Click here to switch to the map view.

The map label for this gene is hmuV

Identifier: 94314297

GI number: 94314297

Start: 2104505

End: 2105290

Strand: Direct

Name: hmuV

Synonym: Rmet_5378

Alternate gene names: 94314297

Gene position: 2104505-2105290 (Clockwise)

Preceding gene: 94314296

Following gene: 94314302

Centisome position: 81.57

GC content: 68.7

Gene sequence:

>786_bases
ATGCTGATTGCCCGCAATCTTTCATGCAGCCGCGGTCGGCGGCAGATCCTGTCCGGTATCGACCTGACCCTGCCGGCCGG
CGAGATGGTCGGCGTGCTCGGTGCCAACGGCGCCGGCAAGAGCACGCTGCTCGGCACGCTGGCAGGTGAACTGCCCGGCG
ACGACGCGGCGGTGTCGCTCTGCAACCGGCCATTGACGGACTGGCCCGTGGACGAGCTCGCCCGTAGCCGTGCGGTGCTG
CCGCAATCGCCCGGTCTGGGCTTCGACCTGGGTGTGACCGAGGTGGTGGCGATGGGCGGCTATCCATTTCCAGAGATGGG
CAAGCACACGCTCGATACCCTGCTGGACCGCGCCCTGGCGCTGGCCGACGTCGCGCATCTGGCCACGCGTTCGTACCAGA
GCCTATCCGGCGGCGAACAGCAGCGCGTGCAGTTCGCTCGCGCGCTGGTGCAGGTGCTGGCCTGCCGCACGGCCGACAGC
TACCGCGCGCTACTGCTCGATGAACCGATTTCGAGCCTCGACCCCCGGCATCAGTTGCAACTGCTCGGCACGGCGCGCAA
CCTGTGCCATACCGACGCCCTGGCGGTGCTGGTCGTGCTCCACGACGTCAATCTCGCCGCCCGCTGGTGCGACAGGCTCG
TGCTGCTGGCCGATGGCCGTACCGTGGCCAGCGGCACCCCCGCCGACGTGCTGACCCCGCCGAACCTCGCCACGGTGTAC
GGCATTCCAGCCACCGTCATGGAATCGCCAGTTCACCGGGGCGTGCCGATGGTGGTGTTTGGCTGA

Upstream 100 bases:

>100_bases
GCGGAACTGCCGATCGGCATCGTCACGAGCCTGGTGGGTGGGCCATTCCTGCTCTGGATGCTGACACGCAAAAGACCCTG
ATGAACCTGACGAACCTGAC

Downstream 100 bases:

>100_bases
TTCGGCTGAGCGGCTGAGCAGCTGAGCGGCGCCCATGGGGGACGCACCTATGCGTACTTCCCCGTTATCCCTCCATCGAC
CACCAGCTCGGTGCCGGTAA

Product: hemin importer ATP-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MLIARNLSCSRGRRQILSGIDLTLPAGEMVGVLGANGAGKSTLLGTLAGELPGDDAAVSLCNRPLTDWPVDELARSRAVL
PQSPGLGFDLGVTEVVAMGGYPFPEMGKHTLDTLLDRALALADVAHLATRSYQSLSGGEQQRVQFARALVQVLACRTADS
YRALLLDEPISSLDPRHQLQLLGTARNLCHTDALAVLVVLHDVNLAARWCDRLVLLADGRTVASGTPADVLTPPNLATVY
GIPATVMESPVHRGVPMVVFG

Sequences:

>Translated_261_residues
MLIARNLSCSRGRRQILSGIDLTLPAGEMVGVLGANGAGKSTLLGTLAGELPGDDAAVSLCNRPLTDWPVDELARSRAVL
PQSPGLGFDLGVTEVVAMGGYPFPEMGKHTLDTLLDRALALADVAHLATRSYQSLSGGEQQRVQFARALVQVLACRTADS
YRALLLDEPISSLDPRHQLQLLGTARNLCHTDALAVLVVLHDVNLAARWCDRLVLLADGRTVASGTPADVLTPPNLATVY
GIPATVMESPVHRGVPMVVFG
>Mature_261_residues
MLIARNLSCSRGRRQILSGIDLTLPAGEMVGVLGANGAGKSTLLGTLAGELPGDDAAVSLCNRPLTDWPVDELARSRAVL
PQSPGLGFDLGVTEVVAMGGYPFPEMGKHTLDTLLDRALALADVAHLATRSYQSLSGGEQQRVQFARALVQVLACRTADS
YRALLLDEPISSLDPRHQLQLLGTARNLCHTDALAVLVVLHDVNLAARWCDRLVLLADGRTVASGTPADVLTPPNLATVY
GIPATVMESPVHRGVPMVVFG

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system

COG id: COG4559

COG function: function code P; ABC-type hemin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI105990541, Length=217, Percent_Identity=27.6497695852535, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786345, Length=249, Percent_Identity=39.3574297188755, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1790739, Length=262, Percent_Identity=34.7328244274809, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786803, Length=262, Percent_Identity=31.6793893129771, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788002, Length=228, Percent_Identity=37.280701754386, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790544, Length=239, Percent_Identity=33.8912133891213, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787370, Length=239, Percent_Identity=31.3807531380753, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1789593, Length=243, Percent_Identity=29.2181069958848, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082268, Length=245, Percent_Identity=31.0204081632653, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787029, Length=238, Percent_Identity=31.5126050420168, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87081709, Length=235, Percent_Identity=29.7872340425532, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788761, Length=235, Percent_Identity=32.3404255319149, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87081791, Length=239, Percent_Identity=28.4518828451883, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1786398, Length=249, Percent_Identity=28.5140562248996, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1786253, Length=213, Percent_Identity=32.3943661971831, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788450, Length=238, Percent_Identity=28.9915966386555, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787712, Length=245, Percent_Identity=26.9387755102041, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI48994943, Length=230, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788165, Length=236, Percent_Identity=31.3559322033898, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790467, Length=230, Percent_Identity=28.2608695652174, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI48994997, Length=242, Percent_Identity=28.9256198347107, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787089, Length=243, Percent_Identity=30.8641975308642, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786563, Length=219, Percent_Identity=31.9634703196347, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87082267, Length=237, Percent_Identity=28.6919831223629, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87081834, Length=225, Percent_Identity=32.8888888888889, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788225, Length=245, Percent_Identity=28.1632653061224, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787792, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1786703, Length=212, Percent_Identity=32.0754716981132, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789032, Length=226, Percent_Identity=29.646017699115, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787500, Length=225, Percent_Identity=26.2222222222222, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI48994883, Length=238, Percent_Identity=25.2100840336134, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787164, Length=244, Percent_Identity=31.5573770491803, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788506, Length=232, Percent_Identity=28.448275862069, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789864, Length=239, Percent_Identity=25.1046025104602, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790162, Length=242, Percent_Identity=27.6859504132231, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786872, Length=237, Percent_Identity=28.2700421940928, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789873, Length=214, Percent_Identity=31.7757009345794, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693107, Length=252, Percent_Identity=24.2063492063492, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534520, Length=254, Percent_Identity=25.1968503937008, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533608, Length=227, Percent_Identity=25.5506607929515, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=247, Percent_Identity=24.6963562753036, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650855, Length=224, Percent_Identity=26.3392857142857, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650853, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585091, Length=224, Percent_Identity=27.2321428571429, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281362751, Length=221, Percent_Identity=27.1493212669683, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574259, Length=229, Percent_Identity=24.4541484716157, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007184, Length=209, Percent_Identity=28.2296650717703, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221500365, Length=221, Percent_Identity=28.0542986425339, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMUV_RALME (Q1LC89)

Other databases:

- EMBL:   CP000353
- RefSeq:   YP_587506.1
- ProteinModelPortal:   Q1LC89
- SMR:   Q1LC89
- STRING:   Q1LC89
- GeneID:   4042239
- GenomeReviews:   CP000353_GR
- KEGG:   rme:Rmet_5378
- eggNOG:   COG4559
- HOGENOM:   HBG758042
- OMA:   ITRHPET
- PhylomeDB:   Q1LC89
- ProtClustDB:   PRK13548
- BioCyc:   RMET266264:RMET_5378-MONOMER
- HAMAP:   MF_01718
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015863
- InterPro:   IPR003593
- SMART:   SM00382

Pfam domain/function: PF00005 ABC_tran

EC number: NA

Molecular weight: Translated: 27585; Mature: 27585

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51261 HMUV

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIARNLSCSRGRRQILSGIDLTLPAGEMVGVLGANGAGKSTLLGTLAGELPGDDAAVSL
CEEECCCCHHHHHHHHHCCCCCCCCCHHHEEEECCCCCCCHHHHHHHHCCCCCCHHHHHH
CNRPLTDWPVDELARSRAVLPQSPGLGFDLGVTEVVAMGGYPFPEMGKHTLDTLLDRALA
HCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LADVAHLATRSYQSLSGGEQQRVQFARALVQVLACRTADSYRALLLDEPISSLDPRHQLQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCHHHCCHHHHHH
LLGTARNLCHTDALAVLVVLHDVNLAARWCDRLVLLADGRTVASGTPADVLTPPNLATVY
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCEEEEECCCEECCCCCCCCCCCCCCEEEE
GIPATVMESPVHRGVPMVVFG
CCCHHHHHCHHHCCCCEEEEC
>Mature Secondary Structure
MLIARNLSCSRGRRQILSGIDLTLPAGEMVGVLGANGAGKSTLLGTLAGELPGDDAAVSL
CEEECCCCHHHHHHHHHCCCCCCCCCHHHEEEECCCCCCCHHHHHHHHCCCCCCHHHHHH
CNRPLTDWPVDELARSRAVLPQSPGLGFDLGVTEVVAMGGYPFPEMGKHTLDTLLDRALA
HCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LADVAHLATRSYQSLSGGEQQRVQFARALVQVLACRTADSYRALLLDEPISSLDPRHQLQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCHHHCCHHHHHH
LLGTARNLCHTDALAVLVVLHDVNLAARWCDRLVLLADGRTVASGTPADVLTPPNLATVY
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCEEEEECCCEECCCCCCCCCCCCCCEEEE
GIPATVMESPVHRGVPMVVFG
CCCHHHHHCHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA