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The map label for this gene is hutT [H]

Identifier: 94313968

GI number: 94313968

Start: 1732551

End: 1733975

Strand: Reverse

Name: hutT [H]

Synonym: Rmet_5046

Alternate gene names: 94313968

Gene position: 1733975-1732551 (Counterclockwise)

Preceding gene: 94313969

Following gene: 94313967

Centisome position: 67.21

GC content: 63.79

Gene sequence:

>1425_bases
ATGGGCCTTCGGTCCCAATCTAGACATCCTTCTGGAGACAGCTTGAAAAACCTGCAACGCAATCTGAGCGCGCGGCATAT
CCGCTTTCTCGCGCTCGGCTCGGCCATCGGCACGGGCCTGTTCTACGGTTCGGCATCGGCGATCCAGCTGGCCGGCCCGG
CCGTTATCCTGGCGTACATCGTGGGCGGCGCGGCGGTCTACATGGTTATGCGCGCGCTGGGCGAGATGGCTGTGCGCGAG
CCGGTGACCGGCTCGTTCGGCCGCTACGCCAGCGAGTACCTGGGGCCGCTCGCGGGCTTTCTTACCGGATGGACCTACAT
CCTCGAGATGATCATCGTCTGTCTGGCGGACGTGACCGCATTCGGTATCTACATGGGATTCTGGTTCCCCGAAGTGCCGC
AATGGATATGGGTGCTCGGCATCGTCATGCTGATCTGCGGGCTGAACCTGTGCAATGTGAAGGTGTTCGGCGAGCTCGAG
TTCTGGCTGGCGTTGGTGAAGATCCTGGCCATCGCGGCGATGATCATCGGCGGCACGCTGATCCTGTTCCTCGGCGTGAA
GATGAATGGCGAGCATTCGCCGGGCTTGACCAATCTGTGGGCGCATGGCGGCTTCCTGCCGCACGGCGCGGGCGGGTTGA
TCGCGTCACTGGCGGTGGTGATGTTTGCCTACGGCGGCATCGAGATCATCGGCATCACTGGCGGTGAAGCCCAGAATCCG
GAGAAGGTGATTCCGCGCGCCATCAACGCCGTGCCCGCCCGCATCCTGCTGTTCTACGTGCTGACGATGACCGTGCTGAT
GGCCATCTTCCCGTGGACCGGCATCGGTAGCCAGGGCAGCCCGTTCGTGCAAATCTTCTCCGGGCTGGGGATCAAATCGG
CTGCGGCGGTGCTCAACCTGATCGTCATCTCGGCCGCCATCTCGGCGATCAACAGCAATATCTTTGGCGCAGGCCGCATG
ATGTATGGCATGGCGGAGCAGGGCCAGGCGCCGCGCCTGTTCGCCACCACCTCGCGTCATGGCGTGCCCTGGGTGACAGT
GCTGGCGATGGCTGCTGCCTTGCTCGGCGGTGTGGTGCTGAACTACCTGATCCCCGAGCAGGTGTTTGTGATCATCGCGT
CGATTGCGACCTTCGCCACCGTGTGGGTCTGGCTGATGATCCTGCTGTCGCAGGTTGCCATGCGACGCCGCCTGTCGGCC
GAAGAGGTTCGCGCCCTCAAGTTCAAGGTGCCGCTGTGGCCGGTCGGTCCGGCGCTGGCGATCGCCTTCATGCTGTTCGT
GATCGGCGTGCTGGGGTATGTCGAGGACACGCGCGTGGCTCTGTACGTTGGCGCGGGCTGGGTCGTGCTGCTGTCGCTGG
CCTGGTTCCTGCGGGCCAAGCCGAAGGCGGACGCGCTGCTCGCCCGGGAAACCAGTGTTTCGTGA

Upstream 100 bases:

>100_bases
ATCGCCGAGCGTCACCTGACGGCCCTGCTGCCTGCAGGCATCCTGCCGAGCGTCTGACGGACGCTTGCGCCGGCGCCAAG
CGGGCGAAGATCCGCGCGCC

Downstream 100 bases:

>100_bases
AACGGACGTGCGGCAAATGACGGCATTGACGCAAGCCGAGGCCCTTGATGCGGTCTGGCAGGGGCGCGCCGATACCGGTG
AGCGCGGGGATACGCGGCGG

Product: histidine transport protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MGLRSQSRHPSGDSLKNLQRNLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIVGGAAVYMVMRALGEMAVRE
PVTGSFGRYASEYLGPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELE
FWLALVKILAIAAMIIGGTLILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAQNP
EKVIPRAINAVPARILLFYVLTMTVLMAIFPWTGIGSQGSPFVQIFSGLGIKSAAAVLNLIVISAAISAINSNIFGAGRM
MYGMAEQGQAPRLFATTSRHGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSA
EEVRALKFKVPLWPVGPALAIAFMLFVIGVLGYVEDTRVALYVGAGWVVLLSLAWFLRAKPKADALLARETSVS

Sequences:

>Translated_474_residues
MGLRSQSRHPSGDSLKNLQRNLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIVGGAAVYMVMRALGEMAVRE
PVTGSFGRYASEYLGPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELE
FWLALVKILAIAAMIIGGTLILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAQNP
EKVIPRAINAVPARILLFYVLTMTVLMAIFPWTGIGSQGSPFVQIFSGLGIKSAAAVLNLIVISAAISAINSNIFGAGRM
MYGMAEQGQAPRLFATTSRHGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSA
EEVRALKFKVPLWPVGPALAIAFMLFVIGVLGYVEDTRVALYVGAGWVVLLSLAWFLRAKPKADALLARETSVS
>Mature_473_residues
GLRSQSRHPSGDSLKNLQRNLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIVGGAAVYMVMRALGEMAVREP
VTGSFGRYASEYLGPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELEF
WLALVKILAIAAMIIGGTLILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAQNPE
KVIPRAINAVPARILLFYVLTMTVLMAIFPWTGIGSQGSPFVQIFSGLGIKSAAAVLNLIVISAAISAINSNIFGAGRMM
YGMAEQGQAPRLFATTSRHGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSAE
EVRALKFKVPLWPVGPALAIAFMLFVIGVLGYVEDTRVALYVGAGWVVLLSLAWFLRAKPKADALLARETSVS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=353, Percent_Identity=28.0453257790368, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI110347453, Length=369, Percent_Identity=29.2682926829268, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI258645169, Length=403, Percent_Identity=25.0620347394541, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI258614003, Length=401, Percent_Identity=24.9376558603491, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI258614005, Length=401, Percent_Identity=24.9376558603491, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI114326544, Length=460, Percent_Identity=22.6086956521739, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI114326550, Length=460, Percent_Identity=22.6086956521739, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=59.825327510917, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=43.3333333333333, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1786302, Length=445, Percent_Identity=42.4719101123596, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790653, Length=453, Percent_Identity=38.6313465783664, Blast_Score=351, Evalue=6e-98,
Organism=Escherichia coli, GI48994972, Length=434, Percent_Identity=44.0092165898618, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI87081708, Length=454, Percent_Identity=37.6651982378855, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI87081915, Length=398, Percent_Identity=36.4321608040201, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI1789017, Length=428, Percent_Identity=36.214953271028, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788480, Length=443, Percent_Identity=36.3431151241535, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87081869, Length=194, Percent_Identity=25.7731958762887, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082023, Length=285, Percent_Identity=23.1578947368421, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=376, Percent_Identity=24.7340425531915, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532491, Length=346, Percent_Identity=23.9884393063584, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=436, Percent_Identity=23.1651376146789, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=452, Percent_Identity=33.1858407079646, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=31.1363636363636, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=423, Percent_Identity=30.0236406619385, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=396, Percent_Identity=32.0707070707071, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=30.1098901098901, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=439, Percent_Identity=28.7015945330296, Blast_Score=177, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324059, Length=464, Percent_Identity=29.3103448275862, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=419, Percent_Identity=26.491646778043, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=448, Percent_Identity=27.0089285714286, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=423, Percent_Identity=28.3687943262411, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=406, Percent_Identity=27.0935960591133, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=27.1604938271605, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=26.8292682926829, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6321053, Length=430, Percent_Identity=25.8139534883721, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=27.3869346733668, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=380, Percent_Identity=28.1578947368421, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=26.448362720403, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=504, Percent_Identity=24.6031746031746, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI161077963, Length=331, Percent_Identity=27.190332326284, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24667468, Length=331, Percent_Identity=25.6797583081571, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50705; Mature: 50574

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLRSQSRHPSGDSLKNLQRNLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHH
VGGAAVYMVMRALGEMAVREPVTGSFGRYASEYLGPLAGFLTGWTYILEMIIVCLADVTA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELEFWLALVKILAIAAMIIGGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAQNP
HHHCCCEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
EKVIPRAINAVPARILLFYVLTMTVLMAIFPWTGIGSQGSPFVQIFSGLGIKSAAAVLNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
IVISAAISAINSNIFGAGRMMYGMAEQGQAPRLFATTSRHGVPWVTVLAMAAALLGGVVL
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
NYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPLWPVGPALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCHHHH
IAFMLFVIGVLGYVEDTRVALYVGAGWVVLLSLAWFLRAKPKADALLARETSVS
HHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
GLRSQSRHPSGDSLKNLQRNLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHH
VGGAAVYMVMRALGEMAVREPVTGSFGRYASEYLGPLAGFLTGWTYILEMIIVCLADVTA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELEFWLALVKILAIAAMIIGGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAQNP
HHHCCCEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
EKVIPRAINAVPARILLFYVLTMTVLMAIFPWTGIGSQGSPFVQIFSGLGIKSAAAVLNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
IVISAAISAINSNIFGAGRMMYGMAEQGQAPRLFATTSRHGVPWVTVLAMAAALLGGVVL
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
NYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPLWPVGPALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCHHHH
IAFMLFVIGVLGYVEDTRVALYVGAGWVVLLSLAWFLRAKPKADALLARETSVS
HHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]