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The map label for this gene is pcaI [H]

Identifier: 94312599

GI number: 94312599

Start: 204966

End: 205631

Strand: Direct

Name: pcaI [H]

Synonym: Rmet_3667

Alternate gene names: 94312599

Gene position: 204966-205631 (Clockwise)

Preceding gene: 94312598

Following gene: 94312600

Centisome position: 7.94

GC content: 65.47

Gene sequence:

>666_bases
GTGGAATCGGCAATGGCCGACATCCACGATGGCGCCACGATCCTGATTGGCGGTTTCGGCCTGGCCGGCATGCCGGCGGA
GCTGATCGACGCGCTGATCGCCCAGGGCGCGCGCGACCTGACCATCGTCAACAACAACGCCGGCAATGGCGACACGGGCC
TGGCAGCGCTGCTCAAGGCCAAGCGTGTCCGCAAGATCATTTGCTCGTTCCCGCGCCAGGCGGACTCCTACGTATTCGAC
TCGCTGTTCCATGCCGGTGAAATCGAGCTGGAACTCGTGCCCCAGGGCAATCTGGCCGAGCGCATCCGCGCGGCCGGCGC
CGGCATCGGCGGTTTCTTCACGCGCACGGCCTACGGCACGCCGCTGGCCGAAGGCAAGGAAACGCGCATCATCGACGGCC
AGGGCTATGTGTTCGAAAAGCCGATCCACGCTGACTTCGCGCTGATCAAGGCCGAGACCGCCGACCGCTGGGGCAATCTG
GTCTATCGCAAGACCGCCCGCAACTTCGGCCCGATCATGGCCATGGCTGCCAAGTGCCCGATCGTGCAGGTCAGCAACGT
AGTGGAACTGGGCGAACTCGACCCCGAGCACATCATCACGCCGGGTCTGTTCGTCAAGCGCGTGGTCAAGGTTGCAAGCG
CCGCCAAGCCGGCCAGCGCGGCCTGA

Upstream 100 bases:

>100_bases
GAGACAGCTTTGCGTGCCGCGCCCCTTTGCGGCCGGTCCCGGTATGCGCGCCGGACCCTTCCATACTGGAACGCAAGTGA
TCAACAAGCTATATGACTCG

Downstream 100 bases:

>100_bases
TCCGAATCGAGCGAAGAAGGAGAAACACATGCAACGCCTGACCCGCGACCAAATGGCCGCCCGCGTGGCCAAAGACATTC
CGGACGGTGCCGTGGTGAAC

Product: 3-oxoacid CoA-transferase subunit A

Products: NA

Alternate protein names: Beta-ketoadipate:succinyl-CoA transferase subunit A [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MESAMADIHDGATILIGGFGLAGMPAELIDALIAQGARDLTIVNNNAGNGDTGLAALLKAKRVRKIICSFPRQADSYVFD
SLFHAGEIELELVPQGNLAERIRAAGAGIGGFFTRTAYGTPLAEGKETRIIDGQGYVFEKPIHADFALIKAETADRWGNL
VYRKTARNFGPIMAMAAKCPIVQVSNVVELGELDPEHIITPGLFVKRVVKVASAAKPASAA

Sequences:

>Translated_221_residues
MESAMADIHDGATILIGGFGLAGMPAELIDALIAQGARDLTIVNNNAGNGDTGLAALLKAKRVRKIICSFPRQADSYVFD
SLFHAGEIELELVPQGNLAERIRAAGAGIGGFFTRTAYGTPLAEGKETRIIDGQGYVFEKPIHADFALIKAETADRWGNL
VYRKTARNFGPIMAMAAKCPIVQVSNVVELGELDPEHIITPGLFVKRVVKVASAAKPASAA
>Mature_221_residues
MESAMADIHDGATILIGGFGLAGMPAELIDALIAQGARDLTIVNNNAGNGDTGLAALLKAKRVRKIICSFPRQADSYVFD
SLFHAGEIELELVPQGNLAERIRAAGAGIGGFFTRTAYGTPLAEGKETRIIDGQGYVFEKPIHADFALIKAETADRWGNL
VYRKTARNFGPIMAMAAKCPIVQVSNVVELGELDPEHIITPGLFVKRVVKVASAAKPASAA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=225, Percent_Identity=43.5555555555556, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI11545841, Length=222, Percent_Identity=45.4954954954955, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1788551, Length=213, Percent_Identity=42.2535211267606, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17531517, Length=236, Percent_Identity=42.3728813559322, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI21358325, Length=225, Percent_Identity=43.1111111111111, Blast_Score=180, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24655794, Length=225, Percent_Identity=43.1111111111111, Blast_Score=180, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.6 [H]

Molecular weight: Translated: 23417; Mature: 23417

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESAMADIHDGATILIGGFGLAGMPAELIDALIAQGARDLTIVNNNAGNGDTGLAALLKA
CCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
KRVRKIICSFPRQADSYVFDSLFHAGEIELELVPQGNLAERIRAAGAGIGGFFTRTAYGT
HHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHCCCC
PLAEGKETRIIDGQGYVFEKPIHADFALIKAETADRWGNLVYRKTARNFGPIMAMAAKCP
CCCCCCCEEEECCCCCEEECCCCCCEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHCCC
IVQVSNVVELGELDPEHIITPGLFVKRVVKVASAAKPASAA
EEEHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MESAMADIHDGATILIGGFGLAGMPAELIDALIAQGARDLTIVNNNAGNGDTGLAALLKA
CCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
KRVRKIICSFPRQADSYVFDSLFHAGEIELELVPQGNLAERIRAAGAGIGGFFTRTAYGT
HHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHCCCC
PLAEGKETRIIDGQGYVFEKPIHADFALIKAETADRWGNLVYRKTARNFGPIMAMAAKCP
CCCCCCCEEEECCCCCEEECCCCCCEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHCCC
IVQVSNVVELGELDPEHIITPGLFVKRVVKVASAAKPASAA
EEEHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1624453; 6780551 [H]