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The map label for this gene is betA2 [H]

Identifier: 94312452

GI number: 94312452

Start: 3812356

End: 3814023

Strand: Reverse

Name: betA2 [H]

Synonym: Rmet_3521

Alternate gene names: 94312452

Gene position: 3814023-3812356 (Counterclockwise)

Preceding gene: 94312453

Following gene: 94312451

Centisome position: 97.1

GC content: 64.93

Gene sequence:

>1668_bases
ATGGAGACGTTCGACTACATCATCGTGGGTGCGGGTTCGGCGGGTTGTGTGCTGGCCAACCGGCTGACGCAGGACAGCGA
TGTCAACGTGCTGCTGCTCGAAGCGGGCGGCAAGGACGACTATCACTGGATTCATATTCCAGTCGGCTATCTCTATTGCA
TCGGCAATCCGCGCACCGACTGGCTCTATCGCACCGTGGCCGAAGCCGGCCTGAACGGCCGCTCGCTCGGCTATCCGCGT
GGCCGTGTGCTGGGCGGGTCATCGTCGATCAACGGCATGATCTACATGCGTGGCCAACGCGAGGACTACGACGACTGGGC
ACGCATCACTGGCGATGACGGCTGGCGCTGGGACAACGTGCTGCCGTTCTTCAAACGCAGCGAGGACCATCACCGTGGCG
CGAACGAGTTCCACGGGGCCGGCGGCGAATGGCGCGTGGAAGCGCAGCGGCTGCGCTGGGAAATCCTCGAGTGCTTCATC
GAGGCCGCCGAGCAGGCTGGCATTCCCCGTACCGACGATTTCAATCGTGGCGACAACTTCGGCGTGGGATATTTCGAGGT
CAACCAGCGTCGCGGCATTCGATGGAATACGTCGAAGGCGTTCCTGCGCCGTGCGGCGGAACGGCCCAACCTGACCATCG
TCACCGGCGCGCAGGTCAGCGCGTTGACGTTCGATAGCCCGGACGGCCTGCGCTGCACCGGCGTGCAATACCTGGGCGGT
GGCCAGCCCCACGAGGCGCGCGCGAAGCAGGAGGTGATACTTGCTGCCGGCGCGATTGGCTCGCCGCAGTTGCTGGAGCT
CGCGGGCATCGGCCAGCCAGACCGGCTGCAGGCGCTGGGCATCCGCGTGCGCCACGCGCTGCGCGGTGTGGGCGAGAATC
TGCAGGATCACCTGCAGTTGCGTTCGGTGGTCAAGGTCCAGGGCGTGCGCACGCTCAACACGCAGGCGGCGCATTGGTGG
GGCAAGCTTGGCATCGGCCTGCAATACGCCTTCAACCAGAGCGGGCCGATGAGCATGGCGCCGTCGCAACTCGGCGCGTT
CGCGCGCAGCGATCCGGAGCAGCCTCGCGCCAATATCGAATACCACGTGCAGCCGCTGTCGCTGGACAAGTTCGGCGATC
CATTGCACAGCTTCAATGCCTTCACGGCGAGCGCCTGCAATCTGCGCCCCACGTCGCGCGGCAGCGTGCATATCGAAGAC
ACCGATTTCCGTCGCGCGCCATTGATCGCGCCGAACTATCTGTCCACCGAGGAAGACCGCAAGGTCGCCGCCGATTCGAT
CCGCCTGACGCGGCGCATCGTGTCTTCGCCGGCATTGGCGCGCTACAAGCCGCAGGAGTATCTGCCCGGCGCAACATTCC
AGACCGACGAGGAACTGGCGGAAGCTGCTGGCGCGATCGGCACGACAATTTTCCATCCCGTCGGCACTTGCCGCATGGGT
GGCGCGGACGATGCCGACGCCGTCGTCGACAACCGCCTTCGCGTGCGGGGCATCAGTGGTCTGCGCGTGGTCGATGCGTC
GGTGATGCCGTTGATCACGTCCGGCAATACGAACTCGCCGACGATCATGATTGCCGAGCGCGCCAGCGATATGATCCGCG
CGGATCGCAAGGCAAGCGCTGGTAATCCGGACATCGTCACGGCGCCGTCACCAGCAGTCACTGCATAG

Upstream 100 bases:

>100_bases
AGACTCCGGCAAAGCACTGACGGCGGAAGCACCCCGAGTCGTGCGATGATTTCGGGCATTCCAGCAGTAACTGCCGGTGT
CTGAATAGGATCGCAGGGAA

Downstream 100 bases:

>100_bases
TCAGTATGCGGTGCGACACGCACCGCATGAAGACCTGCTGATTACATCATCTTCACGCAGTTTCGACGTCTCTCGCAGAC
GTCGGTACGCGCTCGCACGT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
METFDYIIVGAGSAGCVLANRLTQDSDVNVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTDWLYRTVAEAGLNGRSLGYPR
GRVLGGSSSINGMIYMRGQREDYDDWARITGDDGWRWDNVLPFFKRSEDHHRGANEFHGAGGEWRVEAQRLRWEILECFI
EAAEQAGIPRTDDFNRGDNFGVGYFEVNQRRGIRWNTSKAFLRRAAERPNLTIVTGAQVSALTFDSPDGLRCTGVQYLGG
GQPHEARAKQEVILAAGAIGSPQLLELAGIGQPDRLQALGIRVRHALRGVGENLQDHLQLRSVVKVQGVRTLNTQAAHWW
GKLGIGLQYAFNQSGPMSMAPSQLGAFARSDPEQPRANIEYHVQPLSLDKFGDPLHSFNAFTASACNLRPTSRGSVHIED
TDFRRAPLIAPNYLSTEEDRKVAADSIRLTRRIVSSPALARYKPQEYLPGATFQTDEELAEAAGAIGTTIFHPVGTCRMG
GADDADAVVDNRLRVRGISGLRVVDASVMPLITSGNTNSPTIMIAERASDMIRADRKASAGNPDIVTAPSPAVTA

Sequences:

>Translated_555_residues
METFDYIIVGAGSAGCVLANRLTQDSDVNVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTDWLYRTVAEAGLNGRSLGYPR
GRVLGGSSSINGMIYMRGQREDYDDWARITGDDGWRWDNVLPFFKRSEDHHRGANEFHGAGGEWRVEAQRLRWEILECFI
EAAEQAGIPRTDDFNRGDNFGVGYFEVNQRRGIRWNTSKAFLRRAAERPNLTIVTGAQVSALTFDSPDGLRCTGVQYLGG
GQPHEARAKQEVILAAGAIGSPQLLELAGIGQPDRLQALGIRVRHALRGVGENLQDHLQLRSVVKVQGVRTLNTQAAHWW
GKLGIGLQYAFNQSGPMSMAPSQLGAFARSDPEQPRANIEYHVQPLSLDKFGDPLHSFNAFTASACNLRPTSRGSVHIED
TDFRRAPLIAPNYLSTEEDRKVAADSIRLTRRIVSSPALARYKPQEYLPGATFQTDEELAEAAGAIGTTIFHPVGTCRMG
GADDADAVVDNRLRVRGISGLRVVDASVMPLITSGNTNSPTIMIAERASDMIRADRKASAGNPDIVTAPSPAVTA
>Mature_555_residues
METFDYIIVGAGSAGCVLANRLTQDSDVNVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTDWLYRTVAEAGLNGRSLGYPR
GRVLGGSSSINGMIYMRGQREDYDDWARITGDDGWRWDNVLPFFKRSEDHHRGANEFHGAGGEWRVEAQRLRWEILECFI
EAAEQAGIPRTDDFNRGDNFGVGYFEVNQRRGIRWNTSKAFLRRAAERPNLTIVTGAQVSALTFDSPDGLRCTGVQYLGG
GQPHEARAKQEVILAAGAIGSPQLLELAGIGQPDRLQALGIRVRHALRGVGENLQDHLQLRSVVKVQGVRTLNTQAAHWW
GKLGIGLQYAFNQSGPMSMAPSQLGAFARSDPEQPRANIEYHVQPLSLDKFGDPLHSFNAFTASACNLRPTSRGSVHIED
TDFRRAPLIAPNYLSTEEDRKVAADSIRLTRRIVSSPALARYKPQEYLPGATFQTDEELAEAAGAIGTTIFHPVGTCRMG
GADDADAVVDNRLRVRGISGLRVVDASVMPLITSGNTNSPTIMIAERASDMIRADRKASAGNPDIVTAPSPAVTA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=540, Percent_Identity=41.1111111111111, Blast_Score=392, Evalue=1e-109,
Organism=Escherichia coli, GI1786503, Length=537, Percent_Identity=41.5270018621974, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17532301, Length=550, Percent_Identity=34.3636363636364, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24642055, Length=573, Percent_Identity=36.1256544502618, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24642042, Length=568, Percent_Identity=35.0352112676056, Blast_Score=311, Evalue=1e-84,
Organism=Drosophila melanogaster, GI45551458, Length=571, Percent_Identity=34.3257443082312, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI45549471, Length=571, Percent_Identity=34.3257443082312, Blast_Score=304, Evalue=8e-83,
Organism=Drosophila melanogaster, GI24642048, Length=578, Percent_Identity=34.2560553633218, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24642059, Length=578, Percent_Identity=34.6020761245675, Blast_Score=291, Evalue=8e-79,
Organism=Drosophila melanogaster, GI24650267, Length=569, Percent_Identity=34.2706502636204, Blast_Score=276, Evalue=4e-74,
Organism=Drosophila melanogaster, GI17137792, Length=565, Percent_Identity=32.5663716814159, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI18859995, Length=564, Percent_Identity=33.6879432624113, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24642051, Length=578, Percent_Identity=32.0069204152249, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24642039, Length=571, Percent_Identity=32.2241681260946, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI18859993, Length=571, Percent_Identity=30.6479859894921, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24642037, Length=572, Percent_Identity=31.2937062937063, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24642035, Length=307, Percent_Identity=38.4364820846906, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24645930, Length=574, Percent_Identity=30.4878048780488, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24642057, Length=590, Percent_Identity=28.9830508474576, Blast_Score=172, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 60734; Mature: 60734

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00623 GMC_OXRED_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METFDYIIVGAGSAGCVLANRLTQDSDVNVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTD
CCCEEEEEEECCCCCCHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEEEEEECCCCCCH
WLYRTVAEAGLNGRSLGYPRGRVLGGSSSINGMIYMRGQREDYDDWARITGDDGWRWDNV
HHHHHHHHCCCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCHHEECCCCCCCCCCC
LPFFKRSEDHHRGANEFHGAGGEWRVEAQRLRWEILECFIEAAEQAGIPRTDDFNRGDNF
CHHHHCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GVGYFEVNQRRGIRWNTSKAFLRRAAERPNLTIVTGAQVSALTFDSPDGLRCTGVQYLGG
CEEEEEECCCCCCEECCHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCCEEEEEEECCC
GQPHEARAKQEVILAAGAIGSPQLLELAGIGQPDRLQALGIRVRHALRGVGENLQDHLQL
CCCHHHHHHHEEEEEECCCCCCCHHHEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
RSVVKVQGVRTLNTQAAHWWGKLGIGLQYAFNQSGPMSMAPSQLGAFARSDPEQPRANIE
HHHHHHCCCEECCCCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCE
YHVQPLSLDKFGDPLHSFNAFTASACNLRPTSRGSVHIEDTDFRRAPLIAPNYLSTEEDR
EEEEEECHHHCCCCHHHCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHH
KVAADSIRLTRRIVSSPALARYKPQEYLPGATFQTDEELAEAAGAIGTTIFHPVGTCRMG
HHHHHHHHHHHHHHCCCCHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
GADDADAVVDNRLRVRGISGLRVVDASVMPLITSGNTNSPTIMIAERASDMIRADRKASA
CCCCHHHHHCCCEEEECCCCEEEECCCEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCC
GNPDIVTAPSPAVTA
CCCCEEECCCCCCCC
>Mature Secondary Structure
METFDYIIVGAGSAGCVLANRLTQDSDVNVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTD
CCCEEEEEEECCCCCCHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEEEEEECCCCCCH
WLYRTVAEAGLNGRSLGYPRGRVLGGSSSINGMIYMRGQREDYDDWARITGDDGWRWDNV
HHHHHHHHCCCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCHHEECCCCCCCCCCC
LPFFKRSEDHHRGANEFHGAGGEWRVEAQRLRWEILECFIEAAEQAGIPRTDDFNRGDNF
CHHHHCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GVGYFEVNQRRGIRWNTSKAFLRRAAERPNLTIVTGAQVSALTFDSPDGLRCTGVQYLGG
CEEEEEECCCCCCEECCHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCCEEEEEEECCC
GQPHEARAKQEVILAAGAIGSPQLLELAGIGQPDRLQALGIRVRHALRGVGENLQDHLQL
CCCHHHHHHHEEEEEECCCCCCCHHHEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
RSVVKVQGVRTLNTQAAHWWGKLGIGLQYAFNQSGPMSMAPSQLGAFARSDPEQPRANIE
HHHHHHCCCEECCCCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCE
YHVQPLSLDKFGDPLHSFNAFTASACNLRPTSRGSVHIEDTDFRRAPLIAPNYLSTEEDR
EEEEEECHHHCCCCHHHCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHH
KVAADSIRLTRRIVSSPALARYKPQEYLPGATFQTDEELAEAAGAIGTTIFHPVGTCRMG
HHHHHHHHHHHHHHCCCCHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
GADDADAVVDNRLRVRGISGLRVVDASVMPLITSGNTNSPTIMIAERASDMIRADRKASA
CCCCHHHHHCCCEEEECCCCEEEECCCEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCC
GNPDIVTAPSPAVTA
CCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA