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The map label for this gene is tyrB [H]

Identifier: 94313849

GI number: 94313849

Start: 1589611

End: 1590807

Strand: Direct

Name: tyrB [H]

Synonym: Rmet_4927

Alternate gene names: 94313849

Gene position: 1589611-1590807 (Clockwise)

Preceding gene: 94313848

Following gene: 94313850

Centisome position: 61.61

GC content: 66.67

Gene sequence:

>1197_bases
ATGTTCGAACATATAGAAGCCTTTCCGGGTGACCCGATCCTCTCGCTCAACGAGGACTTCCAGCAGGACCCGCGTACCAA
CAAGGTCAATCTGAGCATCGGCATCTACTTCGACGACGAAGGCCGCCTGCCGGTGATGAAGGCCGTGGCGGAAGCCGAGG
CCGCGCTGCTGTCGGACATGGGTCCGCGCCCGTACCTGCCGATGTCCGGCATGGCCGCGTATCGTCAGGCCGTGCAGGCG
CTGGTGTTCGGCGAGGATTGCGCCGCCCGCGCCGAAGGCCGCGTCGCCACGCTGCAGACGCTGGGCGGCTCGGGCGCGCT
GCGCGTCGGCGCCGATTTCCTGAAGCGCTACTTCCCGAAGGCGGAGATGTGGATCAGCGATCCGAGCTGGGAGAATCACC
GCGTGGTCTTCGAGCGTGCCGGCTTCAAGGTCAACACTTACCCGTACTACGATCCGGCCACCGGCGGCCTGAAATTCGAC
GCGATGCTTGCCGCGATCGAAGCGATCCCGCAAGGCGACATCGTGCTGCTGCACGCGTGCTGCCACAACCCGACCGGCGT
CGACCTGAACCAGGACCAGTGGCGCCAGGTGATCGGCGTGCTCAAGGCGCGCAAGCTGCTGCCGTTCGTCGACATGGCCT
ACCAGGGTTTCGGCTCGGGCCTGGACGATGACGCCTTCGCCGTGCGCGAACTGGCCCGCCAGAATGTGCCCTGCCTGGTG
GCCAATTCGTTCTCGAAGAACTTCTCGCTGTACGGCGAGCGTTGCGGCGGCCTTTCGGTGGTCTGCCAAAGCGCCGACGA
AGCCAGCCGTGTGCTGGGCCAGCTTACCGGCGCCGTGCGCGCCAACTACAGCAACCCGCCGACCCACGGCGCGCGCGTGG
TGGCCCGTGTGCTGACCACGCCGGCGCTGCGCGCGAACTGGGAGCAGGAACTGGCCGCGATGTGCCAGCGCATCACCCGT
ATGCGCCAGGCCATCCACGACCACCTGCGCGAGCATGTGAGCGGCGAAAAGCTCTCGCGCTACATCACCCAGCGCGGCAT
GTTCACGTACACCGGTCTGTCGGCCGATCAGGTCGACCGCCTGAAGAACGAGCACGGCGTGTACGTGCTGCGCTCGGGCC
GCATGTGCGTGGCCGGTCTGAACGAGCGCAACGTGGGCGTCGTCGCCAACGCCATCGGGCAGGTGCTGAAGGCCTGA

Upstream 100 bases:

>100_bases
GGCCGGTTCGGCCATGCCCGCCGCCAGCGCCCAGATCCAGTAATTGCCGGTGCGGCCTCCGGGCCGCCGCCCTCCTGAAC
CAAACAGCCAGACGCATCCC

Downstream 100 bases:

>100_bases
AACGCCTGAAGCACGCCTTTGCAGTCACAAGGCCACCCTCGGGTGGCCTTGTTCTTTTCCCGTCCGGCGTTTTTGTCTTA
TGATGCCGCCCACCTCCATG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: TyrAT; Aromatic-amino-acid transaminase; Aspartate aminotransferase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MFEHIEAFPGDPILSLNEDFQQDPRTNKVNLSIGIYFDDEGRLPVMKAVAEAEAALLSDMGPRPYLPMSGMAAYRQAVQA
LVFGEDCAARAEGRVATLQTLGGSGALRVGADFLKRYFPKAEMWISDPSWENHRVVFERAGFKVNTYPYYDPATGGLKFD
AMLAAIEAIPQGDIVLLHACCHNPTGVDLNQDQWRQVIGVLKARKLLPFVDMAYQGFGSGLDDDAFAVRELARQNVPCLV
ANSFSKNFSLYGERCGGLSVVCQSADEASRVLGQLTGAVRANYSNPPTHGARVVARVLTTPALRANWEQELAAMCQRITR
MRQAIHDHLREHVSGEKLSRYITQRGMFTYTGLSADQVDRLKNEHGVYVLRSGRMCVAGLNERNVGVVANAIGQVLKA

Sequences:

>Translated_398_residues
MFEHIEAFPGDPILSLNEDFQQDPRTNKVNLSIGIYFDDEGRLPVMKAVAEAEAALLSDMGPRPYLPMSGMAAYRQAVQA
LVFGEDCAARAEGRVATLQTLGGSGALRVGADFLKRYFPKAEMWISDPSWENHRVVFERAGFKVNTYPYYDPATGGLKFD
AMLAAIEAIPQGDIVLLHACCHNPTGVDLNQDQWRQVIGVLKARKLLPFVDMAYQGFGSGLDDDAFAVRELARQNVPCLV
ANSFSKNFSLYGERCGGLSVVCQSADEASRVLGQLTGAVRANYSNPPTHGARVVARVLTTPALRANWEQELAAMCQRITR
MRQAIHDHLREHVSGEKLSRYITQRGMFTYTGLSADQVDRLKNEHGVYVLRSGRMCVAGLNERNVGVVANAIGQVLKA
>Mature_398_residues
MFEHIEAFPGDPILSLNEDFQQDPRTNKVNLSIGIYFDDEGRLPVMKAVAEAEAALLSDMGPRPYLPMSGMAAYRQAVQA
LVFGEDCAARAEGRVATLQTLGGSGALRVGADFLKRYFPKAEMWISDPSWENHRVVFERAGFKVNTYPYYDPATGGLKFD
AMLAAIEAIPQGDIVLLHACCHNPTGVDLNQDQWRQVIGVLKARKLLPFVDMAYQGFGSGLDDDAFAVRELARQNVPCLV
ANSFSKNFSLYGERCGGLSVVCQSADEASRVLGQLTGAVRANYSNPPTHGARVVARVLTTPALRANWEQELAAMCQRITR
MRQAIHDHLREHVSGEKLSRYITQRGMFTYTGLSADQVDRLKNEHGVYVLRSGRMCVAGLNERNVGVVANAIGQVLKA

Specific function: catalyzes the formation of methionine from 2-keto-4- methylthiobutyrate (KMTB) primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) or glutamate as the amino donors. Histidine, leucine, asparagine, or arginine are also functional

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=398, Percent_Identity=43.21608040201, Blast_Score=350, Evalue=9e-97,
Organism=Homo sapiens, GI4504067, Length=392, Percent_Identity=40.8163265306122, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI117414139, Length=383, Percent_Identity=28.9817232375979, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=56.4231738035265, Blast_Score=473, Evalue=1e-135,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=44.9494949494949, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=41.5617128463476, Blast_Score=349, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI25147133, Length=397, Percent_Identity=41.3098236775819, Blast_Score=334, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17569539, Length=401, Percent_Identity=40.1496259351621, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17569537, Length=387, Percent_Identity=31.7829457364341, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17550384, Length=270, Percent_Identity=36.2962962962963, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI25147136, Length=220, Percent_Identity=37.2727272727273, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323055, Length=406, Percent_Identity=38.423645320197, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6322743, Length=426, Percent_Identity=34.037558685446, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=39.9497487437186, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=39.9497487437186, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=40.4092071611253, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=41.0852713178295, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=41.0852713178295, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.5; =2.6.1.57; =2.6.1.1 [H]

Molecular weight: Translated: 43770; Mature: 43770

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHIEAFPGDPILSLNEDFQQDPRTNKVNLSIGIYFDDEGRLPVMKAVAEAEAALLSDM
CCCCCCCCCCCCEECCCCHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GPRPYLPMSGMAAYRQAVQALVFGEDCAARAEGRVATLQTLGGSGALRVGADFLKRYFPK
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
AEMWISDPSWENHRVVFERAGFKVNTYPYYDPATGGLKFDAMLAAIEAIPQGDIVLLHAC
CCEEECCCCCCCCEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEC
CHNPTGVDLNQDQWRQVIGVLKARKLLPFVDMAYQGFGSGLDDDAFAVRELARQNVPCLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEE
ANSFSKNFSLYGERCGGLSVVCQSADEASRVLGQLTGAVRANYSNPPTHGARVVARVLTT
ECCCCCCCHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
PALRANWEQELAAMCQRITRMRQAIHDHLREHVSGEKLSRYITQRGMFTYTGLSADQVDR
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEECCCHHHHHH
LKNEHGVYVLRSGRMCVAGLNERNVGVVANAIGQVLKA
HHCCCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFEHIEAFPGDPILSLNEDFQQDPRTNKVNLSIGIYFDDEGRLPVMKAVAEAEAALLSDM
CCCCCCCCCCCCEECCCCHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GPRPYLPMSGMAAYRQAVQALVFGEDCAARAEGRVATLQTLGGSGALRVGADFLKRYFPK
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
AEMWISDPSWENHRVVFERAGFKVNTYPYYDPATGGLKFDAMLAAIEAIPQGDIVLLHAC
CCEEECCCCCCCCEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEC
CHNPTGVDLNQDQWRQVIGVLKARKLLPFVDMAYQGFGSGLDDDAFAVRELARQNVPCLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEE
ANSFSKNFSLYGERCGGLSVVCQSADEASRVLGQLTGAVRANYSNPPTHGARVVARVLTT
ECCCCCCCHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
PALRANWEQELAAMCQRITRMRQAIHDHLREHVSGEKLSRYITQRGMFTYTGLSADQVDR
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEECCCHHHHHH
LKNEHGVYVLRSGRMCVAGLNERNVGVVANAIGQVLKA
HHCCCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10074065 [H]