| Definition | Cupriavidus metallidurans CH34 chromosome, complete genome. |
|---|---|
| Accession | NC_007973 |
| Length | 3,928,089 |
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The map label for this gene is fabG [H]
Identifier: 94312251
GI number: 94312251
Start: 3583250
End: 3584038
Strand: Reverse
Name: fabG [H]
Synonym: Rmet_3320
Alternate gene names: 94312251
Gene position: 3584038-3583250 (Counterclockwise)
Preceding gene: 94312252
Following gene: 94312250
Centisome position: 91.24
GC content: 67.43
Gene sequence:
>789_bases ATGCAAGGCTTGCAGGACAAGGTAGCCATCGTCACAGGCGGCGCCACACTGATCGGCGCGGGGGTTGCCCGCGCATTTGC CGAAGCGGGCACCCGCGTGGCGATTCTCGATATCGACGCCGCCGGCGGCGAGCGCGTGGCGGCGTTGTTGGGACCGATGG CCATGTTCGTGCCCACCGACATCACCCAGGACGATCAGGTCCGCAGCGCGGTGGCGCAGGTGGTCAGCCGATTCGGCGGC GTGGATTTTCTGGTCAACCTGGCCTGCACCTATCTGGATGATGGCTTTCGCTCTTCCCGCGCTGACTGGCTGGCGGCACT CGATGTGAACGTGGTGTCCGGCGTCATGCTGGCGCAGGCCGTGCACCCGCACATGCGCACGCGTGGCGGCGGTGCCATCG TCAATTTCACCAGCATCTCGGCGCGGGTCGCGCAGACCGGGCGCTGGCTCTATCCAGTATCCAAGGCCGCCATGGCGCAA CTGACGCGCAGCATGGCGATGGACCTCGCGCCGGACCGCATCCGCGTCAATGCCGTCTCACCGGGATGGACCTGGTGCCG GCTGATGGACGAAGTCAGCGGTGGCAACCGCGCGCGCACCGATGCCGTGGCCGCGCCCTTCCACATGCTCGGCCGCGTTG GCGAGCCGGACGAGGTCGCACAGGTGGTCCTGTTTCTCTGCTCGGATCACGCCAGCTTCGTCACCGGAGCGGACTACGCG GTGGATGGCGGATACGCCGCCATGGGCCCTGAACAGAACGTCCCGGCCATCGGCAAGCTGGCTGGCTGA
Upstream 100 bases:
>100_bases GCGAAGGCAAGTAACGCCCCCGGCCCACGTTGCGGAACGGGCGGAACGCGGGGACGGCACGTCAGAGGCCGCCCCGCACA TCAACCGAGGAGACACCATC
Downstream 100 bases:
>100_bases ATCGCCTTCCGAAAACAGATCACGGAGACAACCATGAGCCAACGTATTGCCATCGTCGGTGCCGGCCAGTCCGGATTACA GATGGCCCTGGGGCTGCAGG
Product: short chain dehydrogenase
Products: NA
Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]
Number of amino acids: Translated: 262; Mature: 262
Protein sequence:
>262_residues MQGLQDKVAIVTGGATLIGAGVARAFAEAGTRVAILDIDAAGGERVAALLGPMAMFVPTDITQDDQVRSAVAQVVSRFGG VDFLVNLACTYLDDGFRSSRADWLAALDVNVVSGVMLAQAVHPHMRTRGGGAIVNFTSISARVAQTGRWLYPVSKAAMAQ LTRSMAMDLAPDRIRVNAVSPGWTWCRLMDEVSGGNRARTDAVAAPFHMLGRVGEPDEVAQVVLFLCSDHASFVTGADYA VDGGYAAMGPEQNVPAIGKLAG
Sequences:
>Translated_262_residues MQGLQDKVAIVTGGATLIGAGVARAFAEAGTRVAILDIDAAGGERVAALLGPMAMFVPTDITQDDQVRSAVAQVVSRFGG VDFLVNLACTYLDDGFRSSRADWLAALDVNVVSGVMLAQAVHPHMRTRGGGAIVNFTSISARVAQTGRWLYPVSKAAMAQ LTRSMAMDLAPDRIRVNAVSPGWTWCRLMDEVSGGNRARTDAVAAPFHMLGRVGEPDEVAQVVLFLCSDHASFVTGADYA VDGGYAAMGPEQNVPAIGKLAG >Mature_262_residues MQGLQDKVAIVTGGATLIGAGVARAFAEAGTRVAILDIDAAGGERVAALLGPMAMFVPTDITQDDQVRSAVAQVVSRFGG VDFLVNLACTYLDDGFRSSRADWLAALDVNVVSGVMLAQAVHPHMRTRGGGAIVNFTSISARVAQTGRWLYPVSKAAMAQ LTRSMAMDLAPDRIRVNAVSPGWTWCRLMDEVSGGNRARTDAVAAPFHMLGRVGEPDEVAQVVLFLCSDHASFVTGADYA VDGGYAAMGPEQNVPAIGKLAG
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=4e-26, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=32, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=34.2857142857143, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=30.4166666666667, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI19923817, Length=269, Percent_Identity=30.4832713754647, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI4758504, Length=249, Percent_Identity=30.9236947791165, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=28.0632411067194, Blast_Score=91, Evalue=2e-18, Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=30.241935483871, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=30.3149606299213, Blast_Score=89, Evalue=6e-18, Organism=Homo sapiens, GI66933014, Length=253, Percent_Identity=29.6442687747036, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=30.1204819277108, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=34.2391304347826, Blast_Score=81, Evalue=9e-16, Organism=Homo sapiens, GI83715985, Length=249, Percent_Identity=29.3172690763052, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI31542939, Length=201, Percent_Identity=29.3532338308458, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=31.8681318681319, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=25.2, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI224922801, Length=172, Percent_Identity=30.8139534883721, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI302344755, Length=110, Percent_Identity=38.1818181818182, Blast_Score=66, Evalue=4e-11, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=35.2459016393443, Blast_Score=114, Evalue=1e-26, Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=31.9066147859922, Blast_Score=101, Evalue=4e-23, Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=28.5123966942149, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=30.8, Blast_Score=94, Evalue=7e-21, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=29.2, Blast_Score=92, Evalue=5e-20, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=29.4354838709677, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1786812, Length=241, Percent_Identity=33.195020746888, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1788459, Length=257, Percent_Identity=29.5719844357977, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=30.6772908366534, Blast_Score=89, Evalue=2e-19, Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=28.8, Blast_Score=87, Evalue=9e-19, Organism=Escherichia coli, GI2367365, Length=252, Percent_Identity=28.968253968254, Blast_Score=69, Evalue=3e-13, Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=32.9457364341085, Blast_Score=115, Evalue=3e-26, Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=33.4615384615385, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=32.5842696629214, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI71994604, Length=257, Percent_Identity=30.7392996108949, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17538480, Length=258, Percent_Identity=30.6201550387597, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=28.8973384030418, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=29.4573643410853, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=30.5882352941176, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=30.4878048780488, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=29.3893129770992, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=28.5185185185185, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=30.5343511450382, Blast_Score=94, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=28.5140562248996, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=29.9242424242424, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17544670, Length=260, Percent_Identity=29.6153846153846, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=29.5880149812734, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI193204405, Length=257, Percent_Identity=29.9610894941634, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=28.4132841328413, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=27.9693486590038, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=28.735632183908, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=31.1284046692607, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=28.996282527881, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=27.6515151515151, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17563726, Length=275, Percent_Identity=26.9090909090909, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=27.6119402985075, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=29.2307692307692, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17536651, Length=264, Percent_Identity=29.9242424242424, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=30.1204819277108, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17567345, Length=172, Percent_Identity=28.4883720930233, Blast_Score=68, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6324126, Length=267, Percent_Identity=25.4681647940075, Blast_Score=72, Evalue=6e-14, Organism=Saccharomyces cerevisiae, GI6322861, Length=255, Percent_Identity=23.1372549019608, Blast_Score=72, Evalue=7e-14, Organism=Saccharomyces cerevisiae, GI6323882, Length=197, Percent_Identity=27.4111675126904, Blast_Score=67, Evalue=3e-12, Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=35.6862745098039, Blast_Score=128, Evalue=3e-30, Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=36.4341085271318, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI28571526, Length=261, Percent_Identity=33.7164750957854, Blast_Score=110, Evalue=7e-25, Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=30.5882352941176, Blast_Score=100, Evalue=9e-22, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=31.496062992126, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24644337, Length=254, Percent_Identity=34.251968503937, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI17737361, Length=262, Percent_Identity=28.6259541984733, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=28.7449392712551, Blast_Score=87, Evalue=2e-17, Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=29.8804780876494, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI21358495, Length=239, Percent_Identity=27.6150627615063, Blast_Score=72, Evalue=4e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011284 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.100 [H]
Molecular weight: Translated: 27407; Mature: 27407
Theoretical pI: Translated: 5.65; Mature: 5.65
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 4.2 %Met (Translated Protein) 5.3 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 4.2 %Met (Mature Protein) 5.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQGLQDKVAIVTGGATLIGAGVARAFAEAGTRVAILDIDAAGGERVAALLGPMAMFVPTD CCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCC ITQDDQVRSAVAQVVSRFGGVDFLVNLACTYLDDGFRSSRADWLAALDVNVVSGVMLAQA CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH VHPHMRTRGGGAIVNFTSISARVAQTGRWLYPVSKAAMAQLTRSMAMDLAPDRIRVNAVS HHHHHHCCCCCEEEEEHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEC PGWTWCRLMDEVSGGNRARTDAVAAPFHMLGRVGEPDEVAQVVLFLCSDHASFVTGADYA CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEECCCEE VDGGYAAMGPEQNVPAIGKLAG ECCCEECCCCCCCCCCCCCCCC >Mature Secondary Structure MQGLQDKVAIVTGGATLIGAGVARAFAEAGTRVAILDIDAAGGERVAALLGPMAMFVPTD CCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCC ITQDDQVRSAVAQVVSRFGGVDFLVNLACTYLDDGFRSSRADWLAALDVNVVSGVMLAQA CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH VHPHMRTRGGGAIVNFTSISARVAQTGRWLYPVSKAAMAQLTRSMAMDLAPDRIRVNAVS HHHHHHCCCCCEEEEEHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEC PGWTWCRLMDEVSGGNRARTDAVAAPFHMLGRVGEPDEVAQVVLFLCSDHASFVTGADYA CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEECCCEE VDGGYAAMGPEQNVPAIGKLAG ECCCEECCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 10360571 [H]