| Definition | Cupriavidus metallidurans CH34 megaplasmid, complete sequence. |
|---|---|
| Accession | NC_007974 |
| Length | 2,580,084 |
Click here to switch to the map view.
The map label for this gene is lvr [H]
Identifier: 94312910
GI number: 94312910
Start: 548491
End: 549303
Strand: Direct
Name: lvr [H]
Synonym: Rmet_3982
Alternate gene names: 94312910
Gene position: 548491-549303 (Clockwise)
Preceding gene: 94312909
Following gene: 94312911
Centisome position: 21.26
GC content: 64.21
Gene sequence:
>813_bases ATGGAAGTTCGCAACAAGACCGTAATCGTGACCGGTGGTGGCACCGGTATTGGACGCGCCCTGGTGCTGGCGTTTGCCCG GGCCGGCGCACGCGGCATCGCCGTGGCGGATATTGACGAGGCCGGGGCGTCGCAGGTGGCTGCCGAGGCCGTGGCGGCCG CGCCAGGCTGCCAGATCTTCTCGCAACGCGTGGACGTCGCGAATGCCGAAGCCGTGCAGAAGCTGGTCGATACTGCCACG CAGCGTTTCGGTCAGGTGGACGTGTTCTGCTCGAACGCCGGCATCATCCTGCGCAAGGGCCTGGATGCCACCGCGGACGA ATGGCAGCGCATCTGGGAAATCAACGTCATGGCGCATATCCACGCGGCCAAGGCCGTGCTGCCGCAGATGCTCGAACGTG GCGATGGGTACTTCGTGAACACGGTTTCGGCTGCAGGTCTGCTCTCGCAGATCGGATCGGCGCCTTATGCCGTGACCAAG CACGCGGCGATCGGCTTTGCCGAATGGCTGTCGATCACCTACGGCGACCGCGGCATCAAGGTGAGTTGCATCTGCCCGCA GGGCGTGCAGACGAAGATGCTGTTCGGCGAGGGCGGCGAGCGCAAGGGCTTCCTGCAGGCCGGTTCGGTCACGGCCGAGC ACGTTGCCGAGAAGACGCTCGAAGGCGTTGCCAACGAGAGCTTCCTGATCCTGCCACACCCCGAGGTGTTGGAGTACTAC CGTCGCAAGGGGCAGGACTATGATCGGTGGCTGCGTGGCATGCGTCGGCTGCACGACCAAGTCACCAAGGAGTTCGGCAA CATCGTCGTTTAA
Upstream 100 bases:
>100_bases CTTGGCCCCCGCATTCGCGAGTTGGCGGACGCGCTCGCGGCAAGACTCTGGCGGCCAGGCTGATCTTATTCAACGCAGAC ATCGAACCTTGGAGGCATGC
Downstream 100 bases:
>100_bases CGCAGGGCCCCGCGCGGGGCCTATACCATATCCAGAGGCGAAAAGCCCGGAAAATCAGGAGACAGATCCATGTTTGTACG AATGTTCGCGCGTCGCCAGG
Product: putative short-chain dehydrogenase/reductase
Products: NA
Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]
Number of amino acids: Translated: 270; Mature: 270
Protein sequence:
>270_residues MEVRNKTVIVTGGGTGIGRALVLAFARAGARGIAVADIDEAGASQVAAEAVAAAPGCQIFSQRVDVANAEAVQKLVDTAT QRFGQVDVFCSNAGIILRKGLDATADEWQRIWEINVMAHIHAAKAVLPQMLERGDGYFVNTVSAAGLLSQIGSAPYAVTK HAAIGFAEWLSITYGDRGIKVSCICPQGVQTKMLFGEGGERKGFLQAGSVTAEHVAEKTLEGVANESFLILPHPEVLEYY RRKGQDYDRWLRGMRRLHDQVTKEFGNIVV
Sequences:
>Translated_270_residues MEVRNKTVIVTGGGTGIGRALVLAFARAGARGIAVADIDEAGASQVAAEAVAAAPGCQIFSQRVDVANAEAVQKLVDTAT QRFGQVDVFCSNAGIILRKGLDATADEWQRIWEINVMAHIHAAKAVLPQMLERGDGYFVNTVSAAGLLSQIGSAPYAVTK HAAIGFAEWLSITYGDRGIKVSCICPQGVQTKMLFGEGGERKGFLQAGSVTAEHVAEKTLEGVANESFLILPHPEVLEYY RRKGQDYDRWLRGMRRLHDQVTKEFGNIVV >Mature_270_residues MEVRNKTVIVTGGGTGIGRALVLAFARAGARGIAVADIDEAGASQVAAEAVAAAPGCQIFSQRVDVANAEAVQKLVDTAT QRFGQVDVFCSNAGIILRKGLDATADEWQRIWEINVMAHIHAAKAVLPQMLERGDGYFVNTVSAAGLLSQIGSAPYAVTK HAAIGFAEWLSITYGDRGIKVSCICPQGVQTKMLFGEGGERKGFLQAGSVTAEHVAEKTLEGVANESFLILPHPEVLEYY RRKGQDYDRWLRGMRRLHDQVTKEFGNIVV
Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40807363, Length=242, Percent_Identity=29.7520661157025, Blast_Score=105, Evalue=4e-23, Organism=Homo sapiens, GI142976729, Length=239, Percent_Identity=28.8702928870293, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI210032110, Length=188, Percent_Identity=32.9787234042553, Blast_Score=100, Evalue=3e-21, Organism=Homo sapiens, GI310128830, Length=242, Percent_Identity=28.5123966942149, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI310115468, Length=242, Percent_Identity=28.5123966942149, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI32483357, Length=189, Percent_Identity=32.8042328042328, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI25282469, Length=221, Percent_Identity=29.4117647058824, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=31.8681318681319, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=27.9187817258883, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI4504505, Length=186, Percent_Identity=29.5698924731183, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI31542939, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI7706318, Length=198, Percent_Identity=28.2828282828283, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI210032112, Length=120, Percent_Identity=34.1666666666667, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI31543615, Length=212, Percent_Identity=28.3018867924528, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI66933014, Length=246, Percent_Identity=28.8617886178862, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI59889578, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI7657478, Length=271, Percent_Identity=27.6752767527675, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI157739938, Length=253, Percent_Identity=24.5059288537549, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI4758504, Length=206, Percent_Identity=27.1844660194175, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI223718074, Length=182, Percent_Identity=29.6703296703297, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI7705925, Length=190, Percent_Identity=29.4736842105263, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI126723750, Length=192, Percent_Identity=28.6458333333333, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI40254992, Length=191, Percent_Identity=28.7958115183246, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=30, Blast_Score=65, Evalue=9e-11, Organism=Escherichia coli, GI87082100, Length=190, Percent_Identity=33.1578947368421, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1787905, Length=194, Percent_Identity=30.9278350515464, Blast_Score=88, Evalue=7e-19, Organism=Escherichia coli, GI1787335, Length=194, Percent_Identity=29.8969072164948, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI87082160, Length=187, Percent_Identity=29.9465240641711, Blast_Score=85, Evalue=5e-18, Organism=Escherichia coli, GI2367365, Length=187, Percent_Identity=30.4812834224599, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1787820, Length=218, Percent_Identity=24.3119266055046, Blast_Score=68, Evalue=6e-13, Organism=Escherichia coli, GI1789208, Length=190, Percent_Identity=24.7368421052632, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1788459, Length=194, Percent_Identity=27.319587628866, Blast_Score=65, Evalue=4e-12, Organism=Escherichia coli, GI1789378, Length=212, Percent_Identity=25.4716981132075, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI1790717, Length=189, Percent_Identity=26.984126984127, Blast_Score=63, Evalue=2e-11, Organism=Escherichia coli, GI1787526, Length=196, Percent_Identity=28.5714285714286, Blast_Score=61, Evalue=7e-11, Organism=Caenorhabditis elegans, GI193203115, Length=235, Percent_Identity=30.6382978723404, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17508895, Length=236, Percent_Identity=30.5084745762712, Blast_Score=105, Evalue=3e-23, Organism=Caenorhabditis elegans, GI193203117, Length=236, Percent_Identity=30.0847457627119, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17564282, Length=240, Percent_Identity=28.3333333333333, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17567345, Length=229, Percent_Identity=27.0742358078603, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI71994604, Length=195, Percent_Identity=29.7435897435897, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI71994600, Length=191, Percent_Identity=28.2722513089005, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17562908, Length=199, Percent_Identity=29.1457286432161, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17560676, Length=215, Percent_Identity=26.046511627907, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17561402, Length=139, Percent_Identity=30.9352517985612, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17568967, Length=187, Percent_Identity=31.0160427807487, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17555706, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17538480, Length=194, Percent_Identity=27.319587628866, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562904, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17544670, Length=196, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI193204405, Length=205, Percent_Identity=25.3658536585366, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17560150, Length=194, Percent_Identity=26.2886597938144, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17562990, Length=196, Percent_Identity=27.5510204081633, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI25147288, Length=188, Percent_Identity=27.1276595744681, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17563726, Length=197, Percent_Identity=26.3959390862944, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17551412, Length=192, Percent_Identity=25.5208333333333, Blast_Score=64, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17562906, Length=201, Percent_Identity=28.3582089552239, Blast_Score=64, Evalue=9e-11, Organism=Caenorhabditis elegans, GI72000259, Length=201, Percent_Identity=28.3582089552239, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=199, Percent_Identity=28.1407035175879, Blast_Score=82, Evalue=8e-17, Organism=Saccharomyces cerevisiae, GI6323882, Length=193, Percent_Identity=28.4974093264249, Blast_Score=71, Evalue=1e-13, Organism=Drosophila melanogaster, GI24581726, Length=238, Percent_Identity=32.3529411764706, Blast_Score=99, Evalue=4e-21, Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=30.5882352941176, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI21358495, Length=229, Percent_Identity=27.0742358078603, Blast_Score=90, Evalue=2e-18, Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=31.2820512820513, Blast_Score=89, Evalue=4e-18, Organism=Drosophila melanogaster, GI281364892, Length=170, Percent_Identity=32.9411764705882, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI24639444, Length=200, Percent_Identity=33.5, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI221510726, Length=213, Percent_Identity=27.6995305164319, Blast_Score=81, Evalue=7e-16, Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=31.8407960199005, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24644339, Length=222, Percent_Identity=27.9279279279279, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI18859837, Length=210, Percent_Identity=27.6190476190476, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI24649181, Length=237, Percent_Identity=26.1603375527426, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI17737361, Length=217, Percent_Identity=27.1889400921659, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI21357041, Length=192, Percent_Identity=26.0416666666667, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI28571526, Length=184, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24580925, Length=199, Percent_Identity=29.6482412060301, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24643142, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI221331216, Length=199, Percent_Identity=29.1457286432161, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24665247, Length=199, Percent_Identity=29.1457286432161, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI21356301, Length=242, Percent_Identity=24.3801652892562, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI221331218, Length=199, Percent_Identity=30.1507537688442, Blast_Score=68, Evalue=8e-12, Organism=Drosophila melanogaster, GI24665243, Length=199, Percent_Identity=30.1507537688442, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI45554248, Length=220, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI24640117, Length=220, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.-.-.- [C]
Molecular weight: Translated: 29029; Mature: 29029
Theoretical pI: Translated: 7.11; Mature: 7.11
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEVRNKTVIVTGGGTGIGRALVLAFARAGARGIAVADIDEAGASQVAAEAVAAAPGCQIF CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHH SQRVDVANAEAVQKLVDTATQRFGQVDVFCSNAGIILRKGLDATADEWQRIWEINVMAHI HHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHH HAAKAVLPQMLERGDGYFVNTVSAAGLLSQIGSAPYAVTKHAAIGFAEWLSITYGDRGIK HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEE VSCICPQGVQTKMLFGEGGERKGFLQAGSVTAEHVAEKTLEGVANESFLILPHPEVLEYY EEEECCCCCCEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHH RRKGQDYDRWLRGMRRLHDQVTKEFGNIVV HHCCCCHHHHHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure MEVRNKTVIVTGGGTGIGRALVLAFARAGARGIAVADIDEAGASQVAAEAVAAAPGCQIF CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHH SQRVDVANAEAVQKLVDTATQRFGQVDVFCSNAGIILRKGLDATADEWQRIWEINVMAHI HHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHH HAAKAVLPQMLERGDGYFVNTVSAAGLLSQIGSAPYAVTKHAAIGFAEWLSITYGDRGIK HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEE VSCICPQGVQTKMLFGEGGERKGFLQAGSVTAEHVAEKTLEGVANESFLILPHPEVLEYY EEEECCCCCCEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHH RRKGQDYDRWLRGMRRLHDQVTKEFGNIVV HHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11388460; 10508066 [H]