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The map label for this gene is acdA [H]

Identifier: 94313497

GI number: 94313497

Start: 1189924

End: 1191063

Strand: Direct

Name: acdA [H]

Synonym: Rmet_4575

Alternate gene names: 94313497

Gene position: 1189924-1191063 (Clockwise)

Preceding gene: 94313496

Following gene: 94313498

Centisome position: 46.12

GC content: 67.63

Gene sequence:

>1140_bases
ATGCCCATCGTATTCGACGACACGCAGGAAATGCTGCGCGACAGCGCCCTCGCCTTCCTGAAGGACAACGCCCCGATTTC
CGCGCTGCGCACGCTGCGCGACACGCATGACCCCGTCGGATTCTCCCGGGATCTCTGGCGCCAGGCCGCCGAATTGGGAT
TCACCGGCGTGCTGATCGACGAAGCCTATGGCGGCAGTGGCCTCGGCGTGGTCGAGGCCGGCATCATCGCCGAAGCTATC
GGGGCCACGCTTGCGCCGTTGCCGTTCCTTTCCACCTCGGTGCTTGGCGCCTCACTGCTGGGGCTGTTCGGCAGCGACAC
GCAGCGAAGCGCGCTGCTGCCGGAGATGGCATCGGGCCGCCACCTGACGGCGCTCGCGCTGGACGAGGGGAGCAAACACC
GGCCAGAGCGCATCACCCTGCTGGCGCGACGCCATGGCGACGGGTACATGCTCGACGGCAGCAAGGTGTTCGTCGTCGAC
GGCCATGTGGCCGACACGTTGATCGTCGCAGCGAAAGACGCGCAGGCGGGGCCCGATGGCGACATCTCGCTGTTCCTCGT
GCCGCGCGACAACGCCGGCGTCCGCGTCGAACGCTGCGTGATCGCCGATGCCACCAATGCGGCACGCGTCACCTTCGAGG
GCGTCCGAGTTCCGGCCTATGCGCTGCTGGGCCGCGCCGGCAACGGCGCCGCGATGCTCGACAAGGTACTCGACATCGCC
CGCGCGGTGCTGTCGTCCGAACTGGTCGGTATTGCAGATGCCACGTTCGCGCGCACGCTCGCCTACCTGAAGGAGCGCAG
CCAGTTCGGCAAGCAGATCGGCGAGTTCCAGGCCCTGCAGCATCGTGCCGCACATCTGTTCGCGGAGATCGAACTCGCGC
GTGCCGCGGTGCTGCAGTGCCAGCAGCGGCTGGACGCTGGCCGTTCGGATGGGCCGGAGCCGCTAGTTTGCGTCGCCAAG
GCCAAGGCCGGCACCACCGCCACCCTGGCAGTGCAGGAGGGCGTGCAGATGCACGGCGGTATCGGCATGACCGACGAACT
GGACATCGGGTTCTACATGAAGCGCGCACGCACAGCCCAGGAGTGGTTGGGCGACGCCAACTGGCAGCTCAACCGCTGGG
CAGGAATGCGCGGCTACTGA

Upstream 100 bases:

>100_bases
GCCTCCCGGGCGCCTGACGTACCGGCTCGCCCGTACCGCCACGCCTACCGCAGCCCAAAGACATCGAAGCCCTCGAAGCC
CAAGGACCGTCAAAGCCGCC

Downstream 100 bases:

>100_bases
TCTGGCCAGCCCTCCCGCCACGACGCTGGCGGGGCACGACGCAACACCGAGGCGAAAGCGATCGCGCGGATGTCGGCATA
CGCCCATGCCGGCCGATCGC

Product: acyl-CoA dehydrogenase-like protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MPIVFDDTQEMLRDSALAFLKDNAPISALRTLRDTHDPVGFSRDLWRQAAELGFTGVLIDEAYGGSGLGVVEAGIIAEAI
GATLAPLPFLSTSVLGASLLGLFGSDTQRSALLPEMASGRHLTALALDEGSKHRPERITLLARRHGDGYMLDGSKVFVVD
GHVADTLIVAAKDAQAGPDGDISLFLVPRDNAGVRVERCVIADATNAARVTFEGVRVPAYALLGRAGNGAAMLDKVLDIA
RAVLSSELVGIADATFARTLAYLKERSQFGKQIGEFQALQHRAAHLFAEIELARAAVLQCQQRLDAGRSDGPEPLVCVAK
AKAGTTATLAVQEGVQMHGGIGMTDELDIGFYMKRARTAQEWLGDANWQLNRWAGMRGY

Sequences:

>Translated_379_residues
MPIVFDDTQEMLRDSALAFLKDNAPISALRTLRDTHDPVGFSRDLWRQAAELGFTGVLIDEAYGGSGLGVVEAGIIAEAI
GATLAPLPFLSTSVLGASLLGLFGSDTQRSALLPEMASGRHLTALALDEGSKHRPERITLLARRHGDGYMLDGSKVFVVD
GHVADTLIVAAKDAQAGPDGDISLFLVPRDNAGVRVERCVIADATNAARVTFEGVRVPAYALLGRAGNGAAMLDKVLDIA
RAVLSSELVGIADATFARTLAYLKERSQFGKQIGEFQALQHRAAHLFAEIELARAAVLQCQQRLDAGRSDGPEPLVCVAK
AKAGTTATLAVQEGVQMHGGIGMTDELDIGFYMKRARTAQEWLGDANWQLNRWAGMRGY
>Mature_378_residues
PIVFDDTQEMLRDSALAFLKDNAPISALRTLRDTHDPVGFSRDLWRQAAELGFTGVLIDEAYGGSGLGVVEAGIIAEAIG
ATLAPLPFLSTSVLGASLLGLFGSDTQRSALLPEMASGRHLTALALDEGSKHRPERITLLARRHGDGYMLDGSKVFVVDG
HVADTLIVAAKDAQAGPDGDISLFLVPRDNAGVRVERCVIADATNAARVTFEGVRVPAYALLGRAGNGAAMLDKVLDIAR
AVLSSELVGIADATFARTLAYLKERSQFGKQIGEFQALQHRAAHLFAEIELARAAVLQCQQRLDAGRSDGPEPLVCVAKA
KAGTTATLAVQEGVQMHGGIGMTDELDIGFYMKRARTAQEWLGDANWQLNRWAGMRGY

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=27.4406332453826, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI226958412, Length=367, Percent_Identity=28.6103542234332, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI4501857, Length=353, Percent_Identity=29.7450424929178, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI226958414, Length=329, Percent_Identity=29.483282674772, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI7656849, Length=325, Percent_Identity=28.6153846153846, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=27.3936170212766, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=27.3936170212766, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI76496475, Length=361, Percent_Identity=26.3157894736842, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI4557235, Length=361, Percent_Identity=26.3157894736842, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI21361497, Length=314, Percent_Identity=29.2993630573248, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4557233, Length=328, Percent_Identity=26.8292682926829, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=25.207756232687, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4503943, Length=361, Percent_Identity=25.207756232687, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI48976061, Length=339, Percent_Identity=23.0088495575221, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI211971008, Length=339, Percent_Identity=23.0088495575221, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786223, Length=317, Percent_Identity=25.2365930599369, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081958, Length=365, Percent_Identity=24.6575342465753, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=355, Percent_Identity=28.169014084507, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17506239, Length=337, Percent_Identity=28.486646884273, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=26.7716535433071, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17538396, Length=323, Percent_Identity=26.625386996904, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=27.7044854881267, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71985184, Length=316, Percent_Identity=27.2151898734177, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533517, Length=329, Percent_Identity=27.355623100304, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71990804, Length=256, Percent_Identity=28.90625, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71985192, Length=277, Percent_Identity=27.4368231046931, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71982178, Length=265, Percent_Identity=29.0566037735849, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17570075, Length=340, Percent_Identity=26.4705882352941, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=26.2008733624454, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17505929, Length=356, Percent_Identity=26.123595505618, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17551932, Length=358, Percent_Identity=25.6983240223464, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534353, Length=325, Percent_Identity=24.6153846153846, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=29.7650130548303, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24666513, Length=383, Percent_Identity=27.6762402088773, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=26.3440860215054, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=25.8666666666667, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281363737, Length=319, Percent_Identity=26.0188087774295, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24660351, Length=332, Percent_Identity=28.0120481927711, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920834, Length=322, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40465; Mature: 40333

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVFDDTQEMLRDSALAFLKDNAPISALRTLRDTHDPVGFSRDLWRQAAELGFTGVLID
CCEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEE
EAYGGSGLGVVEAGIIAEAIGATLAPLPFLSTSVLGASLLGLFGSDTQRSALLPEMASGR
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCHHCCCC
HLTALALDEGSKHRPERITLLARRHGDGYMLDGSKVFVVDGHVADTLIVAAKDAQAGPDG
EEEEEEECCCCCCCCCEEEEEEEECCCCEEECCCEEEEEECCCCCEEEEEECCCCCCCCC
DISLFLVPRDNAGVRVERCVIADATNAARVTFEGVRVPAYALLGRAGNGAAMLDKVLDIA
CEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHH
RAVLSSELVGIADATFARTLAYLKERSQFGKQIGEFQALQHRAAHLFAEIELARAAVLQC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQRLDAGRSDGPEPLVCVAKAKAGTTATLAVQEGVQMHGGIGMTDELDIGFYMKRARTAQ
HHHHCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHH
EWLGDANWQLNRWAGMRGY
HHCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
PIVFDDTQEMLRDSALAFLKDNAPISALRTLRDTHDPVGFSRDLWRQAAELGFTGVLID
CEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEE
EAYGGSGLGVVEAGIIAEAIGATLAPLPFLSTSVLGASLLGLFGSDTQRSALLPEMASGR
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCHHCCCC
HLTALALDEGSKHRPERITLLARRHGDGYMLDGSKVFVVDGHVADTLIVAAKDAQAGPDG
EEEEEEECCCCCCCCCEEEEEEEECCCCEEECCCEEEEEECCCCCEEEEEECCCCCCCCC
DISLFLVPRDNAGVRVERCVIADATNAARVTFEGVRVPAYALLGRAGNGAAMLDKVLDIA
CEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHH
RAVLSSELVGIADATFARTLAYLKERSQFGKQIGEFQALQHRAAHLFAEIELARAAVLQC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQRLDAGRSDGPEPLVCVAKAKAGTTATLAVQEGVQMHGGIGMTDELDIGFYMKRARTAQ
HHHHCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHH
EWLGDANWQLNRWAGMRGY
HHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]