Click here to switch to the map view.

The map label for this gene is mmfS [H]

Identifier: 94312968

GI number: 94312968

Start: 606412

End: 607743

Strand: Direct

Name: mmfS [H]

Synonym: Rmet_4040

Alternate gene names: 94312968

Gene position: 606412-607743 (Clockwise)

Preceding gene: 94312967

Following gene: 94312969

Centisome position: 23.5

GC content: 60.44

Gene sequence:

>1332_bases
TTGAACGAATCAGTTCAGCTCAAGCTGTCCTTCACCTTGTCGCTGGCCATCCTCGTGGTGGCCGTTGTGGCGGGCGTATT
CTCGTTCCTGTCCGCCTTCGATGAAGCGCACGAACTACAGGACGATGTACTGCGCCAGGTGGCGCAGCTCATGGATCGCC
AGCGCTTGTTGCCTGCCGTGCCAACCACCGATATCCGTCTCAAGGATGTCGATGAAGAGTCGCGCGTGATCGTCCAGCGC
TTGGGTGAGGTCAGTCCCTCTACGGTAGGCGTGGATGCAGGAGGCGTGCTCCCGCTCCCGGCGACCTTGGCGGATGGATT
GCACACGCTGGAAGTTGGTGGCGAGACGTTTCGCGTGCTGGTCAAGACCACGGCGAGCGGCGAACGCATTGCTGTGGCTC
AGGAGTCCGGTTTCCGCAATGAAATTGCCCGCGACGGGGCACTGCGCACGGTGATGCCTTTCTTGATTCTCGTGCCGGTG
CTGCTGTTGATCGTTGCTGACCTGGTGCGCAAGATGTTCCAGCCCATCGCGGCGCTGTCCAAGGAAATAGACCAGCGGGC
AGAGCAGGAACTGCATCCCGTCGAAGACCGCCACCTTCCGGTCGAGGTACGTCCGTTTGTCGTGGCGATCAATCGCCTGC
TCGCTCGTGTCAGCCAGTCGATGGAATCTCAGCGCCGCTTTGTGGCGGATGCCGCGCACGAGCTACGTTCGCCGCTGACA
GCCATGTCGCTGCAAGCAGAACGGCTCGCGGAAGCGGAAATGTCCAGCGTGGCGCGCGAACGGCTGACGGTTTTGCGCCA
AGGGATCGAGCGCGGCCGCAGCCTGCTCGATCAACTCTTGACCTTGGCCAAGGCACAGTCGGCCACCGACCTGCCGAAGT
CGCCTGTATCTGTCCAGAGCATCTACCGCCGCGTGCTGGAAGACCTCATGCCGCTGGCCGAGGCCAAGCACATCGACATC
GGTGTCGAAGGCGCGCTGGACGCCGAAGTGTGGGCAAGCGAGCTGGACATGATCGCTGTGGTCAAGAACCTAGTCGATAA
CGCCATCCGCTACACGCCAGAGGGAGGGCGTGTTGATCTTTCTGTGGGTGTTTCGGAAGGGAAGGTCGTACTACGTATTC
AGGACAGTGGGCCTGGCATTCCGTTGGCTGAACGGGATCGAGTGTTTGATCCCTTCTACCGCACGCTGGGGAGCGAGCAG
ATCGGCTCGGGTCTGGGACTATCCATTGTCCAGACGATTGCCAATCGCATCGGTGCTGAAATCCGCCTCGACTTCTCAGA
TCAAGAGAAGCAAACTGGCTTAAATGTTGCCGTTATCGCTCCCATGCGGTAG

Upstream 100 bases:

>100_bases
GCAATGCCGTCGAATATCTAATCCACGCACTGCGGCGCAAGCTCGGTGGCGAGGTCATCAAGAACGTCAGGGGGGTCGGA
TGGATGGTCTCAAAAGGCGC

Downstream 100 bases:

>100_bases
CGGTTTGAGAAACGCGGAGGCAGGCTAAATGGTTAATTCGGCGGGGTGGTTTTATTGGGCTTTGCTGTCCGCTATCCTTG
CGGCACTGACGGCTATTTTT

Product: periplasmic sensor signal transduction histidine kinase (Tn6048)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNESVQLKLSFTLSLAILVVAVVAGVFSFLSAFDEAHELQDDVLRQVAQLMDRQRLLPAVPTTDIRLKDVDEESRVIVQR
LGEVSPSTVGVDAGGVLPLPATLADGLHTLEVGGETFRVLVKTTASGERIAVAQESGFRNEIARDGALRTVMPFLILVPV
LLLIVADLVRKMFQPIAALSKEIDQRAEQELHPVEDRHLPVEVRPFVVAINRLLARVSQSMESQRRFVADAAHELRSPLT
AMSLQAERLAEAEMSSVARERLTVLRQGIERGRSLLDQLLTLAKAQSATDLPKSPVSVQSIYRRVLEDLMPLAEAKHIDI
GVEGALDAEVWASELDMIAVVKNLVDNAIRYTPEGGRVDLSVGVSEGKVVLRIQDSGPGIPLAERDRVFDPFYRTLGSEQ
IGSGLGLSIVQTIANRIGAEIRLDFSDQEKQTGLNVAVIAPMR

Sequences:

>Translated_443_residues
MNESVQLKLSFTLSLAILVVAVVAGVFSFLSAFDEAHELQDDVLRQVAQLMDRQRLLPAVPTTDIRLKDVDEESRVIVQR
LGEVSPSTVGVDAGGVLPLPATLADGLHTLEVGGETFRVLVKTTASGERIAVAQESGFRNEIARDGALRTVMPFLILVPV
LLLIVADLVRKMFQPIAALSKEIDQRAEQELHPVEDRHLPVEVRPFVVAINRLLARVSQSMESQRRFVADAAHELRSPLT
AMSLQAERLAEAEMSSVARERLTVLRQGIERGRSLLDQLLTLAKAQSATDLPKSPVSVQSIYRRVLEDLMPLAEAKHIDI
GVEGALDAEVWASELDMIAVVKNLVDNAIRYTPEGGRVDLSVGVSEGKVVLRIQDSGPGIPLAERDRVFDPFYRTLGSEQ
IGSGLGLSIVQTIANRIGAEIRLDFSDQEKQTGLNVAVIAPMR
>Mature_443_residues
MNESVQLKLSFTLSLAILVVAVVAGVFSFLSAFDEAHELQDDVLRQVAQLMDRQRLLPAVPTTDIRLKDVDEESRVIVQR
LGEVSPSTVGVDAGGVLPLPATLADGLHTLEVGGETFRVLVKTTASGERIAVAQESGFRNEIARDGALRTVMPFLILVPV
LLLIVADLVRKMFQPIAALSKEIDQRAEQELHPVEDRHLPVEVRPFVVAINRLLARVSQSMESQRRFVADAAHELRSPLT
AMSLQAERLAEAEMSSVARERLTVLRQGIERGRSLLDQLLTLAKAQSATDLPKSPVSVQSIYRRVLEDLMPLAEAKHIDI
GVEGALDAEVWASELDMIAVVKNLVDNAIRYTPEGGRVDLSVGVSEGKVVLRIQDSGPGIPLAERDRVFDPFYRTLGSEQ
IGSGLGLSIVQTIANRIGAEIRLDFSDQEKQTGLNVAVIAPMR

Specific function: Member of the two-component regulatory system rssA/rssB involved in regulation of swarming motility which has been shown to be inhibited by saturated fatty acids. RssA/rssB regulates cellular fatty acid composition, hemolysin production and cell surface t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789403, Length=455, Percent_Identity=29.6703296703297, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790551, Length=280, Percent_Identity=30.7142857142857, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788279, Length=323, Percent_Identity=24.4582043343653, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=30.9917355371901, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=277, Percent_Identity=29.6028880866426, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=294, Percent_Identity=26.8707482993197, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790346, Length=246, Percent_Identity=26.8292682926829, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082128, Length=288, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=276, Percent_Identity=25.3623188405797, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=29.2372881355932, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=27.3469387755102, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788393, Length=219, Percent_Identity=27.3972602739726, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789149, Length=268, Percent_Identity=25, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=212, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=25.4464285714286, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=210, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=28.5067873303167, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788713, Length=279, Percent_Identity=22.5806451612903, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48398; Mature: 48398

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNESVQLKLSFTLSLAILVVAVVAGVFSFLSAFDEAHELQDDVLRQVAQLMDRQRLLPAV
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTTDIRLKDVDEESRVIVQRLGEVSPSTVGVDAGGVLPLPATLADGLHTLEVGGETFRVL
CCCCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCEEEEE
VKTTASGERIAVAQESGFRNEIARDGALRTVMPFLILVPVLLLIVADLVRKMFQPIAALS
EEECCCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIDQRAEQELHPVEDRHLPVEVRPFVVAINRLLARVSQSMESQRRFVADAAHELRSPLT
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AMSLQAERLAEAEMSSVARERLTVLRQGIERGRSLLDQLLTLAKAQSATDLPKSPVSVQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
IYRRVLEDLMPLAEAKHIDIGVEGALDAEVWASELDMIAVVKNLVDNAIRYTPEGGRVDL
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEE
SVGVSEGKVVLRIQDSGPGIPLAERDRVFDPFYRTLGSEQIGSGLGLSIVQTIANRIGAE
EEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCE
IRLDFSDQEKQTGLNVAVIAPMR
EEECCCCCHHHCCCCEEEEECCC
>Mature Secondary Structure
MNESVQLKLSFTLSLAILVVAVVAGVFSFLSAFDEAHELQDDVLRQVAQLMDRQRLLPAV
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTTDIRLKDVDEESRVIVQRLGEVSPSTVGVDAGGVLPLPATLADGLHTLEVGGETFRVL
CCCCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCEEEEE
VKTTASGERIAVAQESGFRNEIARDGALRTVMPFLILVPVLLLIVADLVRKMFQPIAALS
EEECCCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIDQRAEQELHPVEDRHLPVEVRPFVVAINRLLARVSQSMESQRRFVADAAHELRSPLT
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AMSLQAERLAEAEMSSVARERLTVLRQGIERGRSLLDQLLTLAKAQSATDLPKSPVSVQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
IYRRVLEDLMPLAEAKHIDIGVEGALDAEVWASELDMIAVVKNLVDNAIRYTPEGGRVDL
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEE
SVGVSEGKVVLRIQDSGPGIPLAERDRVFDPFYRTLGSEQIGSGLGLSIVQTIANRIGAE
EEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCE
IRLDFSDQEKQTGLNVAVIAPMR
EEECCCCCHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA