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The map label for this gene is serA2 [H]

Identifier: 94313462

GI number: 94313462

Start: 1144358

End: 1145656

Strand: Direct

Name: serA2 [H]

Synonym: Rmet_4537

Alternate gene names: 94313462

Gene position: 1144358-1145656 (Clockwise)

Preceding gene: 94313448

Following gene: 94313464

Centisome position: 44.35

GC content: 66.05

Gene sequence:

>1299_bases
GTGGTAAGGTGTGCCCATGCGCGTCCCGCATATCGCATATTGCATAGGGACGCCCCGTGCCTTTCCAACTCTCCTGCATT
CAGCCCGACCATCATGGCCAGCGCCCTGCTTCTCGAGAACATCCACGCCAGCGCCCAGCAGTTGCTGGGCCGCCACCAGA
TCGACCTCGCCACCCAGGGCAAGGCCCTGGCCGGCGACGCGCTGCTTGCCGCCGTGCGCGATCACGAACTGCTGGGCATT
CGCTCGGCTACCACCCTGACAGCCGAAGCGTTCGCCAAGGCGCAGCGGCTGCTCACGGTCGGCTGCTTCTGCATCGGCAC
GTCCCAAGTGGACCTGGGCGCGGCTGCCCATGCCGGCATCCCGGTTTTCAATGCGCCGTTTTCGAACACACGTTCCGTGG
CCGAGCTGGTCATCGGCCAGGCCATCATGCTGATGCGGCGCATCCCGGAAAAGAGCCGCGCCGCCCACAGCGGCCAATGG
CAGAAAACCGCCAAGGGCGCCTTCGAGATCCGGGGCAAGACCATGGCGGTGATCGGCTATGGGAACATCGGCGCGCAGGT
CGGCATCCTGGCCGAGGCGATGGGGATGCGCGTGGTGTTCTACGACATCCGCCCCCGCCTGTCGATCGGAGGCGCCATGC
CGGTGCACTCGCTCGAAGATGCCCTGTCGCAGGCCGACGTGGTGACGCTGCACGTCCCCGCCACGCCGCAGACACGCAAC
CTGATGGATGCCAAGGCACTGGCTGCCATGCGACATGGCAGCATCCTGATCAATGCCTCGCGCGGCACCGTGGTGGATAT
CCCGGCGCTGGCGCAATTGCTGGACAACGGGCAACTGGCCGGCGCGGCCATCGACGTGTTCCCGGAAGAGCCGCGCAGTA
ACGCCGATCCGTTCGTCTCGCCGCTGCAGGGCAAGCCGAATGTCATCCTGACGCCCCATGTCGGCGGCAGCACCGAGGAA
GCGCAGGAGAACATCGGCGTGGAAGTAGCGACCAAGCTGGTCAACTTTCTCGAAACCGGCGCGACCCTGGGCGCGGTGAA
CCTGCCCCAGATTCAGCCAGCGCCGCAACAGGCTCCAGCCCGCGTGCTCAACATCCACTACAACCGGCCGGGCACGCTGT
CGCACTTCAACCAGGCGCTGGCCGAGATCGGCGCGAATATCGTCGCCCAGCAACTGCAGACCGAGGGCGATATTGGCTAC
GCGATTACCGACATCAGCCTGGTGCCGCCTGCCGGCTGGGCGGAGGCGCTGATGAAGGATGACGCCTTCATTCGCACCCG
GGTGATCGTGGCGCCCTGA

Upstream 100 bases:

>100_bases
GAGTTGAATGTTTTCGCTGTCCCGACTCCTCCGGGGGCCCTGAGTCCTGGCGGAATCGCTTTGATCCCCTTGCCCACGTC
AACAGCACGGGTAAGCGTCG

Downstream 100 bases:

>100_bases
CCGGCGGCTCCATCGCCGCGCTGGTCATCGCGCCTTGCCCGATTTCCGGTGCTCACAGGGCCCGGCCCCGAAATGCGGGC
CGGGCCCTTCTTCCGCCAGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MVRCAHARPAYRILHRDAPCLSNSPAFSPTIMASALLLENIHASAQQLLGRHQIDLATQGKALAGDALLAAVRDHELLGI
RSATTLTAEAFAKAQRLLTVGCFCIGTSQVDLGAAAHAGIPVFNAPFSNTRSVAELVIGQAIMLMRRIPEKSRAAHSGQW
QKTAKGAFEIRGKTMAVIGYGNIGAQVGILAEAMGMRVVFYDIRPRLSIGGAMPVHSLEDALSQADVVTLHVPATPQTRN
LMDAKALAAMRHGSILINASRGTVVDIPALAQLLDNGQLAGAAIDVFPEEPRSNADPFVSPLQGKPNVILTPHVGGSTEE
AQENIGVEVATKLVNFLETGATLGAVNLPQIQPAPQQAPARVLNIHYNRPGTLSHFNQALAEIGANIVAQQLQTEGDIGY
AITDISLVPPAGWAEALMKDDAFIRTRVIVAP

Sequences:

>Translated_432_residues
MVRCAHARPAYRILHRDAPCLSNSPAFSPTIMASALLLENIHASAQQLLGRHQIDLATQGKALAGDALLAAVRDHELLGI
RSATTLTAEAFAKAQRLLTVGCFCIGTSQVDLGAAAHAGIPVFNAPFSNTRSVAELVIGQAIMLMRRIPEKSRAAHSGQW
QKTAKGAFEIRGKTMAVIGYGNIGAQVGILAEAMGMRVVFYDIRPRLSIGGAMPVHSLEDALSQADVVTLHVPATPQTRN
LMDAKALAAMRHGSILINASRGTVVDIPALAQLLDNGQLAGAAIDVFPEEPRSNADPFVSPLQGKPNVILTPHVGGSTEE
AQENIGVEVATKLVNFLETGATLGAVNLPQIQPAPQQAPARVLNIHYNRPGTLSHFNQALAEIGANIVAQQLQTEGDIGY
AITDISLVPPAGWAEALMKDDAFIRTRVIVAP
>Mature_432_residues
MVRCAHARPAYRILHRDAPCLSNSPAFSPTIMASALLLENIHASAQQLLGRHQIDLATQGKALAGDALLAAVRDHELLGI
RSATTLTAEAFAKAQRLLTVGCFCIGTSQVDLGAAAHAGIPVFNAPFSNTRSVAELVIGQAIMLMRRIPEKSRAAHSGQW
QKTAKGAFEIRGKTMAVIGYGNIGAQVGILAEAMGMRVVFYDIRPRLSIGGAMPVHSLEDALSQADVVTLHVPATPQTRN
LMDAKALAAMRHGSILINASRGTVVDIPALAQLLDNGQLAGAAIDVFPEEPRSNADPFVSPLQGKPNVILTPHVGGSTEE
AQENIGVEVATKLVNFLETGATLGAVNLPQIQPAPQQAPARVLNIHYNRPGTLSHFNQALAEIGANIVAQQLQTEGDIGY
AITDISLVPPAGWAEALMKDDAFIRTRVIVAP

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=287, Percent_Identity=36.9337979094077, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI145580578, Length=261, Percent_Identity=36.0153256704981, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557499, Length=261, Percent_Identity=36.0153256704981, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580575, Length=261, Percent_Identity=36.0153256704981, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=34.4827586206897, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=34.4827586206897, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI6912396, Length=244, Percent_Identity=25.8196721311475, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789279, Length=371, Percent_Identity=53.9083557951482, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=31.0756972111554, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87082289, Length=281, Percent_Identity=27.0462633451957, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788660, Length=292, Percent_Identity=28.7671232876712, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87081824, Length=209, Percent_Identity=28.7081339712919, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=319, Percent_Identity=33.8557993730408, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25147481, Length=261, Percent_Identity=28.735632183908, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=385, Percent_Identity=46.2337662337662, Blast_Score=353, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6320925, Length=385, Percent_Identity=45.1948051948052, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6324964, Length=254, Percent_Identity=27.5590551181102, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=261, Percent_Identity=24.5210727969349, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=192, Percent_Identity=25.5208333333333, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=166, Percent_Identity=30.1204819277108, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=154, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=309, Percent_Identity=33.6569579288026, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=32.4528301886792, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=32.4528301886792, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=32.4528301886792, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=32.4528301886792, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=32.4528301886792, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585516, Length=268, Percent_Identity=27.2388059701493, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574286, Length=246, Percent_Identity=28.4552845528455, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551003, Length=248, Percent_Identity=24.5967741935484, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24585514, Length=248, Percent_Identity=24.5967741935484, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28574282, Length=248, Percent_Identity=24.5967741935484, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45552429, Length=248, Percent_Identity=24.5967741935484, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28574284, Length=248, Percent_Identity=24.5967741935484, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571528, Length=236, Percent_Identity=25.4237288135593, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 45666; Mature: 45666

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRCAHARPAYRILHRDAPCLSNSPAFSPTIMASALLLENIHASAQQLLGRHQIDLATQG
CCEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
KALAGDALLAAVRDHELLGIRSATTLTAEAFAKAQRLLTVGCFCIGTSQVDLGAAAHAGI
CCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCCC
PVFNAPFSNTRSVAELVIGQAIMLMRRIPEKSRAAHSGQWQKTAKGAFEIRGKTMAVIGY
CEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHCCEEEECCCEEEEEEE
GNIGAQVGILAEAMGMRVVFYDIRPRLSIGGAMPVHSLEDALSQADVVTLHVPATPQTRN
CCCCCHHHHHHHHHCCEEEEEECCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCC
LMDAKALAAMRHGSILINASRGTVVDIPALAQLLDNGQLAGAAIDVFPEEPRSNADPFVS
HHHHHHHHHHHCCCEEEECCCCCEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
PLQGKPNVILTPHVGGSTEEAQENIGVEVATKLVNFLETGATLGAVNLPQIQPAPQQAPA
CCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
RVLNIHYNRPGTLSHFNQALAEIGANIVAQQLQTEGDIGYAITDISLVPPAGWAEALMKD
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCC
DAFIRTRVIVAP
CCEEEEEEEECC
>Mature Secondary Structure
MVRCAHARPAYRILHRDAPCLSNSPAFSPTIMASALLLENIHASAQQLLGRHQIDLATQG
CCEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
KALAGDALLAAVRDHELLGIRSATTLTAEAFAKAQRLLTVGCFCIGTSQVDLGAAAHAGI
CCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCCC
PVFNAPFSNTRSVAELVIGQAIMLMRRIPEKSRAAHSGQWQKTAKGAFEIRGKTMAVIGY
CEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHCCEEEECCCEEEEEEE
GNIGAQVGILAEAMGMRVVFYDIRPRLSIGGAMPVHSLEDALSQADVVTLHVPATPQTRN
CCCCCHHHHHHHHHCCEEEEEECCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCC
LMDAKALAAMRHGSILINASRGTVVDIPALAQLLDNGQLAGAAIDVFPEEPRSNADPFVS
HHHHHHHHHHHCCCEEEECCCCCEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
PLQGKPNVILTPHVGGSTEEAQENIGVEVATKLVNFLETGATLGAVNLPQIQPAPQQAPA
CCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
RVLNIHYNRPGTLSHFNQALAEIGANIVAQQLQTEGDIGYAITDISLVPPAGWAEALMKD
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCC
DAFIRTRVIVAP
CCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]