Click here to switch to the map view.

The map label for this gene is pbpC [H]

Identifier: 94312460

GI number: 94312460

Start: 3821572

End: 3823752

Strand: Reverse

Name: pbpC [H]

Synonym: Rmet_3529

Alternate gene names: 94312460

Gene position: 3823752-3821572 (Counterclockwise)

Preceding gene: 94312461

Following gene: 94312459

Centisome position: 97.34

GC content: 67.72

Gene sequence:

>2181_bases
GTGGCGCTGCTGTTATTCGCGGGCGCCGCGCAGGCCGTGCCCACGTTTCGAGAGGTTCGCGCCAACTGGCGCAGCGCCGA
TATCGTGGTGGTGGATCGCCACGGCGAAACCGTGGCCCGCGTGCGTGACGACTTCCGCGCGCGGCGCGGCGACTGGGTGA
CGCTGACCGATACATCGCCGGCCTTGCGCACCGCCATCGTGCTATCCGAGGACAAGCGCTTCTACGCGCATAGCGGCGTC
GACTGGCAGGGCGTGGCGGCTGCCGCATGGGCCAATCTGTGGAACACCCGCACACGTGGCGCTTCGACGCTGACGATGCA
GCTCGCCGGGTTGCTCGACGAGGATTTGCGCGCGGGCCGTGGTCGCAGCATCGGGCAGAAAGTCGAGCAGGCGGTCAGCG
CGGCGTCACTCGAGCGTGGCTGGAGCAAGGACCAGATCCTCGAGGCATACCTGAATCTGGTGCCGTTCCGTGGCGAACTG
GTGGGGCTCTCCGCGATGTCGCAGACGCTGTTCGGCAAGGTGCCGAGCGGGCTCGACGCGCGTGAGTCGGCAGTGGCCGT
CGCGCTCGTGCGCGCGCCCAATGCCTCGGCCGCGCAGGTGTCCAAGCGTGCGTGCGGCATTCTGCGCGACATGGGCCAGC
CGCGCGAATGCGAGGGGCTCGACGGTTTCACCGCGCTGGTGCTGGTGAAGTCAGCCAGTGCGCAGACCGGCCCGCAGGCC
CGCAACGCCAATCTCGCGTCGCATCTGGCTCGTGCCGTTATCGCGCAGGCGCGAGAGTCCGGCAAGCCGGTGCCACCGCG
CATCACTTCCACCCTCGATGCCGGGCTGCAACGCGTGGCAGTGACCAGCCTCGATCGCCATCTGCGCGAGCTGGCGGGGC
GCAATGTCGAGGACGGCGCCGTGGTGGTGATCGACAACGCCAGCGGTGACGTGCTGGCCTATGTCGGCTCTTCAGGCATC
CTGTCCGCGGCGTCACAGGTCGATCACGCGGCGGCGCTGCGGCAGGCCGGTTCGACGTTGAAGCCATTCCTCTATGAGCA
GGCCATCGAGGAACGCAGGCTGACCGCGGCATCGCTGCTTGACGATCGTCCGGTGAATCTTCCCACTGGCGGTGGCCTCT
ACATTCCGCAGAACTATGACCATCGCTACGCAGGCTGGGTCAGTCTGCGCGCCGCGCTGGGTTCGTCACTGAACGTGCCG
GCGGTGCGCACGCTGGTGATGGTGACGCCGCACCGCTTTCATCAACGGCTGGTGGCGCTCGGCCTGCCGCTGACGCAATC
AGGCGATTACTACGGCTATAGCCTTGCGTTGGGCAGTGCGGATGTGTCGCTGCTGTCGCTGACCAATGCCTATCGCAGCT
TCGCCAACCAGGGCGCGTATGCGCCATCGCGGATGACGCTGAATGCCGCCGTGCCGTCGAAGCAGAACGTGATGATGCCG
GCGGCGACGTTCGTGATCGGGGATGTGCTGTCTGATCGCCACGCGCGGGCGCGTACGTTCGGGCTCGACAGTCCGCTGAC
CACGCGTTTCTGGACGGCAGTGAAAACCGGCACGAGCAAGGACATGCGCGACAACTGGTGCGTCGGCTGGTCGGAGCGCT
ACACAGTGGGCGTGTGGGTCGGCAATGCCAGCGGCGCGAGCATGCACGACGTATCGGGAGTGTCTGGCGCGGCGCCCGTA
TGGCACGAGGTCATGGAAGCGCTGCATCAGCGCACGCCGAGCCGCGCGCCGGCGATGCCATCAGGCGTCGAACGTGTGGC
ATTGACGTTCGACGACGAACTCGAGCCAGCACGGCAGGAGGTATTCCTGAGCGGCACCGGGATGCGGCGCGTCAGTGTGG
GCACGACGGAGCAGGGCAACACGATGCCGGCTATCGCCAGCCCGGCCGACGGCACGATCTTCGCACTCGATCCCGATATT
CCTCCGGCCGCGCAGCGGATCTGGTTTCATGCCGATGGGCTGACGGGTCAGACCGCGCGCGCGGTGAGCTGGCGCATGGA
CGGCAAGCCGCTCGGCAAGGGCGGGCAGGTTGCCTGGTTGCCATGGCCGGGCCGGCATCGCGTGCAACTGGTCGATGCGG
CGGGGAAGGTAGTGCACGAGATCGGCATCGAGGTGCGCGGCGCGGGCGTTCGTGAGACGGCGGCGCCACGGAAGACGCCT
GCGGGGCCGGTCCGGCAATAG

Upstream 100 bases:

>100_bases
TACGCCATCGCACAGGTGCTGCTGGTGGCGGGCGTGGTGGCCGAGCGGGACGCGTGAGAGGTTGGGGTTCGTGCTGAAGC
GTGGTGGGATTCATGTTGCT

Downstream 100 bases:

>100_bases
CCGCACGACGCGCGTATCATCGCGGGGTTCGCTGAAGTACCTATCCTGAGGAGCTTCCAGATGACCACACCGCGCAAGCT
GGGCCGTAACGGCCCCGAGG

Product: multifunctional transglycosylase/transpeptidase/penicillin binding protein

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 726; Mature: 725

Protein sequence:

>726_residues
MALLLFAGAAQAVPTFREVRANWRSADIVVVDRHGETVARVRDDFRARRGDWVTLTDTSPALRTAIVLSEDKRFYAHSGV
DWQGVAAAAWANLWNTRTRGASTLTMQLAGLLDEDLRAGRGRSIGQKVEQAVSAASLERGWSKDQILEAYLNLVPFRGEL
VGLSAMSQTLFGKVPSGLDARESAVAVALVRAPNASAAQVSKRACGILRDMGQPRECEGLDGFTALVLVKSASAQTGPQA
RNANLASHLARAVIAQARESGKPVPPRITSTLDAGLQRVAVTSLDRHLRELAGRNVEDGAVVVIDNASGDVLAYVGSSGI
LSAASQVDHAAALRQAGSTLKPFLYEQAIEERRLTAASLLDDRPVNLPTGGGLYIPQNYDHRYAGWVSLRAALGSSLNVP
AVRTLVMVTPHRFHQRLVALGLPLTQSGDYYGYSLALGSADVSLLSLTNAYRSFANQGAYAPSRMTLNAAVPSKQNVMMP
AATFVIGDVLSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCVGWSERYTVGVWVGNASGASMHDVSGVSGAAPV
WHEVMEALHQRTPSRAPAMPSGVERVALTFDDELEPARQEVFLSGTGMRRVSVGTTEQGNTMPAIASPADGTIFALDPDI
PPAAQRIWFHADGLTGQTARAVSWRMDGKPLGKGGQVAWLPWPGRHRVQLVDAAGKVVHEIGIEVRGAGVRETAAPRKTP
AGPVRQ

Sequences:

>Translated_726_residues
MALLLFAGAAQAVPTFREVRANWRSADIVVVDRHGETVARVRDDFRARRGDWVTLTDTSPALRTAIVLSEDKRFYAHSGV
DWQGVAAAAWANLWNTRTRGASTLTMQLAGLLDEDLRAGRGRSIGQKVEQAVSAASLERGWSKDQILEAYLNLVPFRGEL
VGLSAMSQTLFGKVPSGLDARESAVAVALVRAPNASAAQVSKRACGILRDMGQPRECEGLDGFTALVLVKSASAQTGPQA
RNANLASHLARAVIAQARESGKPVPPRITSTLDAGLQRVAVTSLDRHLRELAGRNVEDGAVVVIDNASGDVLAYVGSSGI
LSAASQVDHAAALRQAGSTLKPFLYEQAIEERRLTAASLLDDRPVNLPTGGGLYIPQNYDHRYAGWVSLRAALGSSLNVP
AVRTLVMVTPHRFHQRLVALGLPLTQSGDYYGYSLALGSADVSLLSLTNAYRSFANQGAYAPSRMTLNAAVPSKQNVMMP
AATFVIGDVLSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCVGWSERYTVGVWVGNASGASMHDVSGVSGAAPV
WHEVMEALHQRTPSRAPAMPSGVERVALTFDDELEPARQEVFLSGTGMRRVSVGTTEQGNTMPAIASPADGTIFALDPDI
PPAAQRIWFHADGLTGQTARAVSWRMDGKPLGKGGQVAWLPWPGRHRVQLVDAAGKVVHEIGIEVRGAGVRETAAPRKTP
AGPVRQ
>Mature_725_residues
ALLLFAGAAQAVPTFREVRANWRSADIVVVDRHGETVARVRDDFRARRGDWVTLTDTSPALRTAIVLSEDKRFYAHSGVD
WQGVAAAAWANLWNTRTRGASTLTMQLAGLLDEDLRAGRGRSIGQKVEQAVSAASLERGWSKDQILEAYLNLVPFRGELV
GLSAMSQTLFGKVPSGLDARESAVAVALVRAPNASAAQVSKRACGILRDMGQPRECEGLDGFTALVLVKSASAQTGPQAR
NANLASHLARAVIAQARESGKPVPPRITSTLDAGLQRVAVTSLDRHLRELAGRNVEDGAVVVIDNASGDVLAYVGSSGIL
SAASQVDHAAALRQAGSTLKPFLYEQAIEERRLTAASLLDDRPVNLPTGGGLYIPQNYDHRYAGWVSLRAALGSSLNVPA
VRTLVMVTPHRFHQRLVALGLPLTQSGDYYGYSLALGSADVSLLSLTNAYRSFANQGAYAPSRMTLNAAVPSKQNVMMPA
ATFVIGDVLSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCVGWSERYTVGVWVGNASGASMHDVSGVSGAAPVW
HEVMEALHQRTPSRAPAMPSGVERVALTFDDELEPARQEVFLSGTGMRRVSVGTTEQGNTMPAIASPADGTIFALDPDIP
PAAQRIWFHADGLTGQTARAVSWRMDGKPLGKGGQVAWLPWPGRHRVQLVDAAGKVVHEIGIEVRGAGVRETAAPRKTPA
GPVRQ

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=554, Percent_Identity=32.4909747292419, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1786343, Length=595, Percent_Identity=25.0420168067227, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082258, Length=183, Percent_Identity=32.2404371584699, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1789601, Length=192, Percent_Identity=32.8125, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 77693; Mature: 77562

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLLFAGAAQAVPTFREVRANWRSADIVVVDRHGETVARVRDDFRARRGDWVTLTDTSP
CEEEEEECCHHHCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCC
ALRTAIVLSEDKRFYAHSGVDWQGVAAAAWANLWNTRTRGASTLTMQLAGLLDEDLRAGR
CCEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
GRSIGQKVEQAVSAASLERGWSKDQILEAYLNLVPFRGELVGLSAMSQTLFGKVPSGLDA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCC
RESAVAVALVRAPNASAAQVSKRACGILRDMGQPRECEGLDGFTALVLVKSASAQTGPQA
HHCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
RNANLASHLARAVIAQARESGKPVPPRITSTLDAGLQRVAVTSLDRHLRELAGRNVEDGA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VVVIDNASGDVLAYVGSSGILSAASQVDHAAALRQAGSTLKPFLYEQAIEERRLTAASLL
EEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DDRPVNLPTGGGLYIPQNYDHRYAGWVSLRAALGSSLNVPAVRTLVMVTPHRFHQRLVAL
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCHHEEEEEECCHHHHHHHHHH
GLPLTQSGDYYGYSLALGSADVSLLSLTNAYRSFANQGAYAPSRMTLNAAVPSKQNVMMP
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEECH
AATFVIGDVLSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCVGWSERYTVGVWV
HHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEEE
GNASGASMHDVSGVSGAAPVWHEVMEALHQRTPSRAPAMPSGVERVALTFDDELEPARQE
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHE
VFLSGTGMRRVSVGTTEQGNTMPAIASPADGTIFALDPDIPPAAQRIWFHADGLTGQTAR
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHEEEEEECCCCCCCCC
AVSWRMDGKPLGKGGQVAWLPWPGRHRVQLVDAAGKVVHEIGIEVRGAGVRETAAPRKTP
EEEEEECCCCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHCCEEECCCCCCCCCCCCCC
AGPVRQ
CCCCCC
>Mature Secondary Structure 
ALLLFAGAAQAVPTFREVRANWRSADIVVVDRHGETVARVRDDFRARRGDWVTLTDTSP
EEEEEECCHHHCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCC
ALRTAIVLSEDKRFYAHSGVDWQGVAAAAWANLWNTRTRGASTLTMQLAGLLDEDLRAGR
CCEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
GRSIGQKVEQAVSAASLERGWSKDQILEAYLNLVPFRGELVGLSAMSQTLFGKVPSGLDA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCC
RESAVAVALVRAPNASAAQVSKRACGILRDMGQPRECEGLDGFTALVLVKSASAQTGPQA
HHCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
RNANLASHLARAVIAQARESGKPVPPRITSTLDAGLQRVAVTSLDRHLRELAGRNVEDGA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VVVIDNASGDVLAYVGSSGILSAASQVDHAAALRQAGSTLKPFLYEQAIEERRLTAASLL
EEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DDRPVNLPTGGGLYIPQNYDHRYAGWVSLRAALGSSLNVPAVRTLVMVTPHRFHQRLVAL
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCHHEEEEEECCHHHHHHHHHH
GLPLTQSGDYYGYSLALGSADVSLLSLTNAYRSFANQGAYAPSRMTLNAAVPSKQNVMMP
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEECH
AATFVIGDVLSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCVGWSERYTVGVWV
HHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEEE
GNASGASMHDVSGVSGAAPVWHEVMEALHQRTPSRAPAMPSGVERVALTFDDELEPARQE
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHE
VFLSGTGMRRVSVGTTEQGNTMPAIASPADGTIFALDPDIPPAAQRIWFHADGLTGQTAR
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHEEEEEECCCCCCCCC
AVSWRMDGKPLGKGGQVAWLPWPGRHRVQLVDAAGKVVHEIGIEVRGAGVRETAAPRKTP
EEEEEECCCCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHCCEEECCCCCCCCCCCCCC
AGPVRQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]