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The map label for this gene is adh [H]

Identifier: 94314564

GI number: 94314564

Start: 2406565

End: 2407638

Strand: Direct

Name: adh [H]

Synonym: Rmet_5645

Alternate gene names: 94314564

Gene position: 2406565-2407638 (Clockwise)

Preceding gene: 94314560

Following gene: 94314565

Centisome position: 93.27

GC content: 64.53

Gene sequence:

>1074_bases
ATGGCAGGCATGCAAGCTGCGGTTTTTCAGGGGCCCGGCAAGATCGTGCTGCAGGAAAAGCCGATCCCGGCCGTCGGCCC
CACCGACGCACTGATCCGCATCACCACCACCACAATCTGCGGCACCGATATCCACATTCTCAAAGGCGAGTATCCGGTAG
AGCGGGGCCTGACGATCGGTCACGAACCGGTGGGCATCATCGAGAAACTCGGCAGTGGCGTGACCGGTTATCACGAGGGT
CAGCGCGTCATCGCGGGCGCGATCTGCCCCAGCTTCTACTCCTACGCGTGCCAGGACGGTTGCGCCTCGCAGGACGGACA
AGGCCACTCGCACGGCTACAAGCCCATGGGCGGCTGGCGCTTCGGCAATACGATTGACGGCACCCAGGCCGAGTACGTGC
TCGTGCCGGACGCGCAGGCGAACCTCGCGCCCATCCCCGACGGGCTGACCGACGAACAGGTATTGATGTGTCCCGACATC
ATGTCGACGGGCTTCTCCGGCGCGGAGCACGCCAATATCAAGATCGGCGATATCGTTGCCGTGTTCGCGCAGGGTCCGAT
CGGACTGTGCGCGACGGCTGGCGCCCGCCTGCGTGGCGCTTCGCTGATCATCGCCGTAGATGGGATCGATGACCGCCTGA
ACATCTCTCGCCAGATGGGTGCCGACGTTACGCTGAACTTCCGCAATACCGACGTGGTGCAGGAGATCCTGCGCATTACG
GGCGGCCGTGGCGTCGACGCGTCGATCGAAGCACTCGGCACGCAGGCCACCTTCGAATCGGCCCTGCGCGTGCTCAAGCC
CGGCGGCACGCTGTCGAGCCTTGGCGTCTATTCCAGCGACCTGAAGATTCCCCTGGACGCCTTCGCGGCCGGTCTGGGCG
ATCACCGCATCATTACGTCGCTGTGCCCGGGCGGCAAGGAACGGATGCGCCGACTCATGAACGTGATCGAAACGCAGCGG
ATCGACCTCGGGCCACTGGTCACGCACCGCTTCAAGCTCGCCGATATCGAGGCCGCCTACGACCTCTTCGGGCACCAGCG
CGACGGCGTGCTCAAGGTAGCCATCACGCCTTGA

Upstream 100 bases:

>100_bases
GAGTGTCAACTCTCGGCCGCGCCAGCCTGGCCTAGACTGACTGGATCACCGCCCGCGAGGCTGCGGGCGGCCTTTCAGGC
CAACCAGAAGGAGTCTCGAC

Downstream 100 bases:

>100_bases
CGCCCGGCAGGCGCCCTGCCTGCCAAACCCGCCAGTTCCACAAGCCAGCCCCGGGCGTGTTACGTGACACGTAACACGCC
CGGGGTTTCTTTTGGCGCGC

Product: alcohol dehydrogenase, zinc-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MAGMQAAVFQGPGKIVLQEKPIPAVGPTDALIRITTTTICGTDIHILKGEYPVERGLTIGHEPVGIIEKLGSGVTGYHEG
QRVIAGAICPSFYSYACQDGCASQDGQGHSHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPIPDGLTDEQVLMCPDI
MSTGFSGAEHANIKIGDIVAVFAQGPIGLCATAGARLRGASLIIAVDGIDDRLNISRQMGADVTLNFRNTDVVQEILRIT
GGRGVDASIEALGTQATFESALRVLKPGGTLSSLGVYSSDLKIPLDAFAAGLGDHRIITSLCPGGKERMRRLMNVIETQR
IDLGPLVTHRFKLADIEAAYDLFGHQRDGVLKVAITP

Sequences:

>Translated_357_residues
MAGMQAAVFQGPGKIVLQEKPIPAVGPTDALIRITTTTICGTDIHILKGEYPVERGLTIGHEPVGIIEKLGSGVTGYHEG
QRVIAGAICPSFYSYACQDGCASQDGQGHSHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPIPDGLTDEQVLMCPDI
MSTGFSGAEHANIKIGDIVAVFAQGPIGLCATAGARLRGASLIIAVDGIDDRLNISRQMGADVTLNFRNTDVVQEILRIT
GGRGVDASIEALGTQATFESALRVLKPGGTLSSLGVYSSDLKIPLDAFAAGLGDHRIITSLCPGGKERMRRLMNVIETQR
IDLGPLVTHRFKLADIEAAYDLFGHQRDGVLKVAITP
>Mature_356_residues
AGMQAAVFQGPGKIVLQEKPIPAVGPTDALIRITTTTICGTDIHILKGEYPVERGLTIGHEPVGIIEKLGSGVTGYHEGQ
RVIAGAICPSFYSYACQDGCASQDGQGHSHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPIPDGLTDEQVLMCPDIM
STGFSGAEHANIKIGDIVAVFAQGPIGLCATAGARLRGASLIIAVDGIDDRLNISRQMGADVTLNFRNTDVVQEILRITG
GRGVDASIEALGTQATFESALRVLKPGGTLSSLGVYSSDLKIPLDAFAAGLGDHRIITSLCPGGKERMRRLMNVIETQRI
DLGPLVTHRFKLADIEAAYDLFGHQRDGVLKVAITP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=352, Percent_Identity=26.4204545454545, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4501939, Length=371, Percent_Identity=27.2237196765499, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=27.2237196765499, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=27.1505376344086, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4501929, Length=330, Percent_Identity=28.1818181818182, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI34577061, Length=334, Percent_Identity=27.8443113772455, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71743840, Length=358, Percent_Identity=26.536312849162, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=27.7628032345013, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=26.7409470752089, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4501933, Length=334, Percent_Identity=27.2455089820359, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=31.1224489795918, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790045, Length=345, Percent_Identity=26.6666666666667, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI87082125, Length=366, Percent_Identity=26.775956284153, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=26.1627906976744, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787863, Length=362, Percent_Identity=23.4806629834254, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788073, Length=364, Percent_Identity=24.7252747252747, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=27.1929824561404, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=29.8630136986301, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788407, Length=346, Percent_Identity=27.7456647398844, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081918, Length=285, Percent_Identity=25.9649122807018, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790718, Length=285, Percent_Identity=25.2631578947368, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787572, Length=134, Percent_Identity=40.2985074626866, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=363, Percent_Identity=27.8236914600551, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=363, Percent_Identity=28.099173553719, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=343, Percent_Identity=26.8221574344023, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=27.536231884058, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=343, Percent_Identity=26.8221574344023, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=347, Percent_Identity=29.3948126801153, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322619, Length=347, Percent_Identity=29.1066282420749, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323099, Length=367, Percent_Identity=26.4305177111717, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319520, Length=266, Percent_Identity=25.9398496240602, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=323, Percent_Identity=24.4582043343653, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=277, Percent_Identity=24.9097472924188, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=279, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=277, Percent_Identity=23.826714801444, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=390, Percent_Identity=24.8717948717949, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137530, Length=359, Percent_Identity=27.8551532033426, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17737897, Length=359, Percent_Identity=25.6267409470752, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737895, Length=360, Percent_Identity=26.3888888888889, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37715; Mature: 37584

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGMQAAVFQGPGKIVLQEKPIPAVGPTDALIRITTTTICGTDIHILKGEYPVERGLTIG
CCCCCCEEEECCCEEEEECCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCHHCCCCCC
HEPVGIIEKLGSGVTGYHEGQRVIAGAICPSFYSYACQDGCASQDGQGHSHGYKPMGGWR
CCCHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
FGNTIDGTQAEYVLVPDAQANLAPIPDGLTDEQVLMCPDIMSTGFSGAEHANIKIGDIVA
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCCEEEHHEEE
VFAQGPIGLCATAGARLRGASLIIAVDGIDDRLNISRQMGADVTLNFRNTDVVQEILRIT
EEECCCCCEEECCCCCCCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHC
GGRGVDASIEALGTQATFESALRVLKPGGTLSSLGVYSSDLKIPLDAFAAGLGDHRIITS
CCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHHCCCCCCHHHHH
LCPGGKERMRRLMNVIETQRIDLGPLVTHRFKLADIEAAYDLFGHQRDGVLKVAITP
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHEEEEHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
AGMQAAVFQGPGKIVLQEKPIPAVGPTDALIRITTTTICGTDIHILKGEYPVERGLTIG
CCCCCEEEECCCEEEEECCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCHHCCCCCC
HEPVGIIEKLGSGVTGYHEGQRVIAGAICPSFYSYACQDGCASQDGQGHSHGYKPMGGWR
CCCHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
FGNTIDGTQAEYVLVPDAQANLAPIPDGLTDEQVLMCPDIMSTGFSGAEHANIKIGDIVA
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCCEEEHHEEE
VFAQGPIGLCATAGARLRGASLIIAVDGIDDRLNISRQMGADVTLNFRNTDVVQEILRIT
EEECCCCCEEECCCCCCCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHC
GGRGVDASIEALGTQATFESALRVLKPGGTLSSLGVYSSDLKIPLDAFAAGLGDHRIITS
CCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHHCCCCCCHHHHH
LCPGGKERMRRLMNVIETQRIDLGPLVTHRFKLADIEAAYDLFGHQRDGVLKVAITP
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHEEEEHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]