| Definition | Cupriavidus metallidurans CH34 megaplasmid, complete sequence. |
|---|---|
| Accession | NC_007974 |
| Length | 2,580,084 |
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The map label for this gene is yvaG [H]
Identifier: 94313004
GI number: 94313004
Start: 644308
End: 645102
Strand: Reverse
Name: yvaG [H]
Synonym: Rmet_4076
Alternate gene names: 94313004
Gene position: 645102-644308 (Counterclockwise)
Preceding gene: 94313005
Following gene: 94312998
Centisome position: 25.0
GC content: 64.28
Gene sequence:
>795_bases ATGAACATCGATCTGTCGGGCAAGACCGCCCTCGTCACCGGTTCCACCGCCGGCATCGGCTTTGCCACGGCGCGCGGTCT GGCCGAGTCCGGCGCCCACGTGATCGTCAACGGCCGTAGCCAGGCCTCGGTCGATAACGCGCTGGCGTCGCTGAAGAAAT CCTATCCCACCGCCCAGGCCACCGGATTCGCAGGCGACCTGACCGACGCTGCCGTCTGCGACACCCTCGTCAAGACCCAC CCGGCTGTCGACATCCTCGTCAACAACCTCGGCATCTTCGAGCCGAAGGATTTCTTCGATATTCCGGACAGCGACTGGAC ACGCTTTTTCGACGTCAACGTGCTGTCCGGCGTACGCCTCTCGCGCGCCTATGCCAAAGGCATGGCCGAGCGCAAATGGG GCCGCATCGTGTTTATCGCGTCTGAGTCTGGCATCAACATTCCGGTCGAGATGATCCACTACGGCTTCACCAAGACCGCG CAGTTGGCGGTCTCGCGCGGTCTGGCCAAGCGGATGGCGGGCACCGGCGTCACGGTGAACGCCGTGCTGCCCGGCCCGAC GCTATCCGAAGGCGTGACGGCCATGCTCAAGGATGAAATCGCGAAATCCGGCAAAAGCGCCGAGGAAGTGGCGGCCGAGT TCGTCAAGGCACACCGCAGCACGTCGATCATCCAGCGCGCGGCCAGTGTCGAGGAAGTGGCCAACATGATCGTCTACGTC TGCTCGCCACAGGCGTCCGCCACCACCGGGGCGGCCCTGCGCGTTGACGGCGGTGTGGTCGACACGATCGTGTAA
Upstream 100 bases:
>100_bases TCCACAGGCCCGGCTTGCAGTTCGCCGGCGGCTTCATACACTTGACGGGTTGCCCTGCCGTAGCGGCCAAGGGCTCACCT TCCAACGAAATGGAGTCGCC
Downstream 100 bases:
>100_bases CGCACACCAAGGATCGACGACGGCCCGCTCCCGCGTGGAGAGGGCCGTGGCCGTCCCTGCGACTACGCTGCCTCGCCGCT CCACTCGCGTATCAGGTCCA
Product: putative short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 264; Mature: 264
Protein sequence:
>264_residues MNIDLSGKTALVTGSTAGIGFATARGLAESGAHVIVNGRSQASVDNALASLKKSYPTAQATGFAGDLTDAAVCDTLVKTH PAVDILVNNLGIFEPKDFFDIPDSDWTRFFDVNVLSGVRLSRAYAKGMAERKWGRIVFIASESGINIPVEMIHYGFTKTA QLAVSRGLAKRMAGTGVTVNAVLPGPTLSEGVTAMLKDEIAKSGKSAEEVAAEFVKAHRSTSIIQRAASVEEVANMIVYV CSPQASATTGAALRVDGGVVDTIV
Sequences:
>Translated_264_residues MNIDLSGKTALVTGSTAGIGFATARGLAESGAHVIVNGRSQASVDNALASLKKSYPTAQATGFAGDLTDAAVCDTLVKTH PAVDILVNNLGIFEPKDFFDIPDSDWTRFFDVNVLSGVRLSRAYAKGMAERKWGRIVFIASESGINIPVEMIHYGFTKTA QLAVSRGLAKRMAGTGVTVNAVLPGPTLSEGVTAMLKDEIAKSGKSAEEVAAEFVKAHRSTSIIQRAASVEEVANMIVYV CSPQASATTGAALRVDGGVVDTIV >Mature_264_residues MNIDLSGKTALVTGSTAGIGFATARGLAESGAHVIVNGRSQASVDNALASLKKSYPTAQATGFAGDLTDAAVCDTLVKTH PAVDILVNNLGIFEPKDFFDIPDSDWTRFFDVNVLSGVRLSRAYAKGMAERKWGRIVFIASESGINIPVEMIHYGFTKTA QLAVSRGLAKRMAGTGVTVNAVLPGPTLSEGVTAMLKDEIAKSGKSAEEVAAEFVKAHRSTSIIQRAASVEEVANMIVYV CSPQASATTGAALRVDGGVVDTIV
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=32.3076923076923, Blast_Score=111, Evalue=5e-25, Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=31.1284046692607, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=30.1526717557252, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=33.695652173913, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI7705855, Length=186, Percent_Identity=35.4838709677419, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI7705925, Length=264, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI33667109, Length=185, Percent_Identity=34.0540540540541, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI109715829, Length=253, Percent_Identity=28.8537549407115, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=27.7992277992278, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI19923817, Length=264, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI4504505, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI10190746, Length=218, Percent_Identity=29.3577981651376, Blast_Score=72, Evalue=3e-13, Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=31.0344827586207, Blast_Score=106, Evalue=1e-24, Organism=Escherichia coli, GI1787905, Length=266, Percent_Identity=30.0751879699248, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1790717, Length=259, Percent_Identity=28.957528957529, Blast_Score=93, Evalue=1e-20, Organism=Escherichia coli, GI2367365, Length=259, Percent_Identity=31.6602316602317, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=30.9160305343511, Blast_Score=92, Evalue=5e-20, Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=31.2977099236641, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1789208, Length=269, Percent_Identity=26.7657992565056, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI87082160, Length=262, Percent_Identity=26.7175572519084, Blast_Score=75, Evalue=3e-15, Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=25.8687258687259, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=25.968992248062, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=32.4175824175824, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI2367175, Length=265, Percent_Identity=30.9433962264151, Blast_Score=64, Evalue=9e-12, Organism=Escherichia coli, GI1789378, Length=268, Percent_Identity=29.8507462686567, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17561402, Length=261, Percent_Identity=30.6513409961686, Blast_Score=104, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17560676, Length=259, Percent_Identity=28.957528957529, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=28.740157480315, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI115534694, Length=261, Percent_Identity=31.0344827586207, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=28.2352941176471, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17568967, Length=265, Percent_Identity=26.7924528301887, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=29.4339622641509, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=28.8389513108614, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI25147288, Length=265, Percent_Identity=30.188679245283, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=29.0566037735849, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=26.615969581749, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=30.0751879699248, Blast_Score=70, Evalue=9e-13, Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=26.2172284644195, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=28.8389513108614, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=29.0566037735849, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=26.9961977186312, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=7e-12, Organism=Caenorhabditis elegans, GI32565532, Length=218, Percent_Identity=26.605504587156, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI71992402, Length=214, Percent_Identity=27.5700934579439, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=26.3940520446097, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI71997099, Length=240, Percent_Identity=30.4166666666667, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=192, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=1e-13, Organism=Drosophila melanogaster, GI21355319, Length=270, Percent_Identity=30.3703703703704, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24639444, Length=265, Percent_Identity=30.188679245283, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=29.2307692307692, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=31.2741312741313, Blast_Score=92, Evalue=3e-19, Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=32.8185328185328, Blast_Score=91, Evalue=9e-19, Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=30.46875, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI18859837, Length=197, Percent_Identity=29.4416243654822, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=28.6259541984733, Blast_Score=74, Evalue=8e-14, Organism=Drosophila melanogaster, GI24643142, Length=259, Percent_Identity=28.1853281853282, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 27563; Mature: 27563
Theoretical pI: Translated: 6.95; Mature: 6.95
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNIDLSGKTALVTGSTAGIGFATARGLAESGAHVIVNGRSQASVDNALASLKKSYPTAQA CCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC TGFAGDLTDAAVCDTLVKTHPAVDILVNNLGIFEPKDFFDIPDSDWTRFFDVNVLSGVRL CCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHCCHHH SRAYAKGMAERKWGRIVFIASESGINIPVEMIHYGFTKTAQLAVSRGLAKRMAGTGVTVN HHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEE AVLPGPTLSEGVTAMLKDEIAKSGKSAEEVAAEFVKAHRSTSIIQRAASVEEVANMIVYV EEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE CSPQASATTGAALRVDGGVVDTIV ECCCCCCCCCCEEEECCCCHHHCC >Mature Secondary Structure MNIDLSGKTALVTGSTAGIGFATARGLAESGAHVIVNGRSQASVDNALASLKKSYPTAQA CCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC TGFAGDLTDAAVCDTLVKTHPAVDILVNNLGIFEPKDFFDIPDSDWTRFFDVNVLSGVRL CCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHCCHHH SRAYAKGMAERKWGRIVFIASESGINIPVEMIHYGFTKTAQLAVSRGLAKRMAGTGVTVN HHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEE AVLPGPTLSEGVTAMLKDEIAKSGKSAEEVAAEFVKAHRSTSIIQRAASVEEVANMIVYV EEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE CSPQASATTGAALRVDGGVVDTIV ECCCCCCCCCCEEEECCCCHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9384377 [H]