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The map label for this gene is fabB [H]

Identifier: 94313317

GI number: 94313317

Start: 989117

End: 990346

Strand: Direct

Name: fabB [H]

Synonym: Rmet_4392

Alternate gene names: 94313317

Gene position: 989117-990346 (Clockwise)

Preceding gene: 94313316

Following gene: 94313318

Centisome position: 38.34

GC content: 67.32

Gene sequence:

>1230_bases
ATGAAGCGGGTGGTGGTCACGGGAGCGGGCGCGGTCAGCGCGATCGGCAACGACTGGGCGACGGTGCGCGAGCGCCTGGC
CGCCGGTCGCAATGCGATAGTGGTCATGCCAGACTGGCGCGAGATCCGTGGCCTCAACACGCACATCGCGGCGCCGGTGC
CGCCGTTCACGCTGCCGCCGCACTACACGCGCAAACTCATGCGGACCATGGGCCGCGTGTCGCAGATGGCCGTGCTGGCG
ACCGAATCGGCGCTGGCCGGTGCCGGGCTGGCCGGACATCCGCTGGTGACCGGCGGACAGATGGGGATCGCGTACGGGTC
CTCGACCGGCACGCCGTCCGCCGCGCAGGACTTCGCGCGGATGATGAGCGACCGCACCACCGAGGGCGTCAATGCCACCA
CGTACATCCGCATGATGTCGCATACGGCCGCCGTAAACATCGGCGTGTTCTTCGGCATCAAGGGCCGCATCCTGACCACG
TCGAGCGCCTGCACGTCAGGCAGCCACGGCATTGGCTACGCATACGAGACGATCCGCATGGGCCGTCAGGTGGCGATGGT
GGCCGGCGGCGCCGAAGAGCTTGACGCCACGGAGGCGGCCGTCTTCGATACGCTGTTCGCCACCAGCACGCGCAACGATG
CGCCCACGGCGACGCCACGACCGTTCGATGCCGCGCGCGATGGCCTGGTGCTGGGCGAGGGCGCTTGCACGCTGGTACTG
GAGGAACTGGAGCACGCGCGCCAGCGCGGCGCCCCGATCCTGGCCGAGATCGTCGGCTATGGCACCAACAGCGATGGCGT
GCATGTGACCCAGGCCGACGCCGGCACGATGGCCCTGGCCATGCGGATGGCGCTCGACGATGCCGGCGTCTCGCCGGATC
GAATCGGCTACGTGAACGCGCATGGCACGGCTACCGATCAGGGCGATATCGCCGAATCACAGGCCACGCACGCCGTGTTT
GGCGCCCGAATGCCAATCAGTTCGCTCAAGAGCTACGTCGGCCATACGCTGGGCGCGTGTGGTGCGCTCGAGGCGTGGAT
GACGATCGAGATGATGCGCGATGGCTGGTTTGCGCCGACGATCAATCTGGAGAACCCCGATCCCCGCTGCGCGCAACTTG
ACTACATCGTGGGCGAGGGGCGTGCTATCGACACCGAGTACGTGATGAGCAACAATTTCGCGTTCGGCGGCATCAATACG
TCGCTGGTCTTGCGCCGCTGGAGCGACTGA

Upstream 100 bases:

>100_bases
GCACCCCGGACGAGGTGGCGGCCACGGTGGCGTTCCTGCTTTCGCCCGATGCCGGGTACATTACGCGCCAGGTGATTTCG
GTGAACGGAGGCATGTTCGG

Downstream 100 bases:

>100_bases
GTCGTTCCTGACCCTTTCGGCCTTTTTCGATCCTTTTCGATCCTTTTCGACGCATTCGAACCCTTCCACTGACATGCCGC
TCGCACTGCGTACCGGATCT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKRVVVTGAGAVSAIGNDWATVRERLAAGRNAIVVMPDWREIRGLNTHIAAPVPPFTLPPHYTRKLMRTMGRVSQMAVLA
TESALAGAGLAGHPLVTGGQMGIAYGSSTGTPSAAQDFARMMSDRTTEGVNATTYIRMMSHTAAVNIGVFFGIKGRILTT
SSACTSGSHGIGYAYETIRMGRQVAMVAGGAEELDATEAAVFDTLFATSTRNDAPTATPRPFDAARDGLVLGEGACTLVL
EELEHARQRGAPILAEIVGYGTNSDGVHVTQADAGTMALAMRMALDDAGVSPDRIGYVNAHGTATDQGDIAESQATHAVF
GARMPISSLKSYVGHTLGACGALEAWMTIEMMRDGWFAPTINLENPDPRCAQLDYIVGEGRAIDTEYVMSNNFAFGGINT
SLVLRRWSD

Sequences:

>Translated_409_residues
MKRVVVTGAGAVSAIGNDWATVRERLAAGRNAIVVMPDWREIRGLNTHIAAPVPPFTLPPHYTRKLMRTMGRVSQMAVLA
TESALAGAGLAGHPLVTGGQMGIAYGSSTGTPSAAQDFARMMSDRTTEGVNATTYIRMMSHTAAVNIGVFFGIKGRILTT
SSACTSGSHGIGYAYETIRMGRQVAMVAGGAEELDATEAAVFDTLFATSTRNDAPTATPRPFDAARDGLVLGEGACTLVL
EELEHARQRGAPILAEIVGYGTNSDGVHVTQADAGTMALAMRMALDDAGVSPDRIGYVNAHGTATDQGDIAESQATHAVF
GARMPISSLKSYVGHTLGACGALEAWMTIEMMRDGWFAPTINLENPDPRCAQLDYIVGEGRAIDTEYVMSNNFAFGGINT
SLVLRRWSD
>Mature_409_residues
MKRVVVTGAGAVSAIGNDWATVRERLAAGRNAIVVMPDWREIRGLNTHIAAPVPPFTLPPHYTRKLMRTMGRVSQMAVLA
TESALAGAGLAGHPLVTGGQMGIAYGSSTGTPSAAQDFARMMSDRTTEGVNATTYIRMMSHTAAVNIGVFFGIKGRILTT
SSACTSGSHGIGYAYETIRMGRQVAMVAGGAEELDATEAAVFDTLFATSTRNDAPTATPRPFDAARDGLVLGEGACTLVL
EELEHARQRGAPILAEIVGYGTNSDGVHVTQADAGTMALAMRMALDDAGVSPDRIGYVNAHGTATDQGDIAESQATHAVF
GARMPISSLKSYVGHTLGACGALEAWMTIEMMRDGWFAPTINLENPDPRCAQLDYIVGEGRAIDTEYVMSNNFAFGGINT
SLVLRRWSD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=34.5238095238095, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI41872631, Length=274, Percent_Identity=29.9270072992701, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=38.5135135135135, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=38.498789346247, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=38.9423076923077, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=31.9711538461538, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=37.8787878787879, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=319, Percent_Identity=26.6457680250784, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=264, Percent_Identity=24.6212121212121, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=31.6964285714286, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=37.914691943128, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI221330659, Length=356, Percent_Identity=26.123595505618, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920632, Length=356, Percent_Identity=26.123595505618, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581345, Length=277, Percent_Identity=27.4368231046931, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43191; Mature: 43191

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVVTGAGAVSAIGNDWATVRERLAAGRNAIVVMPDWREIRGLNTHIAAPVPPFTLPP
CCEEEEECCCHHHHCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCEECCCCCCCCCCH
HYTRKLMRTMGRVSQMAVLATESALAGAGLAGHPLVTGGQMGIAYGSSTGTPSAAQDFAR
HHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCEEECCCEEEEECCCCCCCHHHHHHHH
MMSDRTTEGVNATTYIRMMSHTAAVNIGVFFGIKGRILTTSSACTSGSHGIGYAYETIRM
HHHCCCCCCCCHHHHEEEHHHHHEEEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHC
GRQVAMVAGGAEELDATEAAVFDTLFATSTRNDAPTATPRPFDAARDGLVLGEGACTLVL
CCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCEEECCCHHHHHH
EELEHARQRGAPILAEIVGYGTNSDGVHVTQADAGTMALAMRMALDDAGVSPDRIGYVNA
HHHHHHHHCCCCEEHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEC
HGTATDQGDIAESQATHAVFGARMPISSLKSYVGHTLGACGALEAWMTIEMMRDGWFAPT
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
INLENPDPRCAQLDYIVGEGRAIDTEYVMSNNFAFGGINTSLVLRRWSD
EECCCCCCCCEEEEEEECCCCEECHHEEEECCEEECCCCCEEEEEECCC
>Mature Secondary Structure
MKRVVVTGAGAVSAIGNDWATVRERLAAGRNAIVVMPDWREIRGLNTHIAAPVPPFTLPP
CCEEEEECCCHHHHCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCEECCCCCCCCCCH
HYTRKLMRTMGRVSQMAVLATESALAGAGLAGHPLVTGGQMGIAYGSSTGTPSAAQDFAR
HHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCEEECCCEEEEECCCCCCCHHHHHHHH
MMSDRTTEGVNATTYIRMMSHTAAVNIGVFFGIKGRILTTSSACTSGSHGIGYAYETIRM
HHHCCCCCCCCHHHHEEEHHHHHEEEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHC
GRQVAMVAGGAEELDATEAAVFDTLFATSTRNDAPTATPRPFDAARDGLVLGEGACTLVL
CCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCEEECCCHHHHHH
EELEHARQRGAPILAEIVGYGTNSDGVHVTQADAGTMALAMRMALDDAGVSPDRIGYVNA
HHHHHHHHCCCCEEHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEC
HGTATDQGDIAESQATHAVFGARMPISSLKSYVGHTLGACGALEAWMTIEMMRDGWFAPT
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
INLENPDPRCAQLDYIVGEGRAIDTEYVMSNNFAFGGINTSLVLRRWSD
EECCCCCCCCEEEEEEECCCCEECHHEEEECCEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]