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The map label for this gene is fadH [H]

Identifier: 94314428

GI number: 94314428

Start: 2254104

End: 2254679

Strand: Direct

Name: fadH [H]

Synonym: Rmet_5509

Alternate gene names: 94314428

Gene position: 2254104-2254679 (Clockwise)

Preceding gene: 94314424

Following gene: 94314429

Centisome position: 87.37

GC content: 58.68

Gene sequence:

>576_bases
GTGTTTAAGGAGGCATCCGAAAGATTCGGTCTGATTGATGTTGTCGTCTCTGGCGCTGCGGGAAACTTCCACGCACCCGC
TGCCTCGCTCTCCGCCAACGGCTTTAAGACGGTCGTCGACATAGACCTGATTGGTAACTTCAATGTCTTGCGGGCCAGCT
TCCCGTTTCTCAGGACGCCTGGTGCATCGCTGATGTCCATTACAGCACCAGGCGGTACGCACCCTTCCGTTTTTCAGGTG
CATGCGAACTCCGCCAAGGCGGGCATCAACATGACGGTGAAGTGCCTGGCGATGGAATGGGGTCCCGCTGGAATTCGCGT
GAACGCAATCTCCCCTGGACCAATTTCCGGAACAACCGGCATGGCGAAGCTCGCCGCCTCGCCCGAACGGGAGCAACAAA
TCAAGGCGCGCCTGCCCCTGCGCGAGTACGGGTCAATTCGAGACATCGCCGACACCGCACTGTTCCTTGCCAGCGACAAC
GCAAAGTACATCACTGGCGCCATCATCGATTGCGACGGGGGAAGCGGCCTAGGGGACGCCTCCGCAGATGCGCTTCTTAA
AGCAACTCAACGTTGA

Upstream 100 bases:

>100_bases
CGAAGAACGCATCACCGCAGCAGCAAGAACAATCACAGACGCCGGCCATGTGGCCTATGGACGGGCAGCCGACGTACGCA
ACTTTGAAGCGGTGGCATCC

Downstream 100 bases:

>100_bases
ATATTTCGACCACGGTCGTGCAAGGAAAAATATGAACGAGGCCTACATCTTTGATGCATTGCGCACCCCCCGCGGCAGAG
GACGTGCCGATGGTAGTCTC

Product: putative 2,4-dienoyl-CoA reductase (NADPH)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MFKEASERFGLIDVVVSGAAGNFHAPAASLSANGFKTVVDIDLIGNFNVLRASFPFLRTPGASLMSITAPGGTHPSVFQV
HANSAKAGINMTVKCLAMEWGPAGIRVNAISPGPISGTTGMAKLAASPEREQQIKARLPLREYGSIRDIADTALFLASDN
AKYITGAIIDCDGGSGLGDASADALLKATQR

Sequences:

>Translated_191_residues
MFKEASERFGLIDVVVSGAAGNFHAPAASLSANGFKTVVDIDLIGNFNVLRASFPFLRTPGASLMSITAPGGTHPSVFQV
HANSAKAGINMTVKCLAMEWGPAGIRVNAISPGPISGTTGMAKLAASPEREQQIKARLPLREYGSIRDIADTALFLASDN
AKYITGAIIDCDGGSGLGDASADALLKATQR
>Mature_191_residues
MFKEASERFGLIDVVVSGAAGNFHAPAASLSANGFKTVVDIDLIGNFNVLRASFPFLRTPGASLMSITAPGGTHPSVFQV
HANSAKAGINMTVKCLAMEWGPAGIRVNAISPGPISGTTGMAKLAASPEREQQIKARLPLREYGSIRDIADTALFLASDN
AKYITGAIIDCDGGSGLGDASADALLKATQR

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=176, Percent_Identity=46.0227272727273, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI4503301, Length=165, Percent_Identity=38.7878787878788, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI19923817, Length=187, Percent_Identity=29.4117647058824, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI59889578, Length=184, Percent_Identity=29.3478260869565, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI32483357, Length=173, Percent_Identity=30.0578034682081, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082100, Length=185, Percent_Identity=31.3513513513514, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1787905, Length=175, Percent_Identity=29.1428571428571, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787545, Length=151, Percent_Identity=31.7880794701987, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788459, Length=171, Percent_Identity=28.6549707602339, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1789208, Length=176, Percent_Identity=25.5681818181818, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=167, Percent_Identity=29.3413173652695, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786812, Length=160, Percent_Identity=29.375, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536651, Length=179, Percent_Identity=35.7541899441341, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561272, Length=169, Percent_Identity=36.6863905325444, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17536025, Length=179, Percent_Identity=34.0782122905028, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=176, Percent_Identity=24.4318181818182, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=175, Percent_Identity=25.1428571428571, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=117, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=189, Percent_Identity=26.4550264550265, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=172, Percent_Identity=44.1860465116279, Blast_Score=147, Evalue=9e-37,
Organism=Drosophila melanogaster, GI23397609, Length=178, Percent_Identity=25.8426966292135, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643142, Length=172, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 19762; Mature: 19762

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKEASERFGLIDVVVSGAAGNFHAPAASLSANGFKTVVDIDLIGNFNVLRASFPFLRTP
CCCCCCHHCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCEEECC
GASLMSITAPGGTHPSVFQVHANSAKAGINMTVKCLAMEWGPAGIRVNAISPGPISGTTG
CCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCCC
MAKLAASPEREQQIKARLPLREYGSIRDIADTALFLASDNAKYITGAIIDCDGGSGLGDA
HHHHHCCCCHHHHHHHCCCHHHCCCHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCCC
SADALLKATQR
CHHHHHHCCCC
>Mature Secondary Structure
MFKEASERFGLIDVVVSGAAGNFHAPAASLSANGFKTVVDIDLIGNFNVLRASFPFLRTP
CCCCCCHHCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCEEECC
GASLMSITAPGGTHPSVFQVHANSAKAGINMTVKCLAMEWGPAGIRVNAISPGPISGTTG
CCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCCC
MAKLAASPEREQQIKARLPLREYGSIRDIADTALFLASDNAKYITGAIIDCDGGSGLGDA
HHHHHCCCCHHHHHHHCCCHHHCCCHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCCC
SADALLKATQR
CHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]