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The map label for this gene is pip [H]

Identifier: 94312955

GI number: 94312955

Start: 596091

End: 597047

Strand: Direct

Name: pip [H]

Synonym: Rmet_4027

Alternate gene names: 94312955

Gene position: 596091-597047 (Clockwise)

Preceding gene: 94312953

Following gene: 94312956

Centisome position: 23.1

GC content: 63.85

Gene sequence:

>957_bases
ATGCCTGAACCGCGCACCCTTTATCCCGCTATCGAACCCTACGAGACCGGCACGCTCGACGTCGGTGATGGCCACGTGCT
GTATTACGAGCGCGTCGGCACGCGCGGTGCCAAACCGGCGGTGTTCCTGCACGGCGGGCCGGGTGGCGGCATCTCGCCAG
ATCATCGACGTCTGTTCGACCCCGCCCGCTACGACGTGCTGCTGTTCGACCAGCGCGGCTGCGGCCAGTCGACGCCTCAT
GCCGAACTGGAGGCCAATACCACCTGGCATCTGGTCGACGACATCGAGAAGCTGCGCGAGCGGATCGGCGTCGAGCGCTG
GCTTGTGTTCGGGGGATCATGGGGATCGACGCTGGCGCTTGCCTACGCGCAGACACATCCTCAGCGCGTGAGCGAACTGG
TGCTGCGTGGCGTCTATACGGTGTCGCGGGCCGAAGTCGACTGGTATTACCAGTTCGGCGTATCGGAGATGTTCCCCGAC
AAATGGGCGCGTTTTCAGGCGCCGGTGCCGGAGGCCGAGCGCGGCAACATGATGGCCGCCTATCGGAAGCTCCTGACCGG
CGACGACAAGGCAAAACAGGTCGAGGCCGCTCAGGCCTGGAGCGTCTGGGAAGGTGAGACGATCACGCTGCTACCGGACG
CCGGTATCAGCACCAAACATGCCGACGGACATTTCGCGCTGGCATTCGCGCGCATCGAAAACCACTACTTCACACACGGT
GCCTGGCTTGACGACGGGCAACTGCTGCGCGACGCCCATCGTCTGGCCGGCATCCCTGGCGTGATCGTGCATGGTCGCTA
CGACATGCCTTGTCCGGTGCGTTACGCCTATGCCCTGCATCAGGCCTGGCCGGACGCGGACTTTCATCTGATCGAAGGCG
CGGGCCATGCCTGGAGCGAACCCGGCATTCTCGACCAATTGATTGCCGCAACGGACCACTTCGCCGGTAAGGAATAA

Upstream 100 bases:

>100_bases
GCTCCACTGTAGGGACCAAGACTTAAACGAAACTTAAAGGCGCGTTGCACTGCACGATGGCGCTACACTTGGCTTCCCTC
AAGGCTTTCCGGGAGGCGAC

Downstream 100 bases:

>100_bases
GTCACACCGCCCGGGCGTGGCGATCGAACGATCGTGCGCCTATACTGGATTCTGCTGCGTTGCACAAAAATCACCTGTCG
CGGGTGTCATTGCCGCGAAT

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MPEPRTLYPAIEPYETGTLDVGDGHVLYYERVGTRGAKPAVFLHGGPGGGISPDHRRLFDPARYDVLLFDQRGCGQSTPH
AELEANTTWHLVDDIEKLRERIGVERWLVFGGSWGSTLALAYAQTHPQRVSELVLRGVYTVSRAEVDWYYQFGVSEMFPD
KWARFQAPVPEAERGNMMAAYRKLLTGDDKAKQVEAAQAWSVWEGETITLLPDAGISTKHADGHFALAFARIENHYFTHG
AWLDDGQLLRDAHRLAGIPGVIVHGRYDMPCPVRYAYALHQAWPDADFHLIEGAGHAWSEPGILDQLIAATDHFAGKE

Sequences:

>Translated_318_residues
MPEPRTLYPAIEPYETGTLDVGDGHVLYYERVGTRGAKPAVFLHGGPGGGISPDHRRLFDPARYDVLLFDQRGCGQSTPH
AELEANTTWHLVDDIEKLRERIGVERWLVFGGSWGSTLALAYAQTHPQRVSELVLRGVYTVSRAEVDWYYQFGVSEMFPD
KWARFQAPVPEAERGNMMAAYRKLLTGDDKAKQVEAAQAWSVWEGETITLLPDAGISTKHADGHFALAFARIENHYFTHG
AWLDDGQLLRDAHRLAGIPGVIVHGRYDMPCPVRYAYALHQAWPDADFHLIEGAGHAWSEPGILDQLIAATDHFAGKE
>Mature_317_residues
PEPRTLYPAIEPYETGTLDVGDGHVLYYERVGTRGAKPAVFLHGGPGGGISPDHRRLFDPARYDVLLFDQRGCGQSTPHA
ELEANTTWHLVDDIEKLRERIGVERWLVFGGSWGSTLALAYAQTHPQRVSELVLRGVYTVSRAEVDWYYQFGVSEMFPDK
WARFQAPVPEAERGNMMAAYRKLLTGDDKAKQVEAAQAWSVWEGETITLLPDAGISTKHADGHFALAFARIENHYFTHGA
WLDDGQLLRDAHRLAGIPGVIVHGRYDMPCPVRYAYALHQAWPDADFHLIEGAGHAWSEPGILDQLIAATDHFAGKE

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 35515; Mature: 35384

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPRTLYPAIEPYETGTLDVGDGHVLYYERVGTRGAKPAVFLHGGPGGGISPDHRRLFD
CCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHCC
PARYDVLLFDQRGCGQSTPHAELEANTTWHLVDDIEKLRERIGVERWLVFGGSWGSTLAL
CCCEEEEEEECCCCCCCCCCCEEECCCEEEHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
AYAQTHPQRVSELVLRGVYTVSRAEVDWYYQFGVSEMFPDKWARFQAPVPEAERGNMMAA
EHHHCCHHHHHHHHHHHHHHEEECCEEEEEECCCHHHCCHHHHHCCCCCCCCCCCCHHHH
YRKLLTGDDKAKQVEAAQAWSVWEGETITLLPDAGISTKHADGHFALAFARIENHYFTHG
HHHHHCCCCHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCCCCEEEEEEEECCCEEECC
AWLDDGQLLRDAHRLAGIPGVIVHGRYDMPCPVRYAYALHQAWPDADFHLIEGAGHAWSE
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCC
PGILDQLIAATDHFAGKE
CCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PEPRTLYPAIEPYETGTLDVGDGHVLYYERVGTRGAKPAVFLHGGPGGGISPDHRRLFD
CCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHCC
PARYDVLLFDQRGCGQSTPHAELEANTTWHLVDDIEKLRERIGVERWLVFGGSWGSTLAL
CCCEEEEEEECCCCCCCCCCCEEECCCEEEHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
AYAQTHPQRVSELVLRGVYTVSRAEVDWYYQFGVSEMFPDKWARFQAPVPEAERGNMMAA
EHHHCCHHHHHHHHHHHHHHEEECCEEEEEECCCHHHCCHHHHHCCCCCCCCCCCCHHHH
YRKLLTGDDKAKQVEAAQAWSVWEGETITLLPDAGISTKHADGHFALAFARIENHYFTHG
HHHHHCCCCHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCCCCEEEEEEEECCCEEECC
AWLDDGQLLRDAHRLAGIPGVIVHGRYDMPCPVRYAYALHQAWPDADFHLIEGAGHAWSE
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCC
PGILDQLIAATDHFAGKE
CCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]