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The map label for this gene is yjcE [H]

Identifier: 94313907

GI number: 94313907

Start: 1659955

End: 1661262

Strand: Reverse

Name: yjcE [H]

Synonym: Rmet_4985

Alternate gene names: 94313907

Gene position: 1661262-1659955 (Counterclockwise)

Preceding gene: 94313913

Following gene: 94313905

Centisome position: 64.39

GC content: 64.91

Gene sequence:

>1308_bases
TTGGACGTTGCCATTGAACTGACTACGCGAGTCGGCGTGCTGCTGTTCTTCATCGCCATTTGCCATGTCATCGCACAACG
TGTGCGGTTGCCCGACCCGATCATCCTGACCGCCGCCGGCGTCACTATCGGCTTCGGCTATGTGGCGCTAGAGCATGTCG
CGCCCGCATTCGCAGCGAATACTATCGCGCCGTTCCTGTCGCCGGCCATGCCGCCCGAGGCCTATCTCTGGATCTTCCTG
CCGCCAATCCTGTTTCAGGCGGCAATCGAGGTCGATAGTTCAGGGTTCGTCGCCGACCTCGGCCCAATCCTGCTGCTGGC
CATCGGCGCCGTGGTCGCGGCAACGCTGAGCGTCGGCGCGGTGGCTTACCTGACCAGCGGGCAGGGACTGATCGCCTGCC
TCTTGCTCGGTGCGATCGTCAGCACCACCGATCCGTCCACGGTCATCGGCCTGTTCCAGAGCAGTGGCGCGCCGGCGCGG
CTGATTCGGCTGGTCGAAGGCGAGAGCCTGTTCAACGATGCCGCCGCGATTGCGATCACAACCTTGCTGACGGGCGTGAT
TTCGGTCATGCCGACACACGATGCCGCGCATTTTCCGCTGGCCCAGTTTCTTCTCTCGCTGCTTGGCGGTTGCGCGGTCG
GCTGGCTCGTGGGCGTGGTGTTGGTGTTCGTGTCGGGCGCGATGCGCAGCCCGCCGTTCGCCGAGTACTCGCTATCGCTC
GCGTTGCCTAACCTGATCTATCCGTTCGCGGAGCGCGTGCTGCATGTGTCGGGCGTGGCGGCGGTGGTGTGCGCGGGGCT
CGTGGTCGGGCGGATCATGCTTTCGCGGCGCCCTGCATCGCACGTCAAGCTGTTTCGCCAGTTGTGGCTCTATCAGGCCA
CTATTGCCAGCGCCAGCGTGTTGCTGCTGGCGACAGCACACGTGCCGTCGCTGCTCGACGACCTGCGCATGATCGACGTC
GTCATCCTGCTGCTCGTGCTGGTCGCGGCGGTGGCGAGCCGGTTCGGCATCTTGTCCGTGAGCATGCCGATGATGAGCCG
GATTGGCATCTGCAAACCGTTGCCGGTCTCGCACCAGTTGCTGATTGCCTGGGGTGGCGTGCGTGGTCCCGTGACGCTGA
CACTGGCCATCTGCCTGGCCCGGAATCAGGACCTGGCGCCAGACACCCGTCATTTCGCGGCGGCCATGGCAGCGGGCTTC
GTGCTGCTGAACCTGTTCTTCAACGGGCTGACGCTCAAGCTCTTCGCCCGTTGGCTCGGTGTGGCGGCGCCGGGTGGGCG
AAGGCCGGCCGCGATCGAAGTCGATTGA

Upstream 100 bases:

>100_bases
CCGTGCATCTAACCGGACTACTCAATGCTCGTCCCGCAATAGTGCAGGAAGAGCCGCCAGCGCCCTCAGCCAACTCCCCA
TCCGTATCAGGAGCCCAACC

Downstream 100 bases:

>100_bases
CCGCGGTCAGGCGGACGGCTTGCGCGCGGCCGACGGCAGGCGCTTGCGCCACGACCATCCCATCGTCATGCCCGCGGCGG
CCAGCAGGATCAGCGTGGCG

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MDVAIELTTRVGVLLFFIAICHVIAQRVRLPDPIILTAAGVTIGFGYVALEHVAPAFAANTIAPFLSPAMPPEAYLWIFL
PPILFQAAIEVDSSGFVADLGPILLLAIGAVVAATLSVGAVAYLTSGQGLIACLLLGAIVSTTDPSTVIGLFQSSGAPAR
LIRLVEGESLFNDAAAIAITTLLTGVISVMPTHDAAHFPLAQFLLSLLGGCAVGWLVGVVLVFVSGAMRSPPFAEYSLSL
ALPNLIYPFAERVLHVSGVAAVVCAGLVVGRIMLSRRPASHVKLFRQLWLYQATIASASVLLLATAHVPSLLDDLRMIDV
VILLLVLVAAVASRFGILSVSMPMMSRIGICKPLPVSHQLLIAWGGVRGPVTLTLAICLARNQDLAPDTRHFAAAMAAGF
VLLNLFFNGLTLKLFARWLGVAAPGGRRPAAIEVD

Sequences:

>Translated_435_residues
MDVAIELTTRVGVLLFFIAICHVIAQRVRLPDPIILTAAGVTIGFGYVALEHVAPAFAANTIAPFLSPAMPPEAYLWIFL
PPILFQAAIEVDSSGFVADLGPILLLAIGAVVAATLSVGAVAYLTSGQGLIACLLLGAIVSTTDPSTVIGLFQSSGAPAR
LIRLVEGESLFNDAAAIAITTLLTGVISVMPTHDAAHFPLAQFLLSLLGGCAVGWLVGVVLVFVSGAMRSPPFAEYSLSL
ALPNLIYPFAERVLHVSGVAAVVCAGLVVGRIMLSRRPASHVKLFRQLWLYQATIASASVLLLATAHVPSLLDDLRMIDV
VILLLVLVAAVASRFGILSVSMPMMSRIGICKPLPVSHQLLIAWGGVRGPVTLTLAICLARNQDLAPDTRHFAAAMAAGF
VLLNLFFNGLTLKLFARWLGVAAPGGRRPAAIEVD
>Mature_435_residues
MDVAIELTTRVGVLLFFIAICHVIAQRVRLPDPIILTAAGVTIGFGYVALEHVAPAFAANTIAPFLSPAMPPEAYLWIFL
PPILFQAAIEVDSSGFVADLGPILLLAIGAVVAATLSVGAVAYLTSGQGLIACLLLGAIVSTTDPSTVIGLFQSSGAPAR
LIRLVEGESLFNDAAAIAITTLLTGVISVMPTHDAAHFPLAQFLLSLLGGCAVGWLVGVVLVFVSGAMRSPPFAEYSLSL
ALPNLIYPFAERVLHVSGVAAVVCAGLVVGRIMLSRRPASHVKLFRQLWLYQATIASASVLLLATAHVPSLLDDLRMIDV
VILLLVLVAAVASRFGILSVSMPMMSRIGICKPLPVSHQLLIAWGGVRGPVTLTLAICLARNQDLAPDTRHFAAAMAAGF
VLLNLFFNGLTLKLFARWLGVAAPGGRRPAAIEVD

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI194239733, Length=392, Percent_Identity=23.9795918367347, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI15529998, Length=389, Percent_Identity=22.3650385604113, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI41872703, Length=284, Percent_Identity=25.3521126760563, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI294997330, Length=242, Percent_Identity=27.6859504132231, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI110227626, Length=239, Percent_Identity=28.0334728033473, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI5454070, Length=239, Percent_Identity=28.0334728033473, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI148727259, Length=425, Percent_Identity=21.8823529411765, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI27734935, Length=372, Percent_Identity=23.1182795698925, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI14211919, Length=167, Percent_Identity=32.3353293413174, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790501, Length=363, Percent_Identity=28.099173553719, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25147678, Length=435, Percent_Identity=22.7586206896552, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71993590, Length=341, Percent_Identity=23.4604105571848, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=341, Percent_Identity=23.4604105571848, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=317, Percent_Identity=22.7129337539432, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71992101, Length=317, Percent_Identity=22.7129337539432, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320663, Length=337, Percent_Identity=24.6290801186944, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510740, Length=385, Percent_Identity=22.8571428571429, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221510734, Length=384, Percent_Identity=22.9166666666667, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221510738, Length=384, Percent_Identity=22.9166666666667, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281364513, Length=378, Percent_Identity=23.015873015873, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221473222, Length=378, Percent_Identity=23.015873015873, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221473212, Length=246, Percent_Identity=27.6422764227642, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221473215, Length=246, Percent_Identity=27.6422764227642, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221510736, Length=394, Percent_Identity=22.3350253807107, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221510732, Length=394, Percent_Identity=22.0812182741117, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281360447, Length=291, Percent_Identity=25.085910652921, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585580, Length=394, Percent_Identity=22.0812182741117, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585578, Length=394, Percent_Identity=22.0812182741117, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 45625; Mature: 45625

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVAIELTTRVGVLLFFIAICHVIAQRVRLPDPIILTAAGVTIGFGYVALEHVAPAFAAN
CCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
TIAPFLSPAMPPEAYLWIFLPPILFQAAIEVDSSGFVADLGPILLLAIGAVVAATLSVGA
HHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAYLTSGQGLIACLLLGAIVSTTDPSTVIGLFQSSGAPARLIRLVEGESLFNDAAAIAIT
HEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHH
TLLTGVISVMPTHDAAHFPLAQFLLSLLGGCAVGWLVGVVLVFVSGAMRSPPFAEYSLSL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ALPNLIYPFAERVLHVSGVAAVVCAGLVVGRIMLSRRPASHVKLFRQLWLYQATIASASV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LLLATAHVPSLLDDLRMIDVVILLLVLVAAVASRFGILSVSMPMMSRIGICKPLPVSHQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEECHHHHHHCCCCCCCCCCCEE
LIAWGGVRGPVTLTLAICLARNQDLAPDTRHFAAAMAAGFVLLNLFFNGLTLKLFARWLG
EEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VAAPGGRRPAAIEVD
CCCCCCCCCCEEECC
>Mature Secondary Structure
MDVAIELTTRVGVLLFFIAICHVIAQRVRLPDPIILTAAGVTIGFGYVALEHVAPAFAAN
CCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
TIAPFLSPAMPPEAYLWIFLPPILFQAAIEVDSSGFVADLGPILLLAIGAVVAATLSVGA
HHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAYLTSGQGLIACLLLGAIVSTTDPSTVIGLFQSSGAPARLIRLVEGESLFNDAAAIAIT
HEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHH
TLLTGVISVMPTHDAAHFPLAQFLLSLLGGCAVGWLVGVVLVFVSGAMRSPPFAEYSLSL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ALPNLIYPFAERVLHVSGVAAVVCAGLVVGRIMLSRRPASHVKLFRQLWLYQATIASASV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LLLATAHVPSLLDDLRMIDVVILLLVLVAAVASRFGILSVSMPMMSRIGICKPLPVSHQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEECHHHHHHCCCCCCCCCCCEE
LIAWGGVRGPVTLTLAICLARNQDLAPDTRHFAAAMAAGFVLLNLFFNGLTLKLFARWLG
EEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VAAPGGRRPAAIEVD
CCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]