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The map label for this gene is paaG [C]

Identifier: 94314690

GI number: 94314690

Start: 2531808

End: 2532584

Strand: Direct

Name: paaG [C]

Synonym: Rmet_5771

Alternate gene names: 94314690

Gene position: 2531808-2532584 (Clockwise)

Preceding gene: 94314687

Following gene: 94314693

Centisome position: 98.13

GC content: 64.61

Gene sequence:

>777_bases
GTGATTCCGGAAATCCAAGCAGGACTTGAACGTGGCGTGCTGACCCTCACGATTTCGCGAGCGGACAAGAAGAACGCGCT
GACCAACGACATGTACGGCGCCCTGGCGGACGCCATCGAGAATGCATCGACCGACGCATCGGTCCGGGTCGTGCTGATTC
AGGCTGACGGTGATTCCTTCACGGCCGGCAACGACATCGGGGAGTTCGCGGCCCAGGCCACCGGGAACGCACCCAAGGAG
CGCCATGTCGTGCGATTCCTGCATAGCCTGGCGAATGCCACAGTGCCGATCGTCGCGGCAGTCCAGGGCAAGGCCGTCGG
CGTCGGCACGACCATGCTGCTGCATTGTGACTATGTGGTTCTGGCCGACGATGCGCAGTTGATCACGCCGTTCGTGAACC
TCGCGCTTGTGCCCGAGGCAGCGTCGAGCTACCTGCTGCCGTTGCGCATCGGCCACGCGCGCGCGTTTGAAATGTTCTCG
CTGGGCGATCCGTTGCCGGCGGACACCGCCGTGGCATGGGGCATCGCGAACCGGACGGTTCCGGGCGACCAGCTGCGCGC
GGAAGGCCGACGCATCGCGGAAAAGATCGCCACCAAGCCGTCCGGCTCTCTGACGGCAATGAAGCGTCTGATGCGGGAGG
CCGAGAAACTGGTCGCGCAGATGGACGCCGAGAGTTCGACGTTCGTGGAGCGGCTGCGCAGCGCGGAAGCGAAGGAAGCC
TTCGCGGCGTTTGTCCAGAAGCGCCAGCCGGACTTCAGCAGGATCGCCAAGCAGTGA

Upstream 100 bases:

>100_bases
GCGCCGGTTTACTTCGCACGCGAATCAACTATACTTTGCATCTACTTCGCATACGAACATCTTCATTGCCCCTACCCCTT
CCATTGCAGGAGACAAAGCC

Downstream 100 bases:

>100_bases
TGGGTCAGAAGGCGTCGTCCGCGTCGTCTGCTTCGGCGCCTTCGTTCATCCCCTGCATCACTCGTCGTCGCTGGCCGGGA
ACTTGTCCTGCAGGCTCGTC

Product: Enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIPEIQAGLERGVLTLTISRADKKNALTNDMYGALADAIENASTDASVRVVLIQADGDSFTAGNDIGEFAAQATGNAPKE
RHVVRFLHSLANATVPIVAAVQGKAVGVGTTMLLHCDYVVLADDAQLITPFVNLALVPEAASSYLLPLRIGHARAFEMFS
LGDPLPADTAVAWGIANRTVPGDQLRAEGRRIAEKIATKPSGSLTAMKRLMREAEKLVAQMDAESSTFVERLRSAEAKEA
FAAFVQKRQPDFSRIAKQ

Sequences:

>Translated_258_residues
MIPEIQAGLERGVLTLTISRADKKNALTNDMYGALADAIENASTDASVRVVLIQADGDSFTAGNDIGEFAAQATGNAPKE
RHVVRFLHSLANATVPIVAAVQGKAVGVGTTMLLHCDYVVLADDAQLITPFVNLALVPEAASSYLLPLRIGHARAFEMFS
LGDPLPADTAVAWGIANRTVPGDQLRAEGRRIAEKIATKPSGSLTAMKRLMREAEKLVAQMDAESSTFVERLRSAEAKEA
FAAFVQKRQPDFSRIAKQ
>Mature_258_residues
MIPEIQAGLERGVLTLTISRADKKNALTNDMYGALADAIENASTDASVRVVLIQADGDSFTAGNDIGEFAAQATGNAPKE
RHVVRFLHSLANATVPIVAAVQGKAVGVGTTMLLHCDYVVLADDAQLITPFVNLALVPEAASSYLLPLRIGHARAFEMFS
LGDPLPADTAVAWGIANRTVPGDQLRAEGRRIAEKIATKPSGSLTAMKRLMREAEKLVAQMDAESSTFVERLRSAEAKEA
FAAFVQKRQPDFSRIAKQ

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI260274832, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI45643119, Length=246, Percent_Identity=29.6747967479675, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI260275230, Length=246, Percent_Identity=29.6747967479675, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=28.1124497991968, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI194097323, Length=254, Percent_Identity=26.3779527559055, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI25453481, Length=251, Percent_Identity=27.4900398406374, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI51538573, Length=251, Percent_Identity=27.4900398406374, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI4757968, Length=251, Percent_Identity=27.4900398406374, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI49355787, Length=251, Percent_Identity=27.4900398406374, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI4757966, Length=175, Percent_Identity=30.2857142857143, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI51538581, Length=175, Percent_Identity=30.2857142857143, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI68989263, Length=237, Percent_Identity=28.6919831223629, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI116235487, Length=168, Percent_Identity=31.547619047619, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI221136756, Length=245, Percent_Identity=25.3061224489796, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI221136753, Length=245, Percent_Identity=25.3061224489796, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI221307494, Length=245, Percent_Identity=25.3061224489796, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=255, Percent_Identity=27.0588235294118, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI20127408, Length=183, Percent_Identity=27.3224043715847, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI62530384, Length=229, Percent_Identity=24.0174672489083, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787660, Length=262, Percent_Identity=32.824427480916, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787659, Length=256, Percent_Identity=29.6875, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI221142681, Length=251, Percent_Identity=28.2868525896414, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=23.1075697211155, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790281, Length=184, Percent_Identity=26.6304347826087, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788682, Length=191, Percent_Identity=27.7486910994764, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17535521, Length=248, Percent_Identity=33.0645161290323, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17554946, Length=259, Percent_Identity=27.4131274131274, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=25.8823529411765, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=207, Percent_Identity=30.4347826086957, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=237, Percent_Identity=27.0042194092827, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=198, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540714, Length=239, Percent_Identity=26.3598326359833, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323314, Length=228, Percent_Identity=25, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20129971, Length=252, Percent_Identity=29.7619047619048, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24653477, Length=252, Percent_Identity=29.7619047619048, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24654903, Length=247, Percent_Identity=27.5303643724696, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922422, Length=254, Percent_Identity=22.8346456692913, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24653139, Length=259, Percent_Identity=25.0965250965251, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27601; Mature: 27601

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEIQAGLERGVLTLTISRADKKNALTNDMYGALADAIENASTDASVRVVLIQADGDSF
CCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCC
TAGNDIGEFAAQATGNAPKERHVVRFLHSLANATVPIVAAVQGKAVGVGTTMLLHCDYVV
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCEECCCCEEEEECCEEE
LADDAQLITPFVNLALVPEAASSYLLPLRIGHARAFEMFSLGDPLPADTAVAWGIANRTV
EECCHHHHHHHHHHEECCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
PGDQLRAEGRRIAEKIATKPSGSLTAMKRLMREAEKLVAQMDAESSTFVERLRSAEAKEA
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHH
FAAFVQKRQPDFSRIAKQ
HHHHHHHCCCCHHHHHCC
>Mature Secondary Structure
MIPEIQAGLERGVLTLTISRADKKNALTNDMYGALADAIENASTDASVRVVLIQADGDSF
CCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCC
TAGNDIGEFAAQATGNAPKERHVVRFLHSLANATVPIVAAVQGKAVGVGTTMLLHCDYVV
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCEECCCCEEEEECCEEE
LADDAQLITPFVNLALVPEAASSYLLPLRIGHARAFEMFSLGDPLPADTAVAWGIANRTV
EECCHHHHHHHHHHEECCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
PGDQLRAEGRRIAEKIATKPSGSLTAMKRLMREAEKLVAQMDAESSTFVERLRSAEAKEA
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHH
FAAFVQKRQPDFSRIAKQ
HHHHHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA