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The map label for this gene is adh [H]

Identifier: 94314464

GI number: 94314464

Start: 2291628

End: 2292686

Strand: Reverse

Name: adh [H]

Synonym: Rmet_5545

Alternate gene names: 94314464

Gene position: 2292686-2291628 (Counterclockwise)

Preceding gene: 94314465

Following gene: 94314463

Centisome position: 88.86

GC content: 58.26

Gene sequence:

>1059_bases
ATGAAGAGCTACGACATCGTGGAGTGGGGCAAGCCTCTCCAGGAGGTTCTGCGAGACAGACCAAAGCCGGTCGGTACTGA
GGTTCTCGTAAAGGTGCAAGCCTGTGGGATTTGCCATAGTGACCTCCATATTCGGGATGGCTTGCTGGATCTTGGCAATG
GGAAGCACATTTCTTTCGAGAGTGTTGGGGTAAAGCTGCCCTTTACGATGGGCCATGAGATCGTTGGGGTCGTTGCAGAG
GCTGGCAGTGAGGCGTCAGTCAAGGCGGGGACGCCTTGTGTTGTCTACCCGTGGCACGGTTGCGGGACTTGTCTGAATTG
CACCAACGGCCGTGAAGTTGACTGTGAGAGTGGGCGGGCGCTCGGTACCCGTAAGCCGGGGGGATACTCTGACTACGTCG
TGGTACCGCATGAGCAATACCTCCTGGATTACGGAAATCTCGATCCGCTGCTTGCAGCTACCTGTGCCTGTTCTGGGCTA
ACCTCGTTCAGTGCATTGAAGAAGCTTCCTCCCATGCTCGAGGCAGACACGCTAGTACTAATCGGCGCTGGCGGGTTAGG
GCTCGCGGCTCTTGGTTTGGCGCCGCAGCTCACTTCTGCGCGGCTAGTGGTCGCAGACATCGATGACGAAAAGCTCGCCC
GCGCATCAGCGGCGGGGGCACATGAGGTGGTCAATCTTCGCTCCGAAAACGCGGCTCGGGATTTGCGAAAAGCAGCGCCA
AATGGGATTCGAGCGATTGTCGACTTTGTCGGCTCGGCGCAGACGACGGGCGTGGCGCTGGAGAGTGTGGCCCGCGGAGG
CACCGTCGTCGTCGTGGGCCTTTTTGGGGGCGCCATCTCTTTGTCGACTGCACTTTTGCCCATGCGGAACGTGACTCTGA
GGGGCTCCTATGTCGGCTCGGTGGAGGAAATGCGAGCGCTTTTGGATTTGCTACAAGAGAAAGGAAAGGGTTCGCCGGTC
AATCTCAAGTCGCTCCCAATGTCTGCGGTCAATGAGGCTTTAGAAGAGCTTGCACAAGGTCGGGTTGCTGGCCGTTTGCT
GGCCATCCCTGGTCAGTGA

Upstream 100 bases:

>100_bases
GCCGCAGACGGCACTCTGCTGAAGGTACGCCGCATGCTGGACGCCCTCCTGCTGGAAGAACGTTCGCCCAAAGCGGCGAC
GCAATAAGCGGAGGAACGAC

Downstream 100 bases:

>100_bases
TCGAGTGAGGACGTCTATGAAATACCTAACTGCGGACGCAATTTCTGAAGCCTTGCGAGGCAATCCGGTCCGGCAACTGA
TTAACGGTTCGATGGTTGAT

Product: alcohol dehydrogenase, NAD-dependent, Zn-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKSYDIVEWGKPLQEVLRDRPKPVGTEVLVKVQACGICHSDLHIRDGLLDLGNGKHISFESVGVKLPFTMGHEIVGVVAE
AGSEASVKAGTPCVVYPWHGCGTCLNCTNGREVDCESGRALGTRKPGGYSDYVVVPHEQYLLDYGNLDPLLAATCACSGL
TSFSALKKLPPMLEADTLVLIGAGGLGLAALGLAPQLTSARLVVADIDDEKLARASAAGAHEVVNLRSENAARDLRKAAP
NGIRAIVDFVGSAQTTGVALESVARGGTVVVVGLFGGAISLSTALLPMRNVTLRGSYVGSVEEMRALLDLLQEKGKGSPV
NLKSLPMSAVNEALEELAQGRVAGRLLAIPGQ

Sequences:

>Translated_352_residues
MKSYDIVEWGKPLQEVLRDRPKPVGTEVLVKVQACGICHSDLHIRDGLLDLGNGKHISFESVGVKLPFTMGHEIVGVVAE
AGSEASVKAGTPCVVYPWHGCGTCLNCTNGREVDCESGRALGTRKPGGYSDYVVVPHEQYLLDYGNLDPLLAATCACSGL
TSFSALKKLPPMLEADTLVLIGAGGLGLAALGLAPQLTSARLVVADIDDEKLARASAAGAHEVVNLRSENAARDLRKAAP
NGIRAIVDFVGSAQTTGVALESVARGGTVVVVGLFGGAISLSTALLPMRNVTLRGSYVGSVEEMRALLDLLQEKGKGSPV
NLKSLPMSAVNEALEELAQGRVAGRLLAIPGQ
>Mature_352_residues
MKSYDIVEWGKPLQEVLRDRPKPVGTEVLVKVQACGICHSDLHIRDGLLDLGNGKHISFESVGVKLPFTMGHEIVGVVAE
AGSEASVKAGTPCVVYPWHGCGTCLNCTNGREVDCESGRALGTRKPGGYSDYVVVPHEQYLLDYGNLDPLLAATCACSGL
TSFSALKKLPPMLEADTLVLIGAGGLGLAALGLAPQLTSARLVVADIDDEKLARASAAGAHEVVNLRSENAARDLRKAAP
NGIRAIVDFVGSAQTTGVALESVARGGTVVVVGLFGGAISLSTALLPMRNVTLRGSYVGSVEEMRALLDLLQEKGKGSPV
NLKSLPMSAVNEALEELAQGRVAGRLLAIPGQ

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=23.8356164383562, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=24.0437158469945, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=23.7704918032787, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71565154, Length=378, Percent_Identity=24.6031746031746, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=324, Percent_Identity=30.8641975308642, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI226510992, Length=317, Percent_Identity=26.1829652996845, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786518, Length=360, Percent_Identity=27.5, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788407, Length=345, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=23.4421364985163, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787863, Length=239, Percent_Identity=31.3807531380753, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082401, Length=351, Percent_Identity=24.5014245014245, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082125, Length=338, Percent_Identity=25.1479289940828, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788073, Length=288, Percent_Identity=27.0833333333333, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790718, Length=311, Percent_Identity=24.7588424437299, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786552, Length=380, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788075, Length=346, Percent_Identity=24.2774566473988, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=348, Percent_Identity=27.2988505747126, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=26.0233918128655, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=294, Percent_Identity=27.2108843537415, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=344, Percent_Identity=24.7093023255814, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=290, Percent_Identity=30, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17544682, Length=342, Percent_Identity=23.9766081871345, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=333, Percent_Identity=27.9279279279279, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=336, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=28.1065088757396, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=25.4691689008043, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=332, Percent_Identity=26.2048192771084, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=365, Percent_Identity=26.027397260274, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=358, Percent_Identity=25.4189944134078, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36726; Mature: 36726

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYDIVEWGKPLQEVLRDRPKPVGTEVLVKVQACGICHSDLHIRDGLLDLGNGKHISFE
CCCCCCHHCCHHHHHHHHCCCCCCCHHHEEEEHHCCCCCCCCEEECCCEECCCCCEEEEE
SVGVKLPFTMGHEIVGVVAEAGSEASVKAGTPCVVYPWHGCGTCLNCTNGREVDCESGRA
CCCEEECHHHCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEECCCCCEECCCCCCC
LGTRKPGGYSDYVVVPHEQYLLDYGNLDPLLAATCACSGLTSFSALKKLPPMLEADTLVL
CCCCCCCCCCCEEEECCHHHHEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEE
IGAGGLGLAALGLAPQLTSARLVVADIDDEKLARASAAGAHEVVNLRSENAARDLRKAAP
EECCCHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCC
NGIRAIVDFVGSAQTTGVALESVARGGTVVVVGLFGGAISLSTALLPMRNVTLRGSYVGS
CHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCC
VEEMRALLDLLQEKGKGSPVNLKSLPMSAVNEALEELAQGRVAGRLLAIPGQ
HHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCHHCCEEEECCCC
>Mature Secondary Structure
MKSYDIVEWGKPLQEVLRDRPKPVGTEVLVKVQACGICHSDLHIRDGLLDLGNGKHISFE
CCCCCCHHCCHHHHHHHHCCCCCCCHHHEEEEHHCCCCCCCCEEECCCEECCCCCEEEEE
SVGVKLPFTMGHEIVGVVAEAGSEASVKAGTPCVVYPWHGCGTCLNCTNGREVDCESGRA
CCCEEECHHHCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEECCCCCEECCCCCCC
LGTRKPGGYSDYVVVPHEQYLLDYGNLDPLLAATCACSGLTSFSALKKLPPMLEADTLVL
CCCCCCCCCCCEEEECCHHHHEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEE
IGAGGLGLAALGLAPQLTSARLVVADIDDEKLARASAAGAHEVVNLRSENAARDLRKAAP
EECCCHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCC
NGIRAIVDFVGSAQTTGVALESVARGGTVVVVGLFGGAISLSTALLPMRNVTLRGSYVGS
CHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCC
VEEMRALLDLLQEKGKGSPVNLKSLPMSAVNEALEELAQGRVAGRLLAIPGQ
HHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCHHCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]