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The map label for this gene is aroP [H]

Identifier: 94313848

GI number: 94313848

Start: 1588165

End: 1589553

Strand: Direct

Name: aroP [H]

Synonym: Rmet_4926

Alternate gene names: 94313848

Gene position: 1588165-1589553 (Clockwise)

Preceding gene: 94313847

Following gene: 94313849

Centisome position: 61.55

GC content: 63.43

Gene sequence:

>1389_bases
ATGCACGCTCCCGACAATCAAGGCACGCTCAAGCGTGGCCTGAAGAATCGTCACATCCAGCTCATCGCGCTGGGCGGCGC
CATCGGCACCGGCCTGTTCCTGGGCATCGCCCAGACCATCAAGCTGGCCGGCCCCTCGGTGCTGCTGGGCTACGCGCTGG
CCGGCGTGGTCGCCTTCTTCATCATGCGCCAGCTCGGCGAAATGGTCGTGGACGAGCCCGTCGCCGGCTCGTTCAGCTAC
TTCGCCAACAAGTACTGCGGACACTTCGCCGGCTTCATGTCCGGCTGGAACTACTGGGTGCTCTACATCCTCGTCAGCAT
GGCCGAGCTATCGGCCGTCGGCATCTACGTCCAGTACTGGTGGCCCGGCATTCCGACCTGGATTTCCGCGCTGGCCTTCT
TCCTGATCATCAACGCGATCAACCTTGCCAGCGTGAAGTCGTTCGGCGAGATGGAATTCTGGTTCTCGATCATCAAGGTG
GCGGCCATCGTCGGCATGATCGGTTTCGGCGGCTACCTGCTGGCCACCGGCACCGCGGGCCCCGACGCCAGCATCGCCAA
CCTGTGGCAACACGGCGGCTTCTTCCCGAACGGCTTCAGCGGCCTGGTGATGGCCATGGCTGTGATCATGTTCTCGTTTG
GCGGCCTCGAACTCGTGGGCATCACCGCTGCGGAAGCAGACAGCCCCGAGAAGAGCATCCCGAAGGCGACCAACCAGGTC
ATCTACCGCATCCTGATCTTCTACGTCGGCGCGCTGGCCGTGCTGCTGTCGCTGTATCCGTGGGAAAAGGTCGTGACCGG
TGGCAGCCCGTTCGTGCTGATCTTCCACGCAATGAACAGCAACGTGGTAGCCACCGTGCTCAATATCGTGGTGCTGACCG
CCGCCCTGTCGGTCTACAACAGCGGCGTCTATTGCAACAGCCGCATGCTGCTGGGCCTGGCGCAGCAAGGCAACGCCCCG
CGCTCGCTGATGCGCGTGAACCGCCGCGGCATTCCGCTGACCGCGCTGGCCGTCTCGGCCATCGCCACCGGCATCTGCGT
GGTGATCAACTACTTCATGCCCGGCGAGGCCTTCGAACTGCTGATGGGCCTGGTGGTCTCGGCCCTGATCATCAACTGGG
CGATGATCAGCATCATCCACCTGATGTTCCGTCGCGCCAAGGCAGCCGCCGGCAAGACCACGCGCTTCCAGAGCCTGGGC
TACCCGCTGACCAACTACGTGACGCTGGCCTTCCTGGCAGGCATCCTCGTGGTGATGTTCCTGACGCCTGGCCTGCGCAT
CTCGGTCTACCTGATTCCGGTATGGCTTGGCGTACTTGGCGTAAGCTATCGCCTCCGGCAGAAAAAGGCCGGTTCGGCCA
TGCCCGCCGCCAGCGCCCAGATCCAGTAA

Upstream 100 bases:

>100_bases
TGCGCCCGGCGTCACCCACGCCGGCGCGCTTTATTGACAAGCGTCCGCCTCAAGAGAGACGCGCCCGACATTCCACAAGA
ATGGGTAGAGGAAACAACTC

Downstream 100 bases:

>100_bases
TTGCCGGTGCGGCCTCCGGGCCGCCGCCCTCCTGAACCAAACAGCCAGACGCATCCCATGTTCGAACATATAGAAGCCTT
TCCGGGTGACCCGATCCTCT

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MHAPDNQGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKLAGPSVLLGYALAGVVAFFIMRQLGEMVVDEPVAGSFSY
FANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYWWPGIPTWISALAFFLIINAINLASVKSFGEMEFWFSIIKV
AAIVGMIGFGGYLLATGTAGPDASIANLWQHGGFFPNGFSGLVMAMAVIMFSFGGLELVGITAAEADSPEKSIPKATNQV
IYRILIFYVGALAVLLSLYPWEKVVTGGSPFVLIFHAMNSNVVATVLNIVVLTAALSVYNSGVYCNSRMLLGLAQQGNAP
RSLMRVNRRGIPLTALAVSAIATGICVVINYFMPGEAFELLMGLVVSALIINWAMISIIHLMFRRAKAAAGKTTRFQSLG
YPLTNYVTLAFLAGILVVMFLTPGLRISVYLIPVWLGVLGVSYRLRQKKAGSAMPAASAQIQ

Sequences:

>Translated_462_residues
MHAPDNQGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKLAGPSVLLGYALAGVVAFFIMRQLGEMVVDEPVAGSFSY
FANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYWWPGIPTWISALAFFLIINAINLASVKSFGEMEFWFSIIKV
AAIVGMIGFGGYLLATGTAGPDASIANLWQHGGFFPNGFSGLVMAMAVIMFSFGGLELVGITAAEADSPEKSIPKATNQV
IYRILIFYVGALAVLLSLYPWEKVVTGGSPFVLIFHAMNSNVVATVLNIVVLTAALSVYNSGVYCNSRMLLGLAQQGNAP
RSLMRVNRRGIPLTALAVSAIATGICVVINYFMPGEAFELLMGLVVSALIINWAMISIIHLMFRRAKAAAGKTTRFQSLG
YPLTNYVTLAFLAGILVVMFLTPGLRISVYLIPVWLGVLGVSYRLRQKKAGSAMPAASAQIQ
>Mature_462_residues
MHAPDNQGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKLAGPSVLLGYALAGVVAFFIMRQLGEMVVDEPVAGSFSY
FANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYWWPGIPTWISALAFFLIINAINLASVKSFGEMEFWFSIIKV
AAIVGMIGFGGYLLATGTAGPDASIANLWQHGGFFPNGFSGLVMAMAVIMFSFGGLELVGITAAEADSPEKSIPKATNQV
IYRILIFYVGALAVLLSLYPWEKVVTGGSPFVLIFHAMNSNVVATVLNIVVLTAALSVYNSGVYCNSRMLLGLAQQGNAP
RSLMRVNRRGIPLTALAVSAIATGICVVINYFMPGEAFELLMGLVVSALIINWAMISIIHLMFRRAKAAAGKTTRFQSLG
YPLTNYVTLAFLAGILVVMFLTPGLRISVYLIPVWLGVLGVSYRLRQKKAGSAMPAASAQIQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=68.6666666666667, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=61.2975391498881, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1786602, Length=448, Percent_Identity=46.2053571428571, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=43.3874709976798, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI1790653, Length=458, Percent_Identity=40.3930131004367, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI87081915, Length=401, Percent_Identity=36.9077306733167, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1789017, Length=419, Percent_Identity=36.9928400954654, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI87081708, Length=468, Percent_Identity=32.4786324786325, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788480, Length=407, Percent_Identity=36.1179361179361, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI87082023, Length=371, Percent_Identity=23.989218328841, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081869, Length=187, Percent_Identity=26.7379679144385, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=373, Percent_Identity=24.1286863270777, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=33.3333333333333, Blast_Score=216, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6322892, Length=412, Percent_Identity=34.7087378640777, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324061, Length=411, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324924, Length=428, Percent_Identity=32.4766355140187, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=33.5012594458438, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=414, Percent_Identity=31.6425120772947, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=30.8823529411765, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319608, Length=451, Percent_Identity=28.8248337028825, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=29.3398533007335, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=419, Percent_Identity=29.5942720763723, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324059, Length=444, Percent_Identity=32.4324324324324, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=30.6372549019608, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=415, Percent_Identity=30.3614457831325, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=396, Percent_Identity=29.2929292929293, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=428, Percent_Identity=29.4392523364486, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=400, Percent_Identity=30.75, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=29.3233082706767, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6320364, Length=472, Percent_Identity=23.9406779661017, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24667468, Length=356, Percent_Identity=23.876404494382, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221512776, Length=366, Percent_Identity=20.2185792349727, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24666159, Length=366, Percent_Identity=20.2185792349727, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161077963, Length=408, Percent_Identity=24.2647058823529, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49656; Mature: 49656

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAPDNQGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKLAGPSVLLGYALAGVVAFF
CCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGIPTWISALAFFLIINAINLASVKSFGEMEFWFSIIKVAAIVGMIGFGGYLLATGTAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PDASIANLWQHGGFFPNGFSGLVMAMAVIMFSFGGLELVGITAAEADSPEKSIPKATNQV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYVGALAVLLSLYPWEKVVTGGSPFVLIFHAMNSNVVATVLNIVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLLGLAQQGNAPRSLMRVNRRGIPLTALAVSAIATGICVVINYFMPGEAFEL
CCCEECCHHHEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LMGLVVSALIINWAMISIIHLMFRRAKAAAGKTTRFQSLGYPLTNYVTLAFLAGILVVMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
LTPGLRISVYLIPVWLGVLGVSYRLRQKKAGSAMPAASAQIQ
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MHAPDNQGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKLAGPSVLLGYALAGVVAFF
CCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGIPTWISALAFFLIINAINLASVKSFGEMEFWFSIIKVAAIVGMIGFGGYLLATGTAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PDASIANLWQHGGFFPNGFSGLVMAMAVIMFSFGGLELVGITAAEADSPEKSIPKATNQV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYVGALAVLLSLYPWEKVVTGGSPFVLIFHAMNSNVVATVLNIVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLLGLAQQGNAPRSLMRVNRRGIPLTALAVSAIATGICVVINYFMPGEAFEL
CCCEECCHHHEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LMGLVVSALIINWAMISIIHLMFRRAKAAAGKTTRFQSLGYPLTNYVTLAFLAGILVVMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
LTPGLRISVYLIPVWLGVLGVSYRLRQKKAGSAMPAASAQIQ
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]