BacMap

Definition	Cupriavidus metallidurans CH34 megaplasmid, complete sequence.
Accession	NC_007974
Length	2,580,084

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The map label for this gene is fabG [H]

Identifier: 94313316

GI number: 94313316

Start: 988389

End: 989120

Strand: Direct

Name: fabG [H]

Synonym: Rmet_4391

Alternate gene names: 94313316

Gene position: 988389-989120 (Clockwise)

Preceding gene: 94313315

Following gene: 94313317

Centisome position: 38.31

GC content: 65.57

Gene sequence:

>732_bases
ATGACAACCCAGACCGTGCTCGTCACGGGATCATCGCGCGGCATCGGCCGCGCCATTGCGCTGCGTCTTGCGCGCGATGG
CTATGACGTGGTGATCCACTGCCGCGCGCGTCGCAACGAAGCCGAATCGGTGGCCGACGCCGTGCGCGCGTTCGGCCGAA
ATGCGCGCGTGCTGTGTTTCGATGTCGGGCAACGCGAGGCCGCGGCCAGCGCATTGCTGGCCGATATCGACCATCACGGC
TGCTACTACGGAGTGGTCTGCAACGCCGGGCTGGCCCGCGATGCAGCGTTTCCGGCCATGAGCGGCGAGGAGTGGGACGA
GGTGATTCACACCAACCTCGATGCGTTCTTCAACGTGCTCAATCCCGTGGTGCTGCCAATGGTGCAGCGGCGTCGGCCGG
GCCGGATCGTCACGCTGTCGTCGGCGTCCGGGATCGTGGGCAATCGCGGGCAGACCAACTACAGCGCTGCCAAGGCTGGG
GTGATCGGCGCCACCAAGGCACTGGCGATCGAACTGGCCAAACGCCAGATCACGGTCAACTGCGTGGCGCCGGGGCTGAT
CGACACGGAAATGATCGAGGAACACGTGCGCGAGGAAGCCATGAAGATGATTCCCGCCCGCCGCATGGGCACCCCGGACG
AGGTGGCGGCCACGGTGGCGTTCCTGCTTTCGCCCGATGCCGGGTACATTACGCGCCAGGTGATTTCGGTGAACGGAGGC
ATGTTCGGATGA

Upstream 100 bases:

>100_bases
TCGCCTGCACGCTGGACATGGGCGGCCAGGAGGTGGCTCGGGCAACGGTTTCGGTATATCGGCCTGCGGACGCGCAGGCC
TTCCTCGAGGGGCAGCAGAC

Downstream 100 bases:

>100_bases
AGCGGGTGGTGGTCACGGGAGCGGGCGCGGTCAGCGCGATCGGCAACGACTGGGCGACGGTGCGCGAGCGCCTGGCCGCC
GGTCGCAATGCGATAGTGGT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTTQTVLVTGSSRGIGRAIALRLARDGYDVVIHCRARRNEAESVADAVRAFGRNARVLCFDVGQREAAASALLADIDHHG
CYYGVVCNAGLARDAAFPAMSGEEWDEVIHTNLDAFFNVLNPVVLPMVQRRRPGRIVTLSSASGIVGNRGQTNYSAAKAG
VIGATKALAIELAKRQITVNCVAPGLIDTEMIEEHVREEAMKMIPARRMGTPDEVAATVAFLLSPDAGYITRQVISVNGG
MFG

Sequences:

>Translated_243_residues
MTTQTVLVTGSSRGIGRAIALRLARDGYDVVIHCRARRNEAESVADAVRAFGRNARVLCFDVGQREAAASALLADIDHHG
CYYGVVCNAGLARDAAFPAMSGEEWDEVIHTNLDAFFNVLNPVVLPMVQRRRPGRIVTLSSASGIVGNRGQTNYSAAKAG
VIGATKALAIELAKRQITVNCVAPGLIDTEMIEEHVREEAMKMIPARRMGTPDEVAATVAFLLSPDAGYITRQVISVNGG
MFG
>Mature_242_residues
TTQTVLVTGSSRGIGRAIALRLARDGYDVVIHCRARRNEAESVADAVRAFGRNARVLCFDVGQREAAASALLADIDHHGC
YYGVVCNAGLARDAAFPAMSGEEWDEVIHTNLDAFFNVLNPVVLPMVQRRRPGRIVTLSSASGIVGNRGQTNYSAAKAGV
IGATKALAIELAKRQITVNCVAPGLIDTEMIEEHVREEAMKMIPARRMGTPDEVAATVAFLLSPDAGYITRQVISVNGGM
FG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=38.7351778656126, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=35.4838709677419, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI40254992, Length=235, Percent_Identity=35.7446808510638, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=32.2448979591837, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI126723750, Length=249, Percent_Identity=31.7269076305221, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=32.5396825396825, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4504505, Length=251, Percent_Identity=34.6613545816733, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=32.2916666666667, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=31.3513513513514, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI7657478, Length=211, Percent_Identity=32.2274881516588, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI66933014, Length=148, Percent_Identity=29.0540540540541, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=28.8537549407115, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=31.4432989690722, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7706318, Length=212, Percent_Identity=29.7169811320755, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI109715829, Length=231, Percent_Identity=28.1385281385281, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=42.5619834710744, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=34.5238095238095, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=33.8842975206612, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=32.258064516129, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI2367175, Length=243, Percent_Identity=35.3909465020576, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=29.3877551020408, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=26.0330578512397, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=31.2, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=29.2887029288703, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=28.1632653061224, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1789378, Length=245, Percent_Identity=28.9795918367347, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=27.2373540856031, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786701, Length=193, Percent_Identity=29.0155440414508, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787526, Length=225, Percent_Identity=27.5555555555556, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787820, Length=185, Percent_Identity=31.3513513513514, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=35.9183673469388, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25147288, Length=239, Percent_Identity=36.8200836820084, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=32.3886639676113, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=30.8300395256917, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=30.4878048780488, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17568967, Length=250, Percent_Identity=29.2, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=29.7709923664122, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=30.4182509505703, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=32.5581395348837, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=246, Percent_Identity=28.0487804878049, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=28.1632653061224, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=27.1698113207547, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=30.1507537688442, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=246, Percent_Identity=27.2357723577236, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=28.4615384615385, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=250, Percent_Identity=26.8, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=260, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=260, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=27.7566539923954, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=27.6679841897233, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=28.1368821292776, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=26.7924528301887, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=253, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=248, Percent_Identity=28.2258064516129, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324126, Length=187, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=32.1782178217822, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=206, Percent_Identity=27.6699029126214, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=34.5679012345679, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=35.7429718875502, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=29.3172690763052, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=30.8943089430894, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=31.3253012048193, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=31.7073170731707, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859837, Length=186, Percent_Identity=32.7956989247312, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=31.2252964426877, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=32.3699421965318, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR011285
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25998; Mature: 25867

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQTVLVTGSSRGIGRAIALRLARDGYDVVIHCRARRNEAESVADAVRAFGRNARVLCF
CCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
DVGQREAAASALLADIDHHGCYYGVVCNAGLARDAAFPAMSGEEWDEVIHTNLDAFFNVL
ECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHCCCCCCCCHHHHHHHHHCHHHHHHHH
NPVVLPMVQRRRPGRIVTLSSASGIVGNRGQTNYSAAKAGVIGATKALAIELAKRQITVN
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHEEEEE
CVAPGLIDTEMIEEHVREEAMKMIPARRMGTPDEVAATVAFLLSPDAGYITRQVISVNGG
EECCCCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCCCCHHHHEEEEECCC
MFG
CCC
>Mature Secondary Structure 
TTQTVLVTGSSRGIGRAIALRLARDGYDVVIHCRARRNEAESVADAVRAFGRNARVLCF
CCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
DVGQREAAASALLADIDHHGCYYGVVCNAGLARDAAFPAMSGEEWDEVIHTNLDAFFNVL
ECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHCCCCCCCCHHHHHHHHHCHHHHHHHH
NPVVLPMVQRRRPGRIVTLSSASGIVGNRGQTNYSAAKAGVIGATKALAIELAKRQITVN
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHEEEEE
CVAPGLIDTEMIEEHVREEAMKMIPARRMGTPDEVAATVAFLLSPDAGYITRQVISVNGG
EECCCCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCCCCHHHHEEEEECCC
MFG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]