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The map label for this gene is hutH [H]

Identifier: 94313969

GI number: 94313969

Start: 1734019

End: 1735575

Strand: Reverse

Name: hutH [H]

Synonym: Rmet_5047

Alternate gene names: 94313969

Gene position: 1735575-1734019 (Counterclockwise)

Preceding gene: 94313970

Following gene: 94313968

Centisome position: 67.27

GC content: 66.6

Gene sequence:

>1557_bases
ATGTCGTACCAAGAAAATCAGCCAGTCTTCGCCCTGCATCTGCAACCCGGTGAGCTCACGCTCGCGCAACTGCGTGCCGT
GCATCAGCAGCCCGTCAAGATCACGCTCGACGAGCGCGCCTTCCCCGCCATCGACCGCAGCGTGGCGTGTGTCGAAAACA
TCATCGCCGAGGGCCGCACGGCCTACGGCATCAACACCGGATTCGGCCTGCTGGCACAGACCCGCATTGCCCGCGAGGAC
CTGGAGAACCTGCAGCGTTCGCTGGTGCTTTCCCACGCGGCAGGTGTGGGCGAGCCGATCGACGACGCGCTGGTGCGCCT
GATCATGGTGCTCAAGATCAACAGCCTGGCGCGTGGCCTGTCTGGCATCCGCCGCAAGGTGATCAGCGCGCTGATCGCGC
TGGTGAACGCCGAGGTGTACCCGTGCATTCCGCTGAAGGGCTCCGTTGGCGCGTCGGGCGATCTGGCGCCGCTGGCCCAT
ATGTCGTTGCTGCTGCTGGGCGAAGGCCGGGCACGCCATCGCGGCGAATGGCTGTCGGCTCGCGAAGCGCTGGCCATTGC
CGATTTGCAGCCGCTGACGCTCGCCGCCAAGGAAGGGCTGGCGCTGCTGAATGGCACGCAGGTTTCCACCGCGTATGCGC
TGCAGGGTTTGTTCCAGGCGGAAGACCTGTACGCGGCGGCCAGCGTTTGCGGCGCGCTGACCGTCGAGGCGACGCTCGGC
TCGCGCGCTCCGTTCGATCCGCGCATTCACGCCGCCCGTGGCCAGCGCGGCCAGATCGACGCGGCGGCGGTCTATCGTCA
CCTGCTGGGGGAGACCAGCCAGCTCGGCCAATCGCACGCGCATTGCGACAAGGTGCAGGACCCGTACTCGCTGCGCTGCC
AGCCCCAGGTCATGGGCGCCTGCCTGACGCAGATCCGCAATGCGGCGGATGTGCTGGGCGTCGAAGCGAACTCGGTTTCC
GACAATCCGCTGGTATTCGCGCAGGAAGGCGATATCATCTCGGGCGGCAATTTCCACGCGGAACCGGTGGCAATGGCCGC
GGACAACCTCGCGCTGGCGCTGGCCGAGATCGGCTCGCTCTCCGAGCGGCGTGTGTCGCTGATGATGGACCAGCACCTGT
CGCAGTTGCCGCCGTTCCTGGTCGCCAATGGCGGCGTGAACTCCGGCTTCATGATCGCGCAGGTCACGGCCGCCGCGCTG
GCATCGGACAACAAAGCGCTTGCGCATCCGGCCAGTGTCGATAGCCTGCCTACCTCGGCGAACCAGGAAGACCATGTGTC
GATGGCGCCCAACGCTGGCAAGCGTCTCTGGGAGATGGCCAGCAACGTCAAGGGCATCGTGGCGATCGAATGGCTGGCGG
CCTGCCAGGGCATGGACTTCCGTGAAGGCGGCAAGACCACCGAAGCGCTGGAGCGCGCGCGCGGCCTGCTGCGTCAGTCG
GTGCCGTTCTACGACAAGGACCGGTACTTCGCGCCGGATATCGAAGACGCCAGCGTGCTGATCGCCGAGCGTCACCTGAC
GGCCCTGCTGCCTGCAGGCATCCTGCCGAGCGTCTGA

Upstream 100 bases:

>100_bases
CCACGCCGATGCCGGCTACGAGATCGCCATCGATTGCGCCCGCGAAAACGGCCTGAACCTGCCGATGCTCGGCACCTCCA
AGTAACTCCGGATTTGAACC

Downstream 100 bases:

>100_bases
CGGACGCTTGCGCCGGCGCCAAGCGGGCGAAGATCCGCGCGCCATGGGCCTTCGGTCCCAATCTAGACATCCTTCTGGAG
ACAGCTTGAAAAACCTGCAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSYQENQPVFALHLQPGELTLAQLRAVHQQPVKITLDERAFPAIDRSVACVENIIAEGRTAYGINTGFGLLAQTRIARED
LENLQRSLVLSHAAGVGEPIDDALVRLIMVLKINSLARGLSGIRRKVISALIALVNAEVYPCIPLKGSVGASGDLAPLAH
MSLLLLGEGRARHRGEWLSAREALAIADLQPLTLAAKEGLALLNGTQVSTAYALQGLFQAEDLYAAASVCGALTVEATLG
SRAPFDPRIHAARGQRGQIDAAAVYRHLLGETSQLGQSHAHCDKVQDPYSLRCQPQVMGACLTQIRNAADVLGVEANSVS
DNPLVFAQEGDIISGGNFHAEPVAMAADNLALALAEIGSLSERRVSLMMDQHLSQLPPFLVANGGVNSGFMIAQVTAAAL
ASDNKALAHPASVDSLPTSANQEDHVSMAPNAGKRLWEMASNVKGIVAIEWLAACQGMDFREGGKTTEALERARGLLRQS
VPFYDKDRYFAPDIEDASVLIAERHLTALLPAGILPSV

Sequences:

>Translated_518_residues
MSYQENQPVFALHLQPGELTLAQLRAVHQQPVKITLDERAFPAIDRSVACVENIIAEGRTAYGINTGFGLLAQTRIARED
LENLQRSLVLSHAAGVGEPIDDALVRLIMVLKINSLARGLSGIRRKVISALIALVNAEVYPCIPLKGSVGASGDLAPLAH
MSLLLLGEGRARHRGEWLSAREALAIADLQPLTLAAKEGLALLNGTQVSTAYALQGLFQAEDLYAAASVCGALTVEATLG
SRAPFDPRIHAARGQRGQIDAAAVYRHLLGETSQLGQSHAHCDKVQDPYSLRCQPQVMGACLTQIRNAADVLGVEANSVS
DNPLVFAQEGDIISGGNFHAEPVAMAADNLALALAEIGSLSERRVSLMMDQHLSQLPPFLVANGGVNSGFMIAQVTAAAL
ASDNKALAHPASVDSLPTSANQEDHVSMAPNAGKRLWEMASNVKGIVAIEWLAACQGMDFREGGKTTEALERARGLLRQS
VPFYDKDRYFAPDIEDASVLIAERHLTALLPAGILPSV
>Mature_517_residues
SYQENQPVFALHLQPGELTLAQLRAVHQQPVKITLDERAFPAIDRSVACVENIIAEGRTAYGINTGFGLLAQTRIAREDL
ENLQRSLVLSHAAGVGEPIDDALVRLIMVLKINSLARGLSGIRRKVISALIALVNAEVYPCIPLKGSVGASGDLAPLAHM
SLLLLGEGRARHRGEWLSAREALAIADLQPLTLAAKEGLALLNGTQVSTAYALQGLFQAEDLYAAASVCGALTVEATLGS
RAPFDPRIHAARGQRGQIDAAAVYRHLLGETSQLGQSHAHCDKVQDPYSLRCQPQVMGACLTQIRNAADVLGVEANSVSD
NPLVFAQEGDIISGGNFHAEPVAMAADNLALALAEIGSLSERRVSLMMDQHLSQLPPFLVANGGVNSGFMIAQVTAAALA
SDNKALAHPASVDSLPTSANQEDHVSMAPNAGKRLWEMASNVKGIVAIEWLAACQGMDFREGGKTTEALERARGLLRQSV
PFYDKDRYFAPDIEDASVLIAERHLTALLPAGILPSV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=504, Percent_Identity=44.2460317460317, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=473, Percent_Identity=43.5517970401691, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55114; Mature: 54983

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQENQPVFALHLQPGELTLAQLRAVHQQPVKITLDERAFPAIDRSVACVENIIAEGRT
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCE
AYGINTGFGLLAQTRIAREDLENLQRSLVLSHAAGVGEPIDDALVRLIMVLKINSLARGL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SGIRRKVISALIALVNAEVYPCIPLKGSVGASGDLAPLAHMSLLLLGEGRARHRGEWLSA
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHEECCCCCHHCCCHHHH
REALAIADLQPLTLAAKEGLALLNGTQVSTAYALQGLFQAEDLYAAASVCGALTVEATLG
HHHHHHCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC
SRAPFDPRIHAARGQRGQIDAAAVYRHLLGETSQLGQSHAHCDKVQDPYSLRCQPQVMGA
CCCCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHHCCHHHHHHHCCCCCCCCCCHHHHHH
CLTQIRNAADVLGVEANSVSDNPLVFAQEGDIISGGNFHAEPVAMAADNLALALAEIGSL
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHCCH
SERRVSLMMDQHLSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSA
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NQEDHVSMAPNAGKRLWEMASNVKGIVAIEWLAACQGMDFREGGKTTEALERARGLLRQS
CCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
VPFYDKDRYFAPDIEDASVLIAERHLTALLPAGILPSV
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SYQENQPVFALHLQPGELTLAQLRAVHQQPVKITLDERAFPAIDRSVACVENIIAEGRT
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCE
AYGINTGFGLLAQTRIAREDLENLQRSLVLSHAAGVGEPIDDALVRLIMVLKINSLARGL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SGIRRKVISALIALVNAEVYPCIPLKGSVGASGDLAPLAHMSLLLLGEGRARHRGEWLSA
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHEECCCCCHHCCCHHHH
REALAIADLQPLTLAAKEGLALLNGTQVSTAYALQGLFQAEDLYAAASVCGALTVEATLG
HHHHHHCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC
SRAPFDPRIHAARGQRGQIDAAAVYRHLLGETSQLGQSHAHCDKVQDPYSLRCQPQVMGA
CCCCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHHCCHHHHHHHCCCCCCCCCCHHHHHH
CLTQIRNAADVLGVEANSVSDNPLVFAQEGDIISGGNFHAEPVAMAADNLALALAEIGSL
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHCCH
SERRVSLMMDQHLSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSA
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NQEDHVSMAPNAGKRLWEMASNVKGIVAIEWLAACQGMDFREGGKTTEALERARGLLRQS
CCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
VPFYDKDRYFAPDIEDASVLIAERHLTALLPAGILPSV
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]