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The map label for this gene is ptxD [H]

Identifier: 94311924

GI number: 94311924

Start: 3249942

End: 3250925

Strand: Reverse

Name: ptxD [H]

Synonym: Rmet_2992

Alternate gene names: 94311924

Gene position: 3250925-3249942 (Counterclockwise)

Preceding gene: 94311925

Following gene: 94311923

Centisome position: 82.76

GC content: 57.42

Gene sequence:

>984_bases
ATGAATCATCGGAAAATCGTCGTAACGCAGCCAGTTCATGAAGAGGTTCTAAGGAAGCTCCAGGCTGAGGGTGAGGTCAT
CATGAATCCAGGGCCTGACCCCTGGAGCCCCAGCCAGCTCAGGGAGTACCTCGTGGATGCTGATGCCATGATGGCCTTCA
TGACAGACAGTGTGACCAAAGAGTCGCTGCTGAACGCTCCCAGGCTCAAGACCATCTCCTGTGCACTCAAGGGGTACGAC
AACTTCGACCTGAGGGCTTGCGCACAAGCCGGGGTGAGCGTCACCTTTGTTCCTGACCTCCTCACAGAGCCCACAGCCGA
GCTGGCCATCGGATTGGCTATTGCTGCTGGCAGGAACGTGCTTCAGGGTGACGCCGCTACAAGAGCAGGCTACTCTGGGT
GGAGGCCAGCTCTATACGGAACCGGGCTTCATGGGTCGGTGGCCAGCGTGATCGGTCTCGGAAAAGTTGGGCAGGCCATA
TTGGCGCGACTCGCGGGCTTTGGCTGCGCGCGGCTGCTTGGTGTAGACCCAAGTGTGCGTCTAGATCAGGTCGAACTGGT
CACGCTTGATGAGGCTGTCAGCACATCGGACTATGTGTTCCTGGCAGTGCCTCTTGTTAGCGATACGCGCCACCTGGTTG
ACTCCAGGATGCTTCAACTATCGAAAAAGGGCCAGATCCTTGTAAACGTGGGTAGGGGGTCTGTGGTCGACGAAAGGGCG
GTTGTCGATGCCTTGGCGAATGAGCAACTTGGCGCGTACGCCGCTGACGTCTATGAGATGGAAGATTGGCTACTTCCAGA
CAGACCTCGCGAAATTCATCCGGGATTGACCAACAACGCCAGAACAGTACTCACTCCCCACATCGGCTCGGCTGTGAGAC
GCGTACGGTTCGAAATTGAAATGCGGGCTGCTGAGAACCTAGTCCGCTCACTCAGGGGCGAGAGTTTGAGTGATGTTGCT
GTCGAGGCCAGCGCGGCAGCATAG

Upstream 100 bases:

>100_bases
ATGACGAGGTCTCAGCCATCCTTCTGTCGATTCTTGCCTGTGTCCTCGTGGTTGACAGCATTGGATCGATGCTGCGAAAG
CGTCTCAAGTAAATCGAAAA

Downstream 100 bases:

>100_bases
GTATGGTTGCTCGGCGGTTTGCACGCCAGCTGAAATGGGCGCGGCTTCAGAGCCTATGTCCTATGGCTGGGTGCAACCTG
CCCGTGTGATGCCATCCTGC

Product: phosphonate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent phosphite dehydrogenase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNHRKIVVTQPVHEEVLRKLQAEGEVIMNPGPDPWSPSQLREYLVDADAMMAFMTDSVTKESLLNAPRLKTISCALKGYD
NFDLRACAQAGVSVTFVPDLLTEPTAELAIGLAIAAGRNVLQGDAATRAGYSGWRPALYGTGLHGSVASVIGLGKVGQAI
LARLAGFGCARLLGVDPSVRLDQVELVTLDEAVSTSDYVFLAVPLVSDTRHLVDSRMLQLSKKGQILVNVGRGSVVDERA
VVDALANEQLGAYAADVYEMEDWLLPDRPREIHPGLTNNARTVLTPHIGSAVRRVRFEIEMRAAENLVRSLRGESLSDVA
VEASAAA

Sequences:

>Translated_327_residues
MNHRKIVVTQPVHEEVLRKLQAEGEVIMNPGPDPWSPSQLREYLVDADAMMAFMTDSVTKESLLNAPRLKTISCALKGYD
NFDLRACAQAGVSVTFVPDLLTEPTAELAIGLAIAAGRNVLQGDAATRAGYSGWRPALYGTGLHGSVASVIGLGKVGQAI
LARLAGFGCARLLGVDPSVRLDQVELVTLDEAVSTSDYVFLAVPLVSDTRHLVDSRMLQLSKKGQILVNVGRGSVVDERA
VVDALANEQLGAYAADVYEMEDWLLPDRPREIHPGLTNNARTVLTPHIGSAVRRVRFEIEMRAAENLVRSLRGESLSDVA
VEASAAA
>Mature_327_residues
MNHRKIVVTQPVHEEVLRKLQAEGEVIMNPGPDPWSPSQLREYLVDADAMMAFMTDSVTKESLLNAPRLKTISCALKGYD
NFDLRACAQAGVSVTFVPDLLTEPTAELAIGLAIAAGRNVLQGDAATRAGYSGWRPALYGTGLHGSVASVIGLGKVGQAI
LARLAGFGCARLLGVDPSVRLDQVELVTLDEAVSTSDYVFLAVPLVSDTRHLVDSRMLQLSKKGQILVNVGRGSVVDERA
VVDALANEQLGAYAADVYEMEDWLLPDRPREIHPGLTNNARTVLTPHIGSAVRRVRFEIEMRAAENLVRSLRGESLSDVA
VEASAAA

Specific function: Catalyzes phosphite (phosphonate) oxidation [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=319, Percent_Identity=32.9153605015674, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI23308577, Length=324, Percent_Identity=26.8518518518519, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI145580578, Length=304, Percent_Identity=27.6315789473684, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4557499, Length=304, Percent_Identity=27.6315789473684, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI61743967, Length=295, Percent_Identity=27.4576271186441, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4557497, Length=295, Percent_Identity=27.4576271186441, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI145580575, Length=292, Percent_Identity=28.0821917808219, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI87082289, Length=318, Percent_Identity=28.6163522012579, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787645, Length=235, Percent_Identity=34.0425531914894, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1789279, Length=320, Percent_Identity=28.4375, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=31.0861423220974, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=320, Percent_Identity=28.75, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=301, Percent_Identity=25.5813953488372, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=30.5439330543933, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=290, Percent_Identity=26.2068965517241, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=292, Percent_Identity=26.027397260274, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=24.4648318042813, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=305, Percent_Identity=24.9180327868852, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571528, Length=324, Percent_Identity=30.8641975308642, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24585514, Length=325, Percent_Identity=29.2307692307692, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574282, Length=325, Percent_Identity=29.2307692307692, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45552429, Length=325, Percent_Identity=29.2307692307692, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574284, Length=325, Percent_Identity=29.2307692307692, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45551003, Length=325, Percent_Identity=29.2307692307692, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI19921140, Length=324, Percent_Identity=28.0864197530864, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28574286, Length=320, Percent_Identity=27.1875, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=27.2373540856031, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646446, Length=297, Percent_Identity=27.6094276094276, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646448, Length=297, Percent_Identity=27.6094276094276, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646452, Length=297, Percent_Identity=27.6094276094276, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646450, Length=297, Percent_Identity=27.6094276094276, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI62472511, Length=298, Percent_Identity=27.5167785234899, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.20.1.1 [H]

Molecular weight: Translated: 35163; Mature: 35163

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHRKIVVTQPVHEEVLRKLQAEGEVIMNPGPDPWSPSQLREYLVDADAMMAFMTDSVTK
CCCCEEEEECCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ESLLNAPRLKTISCALKGYDNFDLRACAQAGVSVTFVPDLLTEPTAELAIGLAIAAGRNV
HHHHCCCCCEEEEEEECCCCCCCHHHHHHCCCEEEECCHHHCCCHHHHHHHHHHHCCCCC
LQGDAATRAGYSGWRPALYGTGLHGSVASVIGLGKVGQAILARLAGFGCARLLGVDPSVR
CCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCE
LDQVELVTLDEAVSTSDYVFLAVPLVSDTRHLVDSRMLQLSKKGQILVNVGRGSVVDERA
ECEEEEEEEHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
VVDALANEQLGAYAADVYEMEDWLLPDRPREIHPGLTNNARTVLTPHIGSAVRRVRFEIE
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHH
MRAAENLVRSLRGESLSDVAVEASAAA
HHHHHHHHHHHCCCCCHHHHEECCCCC
>Mature Secondary Structure
MNHRKIVVTQPVHEEVLRKLQAEGEVIMNPGPDPWSPSQLREYLVDADAMMAFMTDSVTK
CCCCEEEEECCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ESLLNAPRLKTISCALKGYDNFDLRACAQAGVSVTFVPDLLTEPTAELAIGLAIAAGRNV
HHHHCCCCCEEEEEEECCCCCCCHHHHHHCCCEEEECCHHHCCCHHHHHHHHHHHCCCCC
LQGDAATRAGYSGWRPALYGTGLHGSVASVIGLGKVGQAILARLAGFGCARLLGVDPSVR
CCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCE
LDQVELVTLDEAVSTSDYVFLAVPLVSDTRHLVDSRMLQLSKKGQILVNVGRGSVVDERA
ECEEEEEEEHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
VVDALANEQLGAYAADVYEMEDWLLPDRPREIHPGLTNNARTVLTPHIGSAVRRVRFEIE
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHH
MRAAENLVRSLRGESLSDVAVEASAAA
HHHHHHHHHHHCCCCCHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9791102; 11278981 [H]