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The map label for this gene is acxB [H]

Identifier: 94313033

GI number: 94313033

Start: 677084

End: 679408

Strand: Direct

Name: acxB [H]

Synonym: Rmet_4106

Alternate gene names: 94313033

Gene position: 677084-679408 (Clockwise)

Preceding gene: 94313032

Following gene: 94313034

Centisome position: 26.24

GC content: 62.37

Gene sequence:

>2325_bases
ATGAACATGATGAGCAACAAGGAAGTCGGGTTCGCCGATCTGTTGAAGAACGGCCAGACCCTCAAGGAATTTCGCGACGA
CATCCTCGCCCGCACCCAGGAATCGGGCCACTACAACGGCCTTACCAGCCTGGACTTCCGGGACAGCGACCCGATCGGCT
ATGAGAAGCTGTTCTCCAAGCTGCGGGGTGGACTGGTCCATGCGCGTGAAACCGCCAAGAAGATTGCCGCCAGCCCGATC
GTCGAGCAGGAGGGCGAGCTCTGCTTCACGCTGTATAACGCGGTCGGGGACTGCGTGCTGACCTCCACCGGCATCATCAT
CCACGTAGGAACGATGGGTGCGGCGATCAAGTACATGATCGAGAACAACTGGGAGGCCAACCCCGGCATCTATCCCGGCG
ACATGTTCACGAACAACGACTGCTCCATCGGCAACGTGCACCCGTGTGACATCGCCACGATCGTGCCGATCTTCTGGGAA
GGCAGACTGATCGGCTGGGTGGGCGGCGTGACCCATGTCATCGACACGGGCTCCGTAACGCCGGGCTCCATGTCCACGGG
CCAGACGCAACGCTTCGGCGACGGCTACATGATCACGTGCCGCAAGACGGGCGCGAACGATGTGCCGTTCCGCGACTGGC
TGCATGAGTCGCAGCGCTCGGTACGGACGCCGAAGTACTGGATTCTCGACGAACGGACCCGCATCGCCGGCTGCCACATG
ATTCGCGAGCTGGTGGAGGAGGTGATCCGCGCCGACGGTATCGAGGCCTACGAGAAGTTCGCCTATGAAGTCATCGAGGA
GGGCCGCCGCGGGCTCCAGAGCCGCATCAAGGCCATGACGCTGCCTGGCAAGTACCGCAAGGTCTCGTTCGTCGACGTGC
CGTACAAGCATCCGGACGTGCAGGTCTCCAACGCCTTTGCCAAGCTCGACTCCATCATGCATTCGCCGGTGGAAATGACG
ATCCGCCCCGACGGCAAGTGGCGCCTGGATTTCGAAGGCGCGAGCCGCTGGGGTTGGCACACGTTCAATGCGCACCAGGT
GGCCTTCACCTCAGGCATCTGGGTGATGATGTGTCAGACCCTGGTGCCGACCCAGCGTATCAACGACGGCGCCTACTTCG
CCACCGAGTTCCGGCTACCCAAGGGTACATGGTGCAATCCCGATGACCGGCGCACCGGCCATGCGTATGCCTGGCATTTC
CTGGTGTCCGGCTGGGCGGCGCTGTGGCGTGGTCTCTCTCAGTCGTACTTCAGCCGCGGCTATCTGGAGGAAGTGAACGC
GGGCAACGCCAATACTTCCAACTGGCTGCAGGGTGGCGGCATCAACCAGGATGGCGAGATTCACGCGGTCAACAGCTTCG
AGGCCAGCTCTTGTGGCACAGGCGCGTGCGCGGTCAAGGACGGTCTCAATCACGCCGCTGCCATCTGGAACCCCGAAGGC
GACATGGGCGACATCGAGATTTGGGAGATGGCCGAGCCATTGCTCTACCTGGGCCGGAACGTCAAGGCCAACTCCGGCGG
CTACGGCAAATATCGCGGCGGTTGCGGCTTCGAGACCCTGCGCATGGTCTGGAACGCCCAGGACTGGACGATGTTCTTCA
TGGGCAACGGCTTCATGAACAGCGACTGGGGCATGATGGGTGGCTATCCATCGGCCACCGGGTATCGCTTCGAAGCGCAC
CGCACCGGGCTGGAACAGCGTATTGCCAGTGGCGATTCACTGCCGCTGGGCGGCGACATCGACCCGGCCAATCCGGACTA
CGAGCGCCATATCGACGCCACCGCCGAGGTCAAGCGCGACAAGCAGTGCATCACGACCGAGGACTGCTACGCCAACCACG
ATCTTTACCTGAACTACCTGCGCGGCGGCCCGGGCTTCGGCGATCCGCTCGATCGGGACCCGAAGGCGATCGAGGCGGAC
CTCAACCAGAAGTTCTTGCTGCCTGAGTATGCGCAGAAGGTCTATGGCGCGGTGTTCGCTCAGGACGCCAGGGGCGTGTT
CGCGGTGGATGCCGCAAAGACCAAGAAGCGTCGCGCGGAGATCCGCAAGGAGCGCCTGGCGCGCGCGGTGCCGACGCGCG
AGTGGATGAAGGAGGAGCGCGAACGCATCCTCAACAAGCACGCATCGGTCCAGGTGCAGCATATGTTCGCCACGAGCTTT
GCCTTGTCGGAGAAGTTCACGCAGAGCTTCAAGGACTTCTGGAACCTGCCCGAGGCATGGCACGTGAGAGAGGAAGAACT
GGGTGTGCCGTGCTATGGCGCCAAGCACCGTATGGACTTGTCGCTGATGCCGGACGTCACCACCGTTGTCCAGGTCGAAG
AGTAA

Upstream 100 bases:

>100_bases
AATCCGACGCCACCACGTTCGTGGTGCCGGGCGGCTTCGAAACCACGATCGACAAGCACCGCCTGTTCCATCTCAAGGAA
GTCAAATAAGGAGACACATC

Downstream 100 bases:

>100_bases
CCACCGCACTCAGGAGTCGAACCATGTCTGTCTATACCAACGAACAAGTCGACCACCTCGTCGAGGGGAAGCTCGACTGG
GAAACCACGTTCCGCATGCT

Product: Acetone carboxylase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 774; Mature: 774

Protein sequence:

>774_residues
MNMMSNKEVGFADLLKNGQTLKEFRDDILARTQESGHYNGLTSLDFRDSDPIGYEKLFSKLRGGLVHARETAKKIAASPI
VEQEGELCFTLYNAVGDCVLTSTGIIIHVGTMGAAIKYMIENNWEANPGIYPGDMFTNNDCSIGNVHPCDIATIVPIFWE
GRLIGWVGGVTHVIDTGSVTPGSMSTGQTQRFGDGYMITCRKTGANDVPFRDWLHESQRSVRTPKYWILDERTRIAGCHM
IRELVEEVIRADGIEAYEKFAYEVIEEGRRGLQSRIKAMTLPGKYRKVSFVDVPYKHPDVQVSNAFAKLDSIMHSPVEMT
IRPDGKWRLDFEGASRWGWHTFNAHQVAFTSGIWVMMCQTLVPTQRINDGAYFATEFRLPKGTWCNPDDRRTGHAYAWHF
LVSGWAALWRGLSQSYFSRGYLEEVNAGNANTSNWLQGGGINQDGEIHAVNSFEASSCGTGACAVKDGLNHAAAIWNPEG
DMGDIEIWEMAEPLLYLGRNVKANSGGYGKYRGGCGFETLRMVWNAQDWTMFFMGNGFMNSDWGMMGGYPSATGYRFEAH
RTGLEQRIASGDSLPLGGDIDPANPDYERHIDATAEVKRDKQCITTEDCYANHDLYLNYLRGGPGFGDPLDRDPKAIEAD
LNQKFLLPEYAQKVYGAVFAQDARGVFAVDAAKTKKRRAEIRKERLARAVPTREWMKEERERILNKHASVQVQHMFATSF
ALSEKFTQSFKDFWNLPEAWHVREEELGVPCYGAKHRMDLSLMPDVTTVVQVEE

Sequences:

>Translated_774_residues
MNMMSNKEVGFADLLKNGQTLKEFRDDILARTQESGHYNGLTSLDFRDSDPIGYEKLFSKLRGGLVHARETAKKIAASPI
VEQEGELCFTLYNAVGDCVLTSTGIIIHVGTMGAAIKYMIENNWEANPGIYPGDMFTNNDCSIGNVHPCDIATIVPIFWE
GRLIGWVGGVTHVIDTGSVTPGSMSTGQTQRFGDGYMITCRKTGANDVPFRDWLHESQRSVRTPKYWILDERTRIAGCHM
IRELVEEVIRADGIEAYEKFAYEVIEEGRRGLQSRIKAMTLPGKYRKVSFVDVPYKHPDVQVSNAFAKLDSIMHSPVEMT
IRPDGKWRLDFEGASRWGWHTFNAHQVAFTSGIWVMMCQTLVPTQRINDGAYFATEFRLPKGTWCNPDDRRTGHAYAWHF
LVSGWAALWRGLSQSYFSRGYLEEVNAGNANTSNWLQGGGINQDGEIHAVNSFEASSCGTGACAVKDGLNHAAAIWNPEG
DMGDIEIWEMAEPLLYLGRNVKANSGGYGKYRGGCGFETLRMVWNAQDWTMFFMGNGFMNSDWGMMGGYPSATGYRFEAH
RTGLEQRIASGDSLPLGGDIDPANPDYERHIDATAEVKRDKQCITTEDCYANHDLYLNYLRGGPGFGDPLDRDPKAIEAD
LNQKFLLPEYAQKVYGAVFAQDARGVFAVDAAKTKKRRAEIRKERLARAVPTREWMKEERERILNKHASVQVQHMFATSF
ALSEKFTQSFKDFWNLPEAWHVREEELGVPCYGAKHRMDLSLMPDVTTVVQVEE
>Mature_774_residues
MNMMSNKEVGFADLLKNGQTLKEFRDDILARTQESGHYNGLTSLDFRDSDPIGYEKLFSKLRGGLVHARETAKKIAASPI
VEQEGELCFTLYNAVGDCVLTSTGIIIHVGTMGAAIKYMIENNWEANPGIYPGDMFTNNDCSIGNVHPCDIATIVPIFWE
GRLIGWVGGVTHVIDTGSVTPGSMSTGQTQRFGDGYMITCRKTGANDVPFRDWLHESQRSVRTPKYWILDERTRIAGCHM
IRELVEEVIRADGIEAYEKFAYEVIEEGRRGLQSRIKAMTLPGKYRKVSFVDVPYKHPDVQVSNAFAKLDSIMHSPVEMT
IRPDGKWRLDFEGASRWGWHTFNAHQVAFTSGIWVMMCQTLVPTQRINDGAYFATEFRLPKGTWCNPDDRRTGHAYAWHF
LVSGWAALWRGLSQSYFSRGYLEEVNAGNANTSNWLQGGGINQDGEIHAVNSFEASSCGTGACAVKDGLNHAAAIWNPEG
DMGDIEIWEMAEPLLYLGRNVKANSGGYGKYRGGCGFETLRMVWNAQDWTMFFMGNGFMNSDWGMMGGYPSATGYRFEAH
RTGLEQRIASGDSLPLGGDIDPANPDYERHIDATAEVKRDKQCITTEDCYANHDLYLNYLRGGPGFGDPLDRDPKAIEAD
LNQKFLLPEYAQKVYGAVFAQDARGVFAVDAAKTKKRRAEIRKERLARAVPTREWMKEERERILNKHASVQVQHMFATSF
ALSEKFTQSFKDFWNLPEAWHVREEELGVPCYGAKHRMDLSLMPDVTTVVQVEE

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=333, Percent_Identity=21.021021021021, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 86984; Mature: 86984

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMMSNKEVGFADLLKNGQTLKEFRDDILARTQESGHYNGLTSLDFRDSDPIGYEKLFSK
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
LRGGLVHARETAKKIAASPIVEQEGELCFTLYNAVGDCVLTSTGIIIHVGTMGAAIKYMI
HHCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHEECCCEEEEECCCCHHEEEEE
ENNWEANPGIYPGDMFTNNDCSIGNVHPCDIATIVPIFWEGRLIGWVGGVTHVIDTGSVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCHHHHEECCCCC
PGSMSTGQTQRFGDGYMITCRKTGANDVPFRDWLHESQRSVRTPKYWILDERTRIAGCHM
CCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
IRELVEEVIRADGIEAYEKFAYEVIEEGRRGLQSRIKAMTLPGKYRKVSFVDVPYKHPDV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCC
QVSNAFAKLDSIMHSPVEMTIRPDGKWRLDFEGASRWGWHTFNAHQVAFTSGIWVMMCQT
CHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCEEECCCCEEEECCCHHHHHHHH
LVPTQRINDGAYFATEFRLPKGTWCNPDDRRTGHAYAWHFLVSGWAALWRGLSQSYFSRG
HCCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
YLEEVNAGNANTSNWLQGGGINQDGEIHAVNSFEASSCGTGACAVKDGLNHAAAIWNPEG
CHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHCCCCCEEEECCCC
DMGDIEIWEMAEPLLYLGRNVKANSGGYGKYRGGCGFETLRMVWNAQDWTMFFMGNGFMN
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEEC
SDWGMMGGYPSATGYRFEAHRTGLEQRIASGDSLPLGGDIDPANPDYERHIDATAEVKRD
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHCC
KQCITTEDCYANHDLYLNYLRGGPGFGDPLDRDPKAIEADLNQKFLLPEYAQKVYGAVFA
CCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHH
QDARGVFAVDAAKTKKRRAEIRKERLARAVPTREWMKEERERILNKHASVQVQHMFATSF
HCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHH
ALSEKFTQSFKDFWNLPEAWHVREEELGVPCYGAKHRMDLSLMPDVTTVVQVEE
HHHHHHHHHHHHHHCCCHHHCCCHHHCCCCCCCCCCCCCEEECCCCEEEEEECC
>Mature Secondary Structure
MNMMSNKEVGFADLLKNGQTLKEFRDDILARTQESGHYNGLTSLDFRDSDPIGYEKLFSK
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
LRGGLVHARETAKKIAASPIVEQEGELCFTLYNAVGDCVLTSTGIIIHVGTMGAAIKYMI
HHCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHEECCCEEEEECCCCHHEEEEE
ENNWEANPGIYPGDMFTNNDCSIGNVHPCDIATIVPIFWEGRLIGWVGGVTHVIDTGSVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCHHHHEECCCCC
PGSMSTGQTQRFGDGYMITCRKTGANDVPFRDWLHESQRSVRTPKYWILDERTRIAGCHM
CCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
IRELVEEVIRADGIEAYEKFAYEVIEEGRRGLQSRIKAMTLPGKYRKVSFVDVPYKHPDV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCC
QVSNAFAKLDSIMHSPVEMTIRPDGKWRLDFEGASRWGWHTFNAHQVAFTSGIWVMMCQT
CHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCEEECCCCEEEECCCHHHHHHHH
LVPTQRINDGAYFATEFRLPKGTWCNPDDRRTGHAYAWHFLVSGWAALWRGLSQSYFSRG
HCCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
YLEEVNAGNANTSNWLQGGGINQDGEIHAVNSFEASSCGTGACAVKDGLNHAAAIWNPEG
CHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHCCCCCEEEECCCC
DMGDIEIWEMAEPLLYLGRNVKANSGGYGKYRGGCGFETLRMVWNAQDWTMFFMGNGFMN
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEEC
SDWGMMGGYPSATGYRFEAHRTGLEQRIASGDSLPLGGDIDPANPDYERHIDATAEVKRD
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHCC
KQCITTEDCYANHDLYLNYLRGGPGFGDPLDRDPKAIEADLNQKFLLPEYAQKVYGAVFA
CCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHH
QDARGVFAVDAAKTKKRRAEIRKERLARAVPTREWMKEERERILNKHASVQVQHMFATSF
HCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHH
ALSEKFTQSFKDFWNLPEAWHVREEELGVPCYGAKHRMDLSLMPDVTTVVQVEE
HHHHHHHHHHHHHHCCCHHHCCCHHHCCCCCCCCCCCCCEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]