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The map label for this gene is ghrB [H]

Identifier: 94313141

GI number: 94313141

Start: 798247

End: 799272

Strand: Direct

Name: ghrB [H]

Synonym: Rmet_4214

Alternate gene names: 94313141

Gene position: 798247-799272 (Clockwise)

Preceding gene: 94313140

Following gene: 94313142

Centisome position: 30.94

GC content: 65.89

Gene sequence:

>1026_bases
ATGTCTCAAACTCAGCCGAAGTCTCAAGTTTCCGTCCAGCCATTGCGCATCCTGTTGTCCGAACCGACGCTGAGGGAGCA
TCGCGCCGCGATCGATCTGTCCATGGACGGCGCGCCGTGGCTGCCTGTATTGGCGCCTGCCACCGATGACCCGAAGGGTG
TCGATGCCGATATCGCCTTCGTGTCGCGCGACGTGACCGGGCTATCGACCAAGCATCAGATCCTGCCGGCTACGCAGCGC
TTCTATTCGGCGATGCTCGAGGCGCCCGCGTTGCGATGGGTGCATGTGCATTCGGCTGGCGCCGATCGCGCCGTGTTCGG
CCAGTTGCGGCAGCGCGGGGTGACCGTCACCACGTCTTCAGGCGCCAATGCGGGCGTGGTGGCGCAAACCGCGCTGGCGG
GATTGCTTGCGCTGGCGAGGCATTTCCCGCTACTGCTCGCCGCGCAGCGCAAGCAACGCTGGGCCCCGTTGCTAGGCACG
GGATTGCCGCGTGACGTGCGGGGGCAGACCGCAACCATTGTGGGGTGGGGCCCGATCGGGCAGCAGATCGGTGCCATGCT
GCGCCTGCTCGGCATGTCGGTGGCCGTGGTCCGGCAACAGCCGACGCCGGCTGGCGAAGGGTTCGAGACCTTTGCGTTCG
ATACCCTGCACGAGGTGCTTCCCCGTACGGACTGGTTGATACTGGCCTGCCCGCTGACGGACCGGACGCGTGGGCTGGTC
GACGGCGCGGCCCTGCGGCGATTGCCGACTGGTGCGCGGCTGATCAATGTGGCGCGTGGAGAAGTGGTGGACGAGCCAGC
GCTGATCGAAGCACTGACAGAAGGAAGGGTGGCCGGCGCCTACCTCGATGTGTTCGCGCATGAACCATTGCCGGCGACGT
CGCCGCTATGGTCGTTGCCGAACGTCATTGCCACGCCGCATAGCGCCGGTTTCTCGGACGGCAATGCGGCGCGTGTGGTC
GACATTTTCCTGGACAATCTCCGCCGTCGGCTGGCGGGTCAGGCAATGCGAAACGTGTCAGCCTAG

Upstream 100 bases:

>100_bases
CGGCTCGCCGCAGCAGTTCGGTGATTTCACGCGCAAGGAATACGAGAAATGGAAGGTCGTGGTCAAGGCCTCCGGTGCCA
CTGTCGATTGAAATTCAGAC

Downstream 100 bases:

>100_bases
CGGCAAATGGGAAGGGGCTGCAGAAAAGGCTGCAAACTGAAGCGGGAAGTTGCGGAGTTTTCAGCAACCTCGCCGCGGCG
TCGACATGCACAATATCGAC

Product: putative Glyoxylate/hydroxypyruvate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSQTQPKSQVSVQPLRILLSEPTLREHRAAIDLSMDGAPWLPVLAPATDDPKGVDADIAFVSRDVTGLSTKHQILPATQR
FYSAMLEAPALRWVHVHSAGADRAVFGQLRQRGVTVTTSSGANAGVVAQTALAGLLALARHFPLLLAAQRKQRWAPLLGT
GLPRDVRGQTATIVGWGPIGQQIGAMLRLLGMSVAVVRQQPTPAGEGFETFAFDTLHEVLPRTDWLILACPLTDRTRGLV
DGAALRRLPTGARLINVARGEVVDEPALIEALTEGRVAGAYLDVFAHEPLPATSPLWSLPNVIATPHSAGFSDGNAARVV
DIFLDNLRRRLAGQAMRNVSA

Sequences:

>Translated_341_residues
MSQTQPKSQVSVQPLRILLSEPTLREHRAAIDLSMDGAPWLPVLAPATDDPKGVDADIAFVSRDVTGLSTKHQILPATQR
FYSAMLEAPALRWVHVHSAGADRAVFGQLRQRGVTVTTSSGANAGVVAQTALAGLLALARHFPLLLAAQRKQRWAPLLGT
GLPRDVRGQTATIVGWGPIGQQIGAMLRLLGMSVAVVRQQPTPAGEGFETFAFDTLHEVLPRTDWLILACPLTDRTRGLV
DGAALRRLPTGARLINVARGEVVDEPALIEALTEGRVAGAYLDVFAHEPLPATSPLWSLPNVIATPHSAGFSDGNAARVV
DIFLDNLRRRLAGQAMRNVSA
>Mature_340_residues
SQTQPKSQVSVQPLRILLSEPTLREHRAAIDLSMDGAPWLPVLAPATDDPKGVDADIAFVSRDVTGLSTKHQILPATQRF
YSAMLEAPALRWVHVHSAGADRAVFGQLRQRGVTVTTSSGANAGVVAQTALAGLLALARHFPLLLAAQRKQRWAPLLGTG
LPRDVRGQTATIVGWGPIGQQIGAMLRLLGMSVAVVRQQPTPAGEGFETFAFDTLHEVLPRTDWLILACPLTDRTRGLVD
GAALRRLPTGARLINVARGEVVDEPALIEALTEGRVAGAYLDVFAHEPLPATSPLWSLPNVIATPHSAGFSDGNAARVVD
IFLDNLRRRLAGQAMRNVSA

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI23308577, Length=249, Percent_Identity=29.3172690763052, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=29.6577946768061, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=29.6577946768061, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=29.8039215686275, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=29.8039215686275, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI145580575, Length=264, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=31.3653136531365, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789279, Length=205, Percent_Identity=33.1707317073171, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081824, Length=216, Percent_Identity=32.4074074074074, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787645, Length=205, Percent_Identity=25.3658536585366, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788660, Length=252, Percent_Identity=28.968253968254, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=256, Percent_Identity=29.296875, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=185, Percent_Identity=29.7297297297297, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=248, Percent_Identity=30.241935483871, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=215, Percent_Identity=31.1627906976744, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=27.0042194092827, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=232, Percent_Identity=25, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=147, Percent_Identity=32.6530612244898, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585516, Length=218, Percent_Identity=28.8990825688073, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=29.5275590551181, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45552429, Length=256, Percent_Identity=30.859375, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585514, Length=256, Percent_Identity=30.859375, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574282, Length=256, Percent_Identity=30.859375, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45551003, Length=256, Percent_Identity=30.859375, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574284, Length=256, Percent_Identity=30.859375, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921140, Length=222, Percent_Identity=30.6306306306306, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28571528, Length=268, Percent_Identity=29.4776119402985, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI62472511, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646446, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646448, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646452, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646450, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 36491; Mature: 36360

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTQPKSQVSVQPLRILLSEPTLREHRAAIDLSMDGAPWLPVLAPATDDPKGVDADIAF
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHEEEEECCCCCCCCEECCCCCCCCCCCCHHHE
VSRDVTGLSTKHQILPATQRFYSAMLEAPALRWVHVHSAGADRAVFGQLRQRGVTVTTSS
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCEEEEECC
GANAGVVAQTALAGLLALARHFPLLLAAQRKQRWAPLLGTGLPRDVRGQTATIVGWGPIG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCHHH
QQIGAMLRLLGMSVAVVRQQPTPAGEGFETFAFDTLHEVLPRTDWLILACPLTDRTRGLV
HHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
DGAALRRLPTGARLINVARGEVVDEPALIEALTEGRVAGAYLDVFAHEPLPATSPLWSLP
HHHHHHHCCCCHHHEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHCC
NVIATPHSAGFSDGNAARVVDIFLDNLRRRLAGQAMRNVSA
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQTQPKSQVSVQPLRILLSEPTLREHRAAIDLSMDGAPWLPVLAPATDDPKGVDADIAF
CCCCCCCCCCHHHHHHHHCCCCHHHHHHEEEEECCCCCCCCEECCCCCCCCCCCCHHHE
VSRDVTGLSTKHQILPATQRFYSAMLEAPALRWVHVHSAGADRAVFGQLRQRGVTVTTSS
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCEEEEECC
GANAGVVAQTALAGLLALARHFPLLLAAQRKQRWAPLLGTGLPRDVRGQTATIVGWGPIG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCHHH
QQIGAMLRLLGMSVAVVRQQPTPAGEGFETFAFDTLHEVLPRTDWLILACPLTDRTRGLV
HHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
DGAALRRLPTGARLINVARGEVVDEPALIEALTEGRVAGAYLDVFAHEPLPATSPLWSLP
HHHHHHHCCCCHHHEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHCC
NVIATPHSAGFSDGNAARVVDIFLDNLRRRLAGQAMRNVSA
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA