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The map label for this gene is hmuU [H]

Identifier: 94314296

GI number: 94314296

Start: 2103484

End: 2104485

Strand: Direct

Name: hmuU [H]

Synonym: Rmet_5377

Alternate gene names: 94314296

Gene position: 2103484-2104485 (Clockwise)

Preceding gene: 94314295

Following gene: 94314297

Centisome position: 81.53

GC content: 67.66

Gene sequence:

>1002_bases
ATGATGCGTGGCCAATGTGGCCGAAGGCCGGGCATGTTGGCCGCCCTGTGCGTCATGCTCGTGATCACCGCGCTCTGGGC
AGCCGCCAGCGGGGCATTGTCGATTCCGCACGGCAAGCTCCTGCCCTTGCTCTGGTCACCTGCCGCCGAAGGAGAGGATG
TCATCTGGCGCAATGTGCTGATCGAGGTGCGGCTGCCGCGCATCGTGCTGGCCATCACCGCCGGCGCGGCGCTAGCACTG
TCTGGCGCGGTGATGCAGGCGCTCTTCCGCAATCCGCTGGCCGAGCCAGGGTTGATCGGGATCTCGCTGGGCGGTGCCGC
GGGTGCCGTGGCCGCGATCGTGCTGGGCGCCGAAGGGCTCGGCAGCGTCGCGCCCGCCGCATTCGCAGGCAGCCTGATTG
CCACCGCCTTCGCCTACGTGCTTGGCACACGGCGCCCGGGCGCGGCCAACCTGCTGCTCGCCGGCGTGGCCATCAATGCG
ATCTGCGCGGCCGTCGTTGGGTTCTTCACCTATCAGGCCAGCGACGTGCAACTGCGCAACCTGACGTTCTGGAACATGGG
CAGCCTTGCTGGCGCGACGTGGTCGATCCTGGCGTGGCTTGTGCCGCTGGTGGCCGTGCTGTGCGCGCTGCTCATGCGTG
ACTGGCGCGCGATGAACGCGCTGCTGCTCGGCGAACGGGAAGCCCAGCACATCGGCTTCGACCTGAAGCGGCTCCGCCGC
CGGTTGATCGTGCTTACCGCGCTGCTGGTAGGGCCCATCGTGGCCGTCACGGGAACGATTTCCTTCGTGGGACTGGTCGT
GCCGCATCTGATCCGGCTGGCACTAGGTGCCGATCATCGCTGGCTGCTGCCGAACACACTGGCGGGCGGCGCTATCGCCT
TGACGCTGGGCGACTGGATGGCACGCACGGTGGTGGTTCCGGCGGAACTGCCGATCGGCATCGTCACGAGCCTGGTGGGT
GGGCCATTCCTGCTCTGGATGCTGACACGCAAAAGACCCTGA

Upstream 100 bases:

>100_bases
TCGTGATGGACGATCTGCTGATGCTCAGCATCGGTCCGCGCCTTCCCGAGGCGCTGCGCCTGCTGCGCAACGGTCTTGCC
AGCCGGCAGGTGGCAGCACG

Downstream 100 bases:

>100_bases
TGAACCTGACGAACCTGACATGCTGATTGCCCGCAATCTTTCATGCAGCCGCGGTCGGCGGCAGATCCTGTCCGGTATCG
ACCTGACCCTGCCGGCCGGC

Product: Hemin ABC-transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MMRGQCGRRPGMLAALCVMLVITALWAAASGALSIPHGKLLPLLWSPAAEGEDVIWRNVLIEVRLPRIVLAITAGAALAL
SGAVMQALFRNPLAEPGLIGISLGGAAGAVAAIVLGAEGLGSVAPAAFAGSLIATAFAYVLGTRRPGAANLLLAGVAINA
ICAAVVGFFTYQASDVQLRNLTFWNMGSLAGATWSILAWLVPLVAVLCALLMRDWRAMNALLLGEREAQHIGFDLKRLRR
RLIVLTALLVGPIVAVTGTISFVGLVVPHLIRLALGADHRWLLPNTLAGGAIALTLGDWMARTVVVPAELPIGIVTSLVG
GPFLLWMLTRKRP

Sequences:

>Translated_333_residues
MMRGQCGRRPGMLAALCVMLVITALWAAASGALSIPHGKLLPLLWSPAAEGEDVIWRNVLIEVRLPRIVLAITAGAALAL
SGAVMQALFRNPLAEPGLIGISLGGAAGAVAAIVLGAEGLGSVAPAAFAGSLIATAFAYVLGTRRPGAANLLLAGVAINA
ICAAVVGFFTYQASDVQLRNLTFWNMGSLAGATWSILAWLVPLVAVLCALLMRDWRAMNALLLGEREAQHIGFDLKRLRR
RLIVLTALLVGPIVAVTGTISFVGLVVPHLIRLALGADHRWLLPNTLAGGAIALTLGDWMARTVVVPAELPIGIVTSLVG
GPFLLWMLTRKRP
>Mature_333_residues
MMRGQCGRRPGMLAALCVMLVITALWAAASGALSIPHGKLLPLLWSPAAEGEDVIWRNVLIEVRLPRIVLAITAGAALAL
SGAVMQALFRNPLAEPGLIGISLGGAAGAVAAIVLGAEGLGSVAPAAFAGSLIATAFAYVLGTRRPGAANLLLAGVAINA
ICAAVVGFFTYQASDVQLRNLTFWNMGSLAGATWSILAWLVPLVAVLCALLMRDWRAMNALLLGEREAQHIGFDLKRLRR
RLIVLTALLVGPIVAVTGTISFVGLVVPHLIRLALGADHRWLLPNTLAGGAIALTLGDWMARTVVVPAELPIGIVTSLVG
GPFLLWMLTRKRP

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=283, Percent_Identity=43.1095406360424, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1790740, Length=276, Percent_Identity=35.5072463768116, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786805, Length=311, Percent_Identity=36.9774919614148, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790741, Length=280, Percent_Identity=33.9285714285714, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786804, Length=323, Percent_Identity=29.7213622291022, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786347, Length=300, Percent_Identity=31, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34821; Mature: 34821

Theoretical pI: Translated: 11.42; Mature: 11.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRGQCGRRPGMLAALCVMLVITALWAAASGALSIPHGKLLPLLWSPAAEGEDVIWRNVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCCCCCHHHHHHH
IEVRLPRIVLAITAGAALALSGAVMQALFRNPLAEPGLIGISLGGAAGAVAAIVLGAEGL
EEEECCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCC
GSVAPAAFAGSLIATAFAYVLGTRRPGAANLLLAGVAINAICAAVVGFFTYQASDVQLRN
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LTFWNMGSLAGATWSILAWLVPLVAVLCALLMRDWRAMNALLLGEREAQHIGFDLKRLRR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHH
RLIVLTALLVGPIVAVTGTISFVGLVVPHLIRLALGADHRWLLPNTLAGGAIALTLGDWM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEHHHHH
ARTVVVPAELPIGIVTSLVGGPFLLWMLTRKRP
HHHEEECCCCCHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MMRGQCGRRPGMLAALCVMLVITALWAAASGALSIPHGKLLPLLWSPAAEGEDVIWRNVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCCCCCHHHHHHH
IEVRLPRIVLAITAGAALALSGAVMQALFRNPLAEPGLIGISLGGAAGAVAAIVLGAEGL
EEEECCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCC
GSVAPAAFAGSLIATAFAYVLGTRRPGAANLLLAGVAINAICAAVVGFFTYQASDVQLRN
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LTFWNMGSLAGATWSILAWLVPLVAVLCALLMRDWRAMNALLLGEREAQHIGFDLKRLRR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHH
RLIVLTALLVGPIVAVTGTISFVGLVVPHLIRLALGADHRWLLPNTLAGGAIALTLGDWM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEHHHHH
ARTVVVPAELPIGIVTSLVGGPFLLWMLTRKRP
HHHEEECCCCCHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]