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The map label for this gene is manC [H]

Identifier: 94314762

GI number: 94314762

Start: 32872

End: 34368

Strand: Direct

Name: manC [H]

Synonym: Rmet_5843

Alternate gene names: 94314762

Gene position: 32872-34368 (Clockwise)

Preceding gene: 94314760

Following gene: 94314763

Centisome position: 1.27

GC content: 65.8

Gene sequence:

>1497_bases
ATGCCTGTGATCCAGCCTGTGAAGCGGCCAGTGATTCAGCCAGTCATCCTTGCGGGCGGCGCCGGCACGCGGCTCTGGCC
GCTGTCGCGTGAGCAGTATCCCAAACAGCTGCTCAACCTGGTGGCCAACGATACGTTGCTGGAAGCCACGGCGGCCCGCC
TGGAAGGCGTTGCCGCGCGCACTGGCCGTCCGGCCGGTGTCGAGGCGCCGCAGATCGTCGTATGCGGCGAAGAGCATCGC
TTCATGGTCGCCGACATGCTCAAGCGCAAGGGCAAGCGCGCGCGTGTCGTTTCGGAGCCGTGCGGCCGCAATACCGCGCC
CGCGCTGACCATGGCTGCGCTGCACGCGATGGCTTCGGCTGGCGAAGGTGGCGATGCCGTGCTGGTGGCCACGCCGGCTG
ATCACAGCGTGACCGATAGCGATGCCTTCCGTGATGCCATTGCCGCCGCTGTACTGCACGCGGAGCGCGGCGCGATCGTC
ACGCTGGGCGTGCGTCCCACCGCGCCGGAAACAGGCTTCGGCTACATCCGCGCCGCCGTGCCGGTGCCGCCGGGCGGGTT
CCTGATCGAGCGGTTCGTCGAGAAGCCACACCTGGAACTTGCGCAGCACTACGTCGACTCGGGCGAGTACTGGTGGAACT
GCGGCATCTTTGTCGTGCTGGCATCGGTATGGCTCAAGGCCGTGATGCAGCTCCAGCCAGAGATGCACGCCCGTTGCTGC
GCGGCCTACGAGACGGGCCAGCCCAGTGAAAGCGGCAAGGATGATGTATTCCGGATCGGACAAGAGGCGTTCGACACTTG
CCCGTCGGATTCGATCGACTACGCGGTGATGGAAAAGCTCGACGGGCTGCGCGGTATCCCCGGCATGCTCGTGCCGATGG
ATGCCGGATGGTCGGACGTGGGCTCGTGGGCGGCCATCTGGGATATCGCCACGAAGGACAACGCCGGCAATGCTGGCCGT
GGCCGCGTGTTGTTCGACGGCGCGAGTTCGTGCCTGGCCCATTCGGAGGGCCGGCTGATCGCGTGCGTGGGCGTGCAGGA
CGTGGTGGTGGTGGAAACCGCCGATGCGGTGCTTGTGGTCGACAAGCACCACGTGCAGGACGTCAAGAACGTGGTGCAGC
GGCTGCGCCAGGAGCATGGCGCGGAGATCGTCAATCACCGCAAGGTACACCGGCCGTGGGGATGCTACGACTCCATCGAC
CATGGCGACCGCTTCCAGGTCAAGCGGATCGTCGTCGAGCCCGGCGCGAGCCTTTCCCTGCAGATGCACTACCACCGCGC
GGAGCATTGGGTCGTCGTGCGCGGCACCGCGCGGGTGACCTGCGGCGAGACCACCAGCATTCTTACCGAAAACCAGTCGA
CCTATATCCCGATCGGCACGCTGCATCGACTCGAGAATCCCGGCAAGACGCCGCTGGAAATCATCGAGGTGCAGTCGGGC
GCGTATCTGGGGGAGGACGACATCGTCAGAGTCGAGGACAACTACGGACGCAAGTAG

Upstream 100 bases:

>100_bases
GATGAGAGTGCGAAGCCGGGAGAGGAAGATCCTGCCACCTGTCATGGTGCAGGCGCAGGTAGAGGCGCCAGCGGTGTTGG
CGCCGGGACGGGCAACCTCC

Downstream 100 bases:

>100_bases
TCCCGCAGCCTCCGGTGCGCCATGGCCACCGGGAGCCAGCCAGGCGTCAGGGGAGTATTACGTGAGCACCATGTCATCTG
CCGGCGCGATGCCGGCGCCA

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyl transferase; GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MPVIQPVKRPVIQPVILAGGAGTRLWPLSREQYPKQLLNLVANDTLLEATAARLEGVAARTGRPAGVEAPQIVVCGEEHR
FMVADMLKRKGKRARVVSEPCGRNTAPALTMAALHAMASAGEGGDAVLVATPADHSVTDSDAFRDAIAAAVLHAERGAIV
TLGVRPTAPETGFGYIRAAVPVPPGGFLIERFVEKPHLELAQHYVDSGEYWWNCGIFVVLASVWLKAVMQLQPEMHARCC
AAYETGQPSESGKDDVFRIGQEAFDTCPSDSIDYAVMEKLDGLRGIPGMLVPMDAGWSDVGSWAAIWDIATKDNAGNAGR
GRVLFDGASSCLAHSEGRLIACVGVQDVVVVETADAVLVVDKHHVQDVKNVVQRLRQEHGAEIVNHRKVHRPWGCYDSID
HGDRFQVKRIVVEPGASLSLQMHYHRAEHWVVVRGTARVTCGETTSILTENQSTYIPIGTLHRLENPGKTPLEIIEVQSG
AYLGEDDIVRVEDNYGRK

Sequences:

>Translated_498_residues
MPVIQPVKRPVIQPVILAGGAGTRLWPLSREQYPKQLLNLVANDTLLEATAARLEGVAARTGRPAGVEAPQIVVCGEEHR
FMVADMLKRKGKRARVVSEPCGRNTAPALTMAALHAMASAGEGGDAVLVATPADHSVTDSDAFRDAIAAAVLHAERGAIV
TLGVRPTAPETGFGYIRAAVPVPPGGFLIERFVEKPHLELAQHYVDSGEYWWNCGIFVVLASVWLKAVMQLQPEMHARCC
AAYETGQPSESGKDDVFRIGQEAFDTCPSDSIDYAVMEKLDGLRGIPGMLVPMDAGWSDVGSWAAIWDIATKDNAGNAGR
GRVLFDGASSCLAHSEGRLIACVGVQDVVVVETADAVLVVDKHHVQDVKNVVQRLRQEHGAEIVNHRKVHRPWGCYDSID
HGDRFQVKRIVVEPGASLSLQMHYHRAEHWVVVRGTARVTCGETTSILTENQSTYIPIGTLHRLENPGKTPLEIIEVQSG
AYLGEDDIVRVEDNYGRK
>Mature_497_residues
PVIQPVKRPVIQPVILAGGAGTRLWPLSREQYPKQLLNLVANDTLLEATAARLEGVAARTGRPAGVEAPQIVVCGEEHRF
MVADMLKRKGKRARVVSEPCGRNTAPALTMAALHAMASAGEGGDAVLVATPADHSVTDSDAFRDAIAAAVLHAERGAIVT
LGVRPTAPETGFGYIRAAVPVPPGGFLIERFVEKPHLELAQHYVDSGEYWWNCGIFVVLASVWLKAVMQLQPEMHARCCA
AYETGQPSESGKDDVFRIGQEAFDTCPSDSIDYAVMEKLDGLRGIPGMLVPMDAGWSDVGSWAAIWDIATKDNAGNAGRG
RVLFDGASSCLAHSEGRLIACVGVQDVVVVETADAVLVVDKHHVQDVKNVVQRLRQEHGAEIVNHRKVHRPWGCYDSIDH
GDRFQVKRIVVEPGASLSLQMHYHRAEHWVVVRGTARVTCGETTSILTENQSTYIPIGTLHRLENPGKTPLEIIEVQSGA
YLGEDDIVRVEDNYGRK

Specific function: Involved in xanthan production [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=492, Percent_Identity=48.1707317073171, Blast_Score=440, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 54048; Mature: 53917

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIQPVKRPVIQPVILAGGAGTRLWPLSREQYPKQLLNLVANDTLLEATAARLEGVAAR
CCCCCHHHHHHCCEEEEECCCCCEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
TGRPAGVEAPQIVVCGEEHRFMVADMLKRKGKRARVVSEPCGRNTAPALTMAALHAMASA
CCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHC
GEGGDAVLVATPADHSVTDSDAFRDAIAAAVLHAERGAIVTLGVRPTAPETGFGYIRAAV
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEC
PVPPGGFLIERFVEKPHLELAQHYVDSGEYWWNCGIFVVLASVWLKAVMQLQPEMHARCC
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCHHHHHHHH
AAYETGQPSESGKDDVFRIGQEAFDTCPSDSIDYAVMEKLDGLRGIPGMLVPMDAGWSDV
HHHCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCHH
GSWAAIWDIATKDNAGNAGRGRVLFDGASSCLAHSEGRLIACVGVQDVVVVETADAVLVV
CCEEEEEEEEECCCCCCCCCCCEEECCCHHHHHCCCCCEEEEECCCEEEEEEECCEEEEE
DKHHVQDVKNVVQRLRQEHGAEIVNHRKVHRPWGCYDSIDHGDRFQVKRIVVEPGASLSL
CHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEE
QMHYHRAEHWVVVRGTARVTCGETTSILTENQSTYIPIGTLHRLENPGKTPLEIIEVQSG
EEEEECCCEEEEEECCEEEECCCCCEEEECCCCCEEECHHHHHCCCCCCCCEEEEEECCC
AYLGEDDIVRVEDNYGRK
CEECCCCEEEECCCCCCC
>Mature Secondary Structure 
PVIQPVKRPVIQPVILAGGAGTRLWPLSREQYPKQLLNLVANDTLLEATAARLEGVAAR
CCCCHHHHHHCCEEEEECCCCCEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
TGRPAGVEAPQIVVCGEEHRFMVADMLKRKGKRARVVSEPCGRNTAPALTMAALHAMASA
CCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHC
GEGGDAVLVATPADHSVTDSDAFRDAIAAAVLHAERGAIVTLGVRPTAPETGFGYIRAAV
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEC
PVPPGGFLIERFVEKPHLELAQHYVDSGEYWWNCGIFVVLASVWLKAVMQLQPEMHARCC
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCHHHHHHHH
AAYETGQPSESGKDDVFRIGQEAFDTCPSDSIDYAVMEKLDGLRGIPGMLVPMDAGWSDV
HHHCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCHH
GSWAAIWDIATKDNAGNAGRGRVLFDGASSCLAHSEGRLIACVGVQDVVVVETADAVLVV
CCEEEEEEEEECCCCCCCCCCCEEECCCHHHHHCCCCCEEEEECCCEEEEEEECCEEEEE
DKHHVQDVKNVVQRLRQEHGAEIVNHRKVHRPWGCYDSIDHGDRFQVKRIVVEPGASLSL
CHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEE
QMHYHRAEHWVVVRGTARVTCGETTSILTENQSTYIPIGTLHRLENPGKTPLEIIEVQSG
EEEEECCCEEEEEECCEEEECCCCCEEEECCCCCEEECHHHHHCCCCCCCCEEEEEECCC
AYLGEDDIVRVEDNYGRK
CEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1370280; 11589581 [H]