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355319, Length=180, Percent_Identity=30, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=29.2307692307692, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=205, Percent_Identity=29.2682926829268, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24581726, Length=196, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644339, Length=185, Percent_Identity=26.4864864864865, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639444, Length=194, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356301, Length=189, Percent_Identity=29.6296296296296, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24649181, Length=202, Percent_Identity=25.7425742574257, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011294
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.30 [H]

Molecular weight: Translated: 28857; Mature: 28857

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQNKIIVVTGAASGIGLALATRFVREGATVVASDRNVAGGEAQAAQIGVRFVPADVSQ
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHEEEEEEEECCCCC
EEGVANLIADVLGREGRIDLFCSNAGIAVGAGPETENRIWDLIYRVNVMSHVWAARHLLP
CCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HYLSRGAGYFLNTASAAGLLTELHSAPYAVTKHAALAFAEWLAITYAERGVKVSALCPEG
HHHHCCCCEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
VWTPMIQNAPILQQTAISTDQLVDVTLQALREERFLITTHPTTLAGFQLKAQDYGTWIGK
CCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCEEECEEEEHHHHHHHHHH
MVRLRGKAMALLEGQQTSQAEVPRTGGHP
HHHHCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEFQNKIIVVTGAASGIGLALATRFVREGATVVASDRNVAGGEAQAAQIGVRFVPADVSQ
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHEEEEEEEECCCCC
EEGVANLIADVLGREGRIDLFCSNAGIAVGAGPETENRIWDLIYRVNVMSHVWAARHLLP
CCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HYLSRGAGYFLNTASAAGLLTELHSAPYAVTKHAALAFAEWLAITYAERGVKVSALCPEG
HHHHCCCCEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
VWTPMIQNAPILQQTAISTDQLVDVTLQALREERFLITTHPTTLAGFQLKAQDYGTWIGK
CCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCEEECEEEEHHHHHHHHHH
MVRLRGKAMALLEGQQTSQAEVPRTGGHP
HHHHCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9922248; 11481431 [H]