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The map label for this gene is bigR [H]

Identifier: 94314595

GI number: 94314595

Start: 2434288

End: 2434608

Strand: Reverse

Name: bigR [H]

Synonym: Rmet_5676

Alternate gene names: 94314595

Gene position: 2434608-2434288 (Counterclockwise)

Preceding gene: 94314596

Following gene: 94314594

Centisome position: 94.36

GC content: 62.62

Gene sequence:

>321_bases
ATGAACCAGACCCATTCCTCCATCGACCTCGTCAGCCTGCAAAGTGCAGCCGCGGACGCCTGCGCGCTGCTCAAGGTGCT
GGCCAACCCCGACCGCCTGCTGCTGATGTGCCAGCTCTCACAGGGCGAACTGTCGGTGGGCGAACTGGAGGCGCGGCTCG
GCATTCACCAGCCCACGTTGTCCCAGCAGCTTGCCGTGCTGCGTGAAAACGGTCTGGTAGTCACGCGCCGCGAGGGCAAG
AACATCATCTATGCCGTGGCCAGCGAACAGGCACTTGCTGTCATGGCCGTGCTGTACGAACAGTTCTGCGCGAATTCCTG
A

Upstream 100 bases:

>100_bases
CGGGTACCCGTTAACAATCTATATTTTTATAGACTATAATTCTCGCAAATGTTGCCCGGCCCGTGCCGGGGCCCATATCG
GCGCATACCGGCACCGGCCC

Downstream 100 bases:

>100_bases
GGAGCGAACATGCTGCTGATCGATCTTGGCAATTTCACCCCGGGCCTGTCCCTGGCCGGGGGCATCGTCATTGGCGTGGC
CGCAGCCGTGCTGGTGCTGT

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 106

Protein sequence:

>106_residues
MNQTHSSIDLVSLQSAAADACALLKVLANPDRLLLMCQLSQGELSVGELEARLGIHQPTLSQQLAVLRENGLVVTRREGK
NIIYAVASEQALAVMAVLYEQFCANS

Sequences:

>Translated_106_residues
MNQTHSSIDLVSLQSAAADACALLKVLANPDRLLLMCQLSQGELSVGELEARLGIHQPTLSQQLAVLRENGLVVTRREGK
NIIYAVASEQALAVMAVLYEQFCANS
>Mature_106_residues
MNQTHSSIDLVSLQSAAADACALLKVLANPDRLLLMCQLSQGELSVGELEARLGIHQPTLSQQLAVLRENGLVVTRREGK
NIIYAVASEQALAVMAVLYEQFCANS

Specific function: Represses an operon that comprises at least itself and blh. Binds to a palindromic AT-rich sequence spanning the -10 region of the blh promoter and blocks transcription of the operon [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789021, Length=96, Percent_Identity=37.5, Blast_Score=68, Evalue=1e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 11422; Mature: 11422

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTHSSIDLVSLQSAAADACALLKVLANPDRLLLMCQLSQGELSVGELEARLGIHQPTL
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCH
SQQLAVLRENGLVVTRREGKNIIYAVASEQALAVMAVLYEQFCANS
HHHHHHHHCCCEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQTHSSIDLVSLQSAAADACALLKVLANPDRLLLMCQLSQGELSVGELEARLGIHQPTL
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCH
SQQLAVLRENGLVVTRREGKNIIYAVASEQALAVMAVLYEQFCANS
HHHHHHHHCCCEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]