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The map label for this gene is acxA [H]

Identifier: 94313032

GI number: 94313032

Start: 674904

End: 677072

Strand: Direct

Name: acxA [H]

Synonym: Rmet_4105

Alternate gene names: 94313032

Gene position: 674904-677072 (Clockwise)

Preceding gene: 94313030

Following gene: 94313033

Centisome position: 26.16

GC content: 63.95

Gene sequence:

>2169_bases
ATGACACCAATGACAGGAGACAACATGCAACCCCACTCCACCGTACAGGTGATGGGCATCGATGCAGGCGGCACGATGAC
CGATACATTCTTCGTGCGCTCGGACGGCCGGTTCGTGGTCGGCAAGGCGCAGAGCAACCCCGGCGACGAATCGCTGGCCA
TCTACAACTCGTCGGAGGATGCGCTGGCGCACTGGGAGCGCACCGTGGACGACGTCTACCCGGAACTACTGACCTGCGTG
TACTCCGGCACGGCCATGCTCAACCGCATTCTTATGCGCAAGGGCCTGGACGTCGGCCTTATCTGCAATCGCGGCTTCGA
GCAGATCCATTCGATGGGGCGCGCGCTGCAGAGCTATCTGGGCTACGCGCTGGAGGACCGCATTCACCTGAACACGCATC
GCTACGACGAACCGCTGGTGCCTGTCTCGCGCACGCGTGGCGTGACCGAGCGCACCGATGTGCAGGGCAAGGTCGTCATT
CCGCTGCGGGAGGAAGAAGTCCGGCAGGCCACGCGGGAACTGGTGGAGGCCAAGTCGCAGGCGATCGTCATCTGCCTGCT
GCAATCCCACAAGAACGAGTCCAGCGAACAACGTGCGCGCGACATCGTGCAGGATGAACTGGCGAAGCTGAAGGTCGATG
TCCCGGTGTTTGCGTCGGTGGACTATTACCCGTCGCGCAAGGAAAGCCACCGGATGAACACCACCATCCTGGAGGCCTAC
GGCGCGGAGCCCTCGCGGCAGACGCTGAAGAAGGTCAGCGACCGCTTCAAGAAACACGGTGCCAAGTTCGATCTGCGTGT
GATGGCCACCCATGGCGGCACGATCAGCTGGAAGGCGAAGGAGCTGGCGCGGACGATCGTGTCGGGGCCGATTGGTGGCG
TGATCGGATCAAAGCTCCTGGGCGAGGCGTTGGGCGACGAGAACATCGCATGCTCGGACATCGGCGGCACCAGCTTCGAC
GTAGCGTTGATCACCAAGGGCAACTTCGCGATCAAGTCGGATCCCGACATGGCGCGCCTGGTGCTGTCGCTGCCGCTGGT
GGCGATGGACTCCGTGGGCGCGGGCGCTGGCAGCTTCGTGCGGCTGGACCCGTACAGCAAGTCGATCAAGCTCGGGCCCG
ACAGCGCCGGCTACCGCGTGGGTACCTGCTGGCCGGAGAGCGGGCTGGATACGGTCACCGTTTCCGACTGCCACGTGGTG
CTCGGCTATCTGAACCCGGAGAACTTTCTTGGCGGTGCGATCAAGCTCGATGTGGCACGCGCCCGCCAGCACATCAAGGC
ACAGATCGCGGACCCGCTCGGGCTGTCGGTCGAGGACGCGGCGGCGGGGGTCATCGAATTGCTGGACCTTACGCTGTCGG
AGTACCTGCGCGCCAACATCAGCGCCAAGGGCTACAACCCGGCCGAGTTCACGTGCTTTTCTTACGGCGGCGCGGGCCCC
GTGCATACCTACGGATACACCGGCGGCGTCGGTTTCAAGGACGTGGTGGTGCCGGCCTGGGCTGCCGGCTTCTCGGCCTT
CGGCTGCGCCTGCGCGGACTTCGAGTATCGCTACGACAAATCGGTGGATCTCGGTGTCGCGCAGTTCGCGCCGGACGGCA
GCAAGGAGACCGCGTGCCGGATCCTGCAGGAGGCGTGGTCGGAACTGGCCGTCAAGGTGATTGAGGAGTTCCGGGCCAAT
GGCTTCGATGCCAGGGACGTCGTGTTGATCCCGGGCTACAAGATGCAGTACATGGGGCAGCTCAATGATCTTGAGATCGT
CTCGCCGGTAGCCACTGCGTCGTCCGCCGAGGACTGGGACCGCATCGTCGACGCGTTCGAGAACACCTACGGCCGCGTCT
ACGCCAGTTCGGCACGCTCGCCGGAACTGGGCTTCTCGATCACGGGGGCCATCCTGCGCGGCATGGTGGTCACGCAGAAG
CCCGTGCTGCCAGAGGACCCGGACGCCGGTCCAACACCGCCCAGGGAGGCCTACCTGGGCGTACGGCCTTTCTACCGCCA
CAAGACATGGATGGATGCCGCGCTCTGGAAGATGGAGTCGCTCAAGGCCGGCAACCACATCGTGGGTCCAGCCATCATCG
AATCCGACGCCACCACGTTCGTGGTGCCGGGCGGCTTCGAAACCACGATCGACAAGCACCGCCTGTTCCATCTCAAGGAA
GTCAAATAA

Upstream 100 bases:

>100_bases
GCAAGGCATTGATTTCAATCACATGTGATCGGCTCCTGCAGGTGCCAATGCCGCCTGGCATGTCCCTTGCCATGAAGGGT
GTGTGGGAACTCCCACGACG

Downstream 100 bases:

>100_bases
GGAGACACATCATGAACATGATGAGCAACAAGGAAGTCGGGTTCGCCGATCTGTTGAAGAACGGCCAGACCCTCAAGGAA
TTTCGCGACGACATCCTCGC

Product: acetone carboxylase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MTPMTGDNMQPHSTVQVMGIDAGGTMTDTFFVRSDGRFVVGKAQSNPGDESLAIYNSSEDALAHWERTVDDVYPELLTCV
YSGTAMLNRILMRKGLDVGLICNRGFEQIHSMGRALQSYLGYALEDRIHLNTHRYDEPLVPVSRTRGVTERTDVQGKVVI
PLREEEVRQATRELVEAKSQAIVICLLQSHKNESSEQRARDIVQDELAKLKVDVPVFASVDYYPSRKESHRMNTTILEAY
GAEPSRQTLKKVSDRFKKHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGEALGDENIACSDIGGTSFD
VALITKGNFAIKSDPDMARLVLSLPLVAMDSVGAGAGSFVRLDPYSKSIKLGPDSAGYRVGTCWPESGLDTVTVSDCHVV
LGYLNPENFLGGAIKLDVARARQHIKAQIADPLGLSVEDAAAGVIELLDLTLSEYLRANISAKGYNPAEFTCFSYGGAGP
VHTYGYTGGVGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDLGVAQFAPDGSKETACRILQEAWSELAVKVIEEFRAN
GFDARDVVLIPGYKMQYMGQLNDLEIVSPVATASSAEDWDRIVDAFENTYGRVYASSARSPELGFSITGAILRGMVVTQK
PVLPEDPDAGPTPPREAYLGVRPFYRHKTWMDAALWKMESLKAGNHIVGPAIIESDATTFVVPGGFETTIDKHRLFHLKE
VK

Sequences:

>Translated_722_residues
MTPMTGDNMQPHSTVQVMGIDAGGTMTDTFFVRSDGRFVVGKAQSNPGDESLAIYNSSEDALAHWERTVDDVYPELLTCV
YSGTAMLNRILMRKGLDVGLICNRGFEQIHSMGRALQSYLGYALEDRIHLNTHRYDEPLVPVSRTRGVTERTDVQGKVVI
PLREEEVRQATRELVEAKSQAIVICLLQSHKNESSEQRARDIVQDELAKLKVDVPVFASVDYYPSRKESHRMNTTILEAY
GAEPSRQTLKKVSDRFKKHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGEALGDENIACSDIGGTSFD
VALITKGNFAIKSDPDMARLVLSLPLVAMDSVGAGAGSFVRLDPYSKSIKLGPDSAGYRVGTCWPESGLDTVTVSDCHVV
LGYLNPENFLGGAIKLDVARARQHIKAQIADPLGLSVEDAAAGVIELLDLTLSEYLRANISAKGYNPAEFTCFSYGGAGP
VHTYGYTGGVGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDLGVAQFAPDGSKETACRILQEAWSELAVKVIEEFRAN
GFDARDVVLIPGYKMQYMGQLNDLEIVSPVATASSAEDWDRIVDAFENTYGRVYASSARSPELGFSITGAILRGMVVTQK
PVLPEDPDAGPTPPREAYLGVRPFYRHKTWMDAALWKMESLKAGNHIVGPAIIESDATTFVVPGGFETTIDKHRLFHLKE
VK
>Mature_721_residues
TPMTGDNMQPHSTVQVMGIDAGGTMTDTFFVRSDGRFVVGKAQSNPGDESLAIYNSSEDALAHWERTVDDVYPELLTCVY
SGTAMLNRILMRKGLDVGLICNRGFEQIHSMGRALQSYLGYALEDRIHLNTHRYDEPLVPVSRTRGVTERTDVQGKVVIP
LREEEVRQATRELVEAKSQAIVICLLQSHKNESSEQRARDIVQDELAKLKVDVPVFASVDYYPSRKESHRMNTTILEAYG
AEPSRQTLKKVSDRFKKHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGEALGDENIACSDIGGTSFDV
ALITKGNFAIKSDPDMARLVLSLPLVAMDSVGAGAGSFVRLDPYSKSIKLGPDSAGYRVGTCWPESGLDTVTVSDCHVVL
GYLNPENFLGGAIKLDVARARQHIKAQIADPLGLSVEDAAAGVIELLDLTLSEYLRANISAKGYNPAEFTCFSYGGAGPV
HTYGYTGGVGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDLGVAQFAPDGSKETACRILQEAWSELAVKVIEEFRANG
FDARDVVLIPGYKMQYMGQLNDLEIVSPVATASSAEDWDRIVDAFENTYGRVYASSARSPELGFSITGAILRGMVVTQKP
VLPEDPDAGPTPPREAYLGVRPFYRHKTWMDAALWKMESLKAGNHIVGPAIIESDATTFVVPGGFETTIDKHRLFHLKEV
K

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=740, Percent_Identity=23.7837837837838, Blast_Score=102, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322634, Length=593, Percent_Identity=21.9224283305228, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI45550492, Length=732, Percent_Identity=25.5464480874317, Blast_Score=132, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 78691; Mature: 78560

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPMTGDNMQPHSTVQVMGIDAGGTMTDTFFVRSDGRFVVGKAQSNPGDESLAIYNSSED
CCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEEECCCH
ALAHWERTVDDVYPELLTCVYSGTAMLNRILMRKGLDVGLICNRGFEQIHSMGRALQSYL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
GYALEDRIHLNTHRYDEPLVPVSRTRGVTERTDVQGKVVIPLREEEVRQATRELVEAKSQ
CHHHHCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCC
AIVICLLQSHKNESSEQRARDIVQDELAKLKVDVPVFASVDYYPSRKESHRMNTTILEAY
EEEEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCHHCCCCHHHHEEC
GAEPSRQTLKKVSDRFKKHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLL
CCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHH
GEALGDENIACSDIGGTSFDVALITKGNFAIKSDPDMARLVLSLPLVAMDSVGAGAGSFV
HHHHCCCCEEEECCCCCEEEEEEEECCCEEECCCCHHHHHHHHCCHHHHHCCCCCCCCEE
RLDPYSKSIKLGPDSAGYRVGTCWPESGLDTVTVSDCHVVLGYLNPENFLGGAIKLDVAR
EECCCCCCEEECCCCCCEEEEEECCCCCCCEEEECCEEEEEEECCCHHHCCCEEEEEHHH
ARQHIKAQIADPLGLSVEDAAAGVIELLDLTLSEYLRANISAKGYNPAEFTCFSYGGAGP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
VHTYGYTGGVGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDLGVAQFAPDGSKETACR
CCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHCCCCCCHHHHHH
ILQEAWSELAVKVIEEFRANGFDARDVVLIPGYKMQYMGQLNDLEIVSPVATASSAEDWD
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCEEECCHHCCCCHHHHH
RIVDAFENTYGRVYASSARSPELGFSITGAILRGMVVTQKPVLPEDPDAGPTPPREAYLG
HHHHHHHCCCCEEEECCCCCCCCCCEEHHHHHHCCCEECCCCCCCCCCCCCCCCHHHEEC
VRPFYRHKTWMDAALWKMESLKAGNHIVGPAIIESDATTFVVPGGFETTIDKHRLFHLKE
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCCEEEECCCCCCCCCHHHEEEEEC
VK
CC
>Mature Secondary Structure 
TPMTGDNMQPHSTVQVMGIDAGGTMTDTFFVRSDGRFVVGKAQSNPGDESLAIYNSSED
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEEECCCH
ALAHWERTVDDVYPELLTCVYSGTAMLNRILMRKGLDVGLICNRGFEQIHSMGRALQSYL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
GYALEDRIHLNTHRYDEPLVPVSRTRGVTERTDVQGKVVIPLREEEVRQATRELVEAKSQ
CHHHHCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCC
AIVICLLQSHKNESSEQRARDIVQDELAKLKVDVPVFASVDYYPSRKESHRMNTTILEAY
EEEEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCHHCCCCHHHHEEC
GAEPSRQTLKKVSDRFKKHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLL
CCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHH
GEALGDENIACSDIGGTSFDVALITKGNFAIKSDPDMARLVLSLPLVAMDSVGAGAGSFV
HHHHCCCCEEEECCCCCEEEEEEEECCCEEECCCCHHHHHHHHCCHHHHHCCCCCCCCEE
RLDPYSKSIKLGPDSAGYRVGTCWPESGLDTVTVSDCHVVLGYLNPENFLGGAIKLDVAR
EECCCCCCEEECCCCCCEEEEEECCCCCCCEEEECCEEEEEEECCCHHHCCCEEEEEHHH
ARQHIKAQIADPLGLSVEDAAAGVIELLDLTLSEYLRANISAKGYNPAEFTCFSYGGAGP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
VHTYGYTGGVGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDLGVAQFAPDGSKETACR
CCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHCCCCCCHHHHHH
ILQEAWSELAVKVIEEFRANGFDARDVVLIPGYKMQYMGQLNDLEIVSPVATASSAEDWD
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCEEECCHHCCCCHHHHH
RIVDAFENTYGRVYASSARSPELGFSITGAILRGMVVTQKPVLPEDPDAGPTPPREAYLG
HHHHHHHCCCCEEEECCCCCCCCCCEEHHHHHHCCCEECCCCCCCCCCCCCCCCHHHEEC
VRPFYRHKTWMDAALWKMESLKAGNHIVGPAIIESDATTFVVPGGFETTIDKHRLFHLKE
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCCEEEECCCCCCCCCHHHEEEEEC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]